scholarly journals Use of Angong Niuhuang in Treating Central Nervous System Diseases and Related Research

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yu Guo ◽  
Shaohua Yan ◽  
Lipeng Xu ◽  
Gexin Zhu ◽  
Xiaotong Yu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chinese Medicine ◽  
Viral Encephalitis ◽  
Current Knowledge ◽  
Pharmacological Effects ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Cns Diseases ◽  
Related Research

In Chinese medicine-based therapeutics, Angong Niuhuang pill (ANP) is one of the three most effective formulas for febrile diseases, and it is also used to treat other diseases. This paper reviews current knowledge regarding the clinical and pharmacological effects of ANP for treating different central nervous system (CNS) diseases to confirm its validity and efficacy. These diseases are like centric fever, coma, stroke, and viral encephalitis. This review reveals that various diseases could be treated using the same agent, which is one of the most important principles of traditional Chinese medicine (TCM). According to the “Same Treatment for Different Diseases” principle, ANP might be efficacious in other CNS diseases.

Roles of glia-derived extracellular vesicles in central nervous system diseases: an update

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Hao Sun ◽  
Xiaojuan Su ◽  
Shiping Li ◽  
Dezhi Mu ◽  
Yi Qu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nucleic Acids ◽  
Extracellular Vesicles ◽  
Extracellular Space ◽  
Cell Communication ◽  
Heterogeneous Group ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Cns Diseases

Abstract Extracellular vesicles (EVs) are a heterogeneous group of cell-derived membranous vesicles secreted by various cells in the extracellular space. Accumulating evidence shows that EVs regulate cell-to-cell communication and signaling in the pathological processes of various diseases by carrying proteins, lipids, and nucleic acids to recipient cells. Glia-derived EVs act as a double-edged sword in the pathogenesis of central nervous system (CNS) diseases. They may be vectors for the spread of diseases or act as effective clearance systems to protect tissues. In this review, we summarize recent studies on glia-derived EVs with a focus on their relationships with CNS diseases.

scholarly journals Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Qingyun Tan ◽  
Yuying Fang ◽  
Qiong Gu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Coenzyme Q ◽  
Lipid Peroxide ◽  
Regulatory Mechanisms ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Intracellular Iron ◽  
Cns Diseases ◽  
Dependent Pathway

Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.

scholarly journals The role of gut microbiota in the pathogenesis of neuropsychiatric and neurodegenerative diseases

2019 ◽  
Vol 73 ◽  
pp. 865-886
Author(s):  
Aleksandra Szewczyk ◽  
Apolonia Witecka ◽  
Anna Kiersztan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Current Knowledge ◽  
Autism Spectrum ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Brain Functions ◽  
Number Of Microorganisms ◽  
The Central Nervous System

According to current knowledge, the number of microorganisms living in our body slightly exceeds the number of our own cells, and most of them occupy the large intestine. New methods for analyzing microorganisms residing in our intestine (intestinal microbiota) enable a better understanding of their metabolic, protective and structural functions as well as complex interactions with the host. The development of microbiota is dynamic, and its composition may change during our lifetime. Many factors can affect the composition of microbiota, such as diet, stress, age, genetic factors and antibiotic therapy. Microbiota-gut-brain communication is bi-directional and is mediated via neuronal, immunological and humoral pathways. This article focuses on gut-brain axis elements, such as the vagus nerve, hypothalamic-pituitary-adrenal axis (HPA), cytokines, neurotransmitters, hormones and intestinal peptides, allowing microbiota to contact with the central nervous system. Moreover, this article shows the mechanisms by which microbiota affects the brain functions related to our behavior, mood and cognitive processes. In addition, the role of microbiota composition disorders in the pathogenesis of central nervous system diseases (such as depression, autism spectrum disorder, schizophrenia, multiple sclerosis, Parkinson’s disease and Alzheimer’s disease) is discussed. This article also focuses on the results from studies in which probiotics have been used as potential therapeutic agents in the treatment of gastrointestinal disorders and also alleviating the symptoms of the central nervous system diseases.

Dimephosphone — vasoactive drug for normalization of nervous system function

1993 ◽  
Vol 74 (1) ◽  
pp. 8-12
Author(s):  
R. Kh. Khafizyaiiova ◽  
I. A. Studentsova ◽  
V. I. Danilov ◽  
I. S. Mokrinskaya ◽  
R. A. Garaev ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Experimental Study ◽  
Nervous System ◽  
Cerebral Circulation ◽  
Vasoactive Drug ◽  
System Function ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Clinical Tests ◽  
Nervous System Function

An experimental study of dimephpsphone, using different models of the disorders of cerebrum and cerebral circulation functions, reveals cerebroprotcctive properties and normalizing type of the effect on the regulating mechanisms of cerebral circulation. Clinical tests indicate the efficacy of the drug in different central nervous system diseases in neurological and neurosurgical clinics.

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