scholarly journals Capillary-Zone Electrophoretic Analyses of the Proteins and Amino Acid Components in Cerebrospinal Fluid of Central Nervous System Diseases.

1993 ◽  
Vol 16 (10) ◽  
pp. 949-952 ◽  
Author(s):  
Atsushi HIRAOKA ◽  
Isao MIURA ◽  
Munekazu HATTORI ◽  
Itaru TOMINAGA ◽  
Sachiko MACHIDA
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Amino Acid ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Capillary Zone

High-resolution peptide mapping of cerebrospinal fluid: a novel concept for diagnosis and research in central nervous system diseases

2002 ◽  
Vol 782 (1-2) ◽  
pp. 353-361 ◽  
Author(s):  
Gabriele Heine ◽  
Hans-Dieter Zucht ◽  
Martin U Schuhmann ◽  
Katharina Bürger ◽  
Michael Jürgens ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
High Resolution ◽  
Peptide Mapping ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Novel Concept

scholarly journals Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Per Kristian Eide ◽  
Lars Magnus Valnes ◽  
Erika Kristina Lindstrøm ◽  
Kent-Andre Mardal ◽  
Geir Ringstad
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Phase Contrast ◽  
Flow Volume ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Csf Flow ◽  
Phase Contrast Mri

Abstract Background Several central nervous system diseases are associated with disturbed cerebrospinal fluid (CSF) flow patterns and have typically been characterized in vivo by phase-contrast magnetic resonance imaging (MRI). This technique is, however, limited by its applicability in space and time. Phase-contrast MRI has yet to be compared directly with CSF tracer enhanced imaging, which can be considered gold standard for assessing long-term CSF flow dynamics within the intracranial compartment. Methods Here, we studied patients with various CSF disorders and compared MRI biomarkers of CSF space anatomy and phase-contrast MRI at level of the aqueduct and cranio-cervical junction with dynamic intrathecal contrast-enhanced MRI using the contrast agent gadobutrol as CSF tracer. Tracer enrichment of cerebral ventricles was graded 0–4 by visual assessment. An intracranial pressure (ICP) score was used as surrogate marker of intracranial compliance. Results The study included 94 patients and disclosed marked variation of CSF flow measures across disease categories. The grade of supra-aqueductal reflux of tracer varied, with strong reflux (grades 3–4) in half of patients. Ventricular tracer reflux correlated with stroke volume and aqueductal CSF pressure gradient. CSF flow in the cerebral aqueduct was retrograde (from 4th to 3rd ventricle) in one third of patients, with estimated CSF net flow volume about 1.0 L/24 h. In the cranio-cervical junction, net flow was cranially directed in 78% patients, with estimated CSF net flow volume about 4.7 L/24 h. Conclusions The present observations provide in vivo quantitative evidence for substantial variation in direction and magnitude of CSF flow, with re-direction of aqueductal flow in communicating hydrocephalus, and significant extra-cranial CSF production. The grading of ventricular reflux of tracer shows promise as a clinical useful method to assess CSF flow pattern disturbances in patients. Graphic abstract

Sign in / Sign up

Export Citation Format

Share Document