scholarly journals Evaluation of Bone Healing on Sandblasted and Acid Etched Implants Coated with Nanocrystalline Hydroxyapatite: AnIn VivoStudy in Rabbit Femur

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Lory Melin Svanborg ◽  
Luiz Meirelles ◽  
Victoria Franke Stenport ◽  
Per Kjellin ◽  
Fredrik Currie ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Bone Healing ◽  
Healing Time ◽  
Titanium Implants ◽  
Bone Area ◽  
Removal Torque ◽  
Nanocrystalline Hydroxyapatite ◽  
Torque Analysis ◽  
Hydroxyapatite Nanocrystals ◽  
Rabbit Femur

This study aimed at investigating if a coating of hydroxyapatite nanocrystals would enhance bone healing over time in trabecular bone. Sandblasted and acid etched titanium implants with and without a submicron thick coat of hydroxyapatite nanocrystals (nano-HA) were implanted in rabbit femur with healing times of 2, 4, and 9 weeks. Removal torque analyses and histological evaluations were performed. The torque analysis did not show any significant differences between the implants at any healing time. The control implant showed a tendency of more newly formed bone after 4 weeks of healing and significantly higher bone area values after 9 weeks of healing. According to the results from this present study, both control and nano-HA surfaces were biocompatible and osteoconductive. A submicron thick coating of hydroxyapatite nanocrystals deposited onto blasted and acid etched screw shaped titanium implants did not enhance bone healing, as compared to blasted and etched control implants when placed in trabecular bone.

scholarly journals The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: AnIn VivoRabbit Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Karin Breding ◽  
Ryo Jimbo ◽  
Mariko Hayashi ◽  
Ying Xue ◽  
Kamal Mustafa ◽  
...  
Keyword(s):  
Surface Chemistry ◽  
Calcium Phosphates ◽  
Surface Characteristics ◽  
Healing Time ◽  
Titanium Implants ◽  
Pcr Analysis ◽  
Rt Pcr ◽  
Implant Surface ◽  
Hydroxyapatite Nanocrystals

Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they affect both the nanotopography and surface chemistry, forming a bone mineral resembling surface. In this work, the osseointegration of titanium implants with and without the presence of hydroxyapatite (HA) nanocrystals has been evaluatedin vivo. The integration was examined using removal torque measurements and real-time polymerase chain reaction (RT-PCR) analysis. The study was performed using two healing time points, 3 and 12 weeks. The results showed that the torque needed to remove the implants was insignificant between the non- and HA-coated implants, both at weeks 3 and 12. The RT-PCR, however, showed significant differences for osteoblast, osteoclast, and proinflammation markers when HA nanocrystals were present.

Removal Torque Analysis of Implants in Rabbit Tibia After Topical Application of Simvastatin Gel

2014 ◽  
Vol 40 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Fatima Neves Faraco-Schwed ◽  
Luiz Macedo Mangueira ◽  
Joao Vitor Albuquerque Ribeiro ◽  
Alexsandro Da Silva Antao ◽  
Jamil Awad Shibli
Keyword(s):  
Topical Application ◽  
Topical Administration ◽  
Titanium Implants ◽  
Removal Torque ◽  
Implant Placement ◽  
Group I ◽  
Torque Wrench ◽  
Rabbit Tibia ◽  
Torque Analysis ◽  
Torque Values

The aim of this study was to evaluate the effects of topical application of simvastatin gel (7.5 mg) on the removal torque of titanium implants in the rabbit tibia. A total of 32 surgeries were performed on 16 New Zealand rabbits for the placement of 2 implants in 1 tibia of each rabbit. Only 1 of the surgical defects was injected with 30 mg/mL of simvastatin gel before implant placement. The initial torque was set at 20 N.cm, and removal torque testing was performed 28 and 56 days postoperatively with a Tonishi torque wrench. Surgical defects were divided into 4 groups: group IG-28 (test, 28 days), group IG-56 (test, 56 days), group I-28 (control, 28 days), and group I-56 (control, 56 days). Removal torque values were higher in group IG-56 than in groups IG-28, I-28, and I-56 (P < .05). Groups IG-28, I-28, and I-56 showed similar values (P > .05). Removal torque force increased under the influence of simvastatin, indicating that topical administration of a 7.5-mg dose of simvastatin gel is effective in improving the torque force required to remove implants inserted in the rabbit tibia.

scholarly journals Histologic evaluation and removal torque analysis of nano- and microtreated titanium implants in the dogs

2009 ◽  
Vol 1 (2) ◽  
pp. 75 ◽  
Author(s):  
Seok Ahn ◽  
Mong-Sook Vang ◽  
Hong-So Yang ◽  
Sang-Won Park ◽  
Hyun-Pil Lim
Keyword(s):  
Titanium Implants ◽  
Removal Torque ◽  
Histologic Evaluation ◽  
Torque Analysis

scholarly journals Early Bone Healing on Hydroxyapatite-Coated and Chemically-Modified Hydrophilic Implant Surfaces in an Ovine Model

2021 ◽  
Vol 22 (17) ◽  
pp. 9361
Author(s):  
Elnaz Ajami ◽  
Cong Fu ◽  
Hai Bo Wen ◽  
Jeffrey Bassett ◽  
Sun Jin Park ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Rough Surface ◽  
Bone Healing ◽  
Healing Time ◽  
Insertion Torque ◽  
Implant Surface ◽  
Chemically Modified ◽  
Biological Environment ◽  
Torque Values ◽  
Over Time

Implant topography affects early peri-implant bone healing by changing the osteoconduction rate in the surrounding biological environment. Implant surfaces have been designed to promote faster and stronger bone formation for rapid and stable prosthesis loading. Early peri-implant bone healing has been observed with a sandblasted, acid-etched implant that was chemically modified to be hydrophilic (cmSLA). The present study investigates whether early peri-implant bone healing extends to a rough surface implant with a high crystalline hydroxyapatite surface (TSV MP-1 HA). Three implants were randomly placed in porous trabecular bone within both medial femoral condyles of 10 sheep. Early peri-implant bone stability was measured at 3- and 6-weeks healing time following implant insertion. Results indicated a similar implant stability quotient between the implants at insertion and over time. The significant increase over time of reverse torque values with respect to insertion torque (p < 0.001) did not differ between the implants. However, the bone-to-implant contact of TSV MP-1 HA was significantly higher than that of cmSLA implants at 6 weeks (p < 0.01). These data validate previous findings of a hydrophilic implant surface and extend the observation of early osseointegration to a rough surface implant in porous trabecular bone.

The effect of strontium-loaded rough titanium surface on early osseointegration

2017 ◽  
Vol 32 (5) ◽  
pp. 561-569 ◽  
Author(s):  
Jiang Huanhuan ◽  
Hao Pengjie ◽  
Xu Sheng ◽  
Wang Binchen ◽  
Shu Li
Keyword(s):  
Magnetron Sputtering ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Atomic Ratio ◽  
Area Ratio ◽  
Titanium Implants ◽  
Bone Area ◽  
Bone Apposition ◽  
Removal Torque ◽  
Torque Values

It is not clear whether surface bioactive chemistry plays an important role in the early osseointegration of micro-structured titanium implants that have the same surface topography at the micrometer and submicrometer scales. In this study, magnetron sputtering methodology was employed for the preparation of Sr coating on sandblasted and acid-etched (SLA) titanium implant without changing the surface characteristics. The study of the surface morphology of the coating was carried out with the use of scanning electron microscopy, and the chemical composition of the surface was examined by X-ray energy-dispersive spectrometry. Twenty SLA implants together with 20 Sr-SLA implants were randomly inserted into the proximal tibia of 20 rats. The early osseointegration of the Sr-SLA implant was compared with SLA implant by removal torque test and histological analysis following two and eight weeks of implantation, correspondingly. As revealed by the surface characteristics, both Sr-SLA and SLA surfaces exhibited similar typical isotropic irregular indentations. The strontium ions were effectively incorporated into the SLA surface (the atomic ratio is 2%). Following two and eight weeks of healing, significant increases in removal torque values ( p < 0.05) were taken into observation in respect of Sr-SLA implant. Histologically, the Sr-SLA implants displayed significantly higher bone-to-implant contact percentages and bone area ratio in comparison with the SLA implant at eight weeks ( p < 0.05). At two weeks, the bone-implant contact percentages, together with bone area ratio of Sr-SLA surface appeared to be a little bit slightly greater than that of SLA surface. But the statistical difference was not significant. These results indicated that the chemical modification with Sr incorporated by magnetron sputtering treatment in moderately rough surfaced implants remarkably increases early bone apposition.

Histomorphometric and removal torque analysis for TiO2 hyphen;blasted titanium implants. An experimental study on dogs.

1992 ◽  
Vol 3 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Klaus Gotfredsen ◽  
Lars Nimb ◽  
Erik Hjörting-hansen ◽  
Jørgen Steen Jensen ◽  
Anders Holmén
Keyword(s):  
Experimental Study ◽  
Titanium Implants ◽  
Removal Torque ◽  
Torque Analysis

scholarly journals Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

2010 ◽  
Vol 24 (2) ◽  
pp. 170-176 ◽  
Author(s):  
Marta Ferreira Bastos ◽  
Felipe Vilhena Brilhante ◽  
Joyce Pinho Bezerra ◽  
Carlos Alberto Silva ◽  
Poliana Mendes Duarte
Keyword(s):  
Trabecular Bone ◽  
Bone Healing ◽  
Spontaneously Hypertensive Rats ◽  
Bone Area ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Trabecular Bone Area

Early Trabecular Bone Healing Around Titanium Implants: A Histologic Study in Rabbits

2007 ◽  
Vol 78 (3) ◽  
pp. 510-517 ◽  
Author(s):  
Elke Slaets ◽  
Geert Carmeliet ◽  
Ignace Naert ◽  
Joke Duyck
Keyword(s):  
Trabecular Bone ◽  
Bone Healing ◽  
Titanium Implants ◽  
Histologic Study
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