Early Trabecular Bone Healing Around Titanium Implants: A Histologic Study in Rabbits

2007 ◽  
Vol 78 (3) ◽  
pp. 510-517 ◽  
Author(s):  
Elke Slaets ◽  
Geert Carmeliet ◽  
Ignace Naert ◽  
Joke Duyck
Keyword(s):  
Trabecular Bone ◽  
Bone Healing ◽  
Titanium Implants ◽  
Histologic Study

scholarly journals Evaluation of Bone Healing on Sandblasted and Acid Etched Implants Coated with Nanocrystalline Hydroxyapatite: AnIn VivoStudy in Rabbit Femur

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Lory Melin Svanborg ◽  
Luiz Meirelles ◽  
Victoria Franke Stenport ◽  
Per Kjellin ◽  
Fredrik Currie ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Bone Healing ◽  
Healing Time ◽  
Titanium Implants ◽  
Bone Area ◽  
Removal Torque ◽  
Nanocrystalline Hydroxyapatite ◽  
Torque Analysis ◽  
Hydroxyapatite Nanocrystals ◽  
Rabbit Femur

This study aimed at investigating if a coating of hydroxyapatite nanocrystals would enhance bone healing over time in trabecular bone. Sandblasted and acid etched titanium implants with and without a submicron thick coat of hydroxyapatite nanocrystals (nano-HA) were implanted in rabbit femur with healing times of 2, 4, and 9 weeks. Removal torque analyses and histological evaluations were performed. The torque analysis did not show any significant differences between the implants at any healing time. The control implant showed a tendency of more newly formed bone after 4 weeks of healing and significantly higher bone area values after 9 weeks of healing. According to the results from this present study, both control and nano-HA surfaces were biocompatible and osteoconductive. A submicron thick coating of hydroxyapatite nanocrystals deposited onto blasted and acid etched screw shaped titanium implants did not enhance bone healing, as compared to blasted and etched control implants when placed in trabecular bone.

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

Thyroid Hormones May Influence Cortical Bone Healing Around Titanium Implants: A Histometric Study in Rats

2008 ◽  
Vol 79 (5) ◽  
pp. 881-887 ◽  
Author(s):  
Daniela da Silva Feitosa ◽  
Beatriz de Brito Bezerra ◽  
Gláucia Maria Bovi Ambrosano ◽  
Francisco Humberto Nociti ◽  
Márcio Zaffalon Casati ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Cortical Bone ◽  
Bone Healing ◽  
Titanium Implants

scholarly journals Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Raluca M. Boteanu ◽  
Viorel I. Suica ◽  
Luminita Ivan ◽  
Florentina Safciuc ◽  
Elena Uyy ◽  
...  
Keyword(s):  
Bone Healing ◽  
Cultured Cells ◽  
Traumatic Event ◽  
Healing Process ◽  
Dip Coating ◽  
Polymer Coatings ◽  
Titanium Implants ◽  
Mass Spectrometry Analysis ◽  
Defect Model ◽  
Tibial Defect

Abstract Due to their excellent mechanical and biocompatibility properties, titanium-based implants are successfully used as biomedical devices. However, when new bone formation fails for different reasons, impaired fracture healing becomes a clinical problem and affects the patient's quality of life. We aimed to design a new bioactive surface of titanium implants with a synergetic PEG biopolymer-based composition for gradual delivery of growth factors (FGF2, VEGF, and BMP4) during bone healing. The optimal architecture of non-cytotoxic polymeric coatings deposited by dip coating under controlled parameters was assessed both in cultured cells and in a rat tibial defect model (100% viability). Notably, the titanium adsorbed polymer matrix induced an improved healing process when compared with the individual action of each biomolecules. High-performance mass spectrometry analysis demonstrated that recovery after a traumatic event is governed by specific differentially regulated proteins, acting in a coordinated response to the external stimulus. Predicted protein interactions shown by STRING analysis were well organized in hub-based networks related with response to chemical, wound healing and response to stress pathways. The proposed functional polymer coatings of the titanium implants demonstrated the significant improvement of bone healing process after injury.

Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice

2016 ◽  
Vol 125 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Xiaofei Zheng ◽  
Anchun Mo ◽  
Yuan Wang ◽  
Yuchen Guo ◽  
Yunshu Wu ◽  
...  
Keyword(s):  
Bone Healing ◽  
Biomechanical Study ◽  
Titanium Implants ◽  
Fk 506 ◽  
Tacrolimus Therapy

High-throughput gene expression analysis in bone healing around titanium implants by DNA microarray

2008 ◽  
Vol 19 (2) ◽  
pp. 173-181 ◽  
Author(s):  
Norinaga Kojima ◽  
Shogo Ozawa ◽  
Yasuhiro Miyata ◽  
Hideki Hasegawa ◽  
Yoshinobu Tanaka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Microarray ◽  
Expression Analysis ◽  
High Throughput ◽  
Bone Healing ◽  
Gene Expression Analysis ◽  
Titanium Implants ◽  
High Throughput Gene Expression

Influence of Cyclosporin A Therapy on Bone Healing Around Titanium Implants: A Histometric and Biomechanic Study in Rabbits

2003 ◽  
Vol 74 (7) ◽  
pp. 976-981 ◽  
Author(s):  
Celso E. Sakakura ◽  
Rogério Margonar ◽  
Marinella Holzhausen ◽  
Francisco H. Nociti ◽  
Rodolfo Candia Alba ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Bone Healing ◽  
Titanium Implants

Effects of metformin on bone healing around titanium implants inserted in non-diabetic rats

2016 ◽  
Vol 28 (10) ◽  
pp. e146-e150 ◽  
Author(s):  
Marta Ferreira Bastos ◽  
Caroline Ribeiro Serrão ◽  
Tamires Szeremeske Miranda ◽  
Daniele Ferreira Cruz ◽  
Fernando de Souza Malta ◽  
...  
Keyword(s):  
Bone Healing ◽  
Diabetic Rats ◽  
Titanium Implants
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