scholarly journals Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
K. M. Rice ◽  
J. C. Fannin ◽  
C. Gillette ◽  
E. R. Blough
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
The United States ◽  
Female Rat ◽  
Aging Research ◽  
Rat Models ◽  
And Gender ◽  
Effects Of Aging ◽  
Derived Data ◽  
Primary Risk Factor

Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging.

scholarly journals Obesity and Cancer: 27-Hydroxycholesterol, the Missing Link

2020 ◽  
Vol 21 (14) ◽  
pp. 4822
Author(s):  
Arvand Asghari ◽  
Michihisa Umetani
Keyword(s):  
United States ◽  
Cardiovascular Disease ◽  
Estrogen Receptor ◽  
Risk Factor ◽  
Cause Of Death ◽  
The United States ◽  
Missing Link ◽  
Receptor Modulator ◽  
Obesity And Cancer

Obesity is currently affecting more than 40% of the Americans, and if it progresses with this rate, soon one out of two Americans will be obese. Obesity is an important risk factor for several disorders including cardiovascular disease, the first cause of death in the United States. Cancer follows as the second deadliest disease, and a link between obesity and cancer has been suggested. However, it is very hard to establish an exact connection between obesity and cancers due to the multifactorial nature of obesity. Hypercholesterolemia is a comorbidity of obesity and also linked to several cancers. Recently a cholesterol metabolite 27-hydroxycholesterol (27HC) was found to be an endogenous selective estrogen receptor modulator (SERM), which opened new doors toward several interesting studies on the role of this molecule in biological disorders. It is speculated that 27HC might be the missing link in the obesity and cancer chain. Here, we explored the effects of 27-hydroxycholesterol on obesity and cancers with a focus on the SERM capacity of 27HC.

Daily Sedentary Time and Risk of Cardiovascular Disease: The National FINRISK 2002 Study

2015 ◽  
Vol 12 (7) ◽  
pp. 904-908 ◽  
Author(s):  
Katja Borodulin ◽  
Anja Kärki ◽  
Tiina Laatikainen ◽  
Markku Peltonen ◽  
Riitta Luoto
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Leisure Time Physical Activity ◽  
Smoking Status ◽  
Sitting Time ◽  
Health Examination ◽  
Hazard Ratios ◽  
And Gender ◽  
Adjusted Model

Background:Daily sitting time may be a risk factor for incident cardiovascular disease (CVD); however, this has not yet been extensively studied. Our aim was to study the association of total sitting time with the risk of CVD.Methods:Participants (n = 4516, free of CVD at baseline) from the National FINRISK 2002 Study were followed for fatal and nonfatal CVD using national registers. Participants underwent a health examination and completed questionnaires, including total daily sitting time.Results:During a mean follow-up of 8.6 years, 183 incident CVD cases occurred. Sitting on a typical weekday, at baseline, was statistically significantly associated with fatal and nonfatal incident CVD. The hazard ratios (with 95% confidence intervals, CI) for the total amount of sitting were 1.05 (95% CI, 1.00–1.10) in the age and gender adjusted model and 1.06 (95% CI, 1.01–1.11) in the fully adjusted model, including age, gender, employment status, education, BMI, smoking status, leisure time physical activity, use of vegetables and fruit, alcohol use, blood pressure or its medication, and cholesterol or its medication.Conclusions:Our findings suggest that total amount of daily sitting is a risk factor for incident CVD. More research is needed to understand the etiology of sedentary behavior and CVD.

Identifying Properties for an Aortic Stent-Graft That Counteracts Hypertension

2018 ◽  
Author(s):  
Shannen B. Kizilski ◽  
Omid Amili ◽  
Filippo Coletti ◽  
Rumi Faizer ◽  
Victor H. Barocas
Keyword(s):  
United States ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Stent Graft ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association ◽  
The United States ◽  
Aortic Stent Graft

In 2017, the American Heart Association reported that one third of deaths in the United States, and 31% of deaths worldwide, are attributed to cardiovascular disease (CVD) [1]. A risk factor pervasive across most types of CVD is chronic high blood pressure, or hypertension [2].

scholarly journals Diabetes and Coronary Heart Disease: A Risk Factor for the Global Epidemic

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Maguy Chiha ◽  
Mario Njeim ◽  
Edgar G. Chedrawy
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
The United States ◽  
Global Scale ◽  
Diabetic Patients ◽  
Global Epidemic ◽  
The Impact

Cardiovascular disease remains a leading cause of death in the United States and the world. In this we will paper focus on type 2 diabetes mellitus as a risk factor for coronary heart disease, review the mechanisms of atherogenesis in diabetics, the impact of hypertension and the treatment goals in diabetics, the guidelines for screening, and review the epidemiologic consequences of diabetes and heart disease on a global scale. The underlying premise to consider diabetes a cardiovascular disease equivalent will be explored as well as the recommendations for screening and cardiac testing for asymptomatic diabetic patients.

scholarly journals Aging and longevity science: where are we in 2015?

2015 ◽  
Author(s):  
Alfred P Yoon ◽  
Christie P Yoon ◽  
Stephen Daane
Keyword(s):  
Metabolic Disease ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Social Perception ◽  
Aging Process ◽  
Loss Of Function ◽  
Comprehensive Review ◽  
The Social ◽  
Effects Of Aging ◽  
Sensory Functions

Aging has been defined as the loss of function and ability to interact with the environment. The social perception of aging involves the inability to live independently due to loss of mobility, cognition, and sensory functions. Aging is a risk factor for pathology including cancer, cardiovascular disease, metabolic disease, and neurodegenerative disease. Due to these accompanying conditions, the esteem and respect once regarded for old age has been replaced by efforts to postpone, stop, or even reverse the aging process. Anti-aging medicine has gained popularity through media and marketing as companies have promoted an approach to delaying the side effects of aging through diet, exercise, supplements and hormonal therapy. The following is a comprehensive review of current research into potential strategies for anti-aging therapy and longevity, supported by current scientific and clinical research.

scholarly journals Cardiovascular Risks Associated with Gender and Aging

2019 ◽  
Vol 6 (2) ◽  
pp. 19 ◽  
Author(s):  
Jennifer L. Rodgers ◽  
Jarrod Jones ◽  
Samuel I. Bolleddu ◽  
Sahit Vanthenapalli ◽  
Lydia E. Rodgers ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Elderly Population ◽  
Hormone Replacement ◽  
Cardiac Risk ◽  
Cardiovascular Risks ◽  
Cardiac Events ◽  
Obesity And Diabetes ◽  
And Gender ◽  
Aging Adults

The aging and elderly population are particularly susceptible to cardiovascular disease. Age is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are compounded by additional factors, including frailty, obesity, and diabetes. These factors are known to complicate and enhance cardiac risk factors that are associated with the onset of advanced age. Sex is another potential risk factor in aging adults, given that older females are reported to be at a greater risk for CVD than age-matched men. However, in both men and women, the risks associated with CVD increase with age, and these correspond to an overall decline in sex hormones, primarily of estrogen and testosterone. Despite this, hormone replacement therapies are largely shown to not improve outcomes in older patients and may also increase the risks of cardiac events in older adults. This review discusses current findings regarding the impacts of age and gender on heart disease.

scholarly journals Aging and longevity science: where are we in 2015?

2015 ◽  
Author(s):  
Alfred P Yoon ◽  
Christie P Yoon ◽  
Stephen Daane
Keyword(s):  
Metabolic Disease ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Social Perception ◽  
Aging Process ◽  
Loss Of Function ◽  
Comprehensive Review ◽  
The Social ◽  
Effects Of Aging ◽  
Sensory Functions

Aging has been defined as the loss of function and ability to interact with the environment. The social perception of aging involves the inability to live independently due to loss of mobility, cognition, and sensory functions. Aging is a risk factor for pathology including cancer, cardiovascular disease, metabolic disease, and neurodegenerative disease. Due to these accompanying conditions, the esteem and respect once regarded for old age has been replaced by efforts to postpone, stop, or even reverse the aging process. Anti-aging medicine has gained popularity through media and marketing as companies have promoted an approach to delaying the side effects of aging through diet, exercise, supplements and hormonal therapy. The following is a comprehensive review of current research into potential strategies for anti-aging therapy and longevity, supported by current scientific and clinical research.

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