scholarly journals Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Aminu Umar Kura ◽  
Samer Hasan Hussein-Al-Ali ◽  
Mohd Zobir Hussein ◽  
Sharida Fakurazi
Keyword(s):  
Drug Delivery ◽  
Tween 80 ◽  
Shielding Effect ◽  
Coating Process ◽  
X Ray Diffraction ◽  
X Ray ◽  
Aggregation Structure ◽  
Viability Study ◽  
Double Hydroxides ◽  
Mitochondrial Dehydrogenase Activity

We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied. The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect. The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay).

SYNTHESIS OF ACECLOFENAC/HYDROXYPROPYL-β-CYCLODEXTRIN INTERCALATED LAYERED DOUBLE HYDROXIDES AND CONTROLLED RELEASE PROPERTIES

2013 ◽  
Vol 06 (03) ◽  
pp. 1350030 ◽  
Author(s):  
SHIFENG LI ◽  
YANMING SHEN ◽  
DONGBIN LIU ◽  
LIHUI FAN ◽  
KEKE WU ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fourier Transform ◽  
Layered Double Hydroxides ◽  
Reconstruction Method ◽  
Thermal Gravimetric ◽  
X Ray Diffraction ◽  
Buffer Solution ◽  
X Ray ◽  
Ph Values ◽  
Double Hydroxides

Aceclofenac (AC)/hydroxypropyl-β-cyclodextrin (HP-β-CD) complex intercalated layered double hydroxides (LDHs) have been synthesized by reconstruction method. X-ray diffraction, Fourier transform infrared and thermal gravimetric analyses indicated a successful intercalation of AC/HP-β-CD complex into the LDHs gallery. The AC release properties were also studied in different pH values buffer solution. The results indicate that the AC/HP-β-CD intercalated LDH has a potential application in drug delivery agent.

scholarly journals A review of nanotechnology with an emphasis on Nanoplex

2015 ◽  
Vol 51 (2) ◽  
pp. 255-263
Author(s):  
Rupali Nanasaheb Kadam ◽  
Raosaheb Sopanrao Shendge ◽  
Vishal Vijay Pande
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Conventional Drug ◽  
Anionic Drugs ◽  
Oppositely Charged ◽  
The Brain

<p>The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. Nanoplex are also easier to prepare. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene drug delivery, drug delivery to the brain and protein and peptide drug delivery.</p>

scholarly journals Effect of Film Formation Method and Annealing on Crystallinity of Poly(L-Lactic Acid) Films

2011 ◽  
Author(s):  
Shan-Ting Hsu ◽  
Y. Lawrence Yao
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Film Formation ◽  
Solvent Casting ◽  
Crystalline Morphology ◽  
X Ray Diffraction ◽  
X Ray ◽  
Lamellar Structures ◽  
Coating Methods ◽  
Formation Method

Poly(L-lactic acid) (PLLA) has been shown to have potential medical usage such as in drug delivery because it can degrade into bioabsorbable products in physiological environments, and its degradation is affected by crystallinity. In this paper, the effect of film formation method and annealing on the crystallinity of PLLA are investigated. The films are made through solvent casting and spin coating methods, and subsequent annealing is conducted. The resulting crystalline morphology, structure, conformation, and intermolecular interaction are examined using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. It is observed that solvent casting produces category 1 spherulites while annealed spin coated films leads to spherulites of category 2. Distinct lamellar structures and intermolecular interactions in the two kinds of films have been shown. The results enable better understanding of the crystallinity in PLLA, which is essential for its drug delivery application.

scholarly journals Photocatalytic Degradation of 2,4,6-Trichlorophenol by MgO–MgFe2O4 Derived from Layered Double Hydroxide Structures

Catalysts ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 454 ◽  
Author(s):  
Esthela Ramos-Ramírez ◽  
Francisco Tzompantzi-Morales ◽  
Norma Gutiérrez-Ortega ◽  
Héctor G. Mojica-Calvillo ◽  
Julio Castillo-Rodríguez
Keyword(s):  
Photocatalytic Degradation ◽  
Layered Double Hydroxides ◽  
X Ray Diffraction ◽  
Application Study ◽  
Toxic Compounds ◽  
X Ray ◽  
Thermally Activated ◽  
Double Hydroxide ◽  
Double Hydroxides ◽  
Scanning Electron

In recent years, the search for solutions for the treatment of water pollution by toxic compounds such as phenols and chlorophenols has been increasing. Phenols and their derivatives are widely used in the manufacture of pesticides, insecticides, paper, and wood preservers, among other things. Chlorophenols are partially biodegradable but not directly photodegradable by sunlight and are extremely toxic—especially 2,4,6-trichlorophenol, which is considered to be potentially carcinogenic. As a viable proposal to be applied in the treatment of water contaminated with 2,4,6-trichlorophenol, this paper presents an application study of the thermally activated Mg/Fe layered double hydroxides as photocatalysts for the mineralization of this contaminant. Activated Mg/Fe layered double hydroxides were characterized by X-ray diffraction, thermal analysis, N2 physisorption, and scanning electron microscopy with X-ray dispersive energy. The results of the photocatalytic degradation of 2,4,6-trichlorophenol in aqueous solution showed good photocatalytic activity, with an efficiency of degradation of up to 93% and mineralization of 82%; degradation values which are higher than that of TiO2-P25, which only reached 18% degradation. The degradation capacity is attributed to the structure of the MgO–MgFe2O4 oxides derived from double laminate hydroxide Mg/Fe. A path of degradation based on a mechanism of superoxide and hollow radicals is proposed.

Evidence of Variations in Atomic Distribution in Disordered Mixed Metal Hydroxides

MRS Advances ◽  
2019 ◽  
Vol 4 (33-34) ◽  
pp. 1843-1850
Author(s):  
Wen Rong ◽  
Sarah Stepan ◽  
Rodney D. L. Smith
Keyword(s):  
Transition Metal Oxides ◽  
Iron Ions ◽  
X Ray Diffraction ◽  
Metal Hydroxides ◽  
X Ray ◽  
Mixed Metal ◽  
Apparent Solubility ◽  
Fundamental Understanding ◽  
Double Hydroxides ◽  
Mixed Metal Hydroxides

ABSTRACTNumerous fabrication protocols are known to yield transition metal oxides with structures related to layered double hydroxides, but the effect of fabrication protocol on the uniformity of mixed-metal compositions remain largely unexplored. We have analysed the apparent solubility limits and the structural implications of iron ions in nickel hydroxide lattices for materials prepared by four different fabrication protocols. Opposing shifts in the (100) and (001) reflection in powder X-ray diffraction results revealed a contraction of the nickel lattice upon successful incorporation of iron, with Ni-M distances exhibiting an apparently linear decrease with respect to iron content. This feature revealed the amount of iron incorporated into nickel-based materials to be dependent on fabrication protocol, varying from apparently negligible concentrations to over fifty atomic percent. The dependency of structure on fabrication protocols provides a handle to improve fundamental understanding of catalytically relevant coordination environments.

scholarly journals Adsorción del naranja de metilo en solución acuosa sobre hidróxidos dobles laminares

2015 ◽  
Vol 25 (3) ◽  
pp. 25-34 ◽  
Author(s):  
Laura Alicia Ramírez Llamas ◽  
Araceli Jacobo Azuara ◽  
J. Merced Martínez Rosales
Keyword(s):  
Methyl Orange ◽  
Adsorption Capacity ◽  
Dye Adsorption ◽  
Temperature Programmed Desorption ◽  
Maximum Adsorption Capacity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Suitable Temperature ◽  
Temperature Programmed ◽  
Double Hydroxides

In this paper, layered double hydroxides (LDH) were synthesized and characterized using techniques of Physisorption of Nitrogen, Infrared, Temperature Programmed Desorption, X-Ray Diffraction, TGA and Immersion Microcalorimetry, in order to determine the basic properties of the adsorbent. The methyl orange (MO) is used as a dye and as a result, it is frequently found in effluents from textile industries. The dye adsorption isotherms on LDH were studied as function of pH and temperature. The maximum adsorption capacity of methyl orange on LDH was carried out at pH 5, and the minimum adsorption capacity at pH 11, being 40.2 mg/g and 22.1 mg/g, respectively. Furthermore, the suitable temperature to promote the adsorption of methyl orange on LDH was at 25 °C, as at 35 °C shows a significant decrease. 

scholarly journals High efficient photocatalytic activity of Zn-Al-Ti layered double hydroxides nanocomposite

2018 ◽  
Vol 149 ◽  
pp. 01087 ◽  
Author(s):  
F. Amor ◽  
A. Diouri ◽  
I. Ellouzi ◽  
F. Ouanji ◽  
M. Kacimi
Keyword(s):  
Methylene Blue ◽  
Photocatalytic Activity ◽  
Uv Irradiation ◽  
Layered Double Hydroxides ◽  
Removal Rate ◽  
X Ray Diffraction ◽  
Simple Method ◽  
X Ray ◽  
High Efficient ◽  
Double Hydroxides

This work establishes a simple method for synthesising layered double hydroxides (LDHs) powders with coprecipitation. The characteristics of the samples were investigated y X-ray diffraction (XRD), scanning electron microscopy (SEM) and spectrophotometer UV–Vis (DRS). Non-uniform distribution was shown for LDHs samples by SEM. Photocatalytic efficiencies were tested using methylene blue (MB) dye as a model contaminant under UV irradiation. In particular, Zn–Al-Ti LDH exhibited an excellent performance towards MB degradation compared with commercial TiO2 nanoparticles. Methylene blue removal percentage was reached at almost 100%, whereas commercial TiO2 reached a removal rate of only 66% under the same conditions within 20 min. The aim of the current work is to prepare Zn-Al-Ti layered double hydroxides nanocomposite and to evaluate their photocatalytic activity in the removal of methylene blue under UV irradiation.

scholarly journals Designing Magnetic Layered Double Hydroxides and Two-Dimensional Magnetic Nano-Nets of Cobalt Ferrite through a Novel Approach

2018 ◽  
Vol 8 (11) ◽  
pp. 2099 ◽  
Author(s):  
Osama Saber ◽  
Abdullah Aljaafari ◽  
Sarah Asiri ◽  
Khalid Batoo
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Layered Double Hydroxides ◽  
Cobalt Ferrite ◽  
High Coercivity ◽  
Two Dimensional ◽  
X Ray Diffraction ◽  
X Ray ◽  
Transmission Electron ◽  
Double Hydroxides

The present study has a dual aim of supporting magnetic nanoparticles over the nanolayers of LDHs and designing two-dimensional magnetic nano-nets of cobalt ferrite. In this trend, nanoparticles of CoFe2O4 were prepared and supported by Co-Fe LDH through urea hydrolysis. The nanolayered structures of Co-Fe LDH were confirmed by X-ray diffraction, energy-dispersive X-ray spectrometry, FT-IR spectra, thermal analyses, and transmission electron microscopy. In addition, they indicated that 13.2% CoFe2O4 were supported over Co-Fe LDH. Transformation of the nanolayered structures of Co-Fe LDH to nano-nets was achieved by the catalytic effect of the supported CoFe2O4 nanoparticles through solvent thermal technique. X-ray diffraction patterns and transmission electron microscopy images confirmed the transformation of the supported Co-Fe LDH to nano-nets of cobalt ferrite. In order to indicate the effect of the LDH for designing the nano-nets, nanoparticles of cobalt ferrite were prepared by the same technique without LDH. The magnetic behavior of the nano-nets and the supported Co-Fe LDH were measured and compared with the nanoparticles through vibrating sample magnetometer technique. The magnetic parameters indicated that the prepared nano-nets have ferromagnetic behavior and high coercivity. However, the prepared nanoparticles revealed a superparamagnetic state and low coercivity. The experimental results concluded that the incorporation of nanoparticles with nanowires into nano-net structures has been found to be an efficient way to improve their magnetic properties and prevent their agglomerations. Finally, layered double hydroxides are an important source for constructing magnetic nanolayered structures and nano-nets.

Electroless Ni-P Coating of Cenospheres Using Copper Sulfate Activator

2012 ◽  
Vol 463-464 ◽  
pp. 375-379
Author(s):  
Ai Xiang Zeng ◽  
Kai Long Hu ◽  
Li Luo
Keyword(s):  
Photoelectron Spectroscopy ◽  
Coating Process ◽  
Emi Shielding ◽  
X Ray Diffraction ◽  
X Ray ◽  
Microwave Absorbing Materials ◽  
Absorbing Materials ◽  
Fly Ash Cenosphere ◽  
Electroless Ni ◽  
The Given

Electroless Ni- P-coating of fly-ash cenosphere particles is demonstrated in the present investigation. The Electroless Ni- P-coating process is modified by replacing the conventional sensitization and activation steps with only using activation step with CuSO4 activator. The cenosphere particles are characterized by scanning electron microscope (SEM), energy dispersive spectroscopy (EDX), X-ray diffraction analysis (XRD) and X-ray photoelectron spectroscopy (XPS) during and after the coating process. Relatively uniform and continuous coating is obtained under the given coating conditions. The possible mechanism of electroless Ni-P-coating of cenosphere particles utilizing CuSO4 activator is suggested. The low density Ni-P coated cenosphere particles may be utilized for manufacturing conducting polymers for EMI-shielding application and microwave absorbing materials.

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