scholarly journals Effects of Water Extracts ofGraptopetalum paraguayenseon Blood Pressure, Fasting Glucose, and Lipid Profiles of Subjects with Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Chi-Hua Yen ◽  
Shu-Ju Chen ◽  
Jen-Tzu Liu ◽  
Yu-Fen Tseng ◽  
Ping-Ting Lin
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Antioxidant Enzymes ◽  
Blood Glucose ◽  
Fasting Glucose ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Water Extracts ◽  
Enzymes Activities ◽  
Antioxidant Enzymes Activities

This study was aimed to investigate the effects of water extracts ofGraptopetalum paraguayense(WGP, 4 g/d) on blood pressure, blood glucose level, and lipid profiles in subjects with metabolic syndrome (MS). Participants with MS (n=54) were randomly assigned to the placebo (n=28) and WGP groups (n=26), and the intervention was administered for 12 weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose (FG), lipid profiles (total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein (HDL-C)), and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)) were measured. Forty-two subjects completed the study (placebo,n=19; WGP,n=23). FG, SBP, and LDL-C levels were significantly lower and HDL-C level and antioxidant enzymes activities (CAT and SOD) were significantly higher after WGP supplementation. Blood pressure, FG, and lipid profiles were significantly correlated with antioxidant enzymes activities after supplementation (P<0.05). The present study demonstrated a significant reduction in blood pressure, blood glucose, and lipid profiles and an increase in antioxidant enzymes activities in subjects with MS after WGP supplementation. Taken together, the antioxidative capacity of WGP might exert a beneficial effect on MS. This trial is registered with ClinicalTrials.govNCT01463748.

scholarly journals The Role of Bioactive Compounds from Dietary Spices in the Management of Metabolic Syndrome: An Overview

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 175
Author(s):  
Dana Hasan Alkhatib ◽  
Abdul Jaleel ◽  
Maryam Naveed Muhammad Tariq ◽  
Jack Feehan ◽  
Vasso Apostolopoulos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Dietary Supplements ◽  
Bioactive Compounds ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Preventive Measure ◽  
Blood Lipid ◽  
Lifestyle Changes

Metabolic syndrome (MetS) is a combination of physiologically dysregulated parameters that can include elevated fasting blood glucose, high blood pressure, central obesity, increased triglyceride levels, insulin resistance, diabetes, elevated low density lipoprotein levels, and reduced high density lipoprotein levels in the blood. Effective clinical management of MetS is critical as it is strongly associated with long lasting and fatal complications in patients. Alongside standard care of lifestyle changes and medication, dietary supplements derived from herbal resources could be an alternative therapeutic strategy that is safe, efficient, culturally acceptable, and has few side effects. Of the dietary supplements, spicy foods have always been considered a great source of functional bioactive compounds. Herbal therapy is broadly used in many countries as a treatment or as a preventive measure in the management of MetS risk factors, including blood glucose, blood pressure, and blood lipid levels. Herein, an attempt is made to evaluate the recent studies in the management of MetS with herbal alternatives, and to explore the possibility of their use as therapeutic treatments or supplements.

scholarly journals Evaluation of Anthropometric Indices for Metabolic Syndrome and their Association with Metabolic Risk Factors among Healthy Individuals in New Belgrade

2013 ◽  
Vol 30 (1) ◽  
pp. 21-30
Author(s):  
Veroslava Stanković ◽  
Svetlana Stojanović ◽  
Nađa Vasiljević
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Health Risk ◽  
Density Lipoprotein ◽  
Metabolic Risk Factors ◽  
Lipoprotein Cholesterol ◽  
Metabolic Risk ◽  
Anthropometric Indices

Summary People with metabolic syndrome (MetSy) are about twice as likely to develop cardiovascular disease and over four times as likely to develop type 2 diabetes compared to subjects without metabolic syndrome. Waist circumferences (WC) and body mass index (BMI) are useful screening tools for making the diagnosis. MetSy has increased the health risk in primary care. The aim of the study was to evaluate the anthropometric indices for MetSy and determine which of simple anthropometric measurements is most closely associated with metabolic risk factors. The research included 264 individuals, of which 132 men with mean age (±SD) of 44.73 ±9.37 years and 132 women with mean age (±SD) of 46.67±8.44 years. Antropometric indicators were measured using standard protocols, without shoes and outerwear. BMI was calculated as weight/height2(kg/m2) ratio, as recommended by the World Health Organization (WHO). Blood pressure measurements were obtained with the subject in a seated position by using a standard mercury sphygmomanometer. Blood samples were obtained after a minimum of 12-h fast; the metabolic parameters (high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, blood glucose) were analyzed by standard procedures. Analysis of the examinees’ medical records was also performed. Metabolic syndrome was diagnosed using the International Diabetes Federation (IDF) criteria. The analysis of the research results were performed using the Statistical Package for Social Science version 10.0 (SPSS 10.0 for Windows). The prevalence of the metabolic syndrome was 44.7% in men and 43.2% in women. Normal-weight subjects of both sexes were significantly younger and had significantly lower blood glucose, total cholesterol, LDL and triglycerides than overweight and obese subjects. Systolic and diastolic blood pressure values were significantly increased in parallel with increasing of BMI. For the whole sample, both anthropometric indices had significant associations with the other five components of MetSy. Waist circumference is a simple measure of adiposity most strongly associated with metabolic abnormalities. The results obtained in this study indicate that WC is a good indicator of health risk in women but not in men. Measurement of WC by BMI categories may indicate a person with an increased risk of development of chronic diseases.

scholarly journals Frequency of Metabolic Syndrome on Diabetes Mellitus Patients in Surabaya

2018 ◽  
Vol 1 (1) ◽  
pp. 43
Author(s):  
Dyah Peni Puspitasari ◽  
Budi Widodo ◽  
Jongky Hendro Prayitno
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Central Obesity ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
High Blood Glucose ◽  
The Metabolic Syndrome ◽  
Low Hdl ◽  
Frequency Components

Backgrounds: Metabolic syndrome is a syndrome characterized by central obesity, high blood glucose or impaired glucose tolerance, dyslipidemia, and high blood pressure. Nearly 70% to 80% of Diabetes melitus (DM) population was diagnosed with metabolic syndrome. We aimed to present the data of frequency of metabolic syndrome in patients with DM for a basis of future research.Method: This is a descriptive study design on DM patients based on NCEP ATP III criteria. The data was collected from direct measurements and laboratory results of all DM patients: waist circumference, weight, height, and blood pressure of the subjects, triglyceride status (TG), high-density lipoprotein cholesterol (HDL-C) status, and fasting blood glucose status.Results: From 77 DM patients, results were obtained in this study were 69 (89.61%) patients with DM-metabolic syndrome  (DM-MetS) and 8 (10.39%) patients with DM-non-metabolic syndrome. From 69 patients with DM-MetS, 52 (75.36%) were female and 17 (24.64%) were male.Discussions: Based on NCEP ATP III criteria, the components profile of metabolic syndrome in women patients with DM-MetS were 96,15% central obesity, 88,46% hypertension, 70,37% low HDL levels and 44,44% hypertriglycerides. While, in men patients with DM-MetS were 70.59% central obesity, 88.24% in hypertension, 70% in the low HDL levels, and 30% hypertriglycerides. Based on the number of components, can be determined the frequency components of the metabolic syndrome were 73.91% on the three components, 14.49% on four components, and 11.59% at five components.Conclusion: A total of 69 (89.61%) patients with T2DM were diagnosed as metabolic syndrome.

scholarly journals The Antioxidant Status and Concentrations of Coenzyme Q10 and Vitamin E in Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Chi-Hua Yen ◽  
Nae-Cherng Yang ◽  
Bor-Jen Lee ◽  
Jui-Yuan Lin ◽  
Simon Hsia ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Antioxidant Enzymes ◽  
Vitamin E ◽  
Coenzyme Q10 ◽  
Antioxidant Status ◽  
Antioxidant Enzyme Activities ◽  
Enzymes Activities ◽  
Blood Biochemical ◽  
Antioxidant Enzymes Activities ◽  
Low Levels

The purpose of this study was to investigate the levels of coenzyme Q10 and vitamin E and the antioxidant status in subjects with metabolic syndrome (MS). Subjects with MS (n=72) were included according to the criteria for MS. The non-MS group (n=105) was comprised of healthy individuals with normal blood biochemical values. The plasma coenzyme Q10, vitamin E concentrations, lipid profiles, and antioxidant enzymes levels (catalase, superoxide dismutase, and glutathione peroxidase) were measured. The subjects with MS had significantly higher concentrations of plasma coenzyme Q10 and vitamin E than those in the non-MS group, but these differences were not significant after being normalized for triglyceride level. The levels of antioxidant enzymes were significantly lower in the MS group than in the non-MS group. The subjects with the higher antioxidant enzymes activities had significant reductions in the risk of MS (P<0.01) after being adjusted for coenzyme Q10 and vitamin E. In conclusion, the subjects with MS might be under higher oxidative stress resulting in low levels of antioxidant enzyme activities. A higher level of antioxidant enzymes activities was significantly associated with a reduction in the risk of MS independent of the levels of coenzyme Q10 and vitamin E.

EFFECTS OF COPPER ON ANTIOXIDANT ENZYMES ACTIVITIES AND METALLOTHIONEIN CONCENTRATION OF BELLAMYA PURIFICATA

2009 ◽  
Vol 33 (4) ◽  
pp. 717-725 ◽  
Author(s):  
Qing-Shun ZHANG ◽  
Jian-Jun HOU ◽  
Xiang-Jiang LIU ◽  
Jie-Xuan LUO ◽  
Bang-Xi XIONG
Keyword(s):  
Antioxidant Enzymes ◽  
Enzymes Activities ◽  
Antioxidant Enzymes Activities

scholarly journals Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations—A Systematic Review of the Literature

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1692
Author(s):  
Teresa Grohmann ◽  
Caroline Litts ◽  
Graham Horgan ◽  
Xuguang Zhang ◽  
Nigel Hoggard ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Ldl Cholesterol ◽  
Cholesterol Metabolism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Good Evidence ◽  
Seed Extract

Intervention with fruit extracts may lower glucose and lipid levels, as well as blood pressure. We reviewed the efficacy of bilberry and grape seed extracts to affect these outcomes across populations with varying health status, age and ethnicity, across intervention doses and durations, in 24 intervention studies with bilberry and blackcurrant (n = 4) and grape seed extract (n = 20). Bilberry and blackcurrant extract lowered average levels of glycated hemoglobin (HbA1c), at least in Chinese subjects, especially in those who were older, who were diagnosed with Type 2 Diabetes Mellitus (T2DM) and who were participating in longer-term studies. We also found good evidence that across studies and in subjects with hypercholesterolemia, T2DM or metabolic syndrome, intervention with bilberry and blackcurrant extract, and to some extent grape seed extract, significantly lowered total and low density lipoprotein (LDL) cholesterol levels after four weeks. Intervention with grape seed extract may reduce systolic and diastolic blood pressure in subjects with hypertension or metabolic syndrome. Differential responsiveness in cholesterol and blood pressure outcomes between stratified populations could not be explained by age, dose or study duration. In conclusion, bilberry and blackcurrant extract appears effective in lowering HbA1c and total and LDL cholesterol, whereas grape seed extract may lower total and LDL cholesterol, and blood pressure, in specific population groups.

scholarly journals Copper-stress induced alterations in protein profile and antioxidant enzymes activities in the in vitro grown Withania somnifera L.

2013 ◽  
Vol 19 (3) ◽  
pp. 353-361 ◽  
Author(s):  
Jyoti R. Rout ◽  
Shidharth S. Ram ◽  
Ritarani Das ◽  
Anindita Chakraborty ◽  
Mathummal Sudarshan ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Withania Somnifera ◽  
Protein Profile ◽  
Copper Stress ◽  
Enzymes Activities ◽  
Antioxidant Enzymes Activities

scholarly journals Caffeic Acid on Metabolic Syndrome: A Review

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5490
Author(s):  
Nellysha Namela Muhammad Abdul Kadar ◽  
Fairus Ahmad ◽  
Seong Lin Teoh ◽  
Mohamad Fairuz Yahaya
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Caffeic Acid ◽  
Central Obesity ◽  
Fruits And Vegetables ◽  
Fasting Glucose ◽  
Density Lipoprotein ◽  
Wide Range ◽  
Single Strategy ◽  
Natural Way

Metabolic syndrome (MetS) is a constellation of risk factors that may lead to a more sinister disease. Raised blood pressure, dyslipidemia in the form of elevated triglycerides and lowered high-density lipoprotein cholesterol, raised fasting glucose, and central obesity are the risk factors that could lead to full-blown diabetes, heart disease, and many others. With increasing sedentary lifestyles, coupled with the current COVID-19 pandemic, the numbers of people affected with MetS will be expected to grow in the coming years. While keeping these factors checked with the polypharmacy available currently, there is no single strategy that can halt or minimize the effect of MetS to patients. This opens the door for a more natural way of controlling the disease. Caffeic acid (CA) is a phytonutrient belonging to the flavonoids that can be found in abundance in plants, fruits, and vegetables. CA possesses a wide range of beneficial properties from antioxidant, immunomodulatory, antimicrobial, neuroprotective, antianxiolytic, antiproliferative, and anti-inflammatory activities. This review discusses the current discovery of the effect of CA against MetS.

scholarly journals Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study

2018 ◽  
Vol 6 ◽  
pp. 205031211875666 ◽  
Author(s):  
Alemu Gebrie ◽  
Natesan Gnanasekaran ◽  
Menakath Menon ◽  
Mekonnen Sisay ◽  
Abriham Zegeye
Keyword(s):  
Blood Pressure ◽  
Blood Cell ◽  
Total Cholesterol ◽  
Hematological Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Low Density ◽  
Blood Cell Count ◽  
Hypertensive Patients

Introduction: Hypertension and dyslipidemia are the two coexisting and synergizing major risk factors for cardiovascular diseases. The cellular constituents of blood affect the volume and viscosity of blood, thus playing a key role in regulating blood pressure. Overweight and obesity are key determinants of adverse metabolic changes including an increase in blood pressure. The aim of this study was to evaluate lipid profiles and hematological parameters in hypertensive patients at Debre Markos Referral Hospital, Northwest Ethiopia. Methods: Laboratory-based cross-sectional study was conducted in 100 eligible hypertensive patients at the hospital. The required amount of blood was withdrawn from the patients by healthcare professionals for immediate automated laboratory analyses. Data were collected on socio-demographic factors, anthropometric measurements, blood pressure, lipid profiles, and hematological parameters. Result: The mean serum levels of triglyceride, total cholesterol, and low-density lipoprotein were significantly higher than their respective cut-off values in the hypertensive patients. Besides, 54%, 52%, 35%, and 11% of the hypertensive patients had abnormal low-density lipoprotein, total cholesterol, triglyceride, and high-density lipoprotein levels, respectively. Higher levels of low-density lipoprotein, hemoglobin, and red blood cell count were observed in the hypertensive patients whose blood pressure had been poorly controlled than the controlled ones ( p < 0.05). Waist circumference had a significant positive association with the serum levels of total cholesterol and white blood cell count ( p < 0.05). Conclusion: Hypertensive patients had a high prevalence of lipid profile abnormalities and poorly controlled blood pressure which synergize in accelerating other cardiovascular diseases. Some hematological parameters such as red blood cell count are also increased as do the severity of hypertension.

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