scholarly journals Caffeic Acid on Metabolic Syndrome: A Review

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5490
Author(s):  
Nellysha Namela Muhammad Abdul Kadar ◽  
Fairus Ahmad ◽  
Seong Lin Teoh ◽  
Mohamad Fairuz Yahaya

Metabolic syndrome (MetS) is a constellation of risk factors that may lead to a more sinister disease. Raised blood pressure, dyslipidemia in the form of elevated triglycerides and lowered high-density lipoprotein cholesterol, raised fasting glucose, and central obesity are the risk factors that could lead to full-blown diabetes, heart disease, and many others. With increasing sedentary lifestyles, coupled with the current COVID-19 pandemic, the numbers of people affected with MetS will be expected to grow in the coming years. While keeping these factors checked with the polypharmacy available currently, there is no single strategy that can halt or minimize the effect of MetS to patients. This opens the door for a more natural way of controlling the disease. Caffeic acid (CA) is a phytonutrient belonging to the flavonoids that can be found in abundance in plants, fruits, and vegetables. CA possesses a wide range of beneficial properties from antioxidant, immunomodulatory, antimicrobial, neuroprotective, antianxiolytic, antiproliferative, and anti-inflammatory activities. This review discusses the current discovery of the effect of CA against MetS.

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e029628 ◽  
Author(s):  
Tanko Abdulai ◽  
Yuqian Li ◽  
Haiqing Zhang ◽  
Runqi Tu ◽  
Xiaotian Liu ◽  
...  

ObjectiveThis study estimated the burden and characterised the risk factors associated with diabetes and impaired fasting glucose (IFG) in an undiagnosed rural population.DesignData for 36 960 participants from the Henan Rural Cohort baseline with undiagnosed diabetes were analysed. X2 test and multivariate logistic regression analyses were performed to test for association between risk factors and diabetes and IFG.ResultsWomen constituted 60.30% of the study participants, mean age of participants was 55.32±12.18 years, risk factors for diabetes and IFG were prevalent (75% dyslipidaemia, 57% overweight/obese, 50% central obesity and 18% metabolic syndrome). The prevalence of diabetes and IFG was 4.19% and 7.22%, respectively. Having a metabolic syndrome (adjusted OR (aOR) 4.7, 95% CI 4.27 to 5.33), dyslipidaemia (aOR 2.76, 95% CI 2.31 to 3.21), centrally obese (aOR 2.38, 95% CI 2.11 to 2.70), being overweight/obese (aOR 1.66, 95% CI 1.45 to 1.79) and a family history of diabetes (aOR 1.50, 95% CI 1.15 to 1.92) were associated with diabetes. These factors were also associated with IFG. Intake of high salt diet (aOR 1.16, 95% CI 1.02 to 1.32) and smoking (aOR 1.22, 95% CI 1.02 to 1.47; significant in men) were also associated with diabetes. Engaging in moderate physical activity (aOR 0.94, 95% CI 0.89 to 0.98) was noted to be negatively associated with diabetes.ConclusionDiabetes and IFG remain prevalent in Chinese population with obesity and dyslipidaemia being some of the most significant predictors. Regular physical activity and consumption of fruits and vegetables may be beneficial in keeping blood glucose level low.Trial registration numberChiCTR-OOC-15006699


Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Rumana J Khan ◽  
Charles N Rotimi ◽  
Samson Y Gebreab ◽  
Pia R Crespo ◽  
Ruihua Xu ◽  
...  

Introduction: Metabolic syndrome (MS) is a clustering of five metabolic risk factors including abdominal obesity (OB), elevated blood pressure, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), and impaired fasting glucose (IFG). Few studies have fully reported the strength of clustering of these risk factors in a parent-offspring relationship. This analysis describes the associations between parents and their adult offspring in regard to MS. It also estimates the association between each risk factor in parents and the presence of MS in their offspring. Methods: We analyzed data for 1193 offspring (565 sons, and 628 daughters) from the Framingham Offspring Study who attended examinations 5, 6, and 7. Information about their parents was collected from examinations 13, 14 and 15 of the Framingham Original Cohort study. We used pedigree file to combine parental and offspring’s data. Participants were classified as having the MS according to the Adult Treatment Panel III criteria. Logistic regression was used to estimate the associations. Results: After adjusting for age, education, smoking, alcohol consumption and physical activity level of offspring, no significant association was found between fathers’ and their offspring’s MS. Mothers’ MS was significantly and positively associated with their daughters’ MS (adjusted odds ratio or adj OR:1.63; 95% confidence Interval, CI:1.02-2.61), but not with their sons’ MS. This gender difference was not observed when both the parents had MS. Daughters (adj OR:4.13; 95% CI:1.31_13.07) and sons (adj OR:4.31; 95% CI:0.98-19.77) both had more than 4 folds of increased odds of having MS if both parents had MS compared to offspring whose neither parent had MS. When analyzed by individual components, mothers’ IFG (adj OR:2.03 ; 95% CI:1.02- 9.31), OB (adj OR:1.56; 95% CI:0.98- 2.55) and HDL-C (adj OR: 2.12; 95% CI:1.35-3.32) were associated daughters’ MS. But none of these were significant for their sons’ MS. For fathers, only IFG (adj OR:4.91; 95% CI:2.07- 11.68) was associated with their daughters’ MS. Conclusions: We found differential associations between parents and their adult offspring in regard to MS. Daughters with mother’s MS were in higher risk than daughters or sons with father’s MS.


2020 ◽  

Background and objective: Managing the decrease in physical function in the elderly is a major task in aging societies globally. Here, we aimed to compare the physical function and metabolic syndrome (MetS) risk factors according to levels of physical activity (PA). Material and methods: We measured PA in 77 elderly Korean men (74.21 ± 6.26 years old) with an accelerometer and recorded body composition, physical function, and MetS-related risk factors. Participants were divided into three groups based on daily moderate-vigorous physical activity (MVPA): low (under 60 min), middle (60-120 min), and high (over 120 min). The groups were compared using a one-way analysis of variance and the Scheffe post hoc test. Odds ratios (OR) were calculated by logistic regression analysis. Results: Significant differences were found between the groups for sedentary behavior time (P < 0.001), light PA (P < 0.05), moderate PA (P < 0.001), vigorous PA (P < 0.05), and total energy expenditure (P < 0.001). The high PA group showed a significantly lower percentage of body fat and fat mass and higher muscle mass than did the low and middle PA groups (P < 0.05). The 6-min walk test was significantly better in the high PA group than in the low and middle PA groups (P < 0.05). Grip strength and the Berg balance scale were also significantly better in the high PA group (P < 0.05). Bone mineral density (BMD) and high-density lipoprotein cholesterol (HDL-C) were significantly higher in the high PA group than in the low PA group (P < 0.05). Systolic blood pressure (SBP) was significantly higher in the middle PA group than in the low PA group (P < 0.05). Participants with more than three MetS criteria showed an OR of 0.09 (95% confidence interval 0.01-0.82) in the high PA group as compared with the low PA group (P < 0.05). Conclusions: Moderate-vigorous physical activity of more than 120 min daily showed better physical function and lower OR of MetS than did lower MVPA levels in elderly Korean men.


BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e038671
Author(s):  
Feng-E Li ◽  
Fu-Liang Zhang ◽  
Peng Zhang ◽  
Dong Liu ◽  
Hao-Yuan Liu ◽  
...  

ObjectivesLow levels of income and education are risk factors for metabolic syndrome in the population of Northeast China, which has a high incidence of metabolic syndrome and cardiovascular diseases. This study aimed to determine sex-based differences associated with the prevalence of and risk factors for metabolic syndrome among people older than 40 years in Northeast China; this has not been previously investigated.DesignThis study analysed a portion of the large sample data of the national cross-sectional screening of China from 2016. Metabolic syndrome was defined as the presence of any three of the following five risk factors: abnormal waist circumference; high levels of triglycerides, high-density lipoprotein cholesterol or fasting plasma glucose; and elevated blood pressure. Multiple regression analysis was used to investigate sex-based differences in the prevalence of, and risk factors for metabolic syndrome.SettingThe study was conducted in Dehui City, Jilin Province, China.ParticipantsA total of 4052 participants with complete questionnaire information and laboratory examination results were included.ResultsThe prevalence of metabolic syndrome was 50.1% overall (38.4% in men and 57.9% in women; p<0.001). High body mass index and hip circumference were associated with metabolic syndrome in both sexes. In addition, physical inactivity (OR and 95% CI 1.44 (1.06 to 1.97); p=0.022) in men and advanced age (OR and 95% CI 1.54 (1.15 to 2.04); p=0.003) in women were factors associated with metabolic syndrome. Women with junior high school education or above and living in rural areas were less likely to have metabolic syndrome. For men, education and rural or urban living had no association with metabolic syndrome.ConclusionsThe risk factors for metabolic syndrome have similarities and differences in different sexes; thus, the prevention and treatment of metabolic syndrome should be based on these sex differences.


Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Todd M Brown ◽  
Joshua Richman ◽  
Vera Bittner ◽  
Cora E Lewis ◽  
Jenifer Voeks ◽  
...  

Background: Some individuals classified as having metabolic syndrome (MetSyn) are centrally obese while others are not with unclear implications for cardiovascular (CV) risk. Methods: REGARDS is following 30,239 individuals ≥45 years of age living in 48 states recruited from 2003-7. MetSyn risk factors were defined using the AHA/NHLBI/IDF harmonized criteria with central obesity being defined as ≥88 cm in women and ≥102 cm in men. Participants with and without central obesity were stratified by whether they met >2 or ≤2 of the other 4 MetSyn criteria, resulting in the creation of 4 groups. To ascertain CV events, participants are telephoned every 6 months with expert adjudication of potential events following national consensus recommendations and based on medical records, death certificates, and interviews with next-of-kin or proxies. Acute coronary heart disease (CHD) was defined as definite or probable myocardial infarction or acute CHD death. To determine the association between these 4 groups and incident acute CHD, we constructed Cox proportional hazards models in those free of CHD at baseline by race/gender group, adjusting for sociodemographic variables. Results: A total of 20,018 individuals with complete data on MetSyn components were free of baseline CHD. Mean age was 64+/−9 years, 58% were women, and 42% were African American. Over a mean follow-up of 3.4 (maximum 5.9) years, there were 442 acute CHD events. In the non-centrally obese with>2 other risk factors, risk for CHD was higher for all but AA men, though significant only for white men. In contrast, in the centrally obese with >2 other risk factors, risk was doubled for women, but only non-significantly and modestly increased for men. Only AA women with central obesity and ≤2 other risk factors had increased CHD risk (Table). Conclusion: The CHD risk associated with the MetSyn varies by the presence of central obesity as well as the race and gender of the individual.


Background. Nowadays the importance of lifestyles in the prevention of type 2 diabetes and the metabolic syndrome has been largely accertained. Objective. The purpose of our work is to implement programs that promote a nutritional culture in adolescents and young adults of the La Sabana University. Methods. The methodology entailed, after the corresponding informed consent, taking measures of the triceps and supraescapular skinfolds, waist circumference, body mass index (BMI), lean mass, and fat mass. Fasting blood samples were also taken to quantify cholesterol, triglycerides, high density lipoprotein (HDL) and low density lipoprotein (LDL). Results. The results obtained show that of the 165 students, 10.3% were underweight, 13.93% were overweight and 0.6% were obese. With regards to gender, 4.8% of the men and 9% of the women were overweight, 3% of the men and 7.2% of the women were underweight, and 0.6% of the women were obese. The blood chemistry showed that 30% had hypercholesterolemia, 18% hypertriglyceridemia, 17% reported low HDL levels and 67% reported high LDL levels. Of all the cases studied, 40% are at risk of a metabolic syndrome. 60% claimed not to practice any physical activity - especially women who reported 44.70%. Conclusions. These findings have allowed us at the institution to implement a culture of healthy habits. The have also allowed us to identify students with risk factors for type 2 diabetes and metabolic syndrome. This is why the cardiometabolic monitoring and control based on healthy eating and physical activity are important.


2020 ◽  
Author(s):  
Shao Chia Chiu Lin ◽  
Mei-Ju Chen

Abstract Background: The effects of different definitions for metabolic syndrome (MetS) on its prevalence were examined, and the differences in the discriminatory power, as well as the optimal cutoff points of relevant risk factors, were analyzed in this study. Methods: 45,756 health checkup data sets from 2011 to 2014 of high school students aged between 15 to 17 years were sourced in Taipei city. The database included the students’ gender, age, height, weight, waist circumference (WC), systolic and diastolic blood pressure, as well as biochemical markers such as triglycerides (TG), high-density lipoprotein cholesterol, and fasting glucose (FG) levels. The ROC curve statistical approach was used to analyze the discriminatory power and optimal cutoff points of the relevant MetS risk factors. Results: The prevalence of MetS among adolescents in Taipei was 2.3% and 1.2%, according to the criteria of the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF) respectively. The prevalence increased to 4.3% when this study’s criteria were used. Among the components of MetS analyzed, WC and TG had stronger discriminatory powers, while FG had the weakest. The optimal cutoff point for WC was approximately the 90 th percentile, while that for the TG was similar to the criteria of the modified NCEP ATP III. About 44.6% of adolescents had at least one MetS component. Body mass index also had good discriminatory power. Conclusions: The prevalence of MetS differs depending on the diagnostic criteria used. Redefining the cutoff points for the components of MetS in adolescents in different regions, as well as further screening and intervention, are crucial to prevent cardiovascular disease and type 2 diabetes mellitus in the future.


Author(s):  
Ravi Retnakaran ◽  
Baiju R. Shah

Background Women with either preterm or small‐for‐gestational‐age (SGA) delivery have an elevated lifetime risk of cardiovascular disease that has been attributed to the accrual of vascular risk factors over time. We sought to determine whether an adverse cardiovascular risk factor profile develops in the years before pregnancies complicated by preterm delivery or SGA. Methods and Results Using administrative databases, we identified all 156 278 nulliparous women in Ontario, Canada, who had singleton pregnancies between January 2011 and December 2018 and ≥2 measurements of the following analytes between January 2008 and the start of pregnancy: glycosylated hemoglobin, glucose, lipids, and alanine aminotransferase. There were 11 078 women with preterm delivery and 19 367 with SGA. The 2 most recent pregravid tests were performed at median 0.6 (interquartile range, 0.3–1.4) and 1.9 (interquartile range, 1.1–3.3) years before pregnancy, respectively. Women with preterm delivery had higher pregravid glycosylated hemoglobin, glucose, low‐density lipoprotein cholesterol, triglycerides, and alanine aminotransferase, and lower high‐density lipoprotein cholesterol, than those without preterm delivery. In contrast, women with SGA had lower pregravid fasting glucose, random glucose, and triglycerides than those without SGA. In the years before pregnancy, women with preterm delivery had higher annual increases than their peers in glycosylated hemoglobin (0.7‐times higher), triglycerides (7.9‐times higher), and alanine aminotransferase (2.2‐times higher). During this time, fasting glucose increased in women who developed preterm delivery but decreased in their peers. Conclusions An adverse cardiovascular risk factor profile evolves over time in the years before pregnancy complicated by preterm delivery, but does not necessarily precede SGA.


2014 ◽  
Vol 3 (2) ◽  
pp. 1
Author(s):  
Ana Roberta Vilarouca da Silva

No Brasil, a Síndrome Metabólica (SM) é desconhecida em várias regiões, e pouco estudada em diferentes populações. Isso porque, é proveniente da globalização, indicador inerente à modificação do estilo de vida da sociedade. Esta síndrome associa-se a Doenças Crônicas Não-Transmissíveis (DCNT), especialmente as cardiovasculares. E por ser multifatorial, destacam-se os níveis pressóricos e glicêmicos elevados, fatores-problema no desenvolvimento de complicações. A SM é um transtorno complexo representado por um conjunto de fatores de risco cardiovascular (a hipertensão arterial, a dislipidemia, a obesidade visceral e as manifestações de disfunção endotelial), usualmente relacionados à disposição central de gordura e à resistência à insulina(1). As três principais definições clínicas da SM em adultos utilizadas são as propostas pela Organização Mundial de Saúde (OMS), pelo National Cholesterol Education Program’s Adult Treatment Panel III (NCEP-ATP III) e pela International Diabetes Federation (IDF)(2). E em adolescentes existem adaptações(3-4). Assim, são fatores de risco para SM agregação de excesso de peso ou adiposidade central, hipertensão arterial, elevação dos triglicerídeos, diminuição do colesterol HDL (high density lipoprotein) e intolerância à glicose/resistência à insulina/diabetes mellitus tipo II (DMII). A prevalência de síndrome metabólica é variável, em função dos diferentes critérios diagnósticos utilizados. Na população pediátrica, as frequências de síndrome metabólica variam de 4,2% a 9,2%, com aumento na prevalência quando se consideram crianças e adolescentes obesos para 17,3% e 35,5%. Alguns estudos destacam que os componentes mais frequentes no diagnóstico de síndrome metabólica são a aumentada circunferência abdominal (88,1%) e pressão arterial (47,5%), seguidos de maior concentração de triglicerídeos (23,4%) e de baixo HDL-colesterol (23,3%)(5). Em se tratando do estado do Piauí, a busca à literatura revelou que até o presente momento, existe uma pesquisa em conclusão com foco na SM entre universitários e outras que iniciaram em 2014 com escolares, incluindo crianças e adolescentes de escolas públicas e privadas. Consequentemente, ainda não se conhece a sua prevalência nesses locais, assim como, não se conhece a prevalência da SM em populações específicas, como em adolescentes escolares. Levando em consideração as informações descritas anteriormente sobre os possíveis agravos que a SM pode causar, a associação às doenças cardiovasculares e ao DM2, acredita-se que a pesquisa sobre os fatores de risco para SM seja de extrema importância ao trazer dados iniciais sobre a SM, o que deverá suscitar o planejamento e a implementação de ações que tenham impacto na promoção da saúde dos estudantes.


Author(s):  
Liye Zou ◽  
Yangjie Zhang ◽  
Jeffer Eidi Sasaki ◽  
Albert S. Yeung ◽  
Lin Yang ◽  
...  

Background: The improvement of living standards has led to increases in the prevalence of hypokinetic diseases. In particular, multifactorial complex diseases, such as metabolic syndrome, are becoming more prevalent. Currently, developing effective methods to combat or prevent metabolic syndrome is of critical public health importance. Thus, we conducted a systematic review to evaluate the existing literature regarding the effects of Wuqinxi exercise on reducing risk factors related to metabolic syndrome. Methods: Both English- and Chinese-language databases were searched for randomized controlled trials investigating the effects of Wuqinxi on these outcomes. Meanwhile, we extracted usable data for computing pooled effect size estimates, along with the random-effects model. Results: The synthesized results showed positive effects of Wuqinxi exercise on systolic blood pressure (SBP, SMD = 0.62, 95% CI 0.38 to 0.85, p < 0.001, I2 = 24.06%), diastolic blood pressure (DBP, SMD = 0.62, 95% CI 0.22 to 1.00, p < 0.001, I2 = 61.28%), total plasma cholesterol (TC, SMD = 0.88, 95% CI 0.41 to 1.36, p < 0.001, I2 = 78.71%), triglyceride (TG, SMD = 0.87, 95% CI 0.49 to 1.24, p < 0.001, I2 = 67.22%), low-density lipoprotein cholesterol (LDL-C, SMD = 1.24, 95% CI 0.76 to 1.72, p < 0.001, I2 = 78.27%), and high-density lipoprotein cholesterol (HDL, SMD = 0.95, 95% CI 0.43 to 1.46, p < 0.001, I2 = 82.27%). In addition, regression results showed that longer-duration Wuqinxi intervention significantly improved DBP (β = 0.00016, Q = 5.72, df = 1, p = 0.02), TC (β = −0.00010, Q = 9.03, df = 1, p = 0.01), TG (β = 0.00012, Q = 6.23, df = 1, p = 0.01), and LDL (β = 0.00011, Q = 5.52, df = 1, p = 0.02). Conclusions: Wuqinxi may be an effective intervention to alleviate the cardiovascular disease risk factors of metabolic syndrome.


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