scholarly journals HTCC-Modified Nanoclay for Tissue Engineering Applications: A Synergistic Cell Growth and Antibacterial Efficiency

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Majid Aliabadi ◽  
Roya Dastjerdi ◽  
Kourosh Kabiri
Keyword(s):  
Tissue Engineering ◽  
Cell Growth ◽  
Cell Attachment ◽  
Exchange Process ◽  
Electrospun Nanofibers ◽  
Chronic Infections ◽  
Engineering Applications ◽  
Antibacterial Efficiency ◽  
Modified Clay ◽  
Modified Montmorillonite

This paper deals with the synthesis of a biocompatible chitosan ammonium salt N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC) and using it in montmorillonite ion-exchange process. HTCC-modified montmorillonite (Mt) with different chemical ratios was successfully synthesized, and their characteristics have been verified by XRD and FTIR analyses. Produced samples have been evaluated in terms of antibacterial efficiency and biocompatibility (cell culture test). Antibacterial efficiency of synthesized HTCC/Mt samples has been confirmed against both gram negative bacteria (Escherichia coli) and gram positive bacteria (Staphylococcus aureus). The results disclosed that the antibacterial efficiency of HTCC-modified montmorillonite was unexpectedly even more than HTCC. This excellent synergistic effect has been referred to entrapping bacteria between the intercalated structures of HTCC-modified montmorillonite. Then HTCC on clay layers can seriously attack and damage the entrapped bacteria. An extraordinary biocompatibility, cell attachment, and cell growth even more than tissue culture polystyrene (TCPS) have been recorded in the case of this novel kind of modified clay. Due to existing concerns about serious and chronic infections after implant placement, this natural-based bioactive and antibacterial modified clay can be used in electrospun nanofibers and other polymeric implants with promising mechanical properties for tissue engineering applications.

Poly(L-Lactic Acid-Co-Aspartic Acid): Interactive Polymers for Tissue Engineering

1995 ◽  
Vol 394 ◽  
Author(s):  
Jeffrey S. Hrkach ◽  
Jean Ou ◽  
Noah Lotan ◽  
Robert Langer
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Cell Growth ◽  
Aspartic Acid ◽  
Biodegradable Polymers ◽  
Cell Attachment ◽  
Biologically Active ◽  
Functional Sites ◽  
Support Cell ◽  
Enhance Cell Attachment

AbstractOne of the challenges in the field of tissue engineering is the development of optimal materials for use as scaffolds to support cell growth and tissue development. For this purpose, we are developing synthetic, biodegradable polymers with functional sites that provide the opportunity to covalently attach biologically active molecules to the polymers, so they can predictably interact with cells in a favorable manner to enhance cell attachment and growth. The preparation of poly(L-lactic acid-co-aspartic acid) comb-like graft copolymers from poly(L-lactic acid-co-β-benzyl-L-aspartate), and the casting of polymer films by solvent evaporation were carried out.

PCL and PCL/PLA Scaffolds for Bone Tissue Regeneration

2013 ◽  
Vol 683 ◽  
pp. 168-171 ◽  
Author(s):  
Tatiana Patrício ◽  
Antonio Gloria ◽  
Paulo J. Bártolo
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Cell Attachment ◽  
Bone Tissue Regeneration ◽  
Engineering Applications ◽  
Printing System

This paper investigates the use of PCL and PCL/PLA scaffolds, produced using a novel additive biomanufacturing system called BioCell Printing, for bone tissue engineering applications. Results show that the BioCell Printing system produces scaffolds with regular and reproducible architecture, presenting no toxicity and enhancing cell attachment and proliferation. It was also possible to observe that the addition of PLA to PCL scaffolds strongly improves the biomechanical performance of the constructs.

scholarly journals Synthesis, characterization and in vitro biocompatibility assessment of a novel tripeptide hydrogelator, as a promising scaffold for tissue engineering applications

2016 ◽  
Vol 4 (10) ◽  
pp. 1412-1416 ◽  
Author(s):  
Tihomir Pospišil ◽  
Lejla Ferhatović Hamzić ◽  
Lada Brkić Ahmed ◽  
Marija Lovrić ◽  
Srećko Gajović ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Growth ◽  
Growth Medium ◽  
Engineering Applications ◽  
In Vitro Biocompatibility ◽  
Hydrogel Matrix

The supramolecular self-assembles of a simple tripeptide Ac-l-Phe-l-Phe-l-Ala-NH2form a hydrogel matrix which may serve as the cell growth medium.

scholarly journals Design of graphene oxide/gelatin electrospun nanocomposite fibers for tissue engineering applications

RSC Advances ◽  
2016 ◽  
Vol 6 (110) ◽  
pp. 109150-109156 ◽  
Author(s):  
Sakthivel Nagarajan ◽  
Céline Pochat-Bohatier ◽  
Catherine Teyssier ◽  
Sébastien Balme ◽  
Philippe Miele ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Graphene Oxide ◽  
Cell Viability ◽  
Significant Influence ◽  
Cell Attachment ◽  
Electrospun Fibers ◽  
Engineering Applications ◽  
Nanocomposite Fibers

2D graphene oxide (GO) is used to enhance the mechanical properties of gelatin electrospun fibers. The GO does not show any significant influence on cell viability and cell attachment even though the expression of osteoblast gene is affected.

scholarly journals A new design of an electrospinning apparatus for tissue engineering applications

2017 ◽  
Vol 3 (2) ◽  
Author(s):  
Juliana R. Dias ◽  
Cyril Dos Santos ◽  
João Horta ◽  
Pedro Lopes Granja ◽  
Paulo Jorge Da Silva Bartolo
Keyword(s):  
Tissue Engineering ◽  
Simple Technique ◽  
Electrospun Nanofibers ◽  
Processing Parameters ◽  
Wound Dressings ◽  
Engineering Applications ◽  
Electrospinning Technique ◽  
Skin Tissue Engineering ◽  
Spinning Process ◽  
The Stability

The electrospinning technique is being widely explored in the biomedical field due to its simplicity to produce meshes and its capacity to mimic the micro-nanostructure of the natural extracellular matrix. For skin tissue engineering applications, wound dressings made from electrospun nanofibers present several advantages compared to conventional dressings, such as the promotion of the hemostasis phase, wound exudate absorption, semi-permeability, easy conformability to the wound, functional ability and no scar induction. Despite being a relatively simple technique, electrospinning is strongly influenced by polymer solution characteristics, processing parameters and environmental conditions, which strongly determine the production of fibers and their morphology. However, most electrospinning systems are wrongly designed, presenting a large number of conductive components that compromises the stability of the spinning process. This paper presents a new design of an electrospinning system solving the abovementioned limitations. The system was assessed through the production of polycaprolactone (PCL) and gelatin nanofibers.  Different solvents and processing parameters were considered. Results show that the proposed electrospinning system is suitable to produce reproducible and homogeneous electrospun fibers for tissue engineering applications.

Design and characterization of biodegradable multi layered electrospun nanofibers for corneal tissue engineering applications

2019 ◽  
Vol 107 (10) ◽  
pp. 2340-2349 ◽  
Author(s):  
Zohreh Arabpour ◽  
Alireza Baradaran‐Rafii ◽  
Nasrin L. Bakhshaiesh ◽  
Jafar Ai ◽  
Somayeh Ebrahimi‐Barough ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Electrospun Nanofibers ◽  
Corneal Tissue ◽  
Engineering Applications
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