scholarly journals Design of graphene oxide/gelatin electrospun nanocomposite fibers for tissue engineering applications

RSC Advances ◽  
2016 ◽  
Vol 6 (110) ◽  
pp. 109150-109156 ◽  
Author(s):  
Sakthivel Nagarajan ◽  
Céline Pochat-Bohatier ◽  
Catherine Teyssier ◽  
Sébastien Balme ◽  
Philippe Miele ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Graphene Oxide ◽  
Cell Viability ◽  
Significant Influence ◽  
Cell Attachment ◽  
Electrospun Fibers ◽  
Engineering Applications ◽  
Nanocomposite Fibers

2D graphene oxide (GO) is used to enhance the mechanical properties of gelatin electrospun fibers. The GO does not show any significant influence on cell viability and cell attachment even though the expression of osteoblast gene is affected.

scholarly journals Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 428 ◽  
Author(s):  
Carolina Angulo-Pineda ◽  
Kasama Srirussamee ◽  
Patricia Palma ◽  
Victor M. Fuenzalida ◽  
Sarah H. Cartmell ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Cell Viability ◽  
Reduced Graphene Oxide ◽  
Human Cell ◽  
Human Mesenchymal Stem Cells ◽  
Fold Increase ◽  
Cellular Mechanisms ◽  
Engineering Applications ◽  
Reduced Graphene

Applying electrical stimulation (ES) could affect different cellular mechanisms, thereby producing a bactericidal effect and an increase in human cell viability. Despite its relevance, this bioelectric effect has been barely reported in percolated conductive biopolymers. In this context, electroactive polycaprolactone (PCL) scaffolds with conductive Thermally Reduced Graphene Oxide (TrGO) nanoparticles were obtained by a 3D printing method. Under direct current (DC) along the percolated scaffolds, a strong antibacterial effect was observed, which completely eradicated S. aureus on the surface of scaffolds. Notably, the same ES regime also produced a four-fold increase in the viability of human mesenchymal stem cells attached to the 3D conductive PCL/TrGO scaffold compared with the pure PCL scaffold. These results have widened the design of novel electroactive composite polymers that could both eliminate the bacteria adhered to the scaffold and increase human cell viability, which have great potential in tissue engineering applications.

scholarly journals Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 590 ◽  
Author(s):  
Yuchao Li ◽  
Chengzhu Liao ◽  
Sie Chin Tjong
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Cell Attachment ◽  
Porous Scaffolds ◽  
Aliphatic Polyester ◽  
Engineering Applications ◽  
Aliphatic Polyesters ◽  
Nanocomposite Scaffolds

This paper provides review updates on the current development of bionanocomposites with polymeric matrices consisting of synthetic biodegradable aliphatic polyesters reinforced with nanohydroxyaptite (nHA) and/or graphene oxide (GO) nanofillers for bone tissue engineering applications. Biodegradable aliphatic polyesters include poly(lactic acid) (PLA), polycaprolactone (PCL) and copolymers of PLA-PGA (PLGA). Those bionanocomposites have been explored for making 3D porous scaffolds for the repair of bone defects since nHA and GO enhance their bioactivity and biocompatibility by promoting biomineralization, bone cell adhesion, proliferation and differentiation, thus facilitating new bone tissue formation upon implantation. The incorporation of nHA or GO into aliphatic polyester scaffolds also improves their mechanical strength greatly, especially hybrid GO/nHA nanofilllers. Those mechanically strong nanocomposite scaffolds can support and promote cell attachment for tissue growth. Porous scaffolds fabricated from conventional porogen leaching, and thermally induced phase separation have many drawbacks inducing the use of organic solvents, poor control of pore shape and pore interconnectivity, while electrospinning mats exhibit small pores that limit cell infiltration and tissue ingrowth. Recent advancement of 3D additive manufacturing allows the production of aliphatic polyester nanocomposite scaffolds with precisely controlled pore geometries and large pores for the cell attachment, growth, and differentiation in vitro, and the new bone formation in vivo.

Preparation of PVA nanocomposites using salep-reduced graphene oxide with enhanced mechanical and biological properties

RSC Advances ◽  
2015 ◽  
Vol 5 (112) ◽  
pp. 92428-92437 ◽  
Author(s):  
Ali Pourjavadi ◽  
Behzad Pourbadiei ◽  
Mohadeseh Doroudian ◽  
Shahram Azari
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Biological Properties ◽  
Engineering Applications ◽  
Reduced Graphene ◽  
Film Nanocomposites

Hydrogel and film nanocomposites based on PVA with desired mechanical properties are prepared using salep functionalized rGO and proposed as new biomaterials for tissue engineering applications.

scholarly journals Synergistic delivery of bFGF and BMP-2 from poly(l-lactic-co-glycolic acid)/graphene oxide/hydroxyapatite nanofibre scaffolds for bone tissue engineering applications

RSC Advances ◽  
2018 ◽  
Vol 8 (56) ◽  
pp. 31911-31923 ◽  
Author(s):  
Xiansheng Ren ◽  
Qinyi Liu ◽  
Shuang Zheng ◽  
Jiaqi Zhu ◽  
Zhiping Qi ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Glycolic Acid ◽  
Engineering Applications

One of the goals of bone tissue engineering is to create scaffolds with excellent biocompatibility, osteoinductive ability and mechanical properties.

Multifunctional poly(glycolic acid-co-propylene fumarate) electrospun fibers reinforced with graphene oxide and hydroxyapatite nanorods

2017 ◽  
Vol 5 (22) ◽  
pp. 4084-4096 ◽  
Author(s):  
Ana M. Díez-Pascual ◽  
Angel L. Díez-Vicente
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Soft Tissue ◽  
Bactericidal Activity ◽  
Glycolic Acid ◽  
Electrospun Fibers ◽  
Hybrid Nanocomposite ◽  
High Stiffness ◽  
Nanocomposite Fibers ◽  
Soft Tissue Engineering

Biocompatible and biodegradable PGA-co-PPF/HA/GO hybrid nanocomposite fibers with high stiffness and good bactericidal activity have been developed for soft tissue engineering.

Graphene oxide reinforced poly(vinyl alcohol): nanocomposite scaffolds for tissue engineering applications

RSC Advances ◽  
2015 ◽  
Vol 5 (32) ◽  
pp. 25416-25423 ◽  
Author(s):  
Cijun Shuai ◽  
Pei Feng ◽  
Chengde Gao ◽  
Xiong Shuai ◽  
Tao Xiao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Graphene Oxide ◽  
Porous Structure ◽  
Vinyl Alcohol ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Poly Vinyl Alcohol ◽  
Engineering Applications ◽  
Nanocomposite Scaffolds

In this study, graphene oxide is incorporated into poly(vinyl alcohol) for the purpose of improving the mechanical properties. Nanocomposite scaffolds with an interconnected porous structure are fabricated by selective laser sintering.

Synthesis and characterization of poly(glycerol sebacate)-based elastomeric copolyesters for tissue engineering applications

2016 ◽  
Vol 7 (14) ◽  
pp. 2553-2564 ◽  
Author(s):  
Yating Jia ◽  
Weizhong Wang ◽  
Xiaojun Zhou ◽  
Wei Nie ◽  
Liang Chen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Water Uptake ◽  
Synthesis And Characterization ◽  
Uptake Capacity ◽  
Engineering Applications ◽  
Water Uptake Capacity

A poly(glycerol sebacate)-based elastomeric copolyesters with improved mechanical properties and higher water uptake capacity.

scholarly journals Effects of Encapsulated Cells on the Physical–Mechanical Properties and Microstructure of Gelatin Methacrylate Hydrogels

2019 ◽  
Vol 20 (20) ◽  
pp. 5061 ◽  
Author(s):  
Srikumar Krishnamoorthy ◽  
Behnam Noorani ◽  
Changxue Xu
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Viability ◽  
Physical Properties ◽  
Pore Size ◽  
Cell Density ◽  
Tensile Modulus ◽  
Encapsulated Cells ◽  
3T3 Fibroblasts ◽  
Cell Densities

Gelatin methacrylate (GelMA) has been gaining popularity in recent years as a photo-crosslinkable biomaterial widely used in a variety of bioprinting and tissue engineering applications. Several studies have established the effects of process-based and material-based parameters on the physical–mechanical properties and microstructure of GelMA hydrogels. However, the effect of encapsulated cells on the physical–mechanical properties and microstructure of GelMA hydrogels has not been fully understood. In this study, 3T3 fibroblasts were encapsulated at different cell densities within the GelMA hydrogels and incubated over 96 h. The effects of encapsulated cells were investigated in terms of mechanical properties (tensile modulus and strength), physical properties (swelling and degradation), and microstructure (pore size). Cell viability was also evaluated to confirm that most cells were alive during the incubation. It was found that with an increase in cell density, the mechanical properties decreased, while the degradation and the pore size increased.

scholarly journals Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

2019 ◽  
Vol 9 (17) ◽  
pp. 3540 ◽  
Author(s):  
Ferdows Afghah ◽  
Caner Dikyol ◽  
Mine Altunbek ◽  
Bahattin Koc
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Attachment ◽  
Three Dimensional ◽  
Future Perspective ◽  
Melt Electrospinning ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Potential Applications ◽  
Homogeneous Cell

Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted.

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