scholarly journals Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Che-Yi Lin ◽  
Tien-Szu Pan ◽  
Chun-Chan Ting ◽  
Shih-Shin Liang ◽  
Shu-Hung Huang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Oral Cavity ◽  
Current Knowledge ◽  
Metabolic Activation ◽  
Screening Tests ◽  
Betel Quid ◽  
Diagnostic Tools ◽  
International Agency ◽  
Oral Potentially Malignant Disorders ◽  
Group I

Betel quid (BQ) products, with or without tobacco, have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens that are associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx. There are estimated 600 million BQ users worldwide. In Taiwan alone there are 2 million habitual users (approximately 10% of the population). Oral and pharyngeal cancers result from interactions between genes and environmental factors (BQ exposure). Cytochrome p450 (CYP) families are implicated in the metabolic activation of BQ- and areca nut-specific nitrosamines. In this review, we summarize the current knowledge base regardingCYPgenetic variants and related oral disorders. In clinical applications, we focus on cancers of the oral cavity and pharynx and OPMDs associated withCYPgene polymorphisms, includingCYP1A1,CYP2A6,CYP2E1, andCYP26B1. Our discussion ofCYPpolymorphisms provides insight into the importance of screening tests in OPMDs patients for the prevention of oral and pharyngeal cancers. Future studies will establish a strong foundation for the development of chemoprevention strategies, polymorphism-based clinical diagnostic tools (e.g., specific single-nucleotide polymorphism (SNP) “barcodes”), and effective treatments for BQ-related oral disorders.

scholarly journals The Influence of Monoamine Oxidase Variants on the Risk of Betel Quid-Associated Oral and Pharyngeal Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ping-Ho Chen ◽  
Bin Huang ◽  
Tien-Yu Shieh ◽  
Yan-Hsiung Wang ◽  
Yuk-Kwan Chen ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Betel Quid ◽  
International Agency ◽  
Pharyngeal Cancer ◽  
Oral Potentially Malignant Disorders ◽  
Group I ◽  
Oral And Pharyngeal Cancer ◽  
Mao A ◽  
Potentially Malignant

Betel quid (BQ) and areca nut (AN) (major BQ ingredient) are group I human carcinogens illustrated by International Agency for Research on Cancer and are closely associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx. The primary alkaloid of AN, arecoline, can be metabolizedviathe monoamine oxidase (MAO) gene by inducing reactive oxygen species (ROS). The aim of this study was to investigate whether the variants of the susceptible candidate MAO genes are associated with OPMDs and oral and pharyngeal cancer. A significant trend of MAO-A mRNA expression was found inin vitrostudies. Using paired human tissues, we confirmed the significantly decreased expression of MAO-A and MAO-B in cancerous tissues when compared with adjacent noncancerous tissues. Moreover, we determined that MAO-A single nucleotide polymorphism variants are significantly linked with oral and pharyngeal cancer patients in comparison to OPMDs patients [rs5953210 risk G-allele, odds ratio = 1.76; 95% confidence interval = 1.02-3.01]. In conclusion, we suggested that susceptible MAO family variants associated with oral and pharyngeal cancer may be implicated in the modulation of MAO gene activity associated with ROS.

scholarly journals Alteration of Macrophage Infiltrating Compartment: A Novel View on Oral Carcinogenesis

Pathobiology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Manabu Shigeoka ◽  
Yu-ichiro Koma ◽  
Mari Nishio ◽  
Masaya Akashi ◽  
Hiroshi Yokozaki
Keyword(s):  
Early Detection ◽  
Oral Cavity ◽  
Current Knowledge ◽  
Precancerous Lesions ◽  
Cancer Development ◽  
Published Data ◽  
Oral Potentially Malignant Disorders ◽  
Oral Carcinogenesis ◽  
Cancer Aggressiveness

<b><i>Background:</i></b> The mortality of oral squamous cell carcinoma (OSCC) has remained high for decades; therefore, methods for early detection of OSCC are warranted. However, in the oral cavity, various mucosal diseases may be encountered, including reactive lesions and oral potentially malignant disorders, and it is difficult to differentiate OSCC from these lesions based on both clinical and histopathological findings. It is well known that chronic inflammation contributes to oral cancer development. Macrophages are among the most common inflammatory cells in cancer stromal tissue and have various roles in cancer aggressiveness. Although the roles of macrophages in cancer development have attracted attention, only a few studies have linked macrophages to carcinogenesis, particularly, oral precancerous lesions. <b><i>Summary:</i></b> This review article consists of 3 parts: first, we summarize current knowledge on macrophages in human various epithelial precancerous lesions, excluding the oral cavity, to show the importance and gaps in knowledge regarding macrophages in carcinogenesis; second, we review published data related to the role of macrophages in oral carcinogenesis; finally, we present a novel view on oral carcinogenesis, focusing on crosstalk between epithelial cells and macrophages. <b><i>Key Messages:</i></b> The biological features of macrophages in oral carcinogenesis differ drastically depending on the anatomical compartment that they infiltrate. Focusing on the alteration of macrophage infiltrating compartment may serve as a useful novel approach for studying the role of the macrophages in oral carcinogenesis and for gaining further insight into cancer prevention and early detection.

scholarly journals Genetic and Proteinic Linkage of MAO and COMT with Oral Potentially Malignant Disorders and Cancers of the Oral Cavity and Pharynx

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3268
Author(s):  
Ping-Ho Chen ◽  
Yen-Yun Wang ◽  
Ting-Hsun Lan ◽  
Leong-Perng Chan ◽  
Shyng-Shiou Yuan
Keyword(s):  
Oral Cavity ◽  
Potential Role ◽  
Nucleotide Polymorphisms ◽  
Oral Potentially Malignant Disorders ◽  
Clinical Biomarkers ◽  
Group I ◽  
Increased Risk ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Betel quid (BQ), a group I human carcinogen, strongly contributes to an increased risk of oral potentially malignant disorders (OPMD) and cancers of the oral cavity and pharynx. This study was conducted to discover whether monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) variants play a potential role in the risk assessment of oral cavity and pharynx cancers and OPMD, particularly among BQ users. We applied a case–control study to confirm the polymorphism of MAO and COMT using single-nucleotide polymorphisms. We used qRT-PCR, Western blotting, and immunohistochemistry (IHC) to determine MAO and COMT expression. Carriers of the MAOA rs6323 G-allele, MAOB rs6324 G-allele, and COMT rs4633 C/C-genotype had a prominently increased risk of oral cavity and pharynx cancers (AOR = 56.99; p < 0.001). Compared to adjacent noncancerous tissues, a significant downregulation of MAO and COMT expression was exhibited in cancerous tissues (p < 0.01). Furthermore, in different cell models, MAO and COMT expression was significantly downregulated with an increased dose of arecoline (p < 0.01). In personalized preventive medicine for oral and pharyngeal cancers, our findings are the first to demonstrate the potential role of lower MAO and COMT expression levels, with the risk polymorphisms utilized as clinical biomarkers.

Role of metabolic activation by cytochrome P450 in thioacetamide-induced suppression of antibody response in male BALB/c mice

2000 ◽  
Vol 114 (1-3) ◽  
pp. 225-235 ◽  
Author(s):  
Kap-Ho Kim ◽  
Ju-Hyun Bae ◽  
Shin-Woo Cha ◽  
Sang-Seop Han ◽  
Kwan Ha Park ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Antibody Response ◽  
Metabolic Activation

SALIVARY CORTISOL LEVELS TO ESTABLISH A CAUSE AND EFFECT RELATIONSHIP IN PROGRESSION OF ORAL POTENTIALLY MALIGNANT DISORDERS

2021 ◽  
pp. 4-7
Author(s):  
Shefali Shefali ◽  
Saurabh Juneja ◽  
Anshi Jain ◽  
Devi Charan Shetty ◽  
Nikita Gulati
Keyword(s):  
Salivary Cortisol ◽  
Study Groups ◽  
Oral Potentially Malignant Disorders ◽  
Group Iii ◽  
Complex Interactions ◽  
Group I ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Elisa Technique ◽  
Cortisol Levels

The progression and development of OPMDs is inuenced by a multitude of factors which include complex interactions between physiological, psychological, behavioral and social factors. The persistent activation of HPA axis through tobacco usage probably impairs immune response and has a role in progression of OPMDs. The quantication of salivary cortisol facilitates the assessment of nicotine impact on the oral mucosa and in the progression of OPMDs. This study was undertaken to estimate the salivary cortisol levels in the OPMDs with and without habits thereby signifying the importance of salivary cortisol in the causation of disease or as an effective biomarker for disease progression during the pathogenetic process of the disease. Salivary cortisol levels were estimated by ELISA technique in 29 cases of differing grades of oral potentially malignant disorders consisting of individuals with habit and lesions (Group I), 32 cases of individuals having habit without lesions (Group II) and 3 cases of individuals having lesion without habit (Group III) and 8 cases with neither habit nor lesions (Group IV). Salivary cortisol levels were correlated within the different study groups and were analyzed using SPSS (version 20). Salivary cortisol levels were raised in group I as compared to all other groups. Clarity in the present study has been achieved that salivary cortisol levels can be researched to the causation of the disease as an important step forward. This study could open up newer avenues in understanding the pathogenetic mechanisms in Oral Potentially malignant disorders.

scholarly journals Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 288
Author(s):  
Julie Massart ◽  
Karima Begriche ◽  
Jessica H. Hartman ◽  
Bernard Fromenty
Keyword(s):  
Oxidative Stress ◽  
Cytochrome P450 ◽  
Liver Disease ◽  
Fatty Liver ◽  
Current Knowledge ◽  
Physiological Role ◽  
Experimental Investigations ◽  
Rat Liver Mitochondria ◽  
Cytochrome P450 2E1

Cytochrome P450 2E1 (CYP2E1) is pivotal in hepatotoxicity induced by alcohol abuse and different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing oxidative stress, mitochondrial dysfunction and cell death. In addition, this enzyme appears to play a role in the progression of obesity-related fatty liver to nonalcoholic steatohepatitis. Indeed, increased CYP2E1 activity in nonalcoholic fatty liver disease (NAFLD) is deemed to induce reactive oxygen species overproduction, which in turn triggers oxidative stress, necroinflammation and fibrosis. In 1997, Avadhani’s group reported for the first time the presence of CYP2E1 in rat liver mitochondria, and subsequent investigations by other groups confirmed that mitochondrial CYP2E1 (mtCYP2E1) could be found in different experimental models. In this review, we first recall the main features of CYP2E1 including its role in the biotransformation of endogenous and exogenous molecules, the regulation of its expression and activity and its involvement in different liver diseases. Then, we present the current knowledge on the physiological role of mtCYP2E1, its contribution to xenobiotic biotransformation as well as the mechanism and regulation of CYP2E1 targeting to mitochondria. Finally, we discuss experimental investigations suggesting that mtCYP2E1 could have a role in alcohol-associated liver disease, xenobiotic-induced hepatotoxicity and NAFLD.

scholarly journals Oral and Perioral Piercing Complications

2008 ◽  
Vol 2 (1) ◽  
pp. 133-136 ◽  
Author(s):  
N Escudero-Castaño ◽  
M.A Perea-García ◽  
J Campo-Trapero ◽  
Cano Sánchez ◽  
A Bascones-Martínez
Keyword(s):  
Hepatitis B ◽  
Adverse Effects ◽  
Oral Cavity ◽  
Current Knowledge ◽  
Case Series ◽  
Clinical Implications ◽  
Adolescent Population ◽  
High Incidence ◽  
Different Types ◽  
Sexual Symbolism

Background.The oral an perioral piercing has a long history as part of religious, tribal,cultural or sexual symbolism and nowdays there is a high incidence of oral and perioral piercing in the adolescent population. This practice has a long history as part of religious, tribal, cultural or sexual symbolism. This article reviews current knowledge on injuries or diseases that might be produced by piercing in the oral cavity. We propose a classification to diagnosed the pathologies related to oral an perioral piercingMethods.A search was conducted of articles in PubMed, Scielo published between 1997 and 2007, using the key words ``oral and perioral, piercing ´´, ``oral, piercing and disease”, ``recessions and oral piercing´´. It has reviewed about twentythree articles 17 were narrative reviews and 6 case seriesResults.A review was carried out on the origins of oral and perioral body piercing and its local implications, classifying the different alterations like recessions, systemic implications that it can produce in the oral and perioral cavity.Conclusion.Patients with oral and perioral piercing should be regularly followed up because of the possible development of different types of adverse effects.Clinical implications.Adverse effects of oral and perioral piercing can be systemic, with transmission of infectious diseases such as hepatitis B or C, or can be local, with alteration of oral mucosae or even of dental structures.

scholarly journals ORAL POTENTIALLY MALIGNANT DISORDERS ASSOCIATED WITH BETEL QUID CHEWING HABIT IN SAMOSIR ISLAND, NORTH SUMATRA INDONESIA

2017 ◽  
Vol 20 (2) ◽  
pp. 72-79
Author(s):  
Indri Lubis ◽  
Ameta Primasari ◽  
Sayuti Hasibuan
Keyword(s):  
Health Centre ◽  
Betel Quid ◽  
Control Group ◽  
Oral Potentially Malignant Disorders ◽  
Public Health Centre ◽  
Increased Risk ◽  
Betel Quid Chewing ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
North Sumatra

Oral potentially malignant disorders have been associated with a betel quid chewing habit. To date, betel quid chewing has a major social and cultural role in the society of Samosir Island, North Sumatra, Indonesia. The purpose of the present study was to evaluate the occurrence of oral potentially malignant disorders associated with the habit of betel quid chewing in the society of Samosir Island, North Sumatra, Indonesia. This case-control study was conducted on all betel quid chewers in the working area of the Ambarita Public Health Centre in Samosir Regency, North Sumatra, Indonesia. All subjects were examined clinically for the presence of any oral lesions and interviewed for their betel quid chewing habit. Chi-square and Fisher’s exact tests were used to analyze the relationship between variables. Among the 51 subjects recruited in the study, 28 subjects suffered from oral potentially malignant disorders who had oral potentially malignant disorders such as submucous fibrosis and/or leukoplakia (the case group) whereas 23 subjects showed no clinically detectable oral potentially malignant disorders (the control group). An increased risk of oral potentially malignant disorders was associated with the habit of chewing areca nut and tobacco (OR=1.600; p=0.542), the duration of betel quid chewing more than 25 years (OR=4.379; p=0.023), and the frequency of betel quid chewing more than 6 times/day (OR=4.800; p=0.021). In conclusion, oral potentially malignant disorders were associated with chewing betel quid habit in the society of Samosir Island, North Sumatra, Indonesia.

Interaction of Aflatoxin B1with Cytochrome P450 2A5 and Its Mutants:  Correlation with Metabolic Activation and Toxicity

1997 ◽  
Vol 10 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Päivi Pelkonen ◽  
Matti A. Lang ◽  
Masahiko Negishi ◽  
Christopher P. Wild ◽  
Risto O. Juvonen
Keyword(s):  
Cytochrome P450 ◽  
Metabolic Activation
Sign in / Sign up

Export Citation Format

Share Document