scholarly journals Gelatin-Modified Polyurethanes for Soft Tissue Scaffold

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Justyna Kucińska-Lipka ◽  
Iga Gubańska ◽  
Helena Janik
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Positive Impact ◽  
Engineering Application ◽  
Synthetic Polymers ◽  
Hexamethylene Diisocyanate ◽  
Tissue Engineering Application ◽  
Natural Polymers ◽  
Tissue Scaffold ◽  
Pu Foams

Recently, in the field of biomaterials for soft tissue scaffolds, the interest of their modification with natural polymersis growing. Synthetic polymers are often tough, and many of them do not possess fine biocompatibility. On the other hand, natural polymers are biocompatible but weak when used alone. The combination of natural and synthetic polymers gives the suitable properties for tissue engineering requirements. In our study, we modified gelatin synthetic polyurethanes prepared from polyester poly(ethylene-butylene adipate) (PEBA), aliphatic 1,6-hexamethylene diisocyanate (HDI), and two different chain extenders 1,4-butanediol (BDO) or 1-ethoxy-2-(2-hydroxyethoxy)ethanol (EHEE). From a chemical point of view, we replaced expensive components for building PU, such as 2,6-diisocyanato methyl caproate (LDI) and 1,4-diisocyanatobutane (BDI), with cost-effective HDI. The gelatin was added in situ (in the first step of synthesis) to polyurethane to increase biocompatibility and biodegradability of the obtained material. It appeared that the obtained gelatin-modified PU foams, in which chain extender was BDO, had enhanced interactions with media and their hydrolytic degradation profile was also improved for tissue engineering application. Furthermore, the gelatin introduction had positive impact on gelatin-modified PU foams by increasing their hemocompatibility.

scholarly journals Evaluation of 3D-Printing Scaffold Fabrication on Biosynthetic Medium-Chain-Length Polyhydroxyalkanoate Terpolyester as Biomaterial-Ink

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2222
Author(s):  
Anuchan Panaksri ◽  
Nuttapol Tanadchangsaeng
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Chain Length ◽  
Cell Attachment ◽  
Carbon Sources ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Medium Chain ◽  
Medium Chain Length ◽  
Study Results

Currently, the selection of materials for tissue engineering scaffolds is still limited because some tissues require flexible and compatible materials with human cells. Medium-chain-length polyhydroxyalkanoate (MCL-PHA) synthesized in microorganisms is an interesting polymer for use in this area and has elastomeric properties compatible with the human body. MCL-PHAs are elastomers with biodegradability and cellular compatibility, making them an attractive material for fabricating soft tissue that requires high elasticity. In this research, MCL-PHA was produced by fed-batch fermentation that Pseudomonas Putida ATCC 47054 was cultured to accumulate MCL-PHA by using glycerol and sodium octanoate as carbon sources. The amounts of dry cell density, MCL-PHA product per dry cells, and MCL-PHA productivity were at 15 g/L, 27%, and 0.067 g/L/h, respectively, and the components of MCL-PHA consisting of 3-hydroxydecanoate (3HD) 64.5%, 3-hydroxyoctanoate (3HO) 32.2%, and 3-hydroxyhexanoate (3HHx) 3.3%. The biosynthesized MCL-PHA terpolyester has a relatively low melting temperature, low crystallinity, and high ductility at 52 °C, 15.7%, and 218%, respectively, and considering as elastomeric polyester. The high-resolution scaffold of MCL-PHA terpolyester biomaterial-ink (approximately 0.36 mm porous size) could be printed in a selected condition with a 3D printer, similar to the optimum pore size for cell attachment and proliferation. The rheological characteristic of this MCL-PHA biomaterial-ink exhibits shear-thinning behavior, leading to good shape fidelity. The study results yielded a condition capable of fabricating an elastomer scaffold of the MCL-PHA terpolyester, giving rise to the ideal soft tissue engineering application.

Fabrication of Three-Dimensional Alginate Porous Scaffold Incorporated with Decellularized Cornu Cervi Pantotrichum Particle for Bone Tissue Engineering

2020 ◽  
Vol 20 (9) ◽  
pp. 5356-5359
Author(s):  
Tae In Hwang ◽  
Joon Yeon Moon ◽  
Jeong In Kim ◽  
Chan Hee Park ◽  
Cheol Sang Kim
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffold ◽  
Three Dimensional ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Liquid Form ◽  
Tissue Scaffold ◽  
Ft Ir ◽  
Highly Porous

Deer antler velvet (DAV), Cornu Cervi Pantotrichum, has been known for the outstanding growth rate and used in extracted liquid form in oriental herbal medicine for the tissue regeneration. The DAV is also famous for the abundance of many different minerals, proteins, growth factors and interleukins. The immense amount of DAV is consumed to produce DAV extract in Asian countries. However, the mechanical strength and the morphologic features of DAV have been overlooked. In this study, we revisited the possibility of DAV as a bone tissue scaffold. We first obtained DAV particles via physical decellularization followed by levigation procedure and then applied to the fabrication of three-dimensional porous alginate/DAVP sponge through lyophilizing alginate/DAVP hydrogel as a potential bone tissue scaffold source. The morphological and physicochemical properties of alginate/DAVP sponge were characterized using UTM, SEM, FE-SEM, and FT-IR. The alginate-based highly porous sponge demonstrated the interconnected porous structure with DAVP and improved mechanical properties. We expected both alginate/DAVP and DAVP are potential for tissue engineering application.

scholarly journals Marine Based Biomaterials in Dental Regeneration

2020 ◽  
Vol 5 (10) ◽  
pp. 443-448
Author(s):  
Dr. Mekha Grace Varghese ◽  
Dr. Thomas George V. ◽  
Dr. Nebu George Thomas ◽  
Dr. Alenya Mary Pyas ◽  
Dr. Arimboor Maymol Francis
Keyword(s):  
Tissue Engineering ◽  
Biomedical Application ◽  
Engineering Application ◽  
The Body ◽  
Local Drug Delivery ◽  
Tissue Engineering Application ◽  
Natural Polymers ◽  
Dental Tissue ◽  
Signalling Molecules ◽  
Periodontal Tissues

The novel approach of tissue engineering aims at regenerating the functional alveolar or periodontal tissues through a series of key events that is modulated by the use of scaffolds, cells and signalling molecules. Many synthetic and natural polymers have been used as tissue engineering constructs so far with varying results in regeneration. Developing a biomaterial to replace the damaged tissue is of paramount importance for effective regeneration. Due to its rich biodiversity, marine environment yields structures with immense potential for biomedical application. These bio molecules offer many applications in cartilage and bone tissue engineering, dental tissue regeneration, wound healing and local drug delivery system. These substances are usually nontoxic, bio compatible and well tolerated by the body, which boost their efficacy for tissue engineering application. In this article, we are trying to brief the various marine based biomaterials used in dental regeneration, their possible sources and clinical applications.

Coating of Laponite on PLA Nanofibrous for Bone Tissue Engineering Application

2021 ◽  
Vol 29 (3) ◽  
pp. 191-198
Author(s):  
Zahra Orafa ◽  
Shiva Irani ◽  
Ali Zamanian ◽  
Hadi Bakhshi ◽  
Habib Nikukar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Bone Tissue Engineering Application

Electrospun nano-bio membrane for bone tissue engineering application- a new approach

2020 ◽  
Vol 249 ◽  
pp. 123010 ◽  
Author(s):  
Senthil Rethinam ◽  
Bahri Basaran ◽  
Sumathi Vijayan ◽  
Ali Mert ◽  
Oğuz Bayraktar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
New Approach ◽  
Bone Tissue Engineering Application
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