scholarly journals Marked Disparity in the Epidemiology of Tuberculosis among Aboriginal Peoples on the Canadian Prairies: the Challenges and Opportunities

2013 ◽  
Vol 20 (4) ◽  
pp. 223-230 ◽  
Author(s):  
Richard Long ◽  
Vernon Hoeppner ◽  
Pamela Orr ◽  
Martha Ainslie ◽  
Malcolm King ◽  
...  
Keyword(s):  
Incidence Rates ◽  
Aboriginal Peoples ◽  
Canadian Prairies ◽  
Pulmonary Tb ◽  
High Incidence ◽  
Challenges And Opportunities ◽  
Marked Disparity ◽  
Statistics Canada ◽  
Adjusted Incidence ◽  
Prairie Provinces

BACKGROUND: While it is established that Aboriginal peoples in the prairie provinces of Canada are disproportionately affected by tuberculosis (TB), little is known about the epidemiology of TB either within or across provincial borders.METHODS: Provincial reporting systems for TB, Statistics Canada censuses and population estimates of Registered Indians provided by Aboriginal Affairs and Northern Development Canada were used to estimate the overall (2004 to 2008) and pulmonary (2007 to 2008) TB rates in the prairie provinces. The place of residence at diagnosis of pulmonary TB cases in 2007 to 2008 was also documented.RESULTS: The age- and sex-adjusted incidence of TB in Registered Indians was 52.6 per 100,000 person-years, 38 times higher than in Canadian-born ‘others’. Incidence rates in Registered Indians were highest in Manitoba and lowest in Alberta. In Alberta and Saskatchewan, on-reserve rates were more than twice that of off-reserve rates. Rates in the Métis and Registered Indians were similar in Saskatchewan (50.0 and 52.2 per 100,000 person-years, respectively). In 2007 to 2008, approximately 90% of Canadian-born pulmonary TB cases in the prairie provinces were Aboriginal. Outside of one metropolitan area (Winnipeg, Manitoba), most Registered Indian and Métis pulmonary TB cases were concentrated in a relatively small number of communities north of the 53rd parallel. Rates of pulmonary TB in 11 of these communities were >300 per 100,000 person-years. In Manitoba, 49% of off-reserve Registered Indian pulmonary cases were linked to high-incidence reserve communities.INTERPRETATION: The epidemiology of TB among Aboriginal peoples on the Canadian prairies is markedly disparate. Pulmonary TB is highly focal, which is both a concern and an opportunity.

scholarly journals Age Conditional Probability of Ocular and Ocular Adnexal Malignancies

2020 ◽  
pp. 1-4
Author(s):  
Mathias Nittmann ◽  
Curtis E. Margo
Keyword(s):  
Conditional Probability ◽  
Uveal Melanoma ◽  
Incidence Rates ◽  
Cross Sectional ◽  
Pedagogical Tool ◽  
United States Population ◽  
Age Dependent ◽  
Cumulative Risks ◽  
Adjusted Incidence ◽  
Communicating Risk

<b><i>Aim:</i></b> The aim of this study was to discuss and illustrate the role age-conditional probability has in communicating risk of developing ocular and ocular adnexal malignancies. <b><i>Methods:</i></b> Cross-sectional incidence for retinoblastoma, uveal melanoma, conjunctival melanoma, and lacrimal gland carcinomas from 2000 to 2017 were obtained from the Surveillance, Epidemiology and End Results (SEER) database. Incidence rates were age-adjusted to the 2000 United States population. Age-adjusted incidence was converted to age-interval and cumulative risks. Outcomes were examined in 20-year intervals and cumulatively for adult cancers and yearly for retinoblastoma. <b><i>Results:</i></b> The risk of each malignancy displayed age-dependent variation. For adult malignancies, men were at higher risk at most age intervals. Uveal melanoma had the greatest cumulative lifetime risk. The probability of developing retinoblastoma declines precipitously after age 3 years. <b><i>Conclusions:</i></b> Age-conditional probability of developing cancer is a conceptually friendly means of understanding and communicating risk. It is particularly useful in comparing the risks of uncommon or rare cancers, such as those found in and around the eye. The assessment of risk in terms of age-conditional probability is a versatile and an underutilized pedagogical tool.

scholarly journals Temporal and geographic analysis of trichinellosis incidence in Chile with risk assessment

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Carlos Landaeta-Aqueveque ◽  
Salvador Ayala ◽  
Denis Poblete-Toledo ◽  
Mauricio Canals
Keyword(s):  
Relative Risk ◽  
Poverty Rate ◽  
Incidence Rates ◽  
Temporal Data ◽  
Rate Fluctuation ◽  
High Incidence ◽  
Domestic Cycle ◽  
Model Residuals ◽  
Free Ranging ◽  
Spearman’S Correlation

AbstractTrichinellosis is a foodborne disease caused by several Trichinella species around the world. In Chile, the domestic cycle was fairly well-studied in previous decades, but has been neglected in recent years. The aims of this study were to analyze, geographically, the incidence of trichinellosis in Chile to assess the relative risk and to analyze the incidence rate fluctuation in the last decades. Using temporal data spanning 1964–2019, as well as geographical data from 2010 to 2019, the time series of cases was analyzed with ARIMA models to explore trends and periodicity. The Dickey-Fuller test was used to study trends, and the Portmanteau test was used to study white noise in the model residuals. The Besag-York-Mollie (BYM) model was used to create Bayesian maps of the level of risk relative to that expected by the overall population. The association of the relative risk with the number of farmed swine was assessed with Spearman’s correlation. The number of annual cases varied between 5 and 220 (mean: 65.13); the annual rate of reported cases varied between 0.03 and 1.9 cases per 105 inhabitants (mean: 0.53). The cases of trichinellosis in Chile showed a downward trend that has become more evident since the 1980s. No periodicities were detected via the autocorrelation function. Communes (the smallest geographical administrative subdivision) with high incidence rates and high relative risk were mostly observed in the Araucanía region. The relative risk of the commune was significantly associated with the number of farmed pigs and boar (Sus scrofa Linnaeus, 1758). The results allowed us to state that trichinellosis is not a (re)emerging disease in Chile, but the severe economic poverty rate of the Mapuche Indigenous peoples and the high number of backyard and free-ranging pigs seem to be associated with the high risk of trichinellosis in the Araucanía region.

High Incidence Rates of Stroke in Örebro, Sweden: Further Support for Regional Incidence Differences within Scandinavia

2002 ◽  
Vol 14 (3-4) ◽  
pp. 161-168 ◽  
Author(s):  
Peter Appelros ◽  
Ingegerd Nydevik ◽  
Åke Seiger ◽  
Andreas Terént
Keyword(s):  
Incidence Rates ◽  
High Incidence

Decreasing incidence of subarachnoid hemorrhage

2018 ◽  
Vol 11 (3) ◽  
pp. 320-322 ◽  
Author(s):  
Patrick Nicholson ◽  
Alan O’Hare ◽  
Sarah Power ◽  
Seamus Looby ◽  
Mohsen Javadpour ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Population Data ◽  
Incidence Rates ◽  
Public Hospitals ◽  
National Database ◽  
Irish Hospital ◽  
Acute Subarachnoid Hemorrhage ◽  
Adjusted Rate ◽  
Using Data ◽  
Adjusted Incidence

ObjectiveTo determine the incidence and trends in subarachnoid hemorrhage in Ireland using data from a national database.Materials and methodsWe performed a retrospective nationwide query of the Irish Hospital In-patient Enquiry System (HIPE). This is a national database of all in-patient activity in acute public hospitals in Ireland. Each HIPE entry records one episode of in-patient care. The study period ranged from 1997 to 2015. Population data was obtained from the Irish Central Statistics Office, and the annual prevalence of smoking from the Irish National Tobacco Control Office. We were therefore able to calculate both crude annual acute subarachnoid hemorrhage (SAH) incidence rates, as well as population-standardized rates, and compared them with trends in the annual smoking rates.ResultsThe mean number of SAH cases per year is 549, with 465 cases in 1997 and 517 in 2015 (range: 465–624). The absolute incidence of SAH, therefore, remained relatively stable. Due to population increases over time, the population-adjusted rate of SAH therefore decreased, from 126.9/million people/year in 1997 to 111.5/million people/year in 2015. Nationally, there was a decrease in smoking prevalence, from 31% in 1998 to 19.2% in 2015. There was a statistically significant correlation between decreasing smoking rates and decreasing population-adjusted incidence of SAH (P=<0.0001).ConclusionsOur data suggests that the incidence of non-traumatic subarachnoid hemorrhage in our population appears to be decreasing, a decrease which is correlated with decreasing smoking rates. This provides important data both in terms of the epidemiology of SAH, as well as the possible role of public-health interventions in tackling both smoking and declining rates of SAH.

scholarly journals Alemtuzumab CARE-MS II 5-year follow-up

Neurology ◽  
2017 ◽  
Vol 89 (11) ◽  
pp. 1117-1126 ◽  
Author(s):  
Alasdair J. Coles ◽  
Jeffrey A. Cohen ◽  
Edward J. Fox ◽  
Gavin Giovannoni ◽  
Hans-Peter Hartung ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Incidence Rates ◽  
Continuous Treatment ◽  
Inadequate Response ◽  
Class Iii ◽  
Prior Therapy ◽  
Link Type ◽  
Brain Volume Loss ◽  
Core Study ◽  
Adjusted Incidence

Objective:To evaluate 5-year efficacy and safety of alemtuzumab in patients with active relapsing-remitting multiple sclerosis and inadequate response to prior therapy.Methods:In the 2-year Comparison of Alemtuzumab and Rebif Efficacy in Multiple Sclerosis (CARE-MS) II study (NCT00548405), alemtuzumab-treated patients received 2 courses (baseline and 12 months later). Patients could enter an extension (NCT00930553), with as-needed alemtuzumab retreatment for relapse or MRI activity. Annualized relapse rate (ARR), 6-month confirmed disability worsening (CDW; ≥1-point Expanded Disability Status Scale [EDSS] score increase [≥1.5 if baseline EDSS = 0]), 6-month confirmed disability improvement (CDI; ≥1-point EDSS decrease [baseline score ≥2.0]), no evidence of disease activity (NEDA), brain volume loss (BVL), and adverse events (AEs) were assessed.Results:Most alemtuzumab-treated patients (92.9%) who completed CARE-MS II entered the extension; 59.8% received no alemtuzumab retreatment. ARR was low in each extension year (years 3–5: 0.22, 0.23, 0.18). Through 5 years, 75.1% of patients were free of 6-month CDW; 42.9% achieved 6-month CDI. In years 3, 4, and 5, proportions with NEDA were 52.9%, 54.2%, and 58.2%, respectively. Median yearly BVL remained low in the extension (years 1–5: −0.48%, −0.22%, −0.10%, −0.19%, −0.07%). AE exposure-adjusted incidence rates in the extension were lower than in the core study. Thyroid disorders peaked at year 3, declining thereafter.Conclusions:Alemtuzumab provides durable efficacy through 5 years in patients with an inadequate response to prior therapy in the absence of continuous treatment.Classification of evidence:This study provides Class III evidence that alemtuzumab provides efficacy and slowing of brain atrophy through 5 years.

scholarly journals Dengue Fever in Italy: The “Eternal Return” of an Emerging Arboviral Disease

2022 ◽  
Vol 7 (1) ◽  
pp. 10
Author(s):  
Matteo Riccò ◽  
Simona Peruzzi ◽  
Federica Balzarini ◽  
Alessandro Zaniboni ◽  
Silvia Ranzieri
Keyword(s):  
Incidence Rate ◽  
Central Italy ◽  
Denv Infection ◽  
Incidence Rates ◽  
Annual Incidence ◽  
Annual Reports ◽  
Foreign Born ◽  
Time Period ◽  
Adjusted Incidence Rate ◽  
Adjusted Incidence

Enhanced surveillance for dengue virus (DENV) infections in Italy has been implemented since 2012, with annual reports from the National Health Institute. In this study, we summarize available evidence on the epidemiology of officially notified DENV infections from 2010–2021. In total, 1043 DENV infection cases were diagnosed, and most of them occurred in travelers, with only 11 autochthonous cases. The annual incidence rates of DENV infections peaked during 2019 with 0.277 cases per 100,000 (95% confidence interval [95% CI] 0.187–0.267), (age-adjusted incidence rate: 0.328, 95% CI 0.314–0.314). Cases of DENV were clustered during the summer months of July (11.4%), August (19.3%), and September (12.7%). The areas characterized by higher notification rates were north-western (29.0%), and mostly north-eastern Italy (41.3%). The risk for DENV infection in travelers increased in the time period 2015–2019 (risk ratio [RR] 1.808, 95% CI 1.594–2.051) and even during 2020–2021 (RR 1.771, 95% CI 1.238–2.543). Higher risk for DENV was additionally reported in male subjects compared with females subjects, and aged 25 to 44 years, and in individuals from northern and central Italy compared to southern regions and islands. In a multivariable Poisson regression model, the increased number of travelers per 100 inhabitants (incidence rate ratio [IRR] 1.065, 95% CI 1.036–1.096), the incidence in other countries (IRR 1.323, 95% CI 1.165–1.481), the share of individuals aged 25 to 44 years (IRR 1.622, 95% CI 1.338–1.968), and foreign-born residents (IRR 2.717, 95% CI 1.555–3.881), were identified as effectors of annual incidence. In summary, although the circulation of DENV remains clustered among travelers, enhanced surveillance is vital for the early detection of human cases and the prompt implementation of response measures.

scholarly journals Incidence Of Diarrheal Infections In Ukraine: Epidemiological Peculiarities

2019 ◽  
Author(s):  
Nina Malysh ◽  
Oksana Chemych ◽  
Roman Rodyna ◽  
Inna Chorna ◽  
Svitlana Doan
Keyword(s):  
Drinking Water ◽  
Food Item ◽  
Analytical Study ◽  
Incidence Rates ◽  
Epidemiological Surveillance ◽  
Statistical Research ◽  
Factors Influencing ◽  
High Incidence ◽  
The World ◽  
Low Incidence

Abstract Background : Diarrheal infections remain relevant for many countries of the world. The processes of globalization, fundamental changes in nutrition and water consumption contributed to the fact that the significance of individual infection sources, etiological structure of diarrheal infections changed. Purpose of the study: on the background of the analytical study of the incidence of diarrheal infections in Ukraine under the current conditions, to determine the factors influencing epidemic situation. Methods: The reports of the Ministry of Health of Ukraine, Main Administrations of Statistics in Kharkiv, Odesa, Zaporizhia oblasts for 2011-2018 are used in the paper. Epidemiological and statistical research methods are applied. Results: The epidemic situation with diarrheal infections in Ukraine is characterized by a low incidence of typhoid fever (from 0.012 to 0.14 per 100 thousand people), shigellosis (from 1.97-6.13 per 100 thousand people), stable incidence rates without the downward trend, salmonellosis (from 17.35 till 24.1 per 100 thousand people), high incidence of diahrreal infections of specified etiology (from 115.5 to141.9 per 100 thousand people) and diahrreal infections of unspecified etiology (from 69.76 to 107.02 per 100 thousand people). The most complicated epidemic situation is observed in economically most developed regions of the country. Most diarrheal infectionsoutbreaks are connected with catering establishments 36.5 % and with children educational establishments 26.1 %. In the region with the highest shigellosis and salmonellosis incidence direct strong correlation relationships are established between the incidence and population, density, natural population movement. The oblasts with the highest diahrreal infections of specified etiology, rotaviral enteritis, diahrreal infections of unspecified etiology incidence are at least provided with water resources and have problems with provision of high-quality drinking water. There is a need to improve the system of epidemiological surveillance over diarrheal infections by extension of the indicators of microbiological study of drinking water quality in the regions of Ukraine, where high diahrreal infections of specified etiology, rotaviral enteritis, diahrreal infections of unspecified etiology incidence is registered; by increasing frequency of food item inspections in the oblasts, where mediana shigellosis and salmonellosis incidence exceeds the average one in Ukraine. Keywords: diarrheal infections, shigellosis, salmonellosis, rotaviral enteritis.

scholarly journals Old Keyam – A Framework for Examining Disproportionate Experience of Tuberculosis Among Aboriginal Peoples of the Canadian Prairies

2013 ◽  
Vol 9 (1) ◽  
pp. 30
Author(s):  
Kathleen McMullin ◽  
Sylvia Abonyi ◽  
Maria Mayan ◽  
Pamela Orr ◽  
Carmen Lopez-Hille ◽  
...  
Keyword(s):  
First Nations ◽  
Aboriginal People ◽  
Qualitative Interviews ◽  
Aboriginal Peoples ◽  
Community Based ◽  
Canadian Prairies ◽  
Tuberculosis Transmission ◽  
The Social ◽  
Interdisciplinary Study ◽  
Collaborative Efforts

On the Canadian Prairies, First Nations and Métis peoples are disproportionately affected by tuberculosis (TB) compared to other Canadians. Statistics show enduring transmission and high rates of active TB disease. Despite awareness of the social determinants of TB transmission—such as substance abuse, comorbidities, and basic needs being unmet—transmission and outbreaks continue to occur among Aboriginal people. The Determinants of Tuberculosis Transmission project is a mixed methods, interdisciplinary study that used quantitative questionnaires and qualitative interviews to look more closely at patients’ experiences of TB. Provincial Network Committees (PNCs) comprised of Elders, traditionalists, community-based TB workers, and health researchers in three participating provinces guided the project from inception through to data analysis, interpretation, and dissemination. The collaborative efforts of the patients, the research team, and the PNCs uncovered a continuing influence of colonization in TB transmission. Overwhelming feelings of apathy and despair for the hold that TB continues to have in the lives of patients, families, and communities is captured by the Cree word “keyam,” which may be translated as “to give up” or to ask, “What is the use?” This paper explores the concept of keyam in relation to TB transmission.

scholarly journals Incidence of outbreak-associated COVID-19 cases by industry in Ontario, Canada, April 1, 2020- March 31, 2021

2021 ◽  
Author(s):  
Sarah A Buchan ◽  
Peter M Smith ◽  
Christine Warren ◽  
Michelle Murti ◽  
Cameron Mustard ◽  
...  
Keyword(s):  
Labour Force ◽  
Population Based ◽  
Cross Sectional Study ◽  
Incidence Rates ◽  
American Industry ◽  
Cross Sectional ◽  
Market Participants ◽  
Working Age ◽  
Time Periods ◽  
Statistics Canada

Objectives The objective of our study was to estimate the rate of workplace outbreak-associated cases of COVID-19 by industry in labour market participants aged 15-69 years who reported working the majority of hours outside the home in Ontario, Canada. Methods We conducted a population based cross-sectional study of COVID-19 workplace outbreaks and associated-cases reported in Ontario between April 1, 2020 and March 31, 2021. All outbreaks were manually classified into two digit North American Industry Classification System (NAICS) codes. We obtained denominator data from the Statistics Canada Labour Force Survey in order to estimate the incidence of outbreak-associated cases per 100,000,000 hours amongst individuals who reported the majority of hours were worked outside the home. We performed this analysis across industries and in three distinct time periods. Results Overall, 12% of cases were attributed to workplace outbreaks among working age adults across our study period. While incidence varied across the time periods, the five industries with the highest incidence rates across our study period were agriculture; healthcare and social assistance; food manufacturing; educational services; and, transportation and warehousing. Conclusions Certain industries have consistently increased incidence of COVID-19 over the course of the pandemic. These results may assist in ongoing efforts to reduce transmission of COVID-19, by prioritizing resources, as well as industry-specific guidance, vaccination, and public health messaging.

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