scholarly journals Evaluation of Serum 25-Hydroxyvitamin D as a Predictor of Carotid Intima-Media Thickness and Carotid Total Plaque Area in Nonsmokers: The Tromsø Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Elena Kamycheva ◽  
Stein Harald Johnsen ◽  
Tom Wilsgaard ◽  
Rolf Jorde ◽  
Ellisiv B. Mathiesen
Keyword(s):  
Serum Calcium ◽  
Calcium Homeostasis ◽  
Intima Media Thickness ◽  
Total Serum ◽  
Hydroxyvitamin D ◽  
Media Thickness ◽  
Plaque Area ◽  
Increased Risk ◽  
25 Hydroxyvitamin D ◽  
Total Plaque Area

Objective. Altered calcium homeostasis has been linked to increased intima-media thickness (IMT) and plaques. We aimed to investigate whether serum 25-hydroxyvitamin D (25(OH)D) and serum calcium are associated with IMT and plaques in nonsmoking population.Methods. Ultrasound of the right carotid artery with the measurements of IMT and plaques was performed in 4194 nonsmoking subjects with available measurements of serum 25(OH)D and total calcium. Linear regression was applied to study the linear relationships between variables. Multinomial logistic regression was used to evaluate predictors of increased IMT and total plaque area (TPA), adjusted for age, body mass index, systolic blood pressure, and total cholesterol.Results. There was no significant linear relationship between mean IMT, TPA, and either serum 25(OH)D or total serum calcium. One SD increase in serum 25(OH)D was independently associated with increased odds of being in the highest quartile of IMT in men (OR 1.30, 95% CI 1.12, 1.51). In women, 1 SD increase in serum 25(OH)D was independently associated with increased risk of being in the upper tertile of TPA (OR 1.15, 95% CI 1.01, 1.33).Conclusions. Impaired calcium homeostasis has no consistent association with mean IMT and TPA; however, increased serum 25(OH)D may predict subclinical atherosclerosis in nonsmokers.

Geometric Total Plaque Area Is an Equally Powerful Phenotype Compared With Carotid Intima-Media Thickness for Stroke Risk Assessment: A Deep Learning Approach

2018 ◽  
Vol 42 (4) ◽  
pp. 162-188 ◽  
Author(s):  
Elisa Cuadrado-Godia ◽  
Saurabh K. Srivastava ◽  
Luca Saba ◽  
Tadashi Araki ◽  
Harman S. Suri ◽  
...  
Keyword(s):  
Deep Learning ◽  
Statistical Significance ◽  
Area Under The Curve ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Fast Method ◽  
Media Thickness ◽  
Plaque Area ◽  
Kolmogorov Smirnov ◽  
Total Plaque Area

Currently, carotid intima-media thickness (cIMT) and geometric total plaque area (gTPA) are computed manually and thus are tedious and prone to interobserver and intraobserver variabilities. This study presents an intelligence-based automated deep learning (DL)–based technique for carotid wall interface detection, cIMT, and lumen diameter (LD) measurements, followed by a 3D cylindrical approach for TPA measurement. The observers were used for manual tracings of which were then used for the design of two DL-based systems. The DL boundaries for inner lumen wall and outer interadventitial borders were used for computing the cIMT and LD. Using cylindrical approach, we computed the gTPA. Furthermore, we compute the 10-year image-based cIMT and gTPA, using the progression rates. A total of 396 B-mode ultrasound right and left common carotid artery images were taken from 203 patients. The mean cIMT and gTPA using DL1 and DL2 is 0.91 mm, 20.52 mm2 and 0.88 mm, 19.44 mm2, respectively. The coefficient of correlation between gTPA and cIMT using DL1 and DL2 is 0.92 ( P < .001) and 0.94 ( P < .001), respectively. The area under the curve (AUC) for gTPA showed an improvement over cIMT by 14.36% and 12.57% for DL1 and DL2, respectively. The corresponding 10-year risk improvements were 9.09% and 6.26%. Our statistical significance tests successfully passed t test, Mann-Whitney, Wilcoxon, Kolmogorov-Smirnov, and Friedman. The study shows gTPA as an equally powerful carotid risk biomarker like cIMT. Given the cIMT and LD, cylindrical fitting is a fast method for gTPA measurements.

scholarly journals Risk Factors for Progression of Carotid Intima-Media Thickness and Total Plaque Area

Stroke ◽  
2012 ◽  
Vol 43 (7) ◽  
pp. 1818-1823 ◽  
Author(s):  
Marit Herder ◽  
Stein Harald Johnsen ◽  
Kjell Arne Arntzen ◽  
Ellisiv B. Mathiesen
Keyword(s):  
Risk Factors ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Plaque Area ◽  
Total Plaque Area

scholarly journals 25-Hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: Results from pSoBid

2012 ◽  
Vol 223 (2) ◽  
pp. 437-441 ◽  
Author(s):  
Susan Knox ◽  
Paul Welsh ◽  
Vladimir Bezlyak ◽  
Alex McConnachie ◽  
Emma Boulton ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Hydroxyvitamin D ◽  
Media Thickness ◽  
25 Hydroxyvitamin D

25-Hydroxyvitamin D is not Associated with Carotid Intima-Media Thickness in Older Men and Women

2009 ◽  
Vol 84 (5) ◽  
pp. 423-424 ◽  
Author(s):  
Stefan Pilz ◽  
Ronald M. A. Henry ◽  
Marieke B. Snijder ◽  
Rob M. van Dam ◽  
Giel Nijpels ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Older Men ◽  
Men And Women ◽  
Hydroxyvitamin D ◽  
Media Thickness ◽  
25 Hydroxyvitamin D ◽  
Older Men And Women
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