scholarly journals Risk Factors for Progression of Carotid Intima-Media Thickness and Total Plaque Area

Stroke ◽  
2012 ◽  
Vol 43 (7) ◽  
pp. 1818-1823 ◽  
Author(s):  
Marit Herder ◽  
Stein Harald Johnsen ◽  
Kjell Arne Arntzen ◽  
Ellisiv B. Mathiesen
Keyword(s):  
Risk Factors ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Plaque Area ◽  
Total Plaque Area

Geometric Total Plaque Area Is an Equally Powerful Phenotype Compared With Carotid Intima-Media Thickness for Stroke Risk Assessment: A Deep Learning Approach

2018 ◽  
Vol 42 (4) ◽  
pp. 162-188 ◽  
Author(s):  
Elisa Cuadrado-Godia ◽  
Saurabh K. Srivastava ◽  
Luca Saba ◽  
Tadashi Araki ◽  
Harman S. Suri ◽  
...  
Keyword(s):  
Deep Learning ◽  
Statistical Significance ◽  
Area Under The Curve ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Fast Method ◽  
Media Thickness ◽  
Plaque Area ◽  
Kolmogorov Smirnov ◽  
Total Plaque Area

Currently, carotid intima-media thickness (cIMT) and geometric total plaque area (gTPA) are computed manually and thus are tedious and prone to interobserver and intraobserver variabilities. This study presents an intelligence-based automated deep learning (DL)–based technique for carotid wall interface detection, cIMT, and lumen diameter (LD) measurements, followed by a 3D cylindrical approach for TPA measurement. The observers were used for manual tracings of which were then used for the design of two DL-based systems. The DL boundaries for inner lumen wall and outer interadventitial borders were used for computing the cIMT and LD. Using cylindrical approach, we computed the gTPA. Furthermore, we compute the 10-year image-based cIMT and gTPA, using the progression rates. A total of 396 B-mode ultrasound right and left common carotid artery images were taken from 203 patients. The mean cIMT and gTPA using DL1 and DL2 is 0.91 mm, 20.52 mm2 and 0.88 mm, 19.44 mm2, respectively. The coefficient of correlation between gTPA and cIMT using DL1 and DL2 is 0.92 ( P < .001) and 0.94 ( P < .001), respectively. The area under the curve (AUC) for gTPA showed an improvement over cIMT by 14.36% and 12.57% for DL1 and DL2, respectively. The corresponding 10-year risk improvements were 9.09% and 6.26%. Our statistical significance tests successfully passed t test, Mann-Whitney, Wilcoxon, Kolmogorov-Smirnov, and Friedman. The study shows gTPA as an equally powerful carotid risk biomarker like cIMT. Given the cIMT and LD, cylindrical fitting is a fast method for gTPA measurements.

Subclinical atherosclerosis in children and adolescents with congenital heart disease

2020 ◽  
pp. 1-8
Author(s):  
Silvia M. Cardoso ◽  
Michele Honicky ◽  
Yara M. F. Moreno ◽  
Luiz R. A. de Lima ◽  
Matheus A. Pacheco ◽  
...  
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Clinical Characteristics ◽  
Congenital Heart ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

Abstract Background: Subclinical atherosclerosis in childhood can be evaluated by carotid intima-media thickness, which is considered a surrogate marker for atherosclerotic disease in adulthood. The aims of this study were to evaluate carotid intima-media thickness and, to investigate associated factors. Methods: Cross-sectional study with children and adolescents with congenital heart disease (CHD). Socio-demographic and clinical characteristics were assessed. Subclinical atherosclerosis was evaluated by carotid intima-media thickness. Cardiovascular risk factors, such as physical activity, screen time, passive smoke, systolic and diastolic blood pressure, waist circumference, dietary intake, lipid parameters, glycaemia, and C-reactive protein, were also assessed. Factors associated with carotid intima-media thickness were analysed using multiple logistic regression. Results: The mean carotid intima-media thickness was 0.518 mm and 46.7% had subclinical atherosclerosis (carotid intima-media thickness ≥ 97th percentile). After adjusting for confounding factors, cyanotic CHD (odds ratio: 0.40; 95% confidence interval: 0.20; 0.78), cardiac surgery (odds ratio: 3.17; 95% confidence interval: 1.35; 7.48), and be hospitalised to treat infections (odds ratio: 1.92; 95% confidence interval: 1.04; 3.54) were associated with subclinical atherosclerosis. Conclusion: Clinical characteristics related to CHD were associated with subclinical atherosclerosis. This finding suggests that the presence of CHD itself is a risk factor for subclinical atherosclerosis. Therefore, the screen and control of modifiable cardiovascular risk factors should be made early and intensively to prevent atherosclerosis.

scholarly journals Meta-analysis of epigenome-wide association studies of carotid intima-media thickness

2021 ◽  
Author(s):  
Eliana Portilla-Fernández ◽  
Shih-Jen Hwang ◽  
Rory Wilson ◽  
Jane Maddock ◽  
W. David Hill ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Dna Methylation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Association Studies ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

AbstractCommon carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study (EWAS) of measures of cIMT in 6400 individuals. Mendelian randomization analysis was applied to investigate the potential causal role of DNA methylation in the link between atherosclerotic cardiovascular risk factors and cIMT or clinical cardiovascular disease. The CpG site cg05575921 was associated with cIMT (beta = −0.0264, p value = 3.5 × 10–8) in the discovery panel and was replicated in replication panel (beta = −0.07, p value = 0.005). This CpG is located at chr5:81649347 in the intron 3 of the aryl hydrocarbon receptor repressor gene (AHRR). Our results indicate that DNA methylation at cg05575921 might be in the pathway between smoking, cIMT and stroke. Moreover, in a region-based analysis, 34 differentially methylated regions (DMRs) were identified of which a DMR upstream of ALOX12 showed the strongest association with cIMT (p value = 1.4 × 10–13). In conclusion, our study suggests that DNA methylation may play a role in the link between cardiovascular risk factors, cIMT and clinical cardiovascular disease.

scholarly journals Carotid Intima Media Thickness in Graves Disease: Comparing Overt Hyperthyroid and Remission State

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A284-A285
Author(s):  
Intan Nurjannah ◽  
Wismandari Wisnu ◽  
Dicky L Tahapary ◽  
Ika Prasetya Wijaya
Keyword(s):  
Risk Factors ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Graves Disease ◽  
Care Hospital ◽  
Media Thickness ◽  
Clinical Signs And Symptoms ◽  
Overt Hyperthyroidism

Abstract Background/Objective: Hyperthyroid has been associated with increased cardiovascular event. Carotidintima media thickness (CIMT) is oftenly measured to evaluate the risk of cardiovascularevent. The aim of this study is to measure CIMT in Graves’ disease and to comparebetween subjects in overt hyperthyroidism and remission state. Methods: Our study was a cross-sectional study performed at the outpatient endocrinologyclinic of Dr. Cipto Mangunkusumo Hospital, a tertiary care hospital in Jakarta, Indonesia. Graves’ disease subjects were recruited, of whom then grouped into overthyperthyroidism (clinical signs and symptoms of hyperthyroidism, low THS, highthyroxine levels, treatment naïve of within 3 months of treatments) and remission state(no clinical signs and symptoms of hyperthyroidism, normal THs and thyroxine levels,without any anti thyroid drugs for at least 6 months). CIMT measurements wereperformed by trained physician on both right and left artery carotid arteries using anultrasound equipped with software that automatically measured the CIMT. We alsomeasured lipid profile, fasting blood glucose, and ECG. Results: We recruited 49 Graves’ disease subjects, of whom 32 and 17 subjects werein overt hyperthyroidism and remission state respectively. Median CIMT in overthyperthyroidism and remission state were 0,473 mm and 0,488 mm respectively, p:0,109. Among clinical and laboratory risk factors, only age which had an independentcorrelation with CIMT in Graves disease. (r: 0,371; p:&lt;0,0001). Discussion: Our is the first study that measured CIMT among subjects with Graves’disease in remission and overt hyperthyroidism state, of which we observed nodifferences. This might be due to the fact that the atherosclerosis risk factors were notdistributed evenly on both group, of which subjects were older in the remission group. Ithas been reported that there are increasing CIMT along with aging (0,003-0,010 mm peryear). Furthermore, in remission state we need to take metabolic and physical changesinto consideration, such as increasing weight as much as 2,5% from prior weight alongwith increasing total cholesterol and LDL-cholesterol which both can affect CIMT levels. Conclusions: There are no significant differences in CIMT between overt hyperthyroid andremission state in Graves’ disease. Keywords: carotid intima media thickness, Graves’ disease, overt hyperthyroid, remission.

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