scholarly journals Serum 25-Hydroxyvitamin D Level and Aortic Intima-Media Thickness in Patients Without Clinical Manifestation of Atherosclerotic Cardiovascular Disease

2014 ◽  
Vol 29 (4) ◽  
pp. 305-311 ◽  
Author(s):  
Gülhan Yüksel Kalkan ◽  
Mustafa Gür ◽  
Nermin Yıldız Koyunsever ◽  
Taner Şeker ◽  
Mehmet Yavuz Gözükara ◽  
...  
2012 ◽  
Vol 30 (4) ◽  
pp. 407-413 ◽  
Author(s):  
Zafer Elbasan ◽  
Durmuş Yıldıray Şahin ◽  
Mustafa Gür ◽  
Gülhan Yüksel Kalkan ◽  
Ali Yıldız ◽  
...  

Angiology ◽  
2013 ◽  
Vol 65 (4) ◽  
pp. 308-312 ◽  
Author(s):  
Gülhan Yüksel Kalkan ◽  
Mustafa Gür ◽  
Ahmet Oytun Baykan ◽  
Nermin Yıldız Koyunsever ◽  
Onur Kaypaklı ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Elena Kamycheva ◽  
Stein Harald Johnsen ◽  
Tom Wilsgaard ◽  
Rolf Jorde ◽  
Ellisiv B. Mathiesen

Objective. Altered calcium homeostasis has been linked to increased intima-media thickness (IMT) and plaques. We aimed to investigate whether serum 25-hydroxyvitamin D (25(OH)D) and serum calcium are associated with IMT and plaques in nonsmoking population.Methods. Ultrasound of the right carotid artery with the measurements of IMT and plaques was performed in 4194 nonsmoking subjects with available measurements of serum 25(OH)D and total calcium. Linear regression was applied to study the linear relationships between variables. Multinomial logistic regression was used to evaluate predictors of increased IMT and total plaque area (TPA), adjusted for age, body mass index, systolic blood pressure, and total cholesterol.Results. There was no significant linear relationship between mean IMT, TPA, and either serum 25(OH)D or total serum calcium. One SD increase in serum 25(OH)D was independently associated with increased odds of being in the highest quartile of IMT in men (OR 1.30, 95% CI 1.12, 1.51). In women, 1 SD increase in serum 25(OH)D was independently associated with increased risk of being in the upper tertile of TPA (OR 1.15, 95% CI 1.01, 1.33).Conclusions. Impaired calcium homeostasis has no consistent association with mean IMT and TPA; however, increased serum 25(OH)D may predict subclinical atherosclerosis in nonsmokers.


2021 ◽  
Author(s):  
Budi Susetyo Pikir ◽  
Agus Subagjo ◽  
Deasy Eka Wardhani ◽  
Andrianto ◽  
Yudi Her Oktaviono ◽  
...  

ABSTRACTBackgroundWomen with a history of preeclampsia are twice as likely to experience long term cardiovascular disease (CVD) compared to women with unaffected pregnancy. The pathophysiology of preeclampsia is not well understood, however there is general agreement that, similar to cardiovascular disease, endothelial dysfunction plays a crucial role. On a clinical level, preeclampsia and atherosclerotic cardiovascular disease share common risk factors. Carotid intima media thickness (CIMT) is ultrasound-based imaging, non-invasive, simple and reproducible method of subclinical atherosclerosis evaluation. Nowadays, there were studies concerning of CIMT among preeclamptic women, although the results were different.ObjectiveTo prove that CIMT among women with histories of preeclampsia was greater compared to normal pregnancy.MethodsWe conducted a meta-analysis of studies that reported CIMT, in women who had preeclampsia and had normal pregnancy. Studies were identified through three databases: PubMed, Google Scholar dan SAGE Journals with publication year of 2010- 2020. Heterogeneity was assessed using the I2 statistic. Standardized mean difference was used as measured of effect size.ResultsNine eligible studies were included in the meta-analysis. This meta-analysis consisted of 439 women with preeclampsia histories and 526 women with normal pregnancy histories. Women who had preeclampsia had significantly higher CIMT compared to those with normal pregnancy with standardized mean difference −0.38 and 95% confidence interval (CI) −0.68 to −0.07 (p=0.02).ConclusionCIMT was greater among women with histories of preeclampsia compared to normal pregnancy.Prospero registration numberID 228825.


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