scholarly journals Significant Increase in Salivary Substance P Level after a Single Oral Dose of Cevimeline in Humans

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Yosuke Suzuki ◽  
Hiroki Itoh ◽  
Kohei Amada ◽  
Ryota Yamamura ◽  
Yuhki Sato ◽  
...  
Keyword(s):  
Substance P ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Plasma Levels ◽  
Therapeutic Agent ◽  
Venous Blood ◽  
Muscarinic Acetylcholine Receptor ◽  
Salivary Secretion ◽  
Calcitonin Gene ◽  
Highly Sensitive

Cevimeline is a novel muscarinic acetylcholine receptor agonist currently being developed as a therapeutic agent for xerostomia. We examined the effects of cevimeline on salivary and plasma levels of substance-P- (SP-), calcitonin-gene-related-peptide- (CGRP-), and vasoactive-intestinal-polypeptide- (VIP-) like immunoreactive substances (ISs) in humans. An open-labeled crossover study was conducted on seven healthy volunteers. Saliva volume was measured, and saliva and venous blood samples were collected before and 30–240 min after a single oral dose of cevimeline or placebo. Salivary and plasma levels of SP-, CGRP-, and VIP-IS were measured using a highly sensitive enzyme immunoassay. A single oral dose of cevimeline resulted in significant increases in salivary but not plasma SP-IS level compared to placebo. Cevimeline administration did not alter the salivary or plasma levels of CGRP-IS or VIP-IS compared to placebo. Significant increases in salivary volume were observed after cevimeline administration compared to placebo. A significant correlation was observed between the total release of SP-IS and that of salivary volume. These findings suggest an association of SP with the enhancement of salivary secretion by cevimeline.

Significant increase in salivary substance P level after a single oral dose of Japanese herbal medicine Dai-kenchu-to in humans

2012 ◽  
Vol 2 (3) ◽  
pp. 81-84 ◽  
Author(s):  
Yosuke Suzuki ◽  
Hiroki Itoh ◽  
Ryota Yamamura ◽  
Ryosuke Tatsuta ◽  
Yuhki Sato ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Substance P ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Japanese Herbal Medicine

BIOLOGICAL HALF-LIFE OF CAFFEINE IN PIGS

1970 ◽  
Vol 50 (1) ◽  
pp. 49-54 ◽  
Author(s):  
H. M. CUNNINGHAM
Keyword(s):  
Oral Dose ◽  
Water Content ◽  
Single Oral Dose ◽  
Plasma Levels ◽  
Half Life ◽  
Intramuscular Injection ◽  
Peak Plasma ◽  
Growing Pigs ◽  
Sufficient Time ◽  
Biological Half Life

Five experiments were conducted with growing pigs to determine the biological half-life of caffeine after injection or various periods of ingestion. Peak plasma caffeine levels were reached within 5 hr after a single oral dose and 2 hr after intramuscular injection, and then declined with a biological half-life of about 12 hr. The caffeine content of tissues was approximately proportional to their water content and 6% of orally administered caffeine was excreted in the urine. Upon continuous ingestion of caffeine, peak plasma levels were reached within 2 days, indicating that accumulation was quite limited. When 1.5 g of caffeine per kg of feed was fed from weaning to market weight, the withdrawal of caffeine 2 days prior to slaughter was sufficient time to insure that caffeine levels in the liver, muscle, kidney and backfat were below 1 μg/g.

Inhibitory effect of cyproheptadine on ACTH secretion in patients with Addison's disease

1983 ◽  
Vol 102 (1) ◽  
pp. 111-115
Author(s):  
P. Loli ◽  
F. Frascatani ◽  
D. Gelli ◽  
M. Maggioni ◽  
F. Muratori ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Drug Administration ◽  
Plasma Levels ◽  
Addison’S Disease ◽  
Inhibitory Effect ◽  
Feedback Mechanism ◽  
Addison's Disease ◽  
Acth Secretion ◽  
Acth Release

Abstract. In 14 patients with Addison's disease plasma levels of ACTH were studied after administration of a single oral dose (16 mg) of cyproheptadine. The drug administration was followed by an inhibition of ACTH release. These results support the view that cyproheptadine may exert an inhibitory effect on ACTH secretion in subjects whose corticosteroid feedback mechanism is normal. We hypothesize that the effect of cyproheptadine might be related to its anti-serotonin or anti-histaminergic action.

Ecabet sodium raises plasma levels of calcitonin gene-related peptide and substance P in healthy humans

2005 ◽  
Vol 57 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Fumihiko Katagiri ◽  
Shin Inoue ◽  
Yuhki Sato ◽  
Hiroki Itoh ◽  
Masaharu Takeyama
Keyword(s):  
Substance P ◽  
Plasma Levels ◽  
Calcitonin Gene Related Peptide ◽  
Ecabet Sodium ◽  
Related Peptide ◽  
Healthy Humans ◽  
Calcitonin Gene

PLASMA LEVELS OF NORETHINDRONE AFTER SINGLE ORAL DOSE ADMINISTRATION OF NORETHINDRONE AND LYNESTRENOL

1979 ◽  
Vol 10 (1) ◽  
pp. 29-38 ◽  
Author(s):  
V. ODLIND ◽  
E. WEINER ◽  
A. VICTOR ◽  
E. D. B. JOHANSSON
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Plasma Levels ◽  
Dose Administration

scholarly journals Evaluation of Nialamide on the Coagulation of Blood

Blood ◽  
1964 ◽  
Vol 24 (3) ◽  
pp. 289-298 ◽  
Author(s):  
CHAPOUR MASCHOUF ◽  
ROGER W. ROBINSON ◽  
RAOUL J. LEBEAU
Keyword(s):  
Body Weight ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Venous Blood ◽  
Glass Beads ◽  
Fine Glass ◽  
Prothrombin Activation

Abstract Nialamide at a single oral dose of about 3 mg./Kg. body weight produced decreased prothrombin activation by rendering the platelets less effective. It also decreased the adhesiveness of the platelets as measured by two different technics. A new technic for measuring the adhesiveness of the platelets has been described. It utilized a principle by which venous blood directly circulated through a column of fine glass beads, after which the platelets were reduced in number.

scholarly journals Plasma levels after a single oral dose of 1.5 g ornidazole.

1977 ◽  
Vol 53 (4) ◽  
pp. 236-239
Author(s):  
I Matheson ◽  
K H Johannessen ◽  
B Bjorkvoll
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Plasma Levels

Plasma levels of m-chlorophenylpiperazine following single oral dose administration of m-chlorophenylpiperazine and trazodone in human volunteers

1997 ◽  
Vol 41 (6) ◽  
pp. 756-757 ◽  
Author(s):  
Brian A. Lawlor ◽  
Jeanne Radcliffe ◽  
Rick Martinez ◽  
Trey Sunderland ◽  
Dennis L. Murphy
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Plasma Levels ◽  
Dose Administration ◽  
Human Volunteers
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