Effect of pilocarpine on substance P and calcitonin gene-related peptide releases correlate with salivary secretion in human saliva and plasma

2012 ◽  
Vol 38 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Y. Sato ◽  
H. Itoh ◽  
Y. Suzuki ◽  
R. Tatsuta ◽  
M. Takeyama
Keyword(s):  
Substance P ◽  
Salivary Secretion ◽  
Human Saliva ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

Twenty six-week repeat dose oral rat toxicity study of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator

2021 ◽  
Vol 122 ◽  
pp. 104916
Author(s):  
Antonio Guzmán ◽  
Gregorio Encina ◽  
Antonio R. Fernández de Henestrosa ◽  
Cristina Vila ◽  
Araceli Tortajada ◽  
...  
Keyword(s):  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Toxicity Study ◽  
Repeat Dose ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Peptide Release ◽  
Dose Oral

Release of Histamine from Dural Mast Cells by Substance P and Calcitonin Gene-Related Peptide

Cephalalgia ◽  
1997 ◽  
Vol 17 (3) ◽  
pp. 166-174 ◽  
Author(s):  
A Ottosson ◽  
L Edvinsson
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Histamine Release ◽  
Dura Mater ◽  
Neurogenic Inflammation ◽  
Calcitonin Gene Related Peptide ◽  
Sampling Procedure ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Peritoneal Mast Cells

The aim of the present study was to examine if the neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) can stimulate histamine release from mast cells in the dura mater and thereby play a role in cranial vasoregulation and local neurogenic inflammation. Dura mater mast cells were compared with peritoneal mast cells in the rat. Histamine was released from dura mater mast cells by compound 48/80, SP and CGRP but from peritoneal mast cells only by compound 8/80 and SP. NPY and VIP released quite small amounts of histamine from dural mast cells. The release on SP and CGRP from rat dura mater mast cells was blocked by the receptor antagonists FK888 and CGRP8-37 respectively, suggesting receptor mediated release mechanisms. None of the stimuli released histamine from human or porcine dural mast cells, possibly because the sampling procedure injures and incapacitates the cells.

509 Substance P and calcitonin gene-related peptide immunoreactivity in the pit membrane of the mamushi

1997 ◽  
Vol 28 ◽  
pp. S80 ◽  
Author(s):  
Tetsuo Kadota ◽  
Masato Nakano ◽  
Yoshitoshi Atobe ◽  
Kengo Funakoshi ◽  
Fumiaki Amemiya ◽  
...  
Keyword(s):  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Pit Membrane
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