Ecabet sodium raises plasma levels of calcitonin gene-related peptide and substance P in healthy humans

2005 ◽  
Vol 57 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Fumihiko Katagiri ◽  
Shin Inoue ◽  
Yuhki Sato ◽  
Hiroki Itoh ◽  
Masaharu Takeyama
Keyword(s):  
Substance P ◽  
Plasma Levels ◽  
Calcitonin Gene Related Peptide ◽  
Ecabet Sodium ◽  
Related Peptide ◽  
Healthy Humans ◽  
Calcitonin Gene

Plasma levels of vasoactive neuropeptides in pediatric patients with migraine during attack and attack-free periods

Cephalalgia ◽  
2020 ◽  
pp. 033310242095758
Author(s):  
Fatma Hanci ◽  
Yasemin Baranoglu Kilinc ◽  
Erkan Kilinc ◽  
Sevim Turay ◽  
Mustafa Dilek ◽  
...  
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Peptide ◽  
Plasma Levels ◽  
Migraine Without Aura ◽  
Pediatric Patients ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Pediatric Migraine ◽  
Calcitonin Gene ◽  
Significant Difference

Background Increasing evidence suggests that vasoactive neuropeptides such as pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38), substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide are involved in the pathophysiology of migraine in adults, but their role in pediatric migraineurs remains unclear. We prospectively investigated plasma levels of these vasoactive neuropeptides in pediatric migraine patients without aura and compared the results with those of age-matched healthy controls. Methods Thirty-eight children aged 6–18 years with migraine without aura and 20 age-matched control subjects were included in the study. Neuropeptides in plasma samples from the controls, and in either the ictal or interictal periods in pediatric migraine without aura, were measured using ELISA. Results PACAP-38 and vasoactive intestinal peptide levels in both ictal and interictal plasma were higher in the patients with pediatric migraine without aura than in the controls ( p < 0.001), although calcitonin gene-related peptide and substance P levels remained unchanged. Otherwise, no significant difference was determined between ictal and interictal periods in terms of all neuropeptide levels. Conclusions This study demonstrates increased plasma PACAP-38 and vasoactive intestinal peptide levels, but not calcitonin gene-related peptide and substance P levels, in pediatric patients with migraine during both attack and attack-free periods. The study findings suggest that PACAP-38 and vasoactive intestinal peptide may be implicated in the pathophysiology of migraine, particularly in pediatric migraineurs.

Twenty six-week repeat dose oral rat toxicity study of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator

2021 ◽  
Vol 122 ◽  
pp. 104916
Author(s):  
Antonio Guzmán ◽  
Gregorio Encina ◽  
Antonio R. Fernández de Henestrosa ◽  
Cristina Vila ◽  
Araceli Tortajada ◽  
...  
Keyword(s):  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Toxicity Study ◽  
Repeat Dose ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Peptide Release ◽  
Dose Oral

Release of Histamine from Dural Mast Cells by Substance P and Calcitonin Gene-Related Peptide

Cephalalgia ◽  
1997 ◽  
Vol 17 (3) ◽  
pp. 166-174 ◽  
Author(s):  
A Ottosson ◽  
L Edvinsson
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Histamine Release ◽  
Dura Mater ◽  
Neurogenic Inflammation ◽  
Calcitonin Gene Related Peptide ◽  
Sampling Procedure ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Peritoneal Mast Cells

The aim of the present study was to examine if the neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) can stimulate histamine release from mast cells in the dura mater and thereby play a role in cranial vasoregulation and local neurogenic inflammation. Dura mater mast cells were compared with peritoneal mast cells in the rat. Histamine was released from dura mater mast cells by compound 48/80, SP and CGRP but from peritoneal mast cells only by compound 8/80 and SP. NPY and VIP released quite small amounts of histamine from dural mast cells. The release on SP and CGRP from rat dura mater mast cells was blocked by the receptor antagonists FK888 and CGRP8-37 respectively, suggesting receptor mediated release mechanisms. None of the stimuli released histamine from human or porcine dural mast cells, possibly because the sampling procedure injures and incapacitates the cells.

509 Substance P and calcitonin gene-related peptide immunoreactivity in the pit membrane of the mamushi

1997 ◽  
Vol 28 ◽  
pp. S80 ◽  
Author(s):  
Tetsuo Kadota ◽  
Masato Nakano ◽  
Yoshitoshi Atobe ◽  
Kengo Funakoshi ◽  
Fumiaki Amemiya ◽  
...  
Keyword(s):  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Pit Membrane
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