scholarly journals Alleviation of Morphine Withdrawal Signs but Not Tolerance by the Essential Oil ofKelussia odoratissimaMozaff.

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammed Rabbani ◽  
Seyed Ebrahim Sajjadi ◽  
Azadeh Izadi
Keyword(s):  
Essential Oil ◽  
Single Injection ◽  
Chronic Administration ◽  
Morphine Tolerance ◽  
Morphine Withdrawal ◽  
Repeated Injection ◽  
Chronic Injection ◽  
The Brain ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

The aim of the present study was to assess the effects of chronic and acute treatment of the essential oil (EO) ofKelussia odoratissimaMozaff. on the development of morphine tolerance and dependence in mice. Mice were rendered tolerant to and dependent on morphine by subcutaneous injection of morphine over a period of 5 days. Tolerance was assessed using the tail-pinch test and withdrawal signs of morphine were precipitated by injecting naloxone 2 h after the final morphine injection. Repeated injection of the EO ofK. odoratissima(5 and 10 mg/kg) for 4 days significantly suppressed morphine-withdrawal jumps, a sign of the development of dependence to opiate as assessed by naloxone precipitation withdrawal on day 5 of testing. A single injection (25, 50, 100 mg/kg) of the EO on day 5, 1 h prior to morphine failed to produce any significant change in morphine withdrawal signs. Neither the acute nor the chronic administration of EO of theK. odoratissimadid significantly influence the development of tolerance to the analgesic effect of morphine. Alleviation in morphine signs of withdrawal after chronic injection withK. odoratissimais indicative of reversal of neuronal adaptation that takes place during morphine presence in the brain.

scholarly journals Evaluation of the Effects of Chronic Administration of Citrus aurantium Essential Oil on the Development of Tolerance and Dependence to Morphine

2019 ◽  
Vol 25 (1) ◽  
pp. 17-23
Author(s):  
Alireza Parvizpur ◽  
Kosar Parnian ◽  
Sama Samankan ◽  
Fatemeh Fathiazad ◽  
Mohammad Charkhpour
Keyword(s):  
Essential Oil ◽  
Withdrawal Syndrome ◽  
Physical Dependence ◽  
Chronic Administration ◽  
Morphine Tolerance ◽  
Morphine Withdrawal ◽  
Vehicle Group ◽  
Control Group ◽  
P Value ◽  
Citrus Aurantium

Background: Long-term exposure to opioids may lead to physical dependence and tolerance. The purpose of this study was to investigate the effects of Citrus aurantium essential oil (CEO) on the morphine-induced tolerance and dependence. Methods: To evaluate morphine tolerance, the experiments were carried out in 6 rat groups (n=8) in the weight range of 225-275 g. The control group received morphine (10 mg/kg/day) and the test groups received morphine with the different doses of essential oil (CEO 20, 40 and 80 mg/kg/day) or 4 mL/kg of essential oil vehicle (KolliphorÒ HS15 30% in normal saline that adjusted in pH=7.4 with phosphate buffer) intraperitoneally. The hot-plate test was carried out every other day, 90 minutes after the injections. To examine morphine withdrawal, male Wistar rats were divided into seven groups (n=8) randomly, including: morphine sulphate, CEO (20, 40 and 80 mg/kg) + morphine, vehicle of CEO + morphine. The rats were rendered morphine-dependent by injection of additive doses of morphine subcutaneously for 9 days. The procedure of the morphine administration was as following protocol: day1: 5 mg/kg/12h, day 2 and 3: 10 mg/kg/12h, day 4 and 5: 15 mg/kg/12h, day 6 and 7: 20 mg/kg/12h and day 8 and 9: 25 mg/kg/12h. In the 9th day, 2 hours after the last dose of morphine, naloxone (4 mg/kg) was injected intraperitoneally. Some withdrawal behaviors were counted for 60 minutes. Results: Morphine tolerance was completed after 5 days in the control group. The vehicle group showed tolerance on the 9th day (p-value=0.991), 20mg group in the 13th day (p-value to control=0.010, to vehicle=0.049), 40 mg group on the 15th day (p-value to control and vehicle<0.001) and 80 mg group on the 13th day (p-value to control= 0.001, to vehicle= 0.007). The results showed that CEO could reduce the morphine withdrawal syndrome and total withdrawal score (TWS). Intraperitoneally injection of CEO in two doses (40 mg/kg with p<0.001 and 80 mg/kg with p<0.01) significantly reduced the TWS in comparison to the morphine+vehicle treated group. Conclusion: The results indicated that chronic administration of C. aurantium essential oil extracted had beneficial effects in reducing morphine withdrawal syndrome and could significantly delay tolerance to morphine.

Attenuation of morphine withdrawal signs by a D1 receptor agonist in the locus coeruleus of rats

Neuroreport ◽  
2005 ◽  
Vol 16 (15) ◽  
pp. 1683-1686 ◽  
Author(s):  
Iraj Mirzaii Dizgah ◽  
Seyed Morteza Karimian ◽  
Mohammad Reza Zarrindast ◽  
Hamid Sohanaki
Keyword(s):  
Locus Coeruleus ◽  
Receptor Agonist ◽  
D1 Receptor ◽  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

Effectiveness of lofexidine in blocking morphine-withdrawal signs in the rat

1980 ◽  
Vol 12 (4) ◽  
pp. 573-575 ◽  
Author(s):  
Gary T. Shearman ◽  
Harbans Lal ◽  
Richard C. Ursillo
Keyword(s):  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

P.6.c.010 The efffect of agmatine in nucleus accumbens on morphine withdrawal signs in rats

2013 ◽  
Vol 23 ◽  
pp. S570-S571
Author(s):  
H. Yananli ◽  
E. Sakalli ◽  
M. Caferova Demirkapu ◽  
B. Topkara ◽  
E. Mammadov ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

Examining the effect of the CaMKII inhibitor administration in the locus coeruleus on the naloxone-precipitated morphine withdrawal signs in rats

2012 ◽  
Vol 226 (2) ◽  
pp. 440-444 ◽  
Author(s):  
M. Navidhamidi ◽  
S. Semnanian ◽  
M. Javan ◽  
M. Goudarzvand ◽  
K. Rohampour ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs
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