Evaluation of the effect of Origanum majorana L. essential oil on morphine withdrawal signs in male mice

2016 ◽  
Keyword(s):  
Essential Oil ◽  
Morphine Withdrawal ◽  
Male Mice ◽  
Origanum Majorana ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

scholarly journals Alleviation of Morphine Withdrawal Signs but Not Tolerance by the Essential Oil ofKelussia odoratissimaMozaff.

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammed Rabbani ◽  
Seyed Ebrahim Sajjadi ◽  
Azadeh Izadi
Keyword(s):  
Essential Oil ◽  
Single Injection ◽  
Chronic Administration ◽  
Morphine Tolerance ◽  
Morphine Withdrawal ◽  
Repeated Injection ◽  
Chronic Injection ◽  
The Brain ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

The aim of the present study was to assess the effects of chronic and acute treatment of the essential oil (EO) ofKelussia odoratissimaMozaff. on the development of morphine tolerance and dependence in mice. Mice were rendered tolerant to and dependent on morphine by subcutaneous injection of morphine over a period of 5 days. Tolerance was assessed using the tail-pinch test and withdrawal signs of morphine were precipitated by injecting naloxone 2 h after the final morphine injection. Repeated injection of the EO ofK. odoratissima(5 and 10 mg/kg) for 4 days significantly suppressed morphine-withdrawal jumps, a sign of the development of dependence to opiate as assessed by naloxone precipitation withdrawal on day 5 of testing. A single injection (25, 50, 100 mg/kg) of the EO on day 5, 1 h prior to morphine failed to produce any significant change in morphine withdrawal signs. Neither the acute nor the chronic administration of EO of theK. odoratissimadid significantly influence the development of tolerance to the analgesic effect of morphine. Alleviation in morphine signs of withdrawal after chronic injection withK. odoratissimais indicative of reversal of neuronal adaptation that takes place during morphine presence in the brain.

Attenuation of morphine withdrawal signs by a D1 receptor agonist in the locus coeruleus of rats

Neuroreport ◽  
2005 ◽  
Vol 16 (15) ◽  
pp. 1683-1686 ◽  
Author(s):  
Iraj Mirzaii Dizgah ◽  
Seyed Morteza Karimian ◽  
Mohammad Reza Zarrindast ◽  
Hamid Sohanaki
Keyword(s):  
Locus Coeruleus ◽  
Receptor Agonist ◽  
D1 Receptor ◽  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

Effectiveness of lofexidine in blocking morphine-withdrawal signs in the rat

1980 ◽  
Vol 12 (4) ◽  
pp. 573-575 ◽  
Author(s):  
Gary T. Shearman ◽  
Harbans Lal ◽  
Richard C. Ursillo
Keyword(s):  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

P.6.c.010 The efffect of agmatine in nucleus accumbens on morphine withdrawal signs in rats

2013 ◽  
Vol 23 ◽  
pp. S570-S571
Author(s):  
H. Yananli ◽  
E. Sakalli ◽  
M. Caferova Demirkapu ◽  
B. Topkara ◽  
E. Mammadov ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

Examining the effect of the CaMKII inhibitor administration in the locus coeruleus on the naloxone-precipitated morphine withdrawal signs in rats

2012 ◽  
Vol 226 (2) ◽  
pp. 440-444 ◽  
Author(s):  
M. Navidhamidi ◽  
S. Semnanian ◽  
M. Javan ◽  
M. Goudarzvand ◽  
K. Rohampour ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs

Hyperglycemic suppression of morphine withdrawal signs in the rat

1988 ◽  
Vol 96 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Hyacinth C. Akunne ◽  
Karam F. A. Soliman
Keyword(s):  
Morphine Withdrawal ◽  
Withdrawal Signs ◽  
Morphine Withdrawal Signs
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