Porous Pd nanoparticles with high photothermal conversion efficiency for efficient ablation of cancer cells

Nanoscale ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. 4345-4351 ◽  
Author(s):  
Jia-Wen Xiao ◽  
Shi-Xuan Fan ◽  
Feng Wang ◽  
Ling-Dong Sun ◽  
Xiao-Yu Zheng ◽  
...  
Keyword(s):  
Porous Structure ◽  
Cancer Cells ◽  
Hela Cells ◽  
Near Infrared ◽  
Pd Nanoparticles ◽  
Photothermal Effect ◽  
High Efficacy ◽  
Photothermal Ablation ◽  
Nir Absorption ◽  
Very High

Pd NPs with a porous structure exhibit enhanced near infrared (NIR) absorption and enhanced photothermal effect compared to Pd nanocubes with a similar size, and show very high efficacy in photothermal ablation of HeLa cells.

scholarly journals Gold Nanorod-Mediated Photothermal Modulation for Localized Ablation of Cancer Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yoochan Hong ◽  
Eugene Lee ◽  
Jihye Choi ◽  
Seung Jae Oh ◽  
Seungjoo Haam ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Laser Power ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Photothermal Effect ◽  
Transduction Efficiency ◽  
Dead Cell ◽  
Photothermal Ablation ◽  
Power Densities ◽  
Nir Laser

We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.

Preparation of Composite Cypate Nanoparticles and Its Application in the Treatment of Pediatric Bladder Tumors

2021 ◽  
Vol 21 (2) ◽  
pp. 868-877
Author(s):  
Ling Wang ◽  
Hong Tao ◽  
Zhigang Li ◽  
Yi Lei ◽  
Bing Bai ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Negative Impact ◽  
Particle Diameter ◽  
Photothermal Effect ◽  
Average Particle ◽  
Bladder Cancer Cells

Cypate is an organic material with tumor treatment function, which has photothermal effect. Based on the characteristics of this material, this study adopted the coupling method to obtain FB-Cypate nano-microspheres, BDI-1-FB-Cypate albumin nano-microsphere diad and CPPs-BDI-1-FB-Cypate albumin nano-microsphere triad. Cypate and FB-Cypate materials were characterized by scanning TEM, particle size analyzer, and spectrophotometer. An injection-ureter introduction device was used to perfuse pediatric bladder cancer cells into the bladder cavity of nude mice, and different Cypate-type material solutions were perfused into the bladder cavity at the same time. Then, the anti-bladdertumor performance of different materials on tumor cells was compared. The test proves that the average particle diameter of FB-Cypate material is (102.3 ±8.6) nm, which can be used for near-infrared imaging, and the temperature rise is obvious under light conditions. In the test of inhibiting bladder cancer cells in children, the use of Cypate type materials can significantly inhibit the survival of bladder tumor cells, and it has less negative impact on physiological functions after surgery.

scholarly journals Intercellular Trafficking of Gold Nanostars in Uveal Melanoma Cells for Plasmonic Photothermal Therapy

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 590 ◽  
Author(s):  
Rubén Ahijado-Guzmán ◽  
Natalia Sánchez-Arribas ◽  
María Martínez-Negro ◽  
Guillermo González-Rubio ◽  
María Santiago-Varela ◽  
...  
Keyword(s):  
Cell Division ◽  
Cancer Cells ◽  
Uveal Melanoma ◽  
Near Infrared ◽  
Melanoma Cells ◽  
Photothermal Effect ◽  
Plasmonic Nanostructures ◽  
Electromagnetic Spectrum ◽  
Pulse Laser Irradiation ◽  
Gold Nanostars

Efficient plasmonic photothermal therapies (PPTTs) using non-harmful pulse laser irradiation at the near-infrared (NIR) are a highly sought goal in nanomedicine. These therapies rely on the use of plasmonic nanostructures to kill cancer cells while minimizing the applied laser power density. Cancer cells have an unsettled capacity to uptake, retain, release, and re-uptake gold nanoparticles, thus offering enormous versatility for research. In this work, we have studied such cell capabilities for nanoparticle trafficking and its impact on the effect of photothermal treatments. As our model system, we chose uveal (eye) melanoma cells, since laser-assisted eye surgery is routinely used to treat glaucoma and cataracts, or vision correction in refractive surgery. As nanostructure, we selected gold nanostars (Au NSs) due to their high photothermal efficiency at the near-infrared (NIR) region of the electromagnetic spectrum. We first investigated the photothermal effect on the basis of the dilution of Au NSs induced by cell division. Using this approach, we obtained high PPTT efficiency after several cell division cycles at an initial low Au NS concentration (pM regime). Subsequently, we evaluated the photothermal effect on account of cell division upon mixing Au NS-loaded and non-loaded cells. Upon such mixing, we observed trafficking of Au NSs between loaded and non-loaded cells, thus achieving effective PPTT after several division cycles under low irradiation conditions (below the maximum permissible exposure threshold of skin). Our study reveals the ability of uveal melanoma cells to release and re-uptake Au NSs that maintain their plasmonic photothermal properties throughout several cell division cycles and re-uptake. This approach may be readily extrapolated to real tissue and even to treat in situ the eye tumor itself. We believe that our method can potentially be used as co-therapy to disperse plasmonic gold nanostructures across affected tissues, thus increasing the effectiveness of classic PPTT.

scholarly journals Chitosan-Capped Au Nanoparticles for Laser Photothermal Ablation Therapy: UV-Vis Characterization and Optothermal Performances

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Giancarlo Margheri ◽  
Silvana Trigari ◽  
Mariabeatrice Berti ◽  
Maurizio Muniz Miranda ◽  
Rita Traversi
Keyword(s):  
Near Infrared ◽  
Au Nanoparticles ◽  
Ablation Therapy ◽  
Synthesis Conditions ◽  
Photothermal Ablation ◽  
Nir Absorption ◽  
One Step ◽  
The One ◽  
Refined Version

We have reported on the synthesis and characterization of near-infrared- (NIR-) absorbing colloidal nanoparticles prepared by exploiting the one-step reaction of HAuCl4 and Na2S2O3, followed by their stabilization with chitosan. This reaction also produces a big amount of unwanted nanoparticles detuned with respect to the NIR spectral region. For this reason, it is usually assumed that the product has to be filtered and enriched to enhance its NIR absorption, and the possible exploitation of the simpler raw product has never been worthy to be considered. Aiming to investigate this missing aspect, we chose to avoid the purification steps and rather focused on the preparation of the unrefined colloid, identifying the synthesis conditions that maximize its NIR absorbance and, subsequently, testing it as an optothermal transducer by measuring its molar heating rate (MHR). As expected, we found that the performances of the raw colloid are indeed lower than those of its refined version, but only to a limited extent. Moreover, MHR is unexpectedly higher than that deducible for other classical NIR-absorbing nanoparticles, like Au nanorods or Au nanostars. Thus, the product of the simpler preparation protocol appears as a competitive trade-off solution between easy manufacturing and optothermal performances.

Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells

2010 ◽  
Vol 123 (2) ◽  
pp. 461-464 ◽  
Author(s):  
Jaemoon Yang ◽  
Jihye Choi ◽  
Doyeon Bang ◽  
Eunjung Kim ◽  
Eun-Kyung Lim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Near Infrared ◽  
Organic Nanoparticles ◽  
Photothermal Ablation

scholarly journals Synthesis of Ag@Fe3O4 Nanoparticles for Photothermal Treatment of Ovarian Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Bing Liu ◽  
Jian Zhou ◽  
Bin Zhang ◽  
Jing Qu
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Cell Counting ◽  
Photothermal Effect ◽  
Ovarian Cancer Cells ◽  
Photothermal Treatment ◽  
Skov3 Cells ◽  
Nir Laser

Photothermal therapy is a promising approach for cancer treatment. In our study, we investigate the photothermal effect of different concentrations of the Ag@Fe3O4 nanoparticles on apoptosis and proliferation in the human epithelial ovarian cancer cells SKOV3. Ovarian cancer cells SKOV3 were treated with the Ag@Fe3O4 nanoparticles under an 808 nm near-infrared (NIR) laser irradiation at different concentrations. The cell proliferation was measured by the cell counting kit-8 (CCK-8) assay. The results show that the Ag@Fe3O4 nanoparticles with NIR laser irradiation could markedly inhibit the proliferation of the ovarian cancer cells SKOV3 independent of a concentration-time manner. Meanwhile, the cell morphology was also seriously damaged under the treatment of high-concentration nanoparticles. However, Ag@Fe3O4 nanoparticles have almost no obvious effect on the growth of SKOV3 cells without NIR laser illumination treatment. Therefore, it is reasonable to believe that the Ag@Fe3O4 nanoparticles have promising applications in photothermal treatment of cancer cells.

scholarly journals Aristolone content analysis in ficus auriculata as predicted apoptotic activity in hela cells

2021 ◽  
Vol 4 (1) ◽  
pp. 15-20
Author(s):  
Kusmayra Ambarwati ◽  
Miftahul Jannah ◽  
Asyifa Robiatul Adawiyah
Keyword(s):  
Cervical Cancer ◽  
Content Analysis ◽  
Natural Resources ◽  
Cancer Cells ◽  
Cause Of Death ◽  
Hela Cells ◽  
Preliminary Study ◽  
Apoptotic Activity ◽  
Positive Effect ◽  
Very High

Antioxidants and herbs have been scientifically proven to be one of the substances that can prevent cervical cancer. The incidence of cervical cancer in Indonesia is very high and is a vital cause of death of women in Indonesia. Every day 40-45 new cases emerge, which means 20-25 people die from cervical cancer in Indonesia. Several previous studies have shown that there are plants, fruits and seeds that contain high antioxidants and are believed to prevent and reduce pain due to cervical cancer. Besides, many herbs that also found in Indonesia are known to affect cancer cells. Ficus auriculata can find in Indonesia. However, not many people use the available natural resources that are suspected to prevent cervical cancer. This study was a preliminary study analyzed of Aristolone in Ara Fruit used as a prediction of apoptosis in HeLa cells. The results showed that the positive effect of Aristolone content in F. auriculata affected proliferation supported by previous studies.

scholarly journals Near-Infrared Light-Triggered Thermo-responsive Poly(N-Isopropylacrylamide)-Pyrrole Nanocomposites for Chemo-photothermal Cancer Therapy

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Ha Hee Shin ◽  
Hyung Woo Choi ◽  
Jae Hyun Lim ◽  
Ji Woon Kim ◽  
Bong Geun Chung
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Near Infrared ◽  
Solution Temperature ◽  
Photothermal Effect ◽  
Synthetic Process ◽  
Nir Laser

AbstractThe combination therapy based on multifunctional nanocomposites has been considered as a promising approach to improve cancer therapeutic efficacy. Herein, we report targeted multi-functional poly(N-isopropylacrylamide) (PNIPAM)-based nanocomposites for synergistic chemo-photothermal therapy toward breast cancer cells. To increase the transition temperature, acrylic acid (AAc) was added in synthetic process of PNIPAM, showing that the intrinsic lower critical solution temperature was changed to 42 °C . To generate the photothermal effect under near-infrared (NIR) laser irradiation (808 nm), polypyrrole (ppy) nanoparticles were uniformly decorated in PNIPAM-AAc. Folic acid (FA), as a cancer targeting ligand, was successfully conjugated on the surplus carboxyl groups in PNIPAM network. The drug release of PNIPAM-ppy-FA nanocomposites was efficiently triggered in response to the temperature change by NIR laser irradiation. We also confirmed that PNIPAM-ppy-FA was internalized to MDA-MB-231 breast cancer cells by folate-receptor-mediated endocytosis and significantly enhanced cancer therapeutic efficacy with combination treatment of chemo-photothermal effects. Therefore, our work encourages further exploration of multi-functional nanocarrier agents for synergistic therapeutic approaches to different types of cancer cells.

scholarly journals Use in vitro of Gold Nanoparticles Functionalized with Folic Acid as a Photothermal Agent on Treatment of HeLa Cells

2018 ◽  
Vol 62 (1) ◽  
Author(s):  
Linda Bertel Garay ◽  
Fernando Martínez Ortega ◽  
Stelia Carolina Méndez-Sanchez
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells ◽  
Hela Cells ◽  
Near Infrared ◽  
Infrared Light ◽  
Molar Ratio ◽  
Functionalized Gold Nanoparticles ◽  
Dose Dependent

<p>Folic acid (FA) is used as a recognition molecule to achieve selective internalization in cancer cells. Here functionalized gold nanoparticles with folic acid (AuNP-FA) are proposed as suitable therapeutic agents for cervix cancer cells by photothermal damage. The functionalized gold nanoparticles with folic acid were synthesized by mixing hydrogen tetrachloroaurate with folic acid in a molar ratio of 0.56/1 under radiation of mercury lamp (λ<sub>max</sub>=254 nm). HeLa cells were incubated with AuNP-FA during 48 h, then were irradiated and the cytotoxicity was analyzed 12 h after irradiation. The AuNP-FA were dose-dependent cytotoxic under irradiation and not cytotoxic in the absence of radiation. The viability of cancer cells treated with functionalized and non-functionalized gold nanoparticles (AuNPs), with and without near infrared light at 808 nm, was measured by MTT assays. This work provides useful guidance toward the synthesis of biocompatible nanomaterials for biological applications.</p>

scholarly journals Photothermally Responsive Conjugated Polymeric Singlet Oxygen Carrier for Phase Change-Controlled and Sustainable Phototherapy for Hypoxic Tumor

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-14 ◽  
Author(s):  
Guo Li ◽  
Ruyi Zhou ◽  
Weili Zhao ◽  
Bo Yu ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Phase Change ◽  
Singlet Oxygen ◽  
Phase Change Materials ◽  
Near Infrared ◽  
Oxygen Carrier ◽  
Photothermal Effect ◽  
Nir Light ◽  
Nir Absorption ◽  
Hypoxic Tumor

Hypoxia significantly compromises the therapeutic performance of photodynamic therapy (PDT) owing to the oxygen level which plays a key role in the production of singlet oxygen (1O2). Herein, the photothermally responsive phase change materials (PCM) are used to encapsulate 1,4-dimethylnaphthalene-functionalized platinum(II)-acetylide conjugated polymer (CP1) with intense near-infrared (NIR) absorption to prepare new 1O2 nanocarriers (CP1-NCs). The 1,4-dimethylnaphthalene moieties in CP1-NCs can trap the 1O2 produced from CP1 under irradiation and form a stable endoperoxide. Then, the endoperoxide undergoes cycloreversion to controllably release 1O2 via the NIR light-triggered photothermal effect of CP1 and controllable phase change of PCM, which can be used for oxygen-independent PDT for hypoxic tumor. Furthermore, the in vivo luminescence imaging-guided synergistic PDT and photothermal therapy showed better efficiency in tumor ablation. The smart design shows the potent promise of CP1-NCs in PCM-controlled and sustainable phototherapy under tumor hypoxic microenvironment, providing new insights for constructing oxygen-independent precise cancer phototherapeutic platform.

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