scholarly journals Beneficial Effects ofOcimum gratissimumAqueous Extract on Rats with CCl4-Induced Acute Liver Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Chun-Ching Chiu ◽  
Chih-Yang Huang ◽  
Tzy-Yen Chen ◽  
Shao-Hsuan Kao ◽  
Jer-Yuh Liu ◽  
...  
Keyword(s):  
Animal Model ◽  
Wistar Rats ◽  
Hepatic Injury ◽  
Stress Proteins ◽  
Acute Liver Injury ◽  
Beneficial Effects ◽  
Liver Injuries ◽  
Chronic Hepatic Injury ◽  
Male Wistar Rats ◽  
Potential Food

Ocimum gratissimum(OG) is known as a food spice and traditional herb, which has been recommended for the treatment of various diseases. To investigate the hepatoprotective effect of OG aqueous extract (OGAE), male Wistar rats challenged by carbon tetrachloride (CCl4) were used as the animal model of chronic hepatic injury. Significantly increased serum catalase and DPPH levels were detected in CCl4-administrated rats that were treated with OGAE or silymarin as compared to those rats that were treated with saline or CCl4. In contrast, significantly decreased stress proteins including HSP70 and iNOS were observed in livers of CCl4-administrated rats that were treated with OGAE or sylimarin as compared to those rats that were treated with saline or CCl4. Moreover, significant decreases of MMP-9/MMP-2 ratio, uPA, phosphorylated ERK (p-ERK) and NF-κB (p-P65) were detected in livers of CCl4-administrated rats that were treated with OGAE or sylimarin as compared to those rats that were treated with saline or CCl4. These findings imply that OGAE can efficiently inhibit CCl4-induced liver injuries in rats and may therefore be a potential food or herb for preventing liver injuries.

Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tosan Peter Omayone ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Acetic Acid ◽  
Untreated Control ◽  
Wistar Rats ◽  
Low Dose ◽  
Healing Process ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Haematological Changes ◽  
Therapeutic Properties ◽  
Histopathological Effects

Abstract Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats

2019 ◽  
Vol 17 (5) ◽  
pp. 366-373 ◽  
Author(s):  
Pierre Watcho ◽  
Ismaelle Rosine Mpeck ◽  
Patrick Brice Deeh Defo ◽  
Modeste Wankeu-Nya ◽  
Esther Ngadjui ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Beneficial Effects ◽  
Male Wistar Rats

scholarly journals Electro-acupuncture reduces the need for additional anesthetics in experimental studies

2010 ◽  
Vol 25 (4) ◽  
pp. 381-384 ◽  
Author(s):  
Agamenon Honório Silva ◽  
Alberico Ximenes do Prado Neto ◽  
Sérgio Botelho Guimarães
Keyword(s):  
Stainless Steel ◽  
Electrical Stimulation ◽  
Wistar Rats ◽  
Experimental Studies ◽  
Needle Insertion ◽  
Additional Treatment ◽  
Human Right ◽  
Beneficial Effects ◽  
Group Control ◽  
Male Wistar Rats

PURPOSE: To evaluate the possible beneficial effects of electro-acupuncture in rats subjected to ketamine/xylazine (KX) intra-peritoneal (i.p.) anesthesia. METHODS: Forty-eight male Wistar rats were distributed in four equal groups. All rats received i.p. injections of ketamine (90 mg/kg) +xylazine (10 mg/kg) anesthesia. Basal values group (control) rats (BV) received no additional treatment. The equivalent of the human right ST36 (Zusanli) and CV-12(Zhongwan) acupoints were chosen for needling and electrical stimulation. AC rats were needled with sterilized disposable stainless steel needles at right ST36 and CV12 acupoints; needles were retained for 30 minutes. EAC10 rats, after needle insertion as described, had electrodes connected to both needles and to an electro stimulator model NKL EL-608; pulsed square waves, 10 Hz, 10 mA, was applied for 30 minutes. EAC100 rats were submitted to EA as described. However, a greater frequency (100 Hz) was used. RESULTS: Thirty-seven rats remained under adequate anesthetic level during the experiment. However, maintenance anesthesia was required by 11 rats. Need for additional anesthesia decreased to 9.1% in EAC100 rats compared to BV (36.3%). CONCLUSION: Both the AC and the EAC10/100 prolong the anesthetic effect of the combination Ketamine-xylazine in rats, allowing longer duration of anesthesia with a lower dose of anesthetic, thereby reducing the occurrence of complications.

scholarly journals Development of Animal Model for Studying Deep Second-Degree Thermal Burns

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Danielle dos Santos Tavares Pereira ◽  
Maria Helena Madruga Lima-Ribeiro ◽  
Nicodemos Teles de Pontes-Filho ◽  
Ana Maria dos Anjos Carneiro-Leão ◽  
Maria Tereza dos Santos Correia
Keyword(s):  
Animal Model ◽  
Wistar Rats ◽  
Therapeutic Agents ◽  
Collagen Fibers ◽  
Thermal Burns ◽  
Thermal Lesions ◽  
Male Wistar Rats ◽  
Tissue Shrinkage ◽  
Fibroblastic Proliferation ◽  
Second Degree

Thermal lesions were produced in 12 male Wistar rats, positioning a massive aluminum bar 10 mm in diameter (51 g), preheated to 99°C ± 2°C/10 min. on the back of each animal for 15 sec. After 7, 14, 21, and 28 days, animals were euthanized. The edema intensity was mild, with no bubble and formation of a thick and dry crust from the 3rd day. The percentage of tissue shrinkage at 28 days was 66.67 ± 1.66%. There was no sign of infection, bleeding, or secretion. Within 28 days reepithelialization was incomplete, with fibroblastic proliferation and moderate fibrosis and presence of modeled dense collagen fibers. It is concluded that the model established is applicable in obtaining deep second-degree thermal burns in order to evaluate the healing action of therapeutic agents of topical use.

scholarly journals Analysing the Hypolipidemic Activities of the Tea Extracts of Moringa oleifera, Glycyrrhiza glabra and their Blend at Different Concentrations, Orally Induced on Adult Male Wistar Rats.

2016 ◽  
Vol 3 ◽  
pp. 76-83
Author(s):  
Olanrewaju Roland Akinseye
Keyword(s):  
Wistar Rats ◽  
Moringa Oleifera ◽  
Glycyrrhiza Glabra ◽  
Atherogenic Index ◽  
Simultaneous Increase ◽  
Hypolipidemic Effect ◽  
Aqueous Extracts ◽  
Water Control ◽  
Beneficial Effects ◽  
Male Wistar Rats

Herbal teas ofMoringa oleifera(Moringa) andGlycyrrhiza glabra(Licorice)were known to have many beneficial effects, their possible hypolipidemic effects were investigated in this paper. Albino wistar rats were fed with aqueous extracts ofM. oleifera,G. glabraand their blend teas(10, 30 and 50 mg/kg.BW/ml). The teas were found to lower the serum cholesterol, triglycerides, VLDL, LDL, and atherogenic index at their higher concentration, but were found to slightly increase the HDL as compared to the corresponding normal healthy rats fed with clean water (control). The phytochemicals screening of the teas aqueous extract were also investigated, the chemicals (tannins, saponins, flavonoids, terpenoids and glycosides) which were known to exhibit cholesterol lowering effect by inhibiting its absorption and simultaneous increase its excretion were found to be present in the teas extract. Thus, the study demonstrates and validates thatM.oleifera,G. glabraand their blend possess hypolipidemic effect at higher concentration.

Beneficial effects of lipidic extracts of saladette tomato pomace andSerenoa repenson prostate and bladder health in obese male Wistar rats

2017 ◽  
Vol 97 (13) ◽  
pp. 4451-4458 ◽  
Author(s):  
Josué V Espinosa-Juárez ◽  
Juventino III Colado-Velázquez ◽  
Patrick Mailloux-Salinas ◽  
JML Medina-Contreras ◽  
P Valentín Correa-López ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Tomato Pomace ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Obese Male

scholarly journals Effect of Carcinogen 1,2-Dimethylhydrazine Treatment on Fiber Types in Skeletal Muscles of Male Wistar Rats

2017 ◽  
pp. 845-858
Author(s):  
V. SMERDU ◽  
M. PERŠE
Keyword(s):  
Animal Model ◽  
Wistar Rats ◽  
Extensor Digitorum Longus ◽  
Extensor Digitorum ◽  
Fiber Types ◽  
Variable Response ◽  
Hybrid Fiber ◽  
Control Male ◽  
Male Wistar Rats ◽  
Isoform Expression

The cancerogen 1,2-dimethylhydrazine (DMH), widely used in the experimental animal model of carcinogenesis, affects various organs, but its effect on muscle fibers is unknown. To evaluate the effect of 15-week DMH treatment on the fiber size and myosin heavy chain (MyHC) isoforms, which substantially determine fiber types and their contractile characteristics, pure and hybrid fiber types were immunohistochemically determined according to the MyHC isoform expression in soleus, extensor digitorum longus, gastrocnemius medialis and lateralis muscles of DMH-treated and control male Wistar rats. Whereas the size of fibers was mostly unaffected, the MyHC isoform expression was partially affected in both gastrocnemius samples, but not in the soleus and extensor digitorum longus of DMH-treated rats. The lower proportions of hybrid fiber types and especially that of type 1/2x in most gastrocnemius samples of DMH-treated rats resulted in a shift towards a single MyHC isoform expression, but the extent and pattern of the MyHC isoform shift varied across the different gastrocnemius samples. Such variable response to DMH treatment across muscles indicates that each muscle possesses its own adaptive range. These findings are essential for an accurate evaluation of skeletal muscle characteristics in DMH animal model.

scholarly journals Male Wistar rats show individual differences in an animal model of conformity

2011 ◽  
Vol 14 (5) ◽  
Author(s):  
Jolle W. Jolles ◽  
Leonie de Visser ◽  
Ruud van den Bos
Keyword(s):  
Animal Model ◽  
Individual Differences ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Effects of imidazoline agents in a rat conditioned place preference model of addiction

2022 ◽  
Author(s):  
V. Şorodoc ◽  
G. Rusu-Zota ◽  
P. Nechita ◽  
C. Moraru ◽  
O. M. Manole
Keyword(s):  
Central Nervous System ◽  
Conditioned Place Preference ◽  
Wistar Rats ◽  
Statistical Significance ◽  
Place Preference ◽  
Receptor Ligands ◽  
Preference Model ◽  
Beneficial Effects ◽  
Central Nervous System Disorders ◽  
Male Wistar Rats

AbstractAgmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm. In the experiment, we used five groups with 8 adult male Wistar rats each. During the condition session, on days 2, 4, 6, and 8, the rats received the drugs (saline, or TR, or IDZ and TR, or EFR and TR, or AG and TR) and were placed in their least preferred compartment. On days 1, 3, 5, and 7, the rats received saline in the preferred compartment. In the preconditioning, the preferred compartment was determined. In the postconditioning, the preference for one of the compartments was reevaluated. TR increased the time spent in the non-preferred compartment. AG decreased time spent in the TR-paired compartment. EFR, more than IDZ, reduced the time spent in the TR-paired compartment, but without statistical significance. AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in the TR-paired compartment, without statistical significance.

scholarly journals Beneficial effects of low dose Musa paradisiaca on the semen quality of male Wistar rats

2013 ◽  
Vol 54 (2) ◽  
pp. 92 ◽  
Author(s):  
GabrielO Omotoso ◽  
C. N. B. Tagoe ◽  
OB Akinola ◽  
AS Alabi ◽  
BU Enaibe
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Semen Quality ◽  
Beneficial Effects ◽  
Musa Paradisiaca ◽  
Male Wistar Rats
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