scholarly journals Extraskeletal Myxoid Chondrosarcoma with Small Bowel Metastasis Causing Bowel Obstruction

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Ernesto Bustinza-Linares ◽  
Francisco Socola ◽  
Vinicius Ernani ◽  
Shelly A. Miller ◽  
Jonathan C. Trent
Keyword(s):  
Small Bowel ◽  
Medical Community ◽  
Low Grade ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Myxoid Chondrosarcoma ◽  
Small Bowel Metastasis ◽  
First Case ◽  
Mesenteric Fat ◽  
History Of ◽  
Hemoccult Test

A 28-year-old female with history of chest wall extraskeletal myxoid chondrosarcoma (EMC) presented to the emergency department complaining of two weeks of lightheadedness and fatigue. Laboratories showed hemoglobin of 7.6 g/dL and a positive hemoccult test. Upper and lower endoscopies were unremarkable, and the patient was discharged after blood transfusion. The next day she returned to the ED with left-sided weakness and perioral numbness. Brain CT scan revealed a 6 cm right frontal mass with midline shift and edema that required urgent craniotomy with resection of a hemorrhagic tumor. The patient continued dropping her hemoglobin, and CT scans showed a rounded 3 cm small bowel mass in the mid ileum. Repeat upper endoscopy revealed a 2 × 2 cm ulcerated mass in the fourth portion of the duodenum. The patient was taken to the operating room and was found to have two lesions; one in the distal duodenum and a second one in the mid ileum causing small bowel intussusception. Pathology was consistent with metastatic EMC grade 2/3, involving the bowel and mesenteric fat. Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft-tissue sarcoma with unique features that distinguishes, it from other sarcomas. It has been often described as a low-grade sarcoma although there are certain characteristics like high mitotic activity and the presence of focal regions of Ki67 staining above 25% that correlate with aggressive behavior of the tumor. This is the first case of EMC metastatic to the small bowel to be reported to the medical community.

Low-Grade Mucosa-Associated Lymphoid Tissue Lymphoma Involving the Kidney: Report of 3 Cases and Review of the Literature

2006 ◽  
Vol 130 (1) ◽  
pp. 86-89 ◽  
Author(s):  
Libo Qiu ◽  
Pamela D. Unger ◽  
Robert W. Dillon ◽  
James A. Strauchen
Keyword(s):  
Lymphoid Tissue ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoid Cells ◽  
Low Grade ◽  
The Third ◽  
First Case ◽  
Abundant Cytoplasm ◽  
History Of

Abstract Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue involving the kidney is rare. We report a series of 3 cases. The first case occurred in an 83-year-old woman who presented with back pain. The second case was a 53-year-old man with a history of sarcoidosis who was found, in the course of evaluation of sarcoidosis, to have a right renal mass. The third case occurred in a 72-year-old man who had a history of periorbital mucosa–associated lymphoid tissue lymphoma and had been treated with surgery and radiation 1 year prior to this presentation. Histologically, all 3 patients showed infiltrate of uniform small-to-medium–sized lymphocytes with irregular nuclear contours and abundant cytoplasm resembling centrocytes or monocytoid lymphoid cells. The first patient received chemotherapy without complications. The second patient underwent a partial nephrectomy and was asymptomatic at the subsequent follow-up. The third patient developed a pulmonary embolism following nephrectomy, and further follow-up is not available.

scholarly journals Extraskeletal Myxoid Chondrosarcoma: Long-Term Survival in the Setting of Metastatic Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Karim Masrouha ◽  
Iqbal Multani ◽  
Om Bhatt ◽  
Michelle Ghert
Keyword(s):  
Pulmonary Metastases ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Myxoid Chondrosarcoma ◽  
Systemic Intervention ◽  
Slow Progression ◽  
Close Observation ◽  
History Of

Three cases of extraskeletal myxoid chondrosarcoma (EMC) in patients who presented with pulmonary metastases and were managed with long-term close observation without systemic intervention are presented. Follow-up imaging showed slow progression of their disease over several years, and the patients remained asymptomatic from their pulmonary metastases. This clinical experience provides insight into the natural history of the disease and suggests that some patients may experience long-term survival and remain asymptomatic even without systemic intervention, thereby improving their quality of life by avoiding potentially debilitating treatments.

Testicular Metastasis of Extraskeletal Myxoid Chondrosarcoma: Report of First Case

Urology ◽  
2008 ◽  
Vol 71 (5) ◽  
pp. 984.e1-984.e4 ◽  
Author(s):  
Ruchika Gupta ◽  
Mehar C. Sharma ◽  
Surinder Attri ◽  
Sandeep Guleria
Keyword(s):  
Extraskeletal Myxoid Chondrosarcoma ◽  
Testicular Metastasis ◽  
Myxoid Chondrosarcoma ◽  
First Case

scholarly journals A Patient with Four-Year Survival after Nonsmall Cell Lung Carcinoma with a Solitary Metachronous Small Bowel Metastasis

2010 ◽  
Vol 2010 ◽  
pp. 1-3
Author(s):  
Klaas M. Kant ◽  
Vincent Noordhoek Hegt ◽  
Joachim G. J. V. Aerts
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Small Bowel ◽  
Lung Carcinoma ◽  
Palliative Surgery ◽  
Cell Lung Carcinoma ◽  
Small Bowel Metastasis ◽  
Nonsmall Cell Lung Carcinoma ◽  
First Case ◽  
Complete Surgical Resection

Solitary small bowel metastasis secondary to lung cancer is very uncommon. In this report, we present a patient with NSCLC and a metachronous solitary metastasis of the jejunum. She is alive without evidence of disease and doing well four years after palliative surgery, radiotherapy, and chemotherapy. To the best of our knowledge, this is the first case report describing a prolonged survival in a patient with a symptomatic solitary small bowel metastasis treated with palliative surgery, chemo- and radiotherapy instead of complete surgical resection.

scholarly journals Longitudinally extensive transverse myelitis with seropositive chikungunya

2019 ◽  
Vol 12 (10) ◽  
pp. e231745 ◽  
Author(s):  
Sajid Hameed ◽  
Mubashar Memon ◽  
Hina Imtiaz ◽  
Dureshahwar Kanwar
Keyword(s):  
Transverse Myelitis ◽  
Febrile Illness ◽  
Neurological Complications ◽  
The Other ◽  
Sensory Level ◽  
Low Grade ◽  
Longitudinally Extensive Transverse Myelitis ◽  
First Case ◽  
History Of ◽  
Extensive Transverse Myelitis

Chikungunya viral (CHIKV) fever is often a self-limiting febrile illness associated with severe debilitating arthralgia. Neurological complications associated with CHIKV, although rare, have been reported in literature; however, longitudinally extensive transverse myelitis (LTEM) is rarely associated with it. We present a case of a middle-aged man with a 1-week history of low-grade fever and arthralgia followed by urinary retention and quadriplegia. A sensory level was noted at T2. On subsequent investigations, he was diagnosed with LETM. Although LETM is commonly seen in patients with neuromyelitis optica, the other possible etiologies are inflammatory and parainfectious. To date, only two cases of LETM are reported worldwide in association with CHIKV fever and this is the first case from Pakistan. With frequent chikungunya outbreaks, neurological complications are increasingly seen in clinical practice. The knowledge of these associations will result in their early diagnosis and treatment.

scholarly journals Sustained response to imatinib in patient with extraskeletal myxoid chondrosarcoma and novel KIT mutation

2021 ◽  
Vol 14 (8) ◽  
pp. e242039
Author(s):  
Brooke Jennings ◽  
John Rieth ◽  
Travis Snyders ◽  
Mohammed Milhem
Keyword(s):  
Kinase Inhibitor ◽  
Lymph Node Involvement ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Palpable Mass ◽  
Kit Mutation ◽  
Myxoid Chondrosarcoma ◽  
Node Involvement ◽  
History Of ◽  
Exon 11 ◽  
The Right

A 55-year-old woman presented with a 3-month history of right groin swelling, discomfort and impaired mobility. On examination, a palpable mass was noted both to the right of midline in the lower abdomen and in the right groin. MRI of the pelvis showed two masses involving the anterior abdominal wall and right groin, as well as lymph node involvement. CT imaging revealed multiple bilateral pulmonary metastases. Pathology demonstrated a myxohayline stroma morphology. Tumour was also notable for NR4A3 gene region rearrangement and mutation in KIT exon 11 at position c.1669 T>G. Based on these findings, she was diagnosed with extraskeletal myxoid chondrosarcoma (EMC). The patient has been on imatinib, a tyrosine kinase inhibitor with activity against KIT, for 3 years with stable disease. Metastatic EMC is generally treated with surgical resection and perioperative radiation therapy with adjuvant chemotherapy and is associated with poor prognosis.

scholarly journals Mixed Adenocarcinoma and Squamous Cell Carcinoma of Duodenum: A Case Report and Review of the Literature

2017 ◽  
Vol 11 (2) ◽  
pp. 402-410 ◽  
Author(s):  
Muhammad Bader Hammami ◽  
Anuj Chhaparia ◽  
Jinhua Piao ◽  
Yihua Zhou ◽  
Christine Hachem ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Small Bowel ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Reports ◽  
Exploratory Laparotomy ◽  
Duodenal Mucosa ◽  
Management Guidelines ◽  
First Case ◽  
History Of

Despite being the largest part of the human gastrointestinal (GI) tract, the small intestine accounts for only 1–1.4% of all GI malignancies. Adenocarcinoma is the most common primary small bowel malignancy, with the most common site being the duodenum. On the other hand, squamous cell carcinoma (SCC) of the duodenum is extremely uncommon. We report the first case of mixed adenocarcinoma and SCC occurring in the third part of duodenum (D3). Our patient, a 64-year-old female with history of GERD, hypertension, and IDDM presented with 4 weeks of nausea, vomiting, and abdominal pain. Tomographic imaging of her abdomen demonstrated a distended stomach and a proximal duodenum with narrow caliber changes at the level of D3. An EGD revealed a tight stricture at D3 that could not be traversed. Stricture biopsies revealed duodenal mucosa with two small foci of SCC (positive for p63 and CK5/6) and adenocarcinoma (positive for CK7 and Moc31). Peritoneal metastases were detected on exploratory laparotomy, making the tumor surgically incurable. As she progressively declined and with worsening liver enzymes and general debility, she was not a candidate for chemotherapy and was eventually discharged on home hospice. Small bowel SCC/adenocarcinoma is an exceedingly uncommon cancer, making further case reports such as ours important to understand the nature of this entity and establish management guidelines.

A case report of long-term survival of metastatic extraskeletal myxoid chondrosarcoma treated with surgery and hypofractionated radiotherapy

2014 ◽  
Vol 13 (4) ◽  
pp. 493-497
Author(s):  
Haoming Qiu ◽  
Mary Hare ◽  
Yuhchyau Chen
Keyword(s):  
Case Report ◽  
Surgical Excision ◽  
Hypofractionated Radiotherapy ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Term Survival ◽  
Myxoid Chondrosarcoma ◽  
History Of ◽  
Locally Recurrent ◽  
Control Disease

AbstractWe describe the case of a patient with a 10-year history of metastatic extraskeletal myxoid chondrosarcoma (EMC), who underwent repeated surgical excision and ten courses of hypofractionated radiotherapy to locally recurrent or metastatic disease. We review the literature on EMC’s and propose that surgery and radiotherapy can be used to control disease progression and palliate symptoms for extended periods of time with acceptable toxicity profiles.

scholarly journals Intraluminal EWSR1-CREB1 gene rearranged, low-grade myxoid sarcoma of the pulmonary artery resembling extraskeletal myxoid chondrosarcoma (EMC)

2018 ◽  
Vol 74 (3) ◽  
pp. 526-530 ◽  
Author(s):  
Isabelle Opitz ◽  
Olivia Lauk ◽  
Didier Schneiter ◽  
Silvia Ulrich ◽  
Francesco Maisano ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Low Grade ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Myxoid Chondrosarcoma ◽  
Myxoid Sarcoma

scholarly journals Radiation-Induced Low Grade Fibromyxoid Sarcoma of the Larynx: a Case Report and Literature Review

Folia Medica ◽  
2021 ◽  
Vol 63 (3) ◽  
pp. 433-437
Author(s):  
Dariya Chivchibashi ◽  
Pavel Pavlov ◽  
Maria Tzaneva ◽  
Nikolay Sapundzhiev ◽  
Georgi Davidov
Keyword(s):  
Case Report ◽  
Latency Period ◽  
Metastatic Potential ◽  
Low Grade ◽  
Imaging Evaluation ◽  
First Case ◽  
Fibromyxoid Sarcoma ◽  
History Of ◽  
Radiation Induced ◽  
Causes And Risk Factors

Low grade fibromyxoid sarcoma (LGFMS) is an uncommon variant of fibrosarcoma with high risk of local recurrence, immense metastatic potential and frequently protracted period between tumour presentation and metastasis. This unusual malignancy rarely affects the region of the head and neck which makes cases of laryngeal LGFMS extremely infrequent. To date, LGFMS of the larynx has been scatteredly mentioned in the literature. Neither incidence nor causes and risk factors for laryngeal LGFMS have been clarified so far. To the authors’ knowledge, this is the first case report that discusses the clinical course, imaging diagnosis, histopathological evaluation and surgical approach to radiation-induced laryngeal LGFMS.We present a case of a 70-year-old man who developed a LGFMS after previous radiotherapy (RT) for squamous cell carcinoma (SCC) of the larynx. The latency period between the time of radiation exposure and the diagnosis of LGFMS was twenty-seven months. After re-confirming the diagnosis with second biopsy and extensive imaging evaluation the patient was subjected to an open partial resection of the larynx. Owing to the rarity of the tumour, there is no established protocol with follow-up recommendations.This case highlights the importance of considering the RT history of the patient in order to monitor radiotherapy-related complications, including the occurrence of LGFMS.

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