scholarly journals Dynamic Associations of Change in Physical Activity and Change in Cognitive Function: Coordinated Analyses of Four Longitudinal Studies

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Magnus Lindwall ◽  
Cynthia R. Cimino ◽  
Laura E. Gibbons ◽  
Meghan B. Mitchell ◽  
Andreana Benitez ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Longitudinal Studies ◽  
Growth Models ◽  
Cognitive Change ◽  
Semantic Knowledge ◽  
Time Varying ◽  
Time Specific ◽  
Baseline Physical Activity ◽  
Over Time

The present study used a coordinated analyses approach to examine the association of physical activity and cognitive change in four longitudinal studies. A series of multilevel growth models with physical activity included both as a fixed (between-person) and time-varying (within-person) predictor of four domains of cognitive function (reasoning, memory, fluency, and semantic knowledge) was used. Baseline physical activity predicted fluency, reasoning and memory in two studies. However, there was a consistent pattern of positive relationships between time-specific changes in physical activity and time-specific changes in cognition, controlling for expected linear trajectories over time, across all four studies. This pattern was most evident for the domains of reasoning and fluency.

scholarly journals Social Activity and Cognitive Functioning Over Time: A Coordinated Analysis of Four Longitudinal Studies

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Cassandra L. Brown ◽  
Laura E. Gibbons ◽  
Robert F. Kennison ◽  
Annie Robitaille ◽  
Magnus Lindwall ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Functioning ◽  
Longitudinal Studies ◽  
Cognitive Abilities ◽  
Growth Models ◽  
Social Activity ◽  
Semantic Knowledge ◽  
Activity Levels ◽  
Rate Of Decline ◽  
Over Time

Social activity is typically viewed as part of an engaged lifestyle that may help mitigate the deleterious effects of advanced age on cognitive function. As such, social activity has been examined in relation to cognitive abilities later in life. However, longitudinal evidence for this hypothesis thus far remains inconclusive. The current study sought to clarify the relationship between social activity and cognitive function over time using a coordinated data analysis approach across four longitudinal studies. A series of multilevel growth models with social activity included as a covariate is presented. Four domains of cognitive function were assessed: reasoning, memory, fluency, and semantic knowledge. Results suggest that baseline social activity is related to some, but not all, cognitive functions. Baseline social activity levels failed to predict rate of decline in most cognitive abilities. Changes in social activity were not consistently associated with cognitive functioning. Our findings do not provide consistent evidence that changes in social activity correspond to immediate benefits in cognitive functioning, except perhaps for verbal fluency.

ALBUMIN, HEMOGLOBIN, AND THE TRAJECTORY OF COGNITIVE FUNCTION IN COMMUNITY-DWELLING OLDER JAPANESE: A 13-YEAR LONGITUDINAL STUDY

2016 ◽  
pp. 1-7 ◽  
Author(s):  
H. Murayama ◽  
S. Shinkai ◽  
M. Nishi ◽  
Y. Taniguchi ◽  
H. Amano ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Cognitive Function ◽  
Hierarchical Linear Modeling ◽  
Cognitive Change ◽  
Albumin Level ◽  
Community Dwelling ◽  
Health Examination ◽  
Linear Modeling ◽  
Function Design ◽  
Over Time

Background: Cognitive function can substantially decline over a long period, and understanding the trajectory of cognitive function is important. However, little is known about the linkage between nutritional biomarkers and long-term cognitive change. Objectives: We analyzed 13-year longitudinal data for older Japanese to examine the associations of serum albumin and hemoglobin levels with the trajectory of cognitive function. Design: Longitudinal study. Setting: Community-based. Participants: A total of 1,744 community-dwelling adults aged 65 years or older who participated in annual health examinations in Kusatsu town, Gunma Prefecture, Japan, from 2002–2014. Measurements: Cognitive function was assessed annually by the Mini-Mental State Examination (MMSE). Albumin and hemoglobin levels at baseline (the year when a respondent first participated in the health examination) were divided into quartiles. Hierarchical linear modeling was used to analyze intrapersonal and interpersonal differences in cognitive function. Results: Participants’ MMSE scores decreased at an accelerated rate over the 13-year period. Participants with the lowest baseline albumin level (below the first quartile line) showed a greater accelerated decline in MMSE scores over time, compared with those with the highest level (above the third quartile line). Moreover, MMSE scores in participants with a lower hemoglobin level and lower MMSE score at baseline tended to decline faster over time at an accelerated rate. Conclusions: These findings yield new insights about the complex and diverse roles of these nutritional biomarkers on the trajectory of cognitive function in old age.

scholarly journals Disaggregating Associations of Between-Person Differences in Change over Time from Associations of Within-Person Fluctuation in Longitudinal Data

2021 ◽  
Author(s):  
Lesa Hoffman
Keyword(s):  
Longitudinal Data ◽  
Structural Equation ◽  
Structural Equation Models ◽  
Mixed Effects ◽  
Mixed Effects Models ◽  
Time Varying ◽  
Simulation Methods ◽  
Longitudinal Models ◽  
Time Specific ◽  
Over Time

In longitudinal models with time-varying predictors, the need to distinguish their within-person (WP) relations of time-specific residuals from their between-person (BP) relations of individual means is relatively well-known. In contrast, the need to further distinguish their BP relations of individual time slopes has received much less attention. This article addresses the deleterious impact that ignoring effects of individual time slopes in time-varying predictors can have on the recovery of BP intercept and WP residual relations in commonly used variants of longitudinal models. Using simulation methods and analyses of example data, this problem is demonstrated within univariate longitudinal models (i.e., multilevel or mixed-effects models using observed predictors), as well as in multivariate longitudinal models (i.e., structural equation models using latent predictors, including those for cross-lagged relations). Recommendations are provided for how to avoid conflating the BP and WP associations of longitudinal variables in practice.

Physical activity and cognitive changes in younger women after breast cancer treatment

2019 ◽  
Vol 10 (1) ◽  
pp. 122-125
Author(s):  
Melissa Arneil ◽  
Debra Anderson ◽  
Kimberly Alexander ◽  
Alexandra McCarthy
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cognitive Function ◽  
Cancer Treatment ◽  
Breast Cancer Treatment ◽  
Younger Women ◽  
Previously Treated ◽  
After Cancer ◽  
Cognitive Alterations ◽  
Over Time

ObjectivesStudies indicate women aged 25–49 years previously treated for cancer report cognitive alterations. Good evidence indicates physical activity can be beneficial after cancer and might additionally benefit cognitive function. This short report presents data from a substudy of the Younger Women’s Wellness after Cancer Program (YWWACP), which explored cognitive alterations and investigated potential associations between physical activity and cognitive function in participants in the YWWACP. The primary aim of this substudy was to determine in younger women previously treated for breast cancer (1) whether subjectively reported cognitive function changed over time and (2) if physical activity is associated with subjectively reported cognitive function, and if time had an impact on this.MethodsAll participants had completed breast cancer treatment. Data were collected at baseline (n=41) and at 12 weeks. Measures assessed demographics, self-reported physical activity, cognitive function, sleep quality, stress, anxiety and depression using validated and reliable, subjectively reported instruments.ResultsCognitive function and physical activity scores increased across the time points, with cognitive function revealing a statistically significant increase over time (p=0.004). Statistical testing revealed that physical activity was not correlated with cognitive function and that change in physical activity was not correlated with change in cognitive function.ConclusionThese data provide early evidence that cognitive function and physical activity improved over time in this sample. However, interpretations of a correlation between physical activity and cognitive function should be made with caution, and future research would benefit from larger samples.

Physical Activity Patterns and Relationships With Cognitive Function in Patients With Breast Cancer Before, During, and After Chemotherapy in a Prospective, Nationwide Study

2021 ◽  
pp. JCO.20.03514
Author(s):  
Elizabeth A. Salerno ◽  
Eva Culakova ◽  
Amber S. Kleckner ◽  
Charles E. Heckler ◽  
Po-Ju Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cognitive Function ◽  
Functional Assessment ◽  
Visual Processing ◽  
Nationwide Study ◽  
Rapid Visual Processing ◽  
Objectively Measured ◽  
Changes Over Time ◽  
Over Time

PURPOSE Physical activity (PA) is a promising intervention for cancer-related cognitive decline, yet research assessing its use during chemotherapy is limited. This study evaluated patterns of PA before, during, and after chemotherapy in patients with breast cancer and the association between PA and cognitive function. METHODS In a nationwide, prospective cohort study, we assessed PA (Aerobics Center Longitudinal Study PA measure) and perceived and objectively measured cognitive functioning (Functional Assessment of Cancer Therapy–Cognitive, Delayed Match to Sample, and Rapid Visual Processing measures) at prechemotherapy (T1), postchemotherapy (T2), and 6 months postchemotherapy (T3) in patients with breast cancer and cancer-free, age-matched controls at equivalent time points. Longitudinal linear mixed-effects models (LMMs) characterized PA changes over time between patients and controls, adjusting for demographic and clinical factors. LMMs further estimated the role of prechemotherapy PA and changes in PA during chemotherapy on cognitive changes over time. RESULTS Patients with stage I-IIIC breast cancer (n = 580; age M [standard deviation] = 53.4 [10.6] years) and controls (n = 363; age M [standard deviation] = 52.6 [10.3] years) were included. One third of patients met national PA guidelines at T1, dropping to 21% at T2 before rising to 37% at T3. LMMs revealed declines in PA from T1 to T2 in patients compared with controls (all P < .001). Patients meeting guidelines at T1 demonstrated better cognitive scores over time on the Functional Assessment of Cancer Therapy–Cognitive and Rapid Visual Processing (all P < .05), with similar patterns of objectively-measured cognitive function as controls. In patients, greater moderate-to-vigorous PA at the previous time point was significantly associated with better cognitive trajectories (all P < .05), and adherence to PA guidelines throughout chemotherapy was associated with better self-reported cognition ( P < .01). CONCLUSION This nationwide study demonstrates that PA maintenance before and during chemotherapy is associated with better cognitive function immediately and 6 months after chemotherapy completion.

scholarly journals Physical Activity as a Predictor of Cognitive Decline in an Elderly Essential Tremor Cohort: A Prospective, Longitudinal Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Keith H. Radler ◽  
Silvia Chapman ◽  
Maria Anna Zdrodowska ◽  
Hollie N. Dowd ◽  
Xinhua Liu ◽  
...  
Keyword(s):  
Physical Activity ◽  
Executive Function ◽  
Longitudinal Study ◽  
Cognitive Decline ◽  
Activity Level ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal ◽  
Baseline Physical Activity ◽  
Lower Physical Activity ◽  
Over Time

Background: Essential tremor (ET), one of the most common neurological diseases, is associated with cognitive impairment. Surprisingly, predictors of cognitive decline in ET remain largely unidentified, as longitudinal studies are rare. In the general population, however, lower physical activity has been linked to cognitive decline.Objectives: To determine whether baseline physical activity level is a predictor of cognitive decline in ET.Methods: One hundred and twenty-seven ET cases (78.1 ± 9.5 years, range = 55–95), enrolled in a prospective, longitudinal study of cognition. At baseline, each completed the Physical Activity Scale for the Elderly (PASE), a validated, self-rated assessment of physical activity. Cases underwent an extensive battery of motor-free neuropsychological testing at baseline, 1.5 years, and 3 years, which incorporated assessments of cognitive subdomains. Generalized estimating equations (GEEs) were used to assess the predictive utility of baseline physical activity for cognitive change.Results: Mean follow-up was 2.9 ± 0.4 years (range = 1.3–3.5). In cross-sectional analyses using baseline data, lower physical activity was associated with lower overall cognitive function as well as lower cognitive scores in numerous cognitive domains (memory, language, executive function, visuospatial function and attention, all p &lt; 0.05). In adjusted GEE models, lower baseline physical activity level significantly predicted overall cognitive decline over time (p=0.047), and declines in the subdomains of memory (p = 0.001) and executive function (p = 0.03).Conclusions: We identified reduced physical activity as a predictor of greater cognitive decline in ET. The identification of risk factors often assists clinicians in determining which patients are at higher risk of cognitive decline over time. Interventional studies, to determine whether increasing physical activity could modify the risk of developing cognitive decline in ET, may be warranted.

An Active Lifestyle Is Associated with Better Cognitive Function Over Time in APOE ɛ4 Non-Carriers

2020 ◽  
pp. 1-12
Author(s):  
Marta Fernández-Matarrubia ◽  
Leticia Goni ◽  
Teresa Rognoni ◽  
Cristina Razquin ◽  
César Ignacio Fernández-Lázaro ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Leisure Time Physical Activity ◽  
Linear Regression Analysis ◽  
Apoe Genotype ◽  
Cognitive Status ◽  
Active Lifestyle ◽  
Multivariable Linear Regression Analysis ◽  
Self Administered Questionnaire ◽  
Over Time

Background: Available evidence on the association of physical activity (PA) or sedentary behavior with cognitive decline is inconclusive. Objective: To assess the association between an active lifestyle score and leisure-time physical activity (LTPA) and changes in cognitive function in the Seguimiento Universidad de Navarra (SUN) prospective cohort. Methods: Cognitive function was evaluated in a subsample of 806 participants of the SUN cohort study using the validated Telephone Interview for Cognitive Status-modified (STICS-m) questionnaire at baseline and after 6 years. LTPA was evaluated with a previously validated 17-item self-administered questionnaire and with information on sedentary lifestyles. We also calculated a multidimensional 8-item PA score. Multivariable linear regression analysis evaluated the association between PA and changes in cognitive function and its interaction by APOE genotype. Results: Mean age of participants was 66 (SD 5.3) years and 69.7% were male. When stratifying by APOE variants, no significant associations between the active lifestyle score or LTPA and changes in cognitive performance over time were found among APOE ɛ4 carriers. However, we observed that a higher adherence to an active lifestyle (high versus low PA score β= 0.76 95% CI 0.15,1.36; p trend = 0.011) and a high LTPA (Q4 versus Q1 β= 0.63; 95% CI –0.01,1.26; p trend = 0.030) were associated with more favorable changes in cognitive function over time among APOE ɛ4 non-carriers with statistically significant interactions in both cases (p for interaction = 0.042 for PA score, and p = 0.039 for LTPA). Conclusion: The results of the present study suggest that an active lifestyle is associated with a better status of cognitive function over time only among APOE ɛ4 non-carriers.

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