scholarly journals Causal ACTH-Depot Therapy during Pregnancies following Infertility Treatment

2012 ◽  
Vol 2012 ◽  
pp. 1-7
Author(s):  
Rudolf Klimek ◽  
Marek Klimek ◽  
Peter Gralek ◽  
Dariusz Jasiczek
Keyword(s):  
Adrenal Glands ◽  
Maternal Blood ◽  
Premature Delivery ◽  
Threatened Miscarriage ◽  
Hypothalamic Hormones ◽  
Corticosteroid Hormones ◽  
Depot Therapy ◽  
Clinical Prevention ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

The aim of this paper was to confirm the efficacy of adrenocorticotropin depot (ACTH-depot) therapy in pregnancies with threatened miscarriage and preterm delivery through the desired stimulation of the adrenal glands controlled by the rest of organism. The activity of hypothalamic-pituitary-adrenal axis plays a key role in pregnancy. Such naturally stimulated endogenous corticosteroid hormones are free from unwanted side effects of their synthetics analogs. Low level of maternal blood ACTH and insufficient increase of induced by hypothalamic hormones oxytocinases (cystine-β-aminopeptidases) were indication to ACTH-depot therapy (0.5 mg/week) in our consecutive prospective studies. Contrary to antenatal use of synthetic corticosteroids, there are no temporal limits of this therapy, which has to be more often recommended into clinical prevention of fetal morbidity, treatment of premature delivery, and finally elimination of the newborn's mortality caused by the neuroendocrinological gestoses.

scholarly journals Rapid intra-adrenal feedback regulation of glucocorticoid synthesis

2015 ◽  
Vol 12 (102) ◽  
pp. 20140875 ◽  
Author(s):  
J. J. Walker ◽  
F. Spiga ◽  
R. Gupta ◽  
Z. Zhao ◽  
S. L. Lightman ◽  
...  
Keyword(s):  
Adrenal Glands ◽  
Feedback Regulation ◽  
Feedback Mechanism ◽  
Acth Secretion ◽  
Primary Mechanism ◽  
Acth Receptor ◽  
Local Feedback ◽  
Short Time ◽  
Pituitary Adrenal Axis ◽  
Short Time Delay

The hypothalamic–pituitary–adrenal axis is a vital neuroendocrine system that regulates the secretion of glucocorticoid hormones from the adrenal glands. This system is characterized by a dynamic ultradian hormonal oscillation, and in addition is highly responsive to stressful stimuli. We have recently shown that a primary mechanism generating this ultradian rhythm is a systems-level interaction where adrenocorticotrophin hormone (ACTH) released from the pituitary stimulates the secretion of adrenal glucocorticoids, which in turn feedback at the level of the pituitary to rapidly inhibit ACTH secretion. In this study, we combine experimental physiology and mathematical modelling to investigate intra-adrenal mechanisms regulating glucocorticoid synthesis. Our modelling results suggest that glucocorticoids can inhibit their own synthesis through a very rapid (within minutes), presumably non-genomic, intra-adrenal pathway. We present further evidence for the existence of a short time delay in this intra-adrenal inhibition, and also that at the initiation of each ACTH stimulus, this local feedback mechanism is rapidly antagonized, presumably via activation of the specific ACTH receptor (MC2R) signalling pathway. This mechanism of intra-adrenal inhibition enables the gland to rapidly release glucocorticoids while at the same time preventing uncontrolled release of glucocorticoids in response to large surges in ACTH associated with stress.

Stimulation of cholesterol biosynthesis from acetate in rat liver and adrenals by whole body X-irradiation

1959 ◽  
Vol 196 (6) ◽  
pp. 1231-1237 ◽  
Author(s):  
R. Gordon Gould ◽  
Virginia L. Bell ◽  
Edith H. Lilly
Keyword(s):  
Rat Liver ◽  
Adrenal Glands ◽  
Cholesterol Biosynthesis ◽  
Whole Body ◽  
Hepatic Cholesterol ◽  
Reliable Measure ◽  
Proximate Cause ◽  
Synthetic Rate ◽  
X Irradiation ◽  
Stimulation Of

Whole body x-irradiation resulted in an increased cholesterol biosynthesis in rat liver and adrenal glands, as measured by the rate of incorporation of either acetate-1-C14 or H3OH in intact animals. The effect was significant 24 hours postirradiation but was much larger at 48 hours, and was proportional to dosage over the range 300–2400 r. In liver the increase in rate was about 100%/100 r. Intestine showed no effect and carcass only a slight increase. Mice showed a small increase in hepatic cholesterol biosynthesis but rabbits and guinea pigs no significant change. Rats injected with both acetate-1-C14 and H3OH gave reasonably constant ratios of C14 and H3 in liver and carcass cholesterol in control and irradiated animals, supporting the hypothesis that the use of acetate-1-C14 in whole animals under standard conditions is a reliable measure of cholesterol biosynthetic rate. The proximate cause of the increased rate of cholesterol synthesis is postulated to be the decreased concentration; in liver a decrease of 0.12 mg/gm was correlated with a doubling of the synthetic rate.

THE GROWTH OF THE VENTRAL AND DORSOLATERAL PROSTATE, THE COAGULATING GLANDS AND THE SEMINAL VESICLES IN FORCE-FED HYPOPHYSECTOMIZED CASTRATED ADRENALECTOMIZED RATS INJECTED WITH CORTISONE AND/OR INSULIN

1972 ◽  
Vol 71 (1) ◽  
pp. 179-190 ◽  
Author(s):  
Lars-Eric Tisell ◽  
Lennart Angervall
Keyword(s):  
Histological Examination ◽  
Anterior Pituitary ◽  
Adrenal Glands ◽  
Reproductive Organs ◽  
Seminal Vesicles ◽  
The Other ◽  
Protamine Zinc Insulin ◽  
Adrenalectomized Rats ◽  
Stimulation Of

ABSTRACT The growth of the ventral and dorsolateral prostate, the coagulating glands and the seminal vesicles was studied in force-fed hypophysectomized castrated adrenalectomized rats following daily injections for fourteen days of protamine zinc insulin or cortisone acetate alone or in combination. Cortisone was given in daily doses of 3 mg and insulin was administered in increasing daily doses of protamine zinc insulin up to 8 IU. Cortisone alone induced slight histological stimulation of the epithelium of the coagulating glands, while no stimulation was demonstrated in the other accessory reproductive organs. After insulin alone the weight of the accessory reproductive organs was slightly increased but no stimulation was demonstrated histologically. Cortisone and insulin given in combination induced distinct signs of stimulation of all the accessory reproductive organs as assesed by histological examination and weight determination of the organs. The results indicate that in the rat the growth stimulating effect of cortisone on the male accessory reproductive organs is markedly decreased or abolished in the absence of the anterior pituitary. Insulin can act synergistically with cortisone in promoting the growth of the accessory reproductive organs through effects which are not dependent on the presence of the adrenal glands or the anterior pituitary.

scholarly journals Investigation of the Hypothalamo-pituitary-adrenal Axis and Changes in the Size of Adrenal Glands in Acute Brucellosis

2005 ◽  
Vol 52 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Orhan YILDIZ ◽  
Cumali GOKCE ◽  
Emine ALP ◽  
Ahmet Candan DURAK ◽  
Bilgehan AYGEN ◽  
...  
Keyword(s):  
Adrenal Glands ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Hypoadrenocorticism in two cats successfully treated with desoxycorticosterone pivalate

2018 ◽  
Vol 6 (3) ◽  
pp. e000600
Author(s):  
Franziska Reimann ◽  
Stefanie Siol ◽  
Charlotte Schlüter ◽  
Reto Neiger
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Adrenal Glands ◽  
Final Concentration ◽  
Stimulation Test ◽  
Acth Stimulation Test ◽  
Acth Stimulation ◽  
Blood Examination ◽  
Stimulation Of

Two cats were presented with lethargy and anorexia. Clinically, the cats showed hypothermia and dehydration. Blood examination in both cats showed hyponatraemia, hyperkalaemia and additionally azotaemia in case 1 and hypercalcaemia in case 2. In both cats, an adrenocorticotropic hormone (ACTH) stimulation test showed an insufficient stimulation of the adrenal glands. In case 1, markedly elevated endogenous ACTH was additionally measured. Both cats were successfully treated with a combination of desoxycorticosterone pivalate (DOCP) and prednisolone (0.15 mg/kg daily). Case 1 received a final concentration of 2.6 mg/kg DOCP every 30 days, while case 2 was successfully managed with 2.2 mg/kg every 28 days. These rare cases of feline hypoadrenocorticism demonstrate that DOCP can be used similarly as in dogs.

scholarly journals STIMULATION OF CATECHOLAMINE RELEASE FROM ISOLATED ADRENAL GLANDS BY SOME AMINO ACIDS

1982 ◽  
Vol 32 (2) ◽  
pp. 291-297
Author(s):  
Takashige NISHIKAWA ◽  
Katsuya IORITA ◽  
Kenji KINJO ◽  
Akira TSUJIMOTO
Keyword(s):  
Amino Acids ◽  
Adrenal Glands ◽  
Catecholamine Release ◽  
Stimulation Of
Sign in / Sign up

Export Citation Format

Share Document