Evidence that Activation of the Hypothalamo-Pituitary-Adrenal Axis by Electrical Stimulation of the Noradrenergic A1 Group Is Not Mediated by Noradrenaline

1995 ◽  
Vol 62 (1) ◽  
pp. 2-12 ◽  
Author(s):  
Sarah E. Gartside ◽  
Marie-Françoise Suaud-Chagny ◽  
Marcel Tappaz
Keyword(s):  
Electrical Stimulation ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

Corticoliberin activity of rat neurohypophysis is distinct from vasopressin

1981 ◽  
Vol 240 (6) ◽  
pp. E689-E693 ◽  
Author(s):  
M. Karteszi ◽  
E. Stark ◽  
G. Rappay ◽  
F. A. Laszlo ◽  
G. B. Makara
Keyword(s):  
Electrical Stimulation ◽  
Median Eminence ◽  
Brattleboro Rats ◽  
Neural Lobe ◽  
Experimental Conditions ◽  
Adrenal Axis ◽  
Corticosterone Secretion ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

Electrical stimulation of the neural lobe of the pituitary resulted in an increase of corticosterone secretion in both normal and Brattleboro rats. Bioassaying the corticoliberin (CRF) activity of stalk-median eminence and neural lobe extracts obtained from normal and Brattleboro rats revealed that the endogenous vasopressin was not a prerequisite of ACTH-releasing potency. Arginine-8-vasopressin failed to potentiate the CRF activity of the different extracts. These data suggest that a nonvasopressin substance(s) with CRF activity can be released from the neurohypophysis of the rat, and it may contribute to activating the pituitary-adrenal axis under certain experimental conditions.

Single-dose metyrapone test at 06.00 h: an accurate method for assessment of pituitary-adrenal reserve

1986 ◽  
Vol 112 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Gabriel Dickstein ◽  
Michal Lahav ◽  
Zila Shen Orr
Keyword(s):  
Single Dose ◽  
Accurate Method ◽  
Accurate Assessment ◽  
Adrenal Failure ◽  
Normal Range ◽  
Normal Response ◽  
Adrenal Axis ◽  
Subsequent Measurement ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

Abstract. One dose of metyrapone (1.5 g) administered at 06.00 h, with subsequent measurement of 11-deoxycortisol and 17-hydroxycorticosteroid (17-OHCS) levels in plasma at 12.00 and 14.00 h, allowed accurate assessment of the pituitary-adrenal reserve. Normal response was defined as achieving a serum 17-OHCS level of more than 10.0 μg/100 ml and a 11-deoxycortisol level of more than 6.0 μg/100 ml at either 12.00 or 14.00 h. These criteria are based on a group of 18 persons with normal pituitary-adrenal axis, and 86 additional cases responded in this normal range. In this group of 104 subjects, 11-deoxycortisol levels rose to 9.2 ± 3.5 μg/100 ml at noon and 17-OHCS levels to 15.4 ± 4.7 μg/100 ml at 14.00 h. Post-metyrapone 17-OHCS levels were significantly higher than normal cortisol levels at these times (P < 0.001) and than those observed at 08.00 h on the day of the test, demonstrating stimulation of adrenal corticoid production in addition to blockade of cortisol production by metyrapone. Thirty-one patients found to suffer from secondary adrenal failure showed impaired response. All these patients had limited pituitary-adrenal reserve, either proven by other pituitary-adrenal tests or implicated by severe pituitary disease.

Naloxone does not antagonize PCP-induced stimulation of the pituitary-adrenal axis in the rat

Life Sciences ◽  
1989 ◽  
Vol 44 (2) ◽  
pp. 143-147 ◽  
Author(s):  
Robert N. Pechnick ◽  
Robert George ◽  
Russell E. Poland
Keyword(s):  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

Stimulation of the Hypothalamic-Pituitary-Adrenal Axis with the Opioid Antagonist Nalmefene

Pituitary ◽  
2005 ◽  
Vol 8 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Eliza B Geer ◽  
Rita E Landman ◽  
Sharon L Wardlaw ◽  
Irene M Conwell ◽  
Pamela U. Freda
Keyword(s):  
Hypothalamic Pituitary Adrenal Axis ◽  
Opioid Antagonist ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of
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