scholarly journals The Effectiveness of Poly-(4-vinyl-N-hexylpyridiniumbromide) as an Antibacterial Implant Coating: AnIn VitroStudy

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
L. Ringenberg ◽  
A. Winkel ◽  
O. Kufelt ◽  
P. Behrens ◽  
M. Stiesch ◽  
...  
Keyword(s):  
Dental Implants ◽  
Bacterial Adhesion ◽  
Soft Tissues ◽  
Clinical Success ◽  
Oral Bacteria ◽  
Inflammatory Reactions ◽  
Strong Adhesion ◽  
Strong Attachment ◽  
Implant Coatings ◽  
Tissue Attachment

The clinical success of osseointegrated dental implants depends on the strong attachment of the surrounding hard and soft tissues. Bacterial adhesion on implant surfaces can cause inflammatory reactions and may influence healing and long-term success of dental implants. Promising implant coatings should minimize bacterial adhesion, but allow epithelial and connective tissue attachment. Therefore, the present study has examined the bioactive effect of poly-(4-vinyl-N-hexylpyridiniumbromide) regarding typical oral bacteria as well as cytotoxicitiy to human cells considering different methods of connecting polymers to silicate-containing surfaces. The results revealed that the application of putative antibacterial and biocompatible polymer in coating strategies is affected by a variety of parameters. Published findings regarding reduced bacterial adhesion could not be verified using oral pathogens whereas hexylated polymers seem problematic for strong adhesion of soft tissue. Concerning innovative coatings for dental implants basic aspects (surface roughness, thickness, alkylation, combination with other polymers) have to be considered in further investigations.

scholarly journals Emerging Antibacterial Coated Dental Implants: A Preventive Measure for Peri-implantitis

2016 ◽  
Vol 7 (4) ◽  
pp. 195-198 ◽  
Author(s):  
Varun Yarramaneni ◽  
Dhanasekar Balakrishnan ◽  
IN Aparna ◽  
Akanksha Sachdeva ◽  
Nayana Prabhu
Keyword(s):  
Dental Implants ◽  
Bacterial Adhesion ◽  
Antimicrobial Agents ◽  
Clinical Success ◽  
Preventive Measure ◽  
Titanium Implant ◽  
Success Rates ◽  
Permeable Barrier ◽  
Short And Long Term

ABSTRACT Dental implants are the modern marvel and are widely accepted as a reconstructive treatment modality for tooth replacement. In recent times, there has been a marked progress in the clinical success rates of dental implants, but implant failures as a result of infections are continuing at an alarming rate of 8% per year, translating into 1 million failures worldwide. Perimucositis and peri-implantitis are the chief complications reported postimplant surgery that effects its short- and long-term success. Peri-implantitis is characterized by clinical and radiological bone loss around the implant accompanied with an inflammatory reaction of the peri-implant mucosa and is an irreversible condition, whereas perimucositis is a reversible inflammatory change. Implant surfaces provide an ideal substrate for bacterial adhesion forming a biofilm. Biofilm performs vast functions ranging from physical defensive barrier against phagocytic predation to working as a selective permeable barrier. This limits the diffusion of systemic antimicrobial agents that are capable of damaging the bacterial complexes. These rapidly growing bacteria give rise to a chronic infection which is difficult to eradicate by conventional antibiotic therapy. To inhibit peri-implant infections, various functional modifications in the implant surfaces have been suggested. The coatings on the titanium implant are incorporated with disinfectants, antibiotics as well as antimicrobial peptides AMPs. This paper is an attempt to review all the antibiotic coatings available for a titanium implant and discuss their prospective future to prevent peri-implant infections. How to cite this article Yarramaneni V, Aparna IN, Sachdeva A, Balakrishnan D, Prabhu N. Emerging Antibacterial Coated Dental Implants: A Preventive Measure for Peri-implantitis. World J Dent 2016;7(4):195-198.

scholarly journals The Biological Activity of Propolis-Containing Toothpaste on Oral Health Environment in Patients Who Underwent Implant-Supported Prosthodontic Rehabilitation

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Tadeusz Morawiec ◽  
Arkadiusz Dziedzic ◽  
Iwona Niedzielska ◽  
Anna Mertas ◽  
Marta Tanasiewicz ◽  
...  
Keyword(s):  
Oral Health ◽  
Dental Implants ◽  
Negative Control ◽  
Oral Bacteria ◽  
Periodontal Health ◽  
Oral Rehabilitation ◽  
Inflammatory Reactions ◽  
Periodontal Tissues ◽  
Oral Microflora ◽  
Quantitative Changes

The soft and periodontal tissues surrounding dental implants are particularly susceptible to bacteria invasion and inflammatory reactions due to complex histological structures. This study was carried out to investigate the influence of a propolis-containing hygienic agent on selected oral health parameters, oral microflora, and the condition of periodontal health. Sixteen subjects who underwent an oral rehabilitation with dental implants were selected and randomly assigned into two groups, which received a newly formulated propolis-containing toothpaste (3% (CA)) or a negative control without an active ingredient (CC). Approximal plaque index (API), oral hygiene index (OHI, debris component), and sulcus bleeding index (SBI) were assessed in three subsequent stages. During the first and last examinations, the swabs were employed for microbiological inoculation. Propolis-containing toothpaste was found to be distinctively effective in improving oral health and the occurrence of gingivitis triggered by dental plaque. The qualitative and quantitative changes in oral bacteria spectrum were observed. Antibacterial measures containing propolis might be used as a natural adjuvant to other active substances in individuals with a high risk of periodontal problems against pathogenic oral microflora.

scholarly journals Customized Therapeutic Surface Coatings for Dental Implants

Coatings ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 568 ◽  
Author(s):  
Muhammad Sohail Zafar ◽  
Muhammad Amber Fareed ◽  
Samiya Riaz ◽  
Muhammad Latif ◽  
Syed Rashid Habib ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Dental Implants ◽  
Clinical Success ◽  
Surface Coatings ◽  
Local Drug Delivery ◽  
Therapeutic Effects ◽  
Implant Surface ◽  
Removable Dental Prostheses ◽  
Implant Coatings

Dental implants are frequently used to support fixed or removable dental prostheses to replace missing teeth. The clinical success of titanium dental implants is owed to the exceptional biocompatibility and osseointegration with the bone. Therefore, the enhanced therapeutic effectiveness of dental implants had always been preferred. Several concepts for implant coating and local drug delivery had been developed during the last decades. A drug is generally released by diffusion-controlled, solvent-controlled, and chemical controlled methods. Although a range of surface modifications and coatings (antimicrobial, bioactive, therapeutic drugs) have been explored for dental implants, it is still a long way from designing sophisticated therapeutic implant surfaces to achieve the specific needs of dental patients. The present article reviews various interdisciplinary aspects of surface coatings on dental implants from the perspectives of biomaterials, coatings, drug release, and related therapeutic effects. Additionally, the various types of implant coatings, localized drug release from coatings, and how released agents influence the bone–implant surface interface characteristics are discussed. This paper also highlights several strategies for local drug delivery and their limitations in dental implant coatings as some of these concepts are yet to be applied in clinical settings due to the specific requirements of individual patients.

Parametric Optimization of Dental Implants

2020 ◽  
Vol 22 (4) ◽  
pp. 1061-1076
Author(s):  
Wafa Bensmain ◽  
Mohammed Benlebna ◽  
Boualem Serier ◽  
Bel Abbes ◽  
Bachir Bouiadjra
Keyword(s):  
Dental Implants ◽  
Clinical Success ◽  
Equivalent Stress ◽  
Radius Of Curvature ◽  
Geometrical Parameters ◽  
Neck Size ◽  
Biomechanical Behavior ◽  
Dynamic Charging ◽  
The Stability ◽  
Masticatory Process

AbstractOsseointegration is a fundamental phenomenon of dental implantology. It ensures the stability, the safety and the durability of dental implants and predictable clinical success in long-term. The geometric form of the implant is a defining parameter of osseointegration and implant-bone charge transfer. This is the essential constitutes of this study. In fact, we demonstrate using the finite elements method with tridimensional numerical computations, that the geometrical parameters of the implant conditionate the level and the repartition of the stresses, induced in the cortical bone and the spongy bone during the masticatory process, simulated here by dynamic charging. The effect of several parameters [size and conicity of the implant neck, size and radius of curvature of the implant apex] and the shape of the implant corps on the biomechanical behavior of the bone. The latest was analyzed in terms of variation of the equivalent stress induced in the bone. The purpose of this analysis was the developing of an implant form allowing stress relaxation, during the mastication process, in the living tissue.

Cytomorphometric characteristics of imprints of the contact area between the gingiva and the dental implant after one-step implantation

2017 ◽  
pp. 77-82
Author(s):  
А.С. Рыбалко ◽  
А.С. Григорьян ◽  
А.А. Орлов
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Contact Area ◽  
Inflammatory Reactions ◽  
Diagnosis And Prognosis ◽  
Dental Implantation ◽  
Data Points ◽  
One Step ◽  
Cytological Method ◽  
Clinical Pictures

Цель исследования состояла в разработке неинвазивного метода диагностики состояния тканей периимплантационной зоны после постановки дентальных имплантатов, а также прогноза течения послеоперационного периода и ранней диагностики послеоперационных осложнений, таких, как мукозит и периимплантит, при одноэтапном методе дентальной имплантации. Методы. В исследовании представлена цитологическая характеристика отпечатков из области контакта имплантата с десной, в которых оценивали состояние эпителиальных клеток при различных проявлениях цитопатологии. Определяли индекс деструкции (ИД) и воспалительно-деструктивный индекс (ВДИ) в клетках воспалительного инфильтрата, которые сопоставляли с клинической картиной течения послеоперационного периода. Сроки забора цитологического материала 1, 5, 15, 25, 30, 60, 120 дней после постановки имплантатов. Количество исследованных цитограмм - 442 от 11 пациентов (по 1-2 имплантата). Общий массив использованных для вычисления интегральных показателей составил »2550. Результаты. Было установлено, что в сроки 1-5 дней после постановки дентальных имплантатов происходит резкое повышение показателей ИД (до 7500 ± 15) и ВДИ (до 80 ± 20), что отражает процесс развития в области имплантатов острых воспалительных реакций. В отдаленные сроки наблюдений отмечалось 2 варианта развития событий. Первый из них характеризовался сохранением во все сроки высоких показателей ИД и ВДИ. Для второго варианта динамики показателей было характерно их падение, что соответствовало развитию процесса остеоинтеграции дентальных имплантатов. The objectives of the investigation were to develop protocols evaluating the validity and effectiveness of the cytological method for diagnosis and prognosis of tissue conditions adjacent to a dental implant. Methods. This study examined the cytological characteristics of imprints of the gingiva-implant contact area, a. the correlation of quantitative ratios of epithelial cells either with or without hystopathological manifestations (an index of destruction, ID); b. ratio of cells of the inflammatory infiltrate (an inflammatory and destructive index, IDI); these data were researched in relation with dynamics of the clinical pictures during a postoperative period.The cytological material was obtained 1, 5, 15, 25, 30, 60, 120 days after dental implantation. Totally 442 cytogramme from 11 patients (1-2 implant per a patient) were assayed. The data array for computation of integrated indicators was composed of ca. 2550 data points. Results. A significant increase of ID (7500 ± 15) and IDI (80 ± 20) indicators, which reflects the development of acute inflammatory reactions in tissues neighboring an implant, was observed within 1-5 days following the insertion of dental implants. Long-term observations revealed two scenarios. The first scenario was characterized by the retention of high levels of ID and IDI over the period of observations. The second scenario featured the reduction of ID and IDI indices, which corresponded to the development of the osseointegration of dental implants.

scholarly journals Ultra-strong bio-glue from genetically engineered polypeptides

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Chao Ma ◽  
Jing Sun ◽  
Bo Li ◽  
Yang Feng ◽  
Yao Sun ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Covalent Bond ◽  
Genetically Engineered ◽  
Supramolecular Interactions ◽  
Molar Ratio ◽  
High Adhesion ◽  
Strong Adhesion ◽  
Order Of Magnitude

AbstractThe development of biomedical glues is an important, yet challenging task as seemingly mutually exclusive properties need to be combined in one material, i.e. strong adhesion and adaption to remodeling processes in healing tissue. Here, we report a biocompatible and biodegradable protein-based adhesive with high adhesion strengths. The maximum strength reaches 16.5 ± 2.2 MPa on hard substrates, which is comparable to that of commercial cyanoacrylate superglue and higher than other protein-based adhesives by at least one order of magnitude. Moreover, the strong adhesion on soft tissues qualifies the adhesive as biomedical glue outperforming some commercial products. Robust mechanical properties are realized without covalent bond formation during the adhesion process. A complex consisting of cationic supercharged polypeptides and anionic aromatic surfactants with lysine to surfactant molar ratio of 1:0.9 is driven by multiple supramolecular interactions enabling such strong adhesion. We demonstrate the glue’s robust performance in vitro and in vivo for cosmetic and hemostasis applications and accelerated wound healing by comparison to surgical wound closures.

scholarly journals Titanium Wear of Dental Implants from Placement, under Loading and Maintenance Protocols

2021 ◽  
Vol 22 (3) ◽  
pp. 1067
Author(s):  
Georgios Romanos ◽  
Gerard Fischer ◽  
Rafael Delgado-Ruiz
Keyword(s):  
Adverse Effects ◽  
Inflammatory Response ◽  
Dental Implants ◽  
Soft Tissues ◽  
Loading Conditions ◽  
Material Change ◽  
Implant Placement ◽  
Implant Abutment ◽  
Hard Tissues ◽  
Titanium Nanoparticles

The objective of this review was to analyze the process of wear of implants leading to the shedding of titanium particles into the peri-implant hard and soft tissues. Titanium is considered highly biocompatible with low corrosion and toxicity, but recent studies indicate that this understanding may be misleading as the properties of the material change drastically when titanium nanoparticles (NPs) are shed from implant surfaces. These NPs are immunogenic and are associated with a macrophage-mediated inflammatory response by the host. The literature discussed in this review indicates that titanium NPs may be shed from implant surfaces at the time of implant placement, under loading conditions, and during implant maintenance procedures. We also discuss the significance of the micro-gap at the implant-abutment interface and the effect of size of the titanium particles on their toxicology. These findings are significant as the titanium particles can have adverse effects on local soft and hard tissues surrounding implants, implant health and prognosis, and even the health of systemic tissues and organs.

Sol-Gel-derived TiO2–SiO2 implant coatings for direct tissue attachment. Part II: Evaluation of cell response

2007 ◽  
Vol 18 (8) ◽  
pp. 1633-1642 ◽  
Author(s):  
Sami Areva ◽  
Virpi Ääritalo ◽  
Sari Tuusa ◽  
Mika Jokinen ◽  
Mika Lindén ◽  
...  
Keyword(s):  
Cell Response ◽  
Sol Gel ◽  
Implant Coatings ◽  
Tissue Attachment

NECROTISING SOFT TISSUE INFECTION OF BILATERAL UPPER LIMB CAUSED BY THE INJECTION OF ORAL BACTERIA: A CASE REPORT

Hand Surgery ◽  
2013 ◽  
Vol 18 (02) ◽  
pp. 243-246 ◽  
Author(s):  
Yuichi Yoshii ◽  
Tomoo Ishii ◽  
Shinsuke Sakai
Keyword(s):  
Soft Tissue ◽  
Upper Limb ◽  
Soft Tissue Infection ◽  
Soft Tissues ◽  
Biceps Brachii ◽  
Subcutaneous Tissue ◽  
Oral Bacteria ◽  
Tissue Infection ◽  
Left Elbow ◽  
The Right

Necrotising soft tissue infection is a rare and rapid process with devastating consequence. We report one case of necrotising soft tissue infection in a bilateral upper limb with uncommon oral bacteria. Radiological imaging revealed the presence of gas in upper limb soft tissues, and an MRI showed the localised signal changes in the biceps muscle of the right upper arm, and the subcutaneous tissue of the left elbow. The patient was treated with surgical resection of the infected muscle and wide debridement of the subcutaneous tissue. Antibiotics were initiated. The patient recovered immediately without functional deficit. The unique features of this patient were possible to observe in the progression of the necrotising soft tissue infection in the bilateral upper limb with intentional injection of oral bacteria, and the effect of biceps brachii resection in a prime age worker.

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