scholarly journals Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals

2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
A. Major-Pedersen ◽  
N. Ihlemann ◽  
T. S. Hermann ◽  
B. Christiansen ◽  
H. Dominguez ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Oral Glucose ◽  
Flow Mediated Dilation ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Healthy Individuals ◽  
Insulin Resistant ◽  
Postprandial State ◽  
Glucose Fluctuations

Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals.Methods. We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects.Results. The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively:4.80±1.41(P= .009) and2.34±1.47(P= .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load.Conclusion. Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.

Decrease of total and undercarboxylated osteocalcin upon oral glucose load in non-insulin-resistant women

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S177-S178
Author(s):  
V. Schwetz⁎ ◽  
E. Lerchbaum ◽  
N. Schweighofer ◽  
N. Hacker ◽  
O. Trummer ◽  
...  
Keyword(s):  
Oral Glucose ◽  
Undercarboxylated Osteocalcin ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Insulin Resistant

Responses of osteocalcin to oral glucose load in insulin-resistant and non-insulin-resistant women

Bone ◽  
2012 ◽  
Vol 51 (6) ◽  
pp. S10
Author(s):  
V. Schwetz ◽  
E. Lerchbaum ◽  
N. Schweighofer ◽  
N. Hacker ◽  
O. Trummer ◽  
...  
Keyword(s):  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Insulin Resistant

scholarly journals The effect of serum insulin on the blood pressure responses after oral glucose load in lean and centrally obese adult male subjects

2021 ◽  
Vol 12 (5) ◽  
pp. 65-68
Author(s):  
Thiri Win Htein ◽  
Zarli Thant ◽  
Ohn Mar
Keyword(s):  
Blood Pressure ◽  
Adult Male ◽  
Serum Insulin ◽  
Oral Glucose ◽  
Obese Adult ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Insulin Resistant ◽  
Blood Pressure Responses ◽  
Male Subjects

Background: The vasodilator action of insulin might contribute to the reduction of blood pressure in the postprandial state and it remains to be clarified whether this action is impaired in the insulin- resistant obese state or not. Aims and Objective: The present study aimed to determine the blood pressure responses after an oral glucose load in lean and insulin resistant centrally obese adult male subjects. Materials and Methods: This study was carried out in eleven lean and eleven centrally obese adult male subjects. After a 75 g oral glucose load, blood pressures were measured at 15-minute intervals and the serum insulin level was determined at 30-minute intervals for two hours. Blood pressure was measured by indirect sphygmomanometry and serum insulin concentration was analyzed by ELISA method. Results: All centrally obese subjects were insulin resistant (HOMA-IR≥2.6). After oral glucose load, the per cent change in glucose-stimulated insulin responses at 30 minutes (626% vs 344%, p<0.05) and at 60 minutes (756% vs 417%, p<0.01) were significantly greater in the lean group than the centrally obese group. The fall in postprandial blood pressures started at 15 minutes and returned to baseline values at 120 minutes. The per cent change in SBP at 15 minutes (-2.2% vs -1.2%, p<0.05) and at 30 minutes (-3.2% vs -2.1%, p<0.05) were significantly greater in the lean group than the centrally obese group. Conclusion: The present findings suggest that attenuation in BP responses as well as a lesser change in glucose-stimulated insulin responses in the centrally obese subjects might be attributable to the presence of insulin resistance.

scholarly journals Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load

2016 ◽  
Vol 130 (21) ◽  
pp. 1881-1888 ◽  
Author(s):  
Lauren K. Walsh ◽  
Robert M. Restaino ◽  
Martha Neuringer ◽  
Camila Manrique ◽  
Jaume Padilla
Keyword(s):  
Endoplasmic Reticulum ◽  
Single Dose ◽  
Endothelial Dysfunction ◽  
Oral Administration ◽  
Vascular Dysfunction ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Tauroursodeoxycholic Acid ◽  
Dose Oral

The key finding of the present study is that vascular dysfunction caused by an oral glucose load can be prevented by a single dose oral administration of tauroursodeoxycholic acid (TUDCA), a compound known to alleviate endoplasmic reticulum stress (ER).

Relationship between insulin response to oral glucose load and creatinine clearance

Diabetes ◽  
1975 ◽  
Vol 24 (12) ◽  
pp. 1066-1071 ◽  
Author(s):  
K. Yasuda ◽  
T. Sato ◽  
T. Furuyama ◽  
K. Yashinaga
Keyword(s):  
Creatinine Clearance ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

The disposal of an oral glucose load in healthy subjects. A quantitative study

Diabetes ◽  
1985 ◽  
Vol 34 (6) ◽  
pp. 580-588 ◽  
Author(s):  
E. Ferrannini ◽  
O. Bjorkman ◽  
G. A. Reichard ◽  
A. Pilo ◽  
M. Olsson ◽  
...  
Keyword(s):  
Quantitative Study ◽  
Healthy Subjects ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

Enhanced Insulin Response to Oral Glucose Load in Patients with Angina Pectoris Associated with ST Segment Elevation in the Absence of Epicardial Coronary Arterial Obstruction

Angiology ◽  
1998 ◽  
Vol 49 (9) ◽  
pp. 815-826 ◽  
Author(s):  
Shigeo Takata ◽  
Atsuhiro Shimakura ◽  
Satoru Sakagami ◽  
Yukio Nakamura ◽  
Hitoshi Ohkuwa ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
St Segment Elevation ◽  
St Segment
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