scholarly journals Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load

2016 ◽  
Vol 130 (21) ◽  
pp. 1881-1888 ◽  
Author(s):  
Lauren K. Walsh ◽  
Robert M. Restaino ◽  
Martha Neuringer ◽  
Camila Manrique ◽  
Jaume Padilla
Keyword(s):  
Endoplasmic Reticulum ◽  
Single Dose ◽  
Endothelial Dysfunction ◽  
Oral Administration ◽  
Vascular Dysfunction ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Tauroursodeoxycholic Acid ◽  
Dose Oral

The key finding of the present study is that vascular dysfunction caused by an oral glucose load can be prevented by a single dose oral administration of tauroursodeoxycholic acid (TUDCA), a compound known to alleviate endoplasmic reticulum stress (ER).

scholarly journals REDUCED DOSE ORAL GLUCOSE LOAD YIELDS EXCELLENT MYOCARDIAL PET VIABILITY IMAGES

2017 ◽  
Vol 69 (11) ◽  
pp. 1523
Author(s):  
Howard Martin Julien ◽  
Albert DeLuca ◽  
Jeffrey Lin ◽  
Sabahat Bokhari
Keyword(s):  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Reduced Dose ◽  
Dose Oral

scholarly journals Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals

2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
A. Major-Pedersen ◽  
N. Ihlemann ◽  
T. S. Hermann ◽  
B. Christiansen ◽  
H. Dominguez ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Oral Glucose ◽  
Flow Mediated Dilation ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Healthy Individuals ◽  
Insulin Resistant ◽  
Postprandial State ◽  
Glucose Fluctuations

Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals.Methods. We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects.Results. The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively:4.80±1.41(P= .009) and2.34±1.47(P= .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load.Conclusion. Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.

Ascorbic acid prevents vascular dysfunction induced by oral glucose load in healthy subjects

2012 ◽  
Vol 23 (1) ◽  
pp. 54-57 ◽  
Author(s):  
Sergio De Marchi ◽  
Manlio Prior ◽  
Anna Rigoni ◽  
Sara Zecchetto ◽  
Fanny Rulfo ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Healthy Subjects ◽  
Vascular Dysfunction ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

Relationship between insulin response to oral glucose load and creatinine clearance

Diabetes ◽  
1975 ◽  
Vol 24 (12) ◽  
pp. 1066-1071 ◽  
Author(s):  
K. Yasuda ◽  
T. Sato ◽  
T. Furuyama ◽  
K. Yashinaga
Keyword(s):  
Creatinine Clearance ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

The disposal of an oral glucose load in healthy subjects. A quantitative study

Diabetes ◽  
1985 ◽  
Vol 34 (6) ◽  
pp. 580-588 ◽  
Author(s):  
E. Ferrannini ◽  
O. Bjorkman ◽  
G. A. Reichard ◽  
A. Pilo ◽  
M. Olsson ◽  
...  
Keyword(s):  
Quantitative Study ◽  
Healthy Subjects ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

scholarly journals The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration

1994 ◽  
Vol 33 (2) ◽  
pp. 289-297 ◽  
Author(s):  
K. W. T. Tsang ◽  
P. Roberts ◽  
R. C. Read ◽  
F. Kees ◽  
R. Wilson ◽  
...  
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Dose Oral ◽  
Hydroxy Metabolite

Enhanced Insulin Response to Oral Glucose Load in Patients with Angina Pectoris Associated with ST Segment Elevation in the Absence of Epicardial Coronary Arterial Obstruction

Angiology ◽  
1998 ◽  
Vol 49 (9) ◽  
pp. 815-826 ◽  
Author(s):  
Shigeo Takata ◽  
Atsuhiro Shimakura ◽  
Satoru Sakagami ◽  
Yukio Nakamura ◽  
Hitoshi Ohkuwa ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
St Segment Elevation ◽  
St Segment

Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans

1986 ◽  
Vol 11 (3) ◽  
pp. 171-174 ◽  
Author(s):  
S. R. Bareggi ◽  
R. Pirola ◽  
S. eva ◽  
L. Zecca
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Dose Oral
Sign in / Sign up

Export Citation Format

Share Document