scholarly journals Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Keiichi Sakamoto ◽  
Eiko Ohno-Okumura ◽  
Taku Kato ◽  
Masaki Watanabe ◽  
Michael J. Cook
Keyword(s):  
Cell Culture ◽  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Dimethyl Sulfate ◽  
Cell Disruption ◽  
Monochloroacetic Acid ◽  
Cyclic Voltammograms ◽  
Produce Cell ◽  
Photodynamic Therapy Of Cancer ◽  
Before And After

The phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products. All quaternized and sulfo-substituted showed amphiphilic character. Identical peaks in cyclic voltammograms appeared for these products before and after quaternization. During the evaluation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for its photodynamic therapy of cancer (PDT) efficacy by cancer cell culture, the light exposed dimethyl sulfate quaternized zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazines in IU-002 cells produce cell disruption that can be detected as a decrease in fluorescence.

scholarly journals Pyridinium-substituted tetraphenylethylene salt-based photosensitizers by varying counter anions: a highly efficient photodynamic therapy for cancer cell ablation and bacterial inactivation

2020 ◽  
Vol 8 (24) ◽  
pp. 5234-5244 ◽  
Author(s):  
Wei Xiong ◽  
Lingyun Wang ◽  
Xiaoli Chen ◽  
Hao Tang ◽  
Derong Cao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Bacterial Inactivation ◽  
Highly Efficient ◽  
Cell Ablation ◽  
Photodynamic Therapy Of Cancer

A highly efficient photodynamic therapy of cancer cell ablation and bacterial inactivation by two AIEgens was reported.

G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugates for targeted cancer cell photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (99) ◽  
pp. 96942-96945 ◽  
Author(s):  
Jun Ai ◽  
Jing Li ◽  
Lu Ga ◽  
Guohong Yun ◽  
Li Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Surface ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Specific Interaction ◽  
Protoporphyrin Ix ◽  
Photodynamic Therapy Of Cancer ◽  
G Quadruplex ◽  
New Type ◽  
Targeted Photodynamic Therapy

A new type of G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugate was prepared and used for the targeted photodynamic therapy of cancer cells via the specific interaction between AS1411 and the nucleolin on the cell surface.

PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells

RSC Advances ◽  
2016 ◽  
Vol 6 (113) ◽  
pp. 112393-112402 ◽  
Author(s):  
Wei Deng ◽  
Zofia Kautzka ◽  
Wenjie Chen ◽  
Ewa M Goldys
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Killing ◽  
Light Illumination ◽  
Killing Effect ◽  
Photodynamic Therapy Of Cancer ◽  
Cell Killing Effect

Enhanced 1O2 generation from PLGA loaded with verteporfin and gold nanoparticles under light illumination has the potential to improve cancer cell-killing effect.

Platelet-Rich and Platelet-Poor Plasma Might Play Supportive Roles in Cancer Cell Culture: A Replacement for Fetal Bovine Serum?

2021 ◽  
Vol 21 ◽  
Author(s):  
Mehdi Talebi ◽  
Mousa Vatanmakanian ◽  
Ali Mirzaei ◽  
Yaghoub Barfar ◽  
Maryam Hemmatzadeh ◽  
...  
Keyword(s):  
Cell Culture ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Cancer ◽  
High Price ◽  
Dependent Manner ◽  
Platelet Poor Plasma ◽  
Protein Levels ◽  
Healthy Donors ◽  
Regulatory Functions

Background: Platelet-rich (PRP) and Platelet-poor plasma (PPP) are widely used in research and clinical platforms mainly due to their capacities to enhance cell growth. Although short half-life (5 days) and the high price of platelet products pose challenges regarding their usage, they maintain the growth regulatory functions for weeks. Thus, we aimed to assess the supplementary values of these products in human CCRF-CEM cancer cells. Mechanistically, we also checked if the PRP/PPP treatment enhances YKL-40 expression as a known protein regulating cell growth. Methods: The PRP/PPP was prepared from healthy donors using manual stepwise centrifugation and phase separation. The viability of the cells treated with gradient PRP/PPP concentrations (2, 5, 10, and 15%) was measured by the MTT assay. The YKL-40 mRNA and protein levels were assessed using qRT-PCR and western blotting. The data were compared to FBS-treated cells. Result: Our findings revealed that the cells treated by PRP/PPP not only were morphologically comparable to those treated by FBS but also, they showed greater viability at the concentrations of 10 and 15%. Moreover, it was shown that PRP/PPP induce cell culture support, at least in part, via inducing YKL-40 expression at both mRNA and protein levels in a time- and dose-dependent manner. Conclusion: Collectively, by showing cell culture support comparable to FBS, the PRP/PPP might be used as good candidates to supplement the cancer cell culture and overcome concerns regarding the use of FBS as a non-human source in human cancer research.

“Stealth” dendrimers with encapsulation of indocyanine green for photothermal and photodynamic therapy of cancer

2021 ◽  
Vol 600 ◽  
pp. 120502 ◽  
Author(s):  
Tianming Cui ◽  
Shukai Li ◽  
Shengfu Chen ◽  
Ying Liang ◽  
Haotian Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Photodynamic Therapy Of Cancer

scholarly journals Self-Assembling Polypeptide Hydrogels as a Platform to Recapitulate the Tumor Microenvironment

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3286
Author(s):  
Dariusz Lachowski ◽  
Carlos Matellan ◽  
Ernesto Cortes ◽  
Alberto Saiani ◽  
Aline F. Miller ◽  
...  
Keyword(s):  
Cell Culture ◽  
Tumor Microenvironment ◽  
Cancer Cell ◽  
Critical Role ◽  
Hypoxia Inducible Factor ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Culture Systems ◽  
A Cell

The tumor microenvironment plays a critical role in modulating cancer cell migration, metabolism, and malignancy, thus, highlighting the need to develop in vitro culture systems that can recapitulate its abnormal properties. While a variety of stiffness-tunable biomaterials, reviewed here, have been developed to mimic the rigidity of the tumor extracellular matrix, culture systems that can recapitulate the broader extracellular context of the tumor microenvironment (including pH and temperature) remain comparably unexplored, partially due to the difficulty in independently tuning these parameters. Here, we investigate a self-assembled polypeptide network hydrogel as a cell culture platform and demonstrate that the culture parameters, including the substrate stiffness, extracellular pH and temperature, can be independently controlled. We then use this biomaterial as a cell culture substrate to assess the effect of stiffness, pH and temperature on Suit2 cells, a pancreatic cancer cell line, and demonstrate that these microenvironmental factors can regulate two critical transcription factors in cancer: yes-associated protein 1 (YAP) and hypoxia inducible factor (HIF-1A).

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