scholarly journals Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature

2003 ◽  
Vol 17 (8) ◽  
pp. 497-500 ◽  
Author(s):  
Robert M Penner ◽  
C Noel Williams
Keyword(s):  
Abdominal Pain ◽  
Complete Resolution ◽  
Nsaid Therapy ◽  
University Hospital ◽  
Review Of The Literature ◽  
Drug Induced ◽  
First Case ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Colonic Strictures

A 69-year-old woman on nonsteroidal anti-inflammatory drugs (NSAIDs) was admitted to a university hospital with abdominal pain, profound anemia and melena stools. Duodenal ulceration and subsequent healing were documented. Colonoscopy revealed haustral ulceration and NSAID-induced colonic diaphragm disease. Discontinuation of NSAID therapy did not result in endoscopic change, but a 20-week course of prednisone was followed by complete resolution. This is the first case describing prednisone monotherapy for such strictures, and only the second in which endoscopic resolution has been documented. With further supporting experience, prednisone may be considered in addition to NSAID discontinuation for patients with this rare but serious complication.

scholarly journals Endoscopic and Pathologic Resolution of Chronic Nonsteroidal Anti-Inflammatory Drug-Induced Diaphragm-Like Colonic Strictures and Ulceration

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Behdod Poushanchi ◽  
Hiren Vallabh ◽  
Justin Kupec
Keyword(s):  
Adverse Effects ◽  
Case Reports ◽  
Nsaid Therapy ◽  
Unique Case ◽  
Drug Induced ◽  
Rare Side Effect ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Chronic Use ◽  
Colonic Strictures

The chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) has steadily increased and, as a result, adverse effects have become more common. Isolated case reports have documented diaphragm-like colonic strictures and ulceration as the result of NSAID use. We report a unique case of this rare side effect with documented endoscopic and histologic healing of multiple proximal diaphragm-like colonic strictures and ulceration months after simple discontinuation of NSAID therapy.

scholarly journals Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication

2019 ◽  
Vol 12 (11) ◽  
pp. e231619 ◽  
Author(s):  
Florian Desgranges ◽  
Nathalie Tebib ◽  
Olivier Lamy ◽  
Antonios Kritikos
Keyword(s):  
Complete Resolution ◽  
Viral Infections ◽  
Empirical Therapy ◽  
Neurological Sequela ◽  
Review Of The Literature ◽  
Acute Meningitis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Tension Type Headaches

A 40-year-old man developed aseptic meningitis after ibuprofen consumption for tension-type headaches. After a thorough diagnostic workup and lack of improvement on empirical therapy for common aetiologies of meningitis (bacterial and viral infections), we suspected non-steroidal anti-inflammatory drug (NSAID) induced meningitis due to the temporal relationship between drug administration and symptom onset. Two days after NSAID suppression, the evolution was progressively favourable with complete resolution of fever and symptoms. On follow-up, symptoms did not recur and there was no neurological sequela. This article summarises the clinical picture and the complementary exams that led to the difficult-to-make diagnosis of NSAID-induced acute meningitis, in parallel with a brief review of the literature.

scholarly journals Acute Myopericarditis in a Pediatric Patient after First Dose of Pfizer BioNTech COVID - 19 Vaccination: First Case Report in the Kingdom of Bahrain

2021 ◽  
Vol 33 (4) ◽  
pp. 29-32
Author(s):  
Ghada Al Qassim ◽  
Vimalarani Arulselvam ◽  
Suad R Al Amer ◽  
Salah Al Ghanem ◽  
Neale Nicola Kalis
Keyword(s):  
Case Report ◽  
Adverse Events ◽  
Pediatric Patient ◽  
Task Force ◽  
Limited Data ◽  
First Case ◽  
National Task ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Coronavirus disease 201 9 (COVID - 1 9 ) vaccination for children over 12 years of age began on May 2021 in the kingdom of Bahrain. Very limited data is available regarding the adverse events related to COVID -19 vaccination in children. This is a case report of a 12-year-old previously healthy boy with acute myopericarditis who presented on day 5 after the first dose of Pfizer COVID - 19 vaccination. Other causes of acute myopericarditis were ruled out. He was treated with non - steroidal anti-inflammatory drugs and recovered fully. This case of vaccine-induced myocarditis was reported to the national task force of Bahrain for combating COVID - 19.

Drug-induced anaphylaxis in children: Nonsteroidal anti-inflammatory drugs and drug provocation test

2014 ◽  
Vol 2 (6) ◽  
pp. 825 ◽  
Author(s):  
Luis Felipe Ensina ◽  
Alex Eustaquio de Lacerda ◽  
Djanira Martins de Andrade ◽  
Ligia Machado ◽  
Inês Camelo-Nunes ◽  
...  
Keyword(s):  
Provocation Test ◽  
Drug Induced ◽  
Drug Provocation Test ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Sa1558 Risk of Non-Steroidal Anti-Inflammatory Drugs-Related Serious Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 150 (4) ◽  
pp. S1066
Author(s):  
Sakkarin Chirapongsathorn ◽  
Chayakrit Krittanawong ◽  
Ann M. Farrell ◽  
Mohammad H. Murad ◽  
Patrick Kamath
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Meta Analysis ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Primary Chronic Osteomyelitis of the Jaws in Children: An Update on Pathophysiology, Radiological Findings, Treatment Strategies, and Prospective Analysis of Two Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Caroline Berglund ◽  
Karin Ekströmer ◽  
Jahan Abtahi
Keyword(s):  
Chronic Osteomyelitis ◽  
Treatment Strategies ◽  
Joint Involvement ◽  
Surgical Removal ◽  
Review Of The Literature ◽  
Clinical Recurrence ◽  
Female Ratio ◽  
First Choice ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Objective.Primary chronic osteomyelitis (PCO) of the jaws in children is associated with pain, trismus, and swelling. In children, temporomandibular joint involvement is rare and few studies have been published due to the relatively low incidence. This paper presents two cases of mandibular PCO in children with the involvement of the collum mandibulae. In addition, a review of the literature regarding demographic data, histological, radiological, and laboratory findings, and treatment strategies of PCO was also performed.Material and Methods.Prospective analyses of two PCO cases. A PubMed search was used and the articles were sorted according to their corresponding key area of focus.Results.Review of the literature revealed twenty-four cases of PCO with two cases of mandibular condyle involvement. The mean age was 18 years; the male to female ratio was 1 : 3. Most of the patients were treated with anti-inflammatory drugs in combination with decortication. Clinical recurrence was seen in 7 cases.Conclusion.A combination of anti-inflammatory drugs and surgical intervention appears to be the first choice of treatment. However, surgical removal of necrotic tissue adjacent to collum mandibulae has its limitations in children. Further investigations are of utmost importance in order to increase our knowledge and understanding of this disease.

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