scholarly journals Endoscopic and Pathologic Resolution of Chronic Nonsteroidal Anti-Inflammatory Drug-Induced Diaphragm-Like Colonic Strictures and Ulceration

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Behdod Poushanchi ◽  
Hiren Vallabh ◽  
Justin Kupec
Keyword(s):  
Adverse Effects ◽  
Case Reports ◽  
Nsaid Therapy ◽  
Unique Case ◽  
Drug Induced ◽  
Rare Side Effect ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Chronic Use ◽  
Colonic Strictures

The chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) has steadily increased and, as a result, adverse effects have become more common. Isolated case reports have documented diaphragm-like colonic strictures and ulceration as the result of NSAID use. We report a unique case of this rare side effect with documented endoscopic and histologic healing of multiple proximal diaphragm-like colonic strictures and ulceration months after simple discontinuation of NSAID therapy.

scholarly journals Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature

2003 ◽  
Vol 17 (8) ◽  
pp. 497-500 ◽  
Author(s):  
Robert M Penner ◽  
C Noel Williams
Keyword(s):  
Abdominal Pain ◽  
Complete Resolution ◽  
Nsaid Therapy ◽  
University Hospital ◽  
Review Of The Literature ◽  
Drug Induced ◽  
First Case ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Colonic Strictures

A 69-year-old woman on nonsteroidal anti-inflammatory drugs (NSAIDs) was admitted to a university hospital with abdominal pain, profound anemia and melena stools. Duodenal ulceration and subsequent healing were documented. Colonoscopy revealed haustral ulceration and NSAID-induced colonic diaphragm disease. Discontinuation of NSAID therapy did not result in endoscopic change, but a 20-week course of prednisone was followed by complete resolution. This is the first case describing prednisone monotherapy for such strictures, and only the second in which endoscopic resolution has been documented. With further supporting experience, prednisone may be considered in addition to NSAID discontinuation for patients with this rare but serious complication.

scholarly journals Analysis of the use and adverse effects of non-steroidal anti-inflammatory drugs: A pilot study

2006 ◽  
Vol 63 (3) ◽  
pp. 271-277 ◽  
Author(s):  
Aneta Peric ◽  
Marija Toskic-Radojicic
Keyword(s):  
Pilot Study ◽  
Adverse Effects ◽  
Rheumatic Diseases ◽  
Test Results ◽  
Stomach Pain ◽  
Antiulcer Drugs ◽  
Inflammatory Drugs ◽  
The Mean ◽  
Anti Inflammatory ◽  
Number Of Males

Background/Aim. The use and adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in outpatients with rheumatic diseases has not yet been studied enough. The aim of this study was to evaluate the data about the efficacy and safety of NSAIDs obtained from the questionnaires submitted to the outpatients receiving these drugs. Methods. The patients who had been prescribed any of NSAIDs within the period from June to September, 2004 were included in the study. The answers obtained from the questionnaires were statistically analyzed by means of ?2-test. Results. At the time of the study, 150 patients had been prescribed ibuprofen or some other NSAID. Out of the total number of dispensed questionnaires (n = 150), only 45 (30%) were shown to be correctly filled-in. Their analysis showed that 64.4% of the patients had suffered from rheumatic diseases for more than five years, and had regularly used NSAIDs. The average age of these patients was about 70 years, and the number of females was double as high as that of the males. The most frequently used NSAIDs were diclofenac and ibuprofen (46.14%, and 23.24%, respectively). According to the answers given by the patients, the most often adverse reactions were gastric complaints such as nausea (11.1%), and stomach pain (8.9%). Due to this, the majority of the patients (64.4%) used some of the antiulcer drugs, most often ranitidine (31.1%). Conclusion. The results of this pilot study revealed that among the outpatients suffering from rheumatic diseases, the number of females was double as high as the number of males, that these patients were of the mean age of 70 years, and that their diseases lasted longer than five years. Gastric complains such as nausea and gastric pain of mild intensity were the most often adverse effects of NSAIDs reported by our patients. It could be the consequence of the predominant use of diclofenac and ibuprofen, NSAIDs with mild to moderate ulcerogenic potential, as well as the concomitant use of H2-receptor antagonists.

scholarly journals Peripheral Tramadol in Dentistry: A New Use for an Old Drug

2016 ◽  
Vol 18 (2) ◽  
pp. 10
Author(s):  
Daniel Chavarría DDS, MSc, PhD ◽  
Amaury Pozos DDS, MSc, PhD
Keyword(s):  
Adverse Effects ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Health Sciences ◽  
Analgesic Drug ◽  
Orofacial Region ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
New Perspective ◽  
Inflammatory Action

Tramadol is a well known central acting analgesic drug, used in a wide variety of treatments within health sciences; including dentistry. Due to its lack of anti-inflammatory action and some adverse effects related mainly to opioid receptors agonism, it is not use as a routine alternative; keeping mainly for patients allergic to non-steroideal anti-inflammatory drugs or as an adjuvant to manage severe odontogenic pain.  Since new available evidence supports the possible analgesic effect of this drug when is applied locally in different sites, recent reports have been done to explore the same effect in the orofacial region, especially to improve the local management of odontogenic pain. This new perspective article summarize some of the current efforts develop to explore the peripheral Tramadol in dentistry; “a new use for an old drug”. 

Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs on the Small and Large Bowel

Endoscopy ◽  
1999 ◽  
Vol 31 (9) ◽  
pp. 761-767 ◽  
Author(s):  
Schneider ◽  
Benz ◽  
Beermann ◽  
Schiebeler ◽  
Riemann
Keyword(s):  
Adverse Effects ◽  
Large Bowel ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Pattern Recognition Analysis for the Prediction of Adverse Effects by Nonsteroidal Anti-Inflammatory Drugs Using1H NMR-Based Metabolomics in Rats

2009 ◽  
Vol 81 (12) ◽  
pp. 4734-4741 ◽  
Author(s):  
So Young Um ◽  
Myeon Woo Chung ◽  
Kyu-Bong Kim ◽  
Seon Hwa Kim ◽  
Ji Seon Oh ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Adverse Effects ◽  
Pattern Recognition Analysis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-Steroidal Anti-Inflammatory Drugs: Usage and Co-prescription with Other Potentially Interacting Drugs in Elderly: a Cross-sectional Study

2019 ◽  
Author(s):  
Nuru Abdu ◽  
Samuel Teweldemedhin ◽  
Asmerom Mosazghi ◽  
Luwam Asfaha ◽  
Makda Teshale ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Drug Interactions ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Protective Agents ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Introduction: Globally, non-steroidal anti-inflammatory drugs (NSAIDs) usage in the elderly with chronic pain has been reported as frequent. Though it is fundamental in maintaining their quality of life, the risk of polypharmacy, drug interactions and adverse effects is of paramount importance as the elderly usually require multiple medications for their co-morbidities. If prescriptions are not appropriately monitored and managed, they are likely to expose patients to serious drug interactions and potentially fatal adverse effects. Thus, the objective of the study was to assess the appropriateness of NSAIDs use and incidence of NSAIDs related potential interactions in elderly. Methods: A descriptive cross-sectional study was conducted among elderly out-patients (aged 60 and above) who visited three hospitals in Asmara between August 22 and September 29, 2018. The sampling design was two-stage random sampling and data was collected using a questionnaire, exit interview and by abstracting information from patients’ clinical cards. Descriptive and analytical statistics including chi-square test and logistic regression were employed using SPSS. Results: A total of 285 elderly respondents were enrolled in the study with similar male to female ratio. One in four of all respondents were chronic NSAIDs users, of which 74.6% were not prescribed prophylactic gastro-protective agents (GPAs). About 20% of the elderly were involved in polypharmacy and nearly all of the encountered potential NSAIDs related interactions (n=322) with prescribed drugs were moderate. Diabetes and hypertension were significantly associated with chronic NSAIDs use (OR=3, 95% CI: 1.54, 5.84; OR=9.99, 95% CI: 4.46, 22.38) and incidence of drug interactions (OR=3.95, 95%CI: 1.92, 8.13; OR=3.12, 95%CI: 1.81, 5.33) while diabetes and cardiac problem were significantly associated with incidence of polypharmacy (OR=4.33, 95% CI: 2.36, 7.96; OR=3.56, 95% CI: 1.05, 12.11). Conclusion: Though the overall reflection of prescription pattern of NSAIDs during the study period was almost satisfactory, gastro-protective agents were poorly prescribed as a prophylaxis.

scholarly journals Bilateral Sesamoiditis as First Manifestation of Gout

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Daniel de Oliveira Beraldo ◽  
Sasha Duarte ◽  
Gustavo Pacheco ◽  
Rodrigo Barbosa ◽  
Carolina Mendes ◽  
...  
Keyword(s):  
Laboratory Tests ◽  
Case Reports ◽  
Systemic Disease ◽  
Positive Family History ◽  
Rare Condition ◽  
Dual Energy ◽  
Male Athlete ◽  
Important Differential Diagnosis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Sesamoiditis secondary to gout is an extremely rare condition with few case reports in the literature. It is an important differential diagnosis because the treatment depends on targeted therapy, unlike the main causes of sesamoiditis that often involves immobilization with special orthoses and prescription of anti-inflammatory drugs. We report here a case of a 38-year-old male, athlete, with bipartite medial sesamoid, who had insidious pain in the base of the left hallux. Laboratory tests showed no alterations, and imaging examinations demonstrated sesamoiditis with suspicion of stress fracture. The patient was initially prescribed an immobilization boot and analgesic and anti-inflammatory drugs, but he did not respond to the measures taken. After the onset of the same condition in the contralateral foot and getting the same imaging findings, we began an investigation of systemic disease, focusing on gout, because of a positive family history, which was confirmed by dual-energy computed tomography.

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