scholarly journals Hemochromatosis and Yersiniosis

1990 ◽  
Vol 4 (4) ◽  
pp. 160-162 ◽  
Author(s):  
Paul C Adams ◽  
James Gregor
Keyword(s):  
Iron Overload ◽  
Yersinia Enterocolitica ◽  
Hip Prosthesis ◽  
Systemic Infection ◽  
Simultaneous Occurrence ◽  
Yersinia Infection ◽  
Previously Treated

Two patients with documented hemochromatosis and systemic infection with Yersinia enterocolitica are described. The first patient presented with Y enterocolitica septicemia and an infected hip prosthesis which led to the diagnosis of hemochromatosis. The second patient was previously treated for Y enterocolitica with antibiotics but did not recover fully until aggressive phlebotomy therapy was started. The simultaneous occurrence of these two uncommon diseases is related to the ability of the yersinia organism to thrive in the presence of large amounts of iron. The association between iron overload and susceptibility to yersinia infection is reviewed within the context of these two cases.

scholarly journals Multilocular Hepatic Abscess Formation and Sepsis due to Yersinia enterocolitica in a Patient with Hereditary Hemochromatosis and Type 2 Diabetes Mellitus

2017 ◽  
Vol 11 (3) ◽  
pp. 724-728
Author(s):  
Matthias Sauter ◽  
Stephan R. Vavricka ◽  
Pascal Locher ◽  
Benjamin Preiswerk ◽  
Dominik Weishaupt ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Iron Overload ◽  
Yersinia Enterocolitica ◽  
Hereditary Hemochromatosis ◽  
Systemic Infection ◽  
Hepatic Abscess ◽  
Patient Refusal ◽  
High Degree ◽  
Diagnosis Of Diabetes Mellitus

Infection with Yersinia enterocolitica (YE) typically presents with mild gastroenteritis without systemic infection. However, systemic YE infection has been described in states of iron overload. We present the case of a patient with sepsis with hepatic abscesses due to YE infection. Workup revealed a past diagnosis of diabetes mellitus and hemochromatosis which had been untreated for the previous 5 years due to patient refusal. This case highlights risk factors for systemic infection with YE. A high degree of suspicion for YE infection is warranted in patients with iron overload, diabetes mellitus, or immunosuppression.

Simultaneous Occurrence of Monoclonal Gammopathy and Acute Secondary Leukemia with Overexpression of P-Glycoprotein

1992 ◽  
Vol 78 (6) ◽  
pp. 403-406 ◽  
Author(s):  
Roberto Stasi ◽  
Maurizio Tribalto ◽  
Adriano Venditti ◽  
Giovanni Del Poeta ◽  
Germano Aronica ◽  
...  
Keyword(s):  
Monoclonal Gammopathy ◽  
Resistance Mechanism ◽  
Leukemic Cells ◽  
Simultaneous Occurrence ◽  
Secondary Leukemia ◽  
Lymphoid Leukemia ◽  
Transmembrane Glycoprotein ◽  
P Glycoprotein ◽  
Major Clone ◽  
Previously Treated

A 52-year-old woman, previously treated with chemo- and radiotherapy for Hodgkin's disease, developed an acute non-lymphoid leukemia and, contemporarily, an IgG-kappa paraproteinemia. Cytogenetic analysis showed a major clone, representing 90% of observed metaphases, with monosomy of chromosomes 5 and 14. In addition, leukemic cells exhibited a high expression of the P-glycoprotein, a transmembrane glycoprotein involved in the multidrug-resistance mechanism. Possible explanations for this cluster of findings are provided.

Systemic Infection with Yersinia enterocolitica in a Hemodialysis Patient

1998 ◽  
Vol 287 (4) ◽  
pp. 485-487
Author(s):  
Markus P. Stoffel ◽  
Manfred Pollok ◽  
Harald Seifert ◽  
Conrad A. Baldamus
Keyword(s):  
Yersinia Enterocolitica ◽  
Hemodialysis Patient ◽  
Systemic Infection

scholarly journals Megaloblastic anemia-related iron overload and erythroid regulators: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Nicolas Vallet ◽  
Jean-Baptiste Delaye ◽  
Martine Ropert ◽  
Amélie Foucault ◽  
Noémie Ravalet ◽  
...  
Keyword(s):  
Iron Overload ◽  
Vitamin B12 ◽  
Megaloblastic Anemia ◽  
Transferrin Saturation ◽  
Cardiac Insufficiency ◽  
Ineffective Erythropoiesis ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Biological Tests ◽  
Previously Treated

Abstract Background In ineffective erythropoiesis, hepcidin synthesis is suppressed by erythroid regulators, namely erythroferrone and growth differentiation factor-15. For the first time, the hypothesis that iron overload in megaloblastic anemia may be related to ineffective erythropoiesis is explored by describing the kinetics of hepcidin, erythroferrone, and growth differentiation factor-15 levels in a patient diagnosed with megaloblastic anemia associated with iron overload. Case presentation An 81-year-old Caucasian male was admitted for fatigue. He had type-2 diabetes previously treated with metformin, ischemic cardiac insufficiency, and stage-3 chronic kidney disease. Vitiligo was observed on both hands. Biological tests revealed normocytic non-regenerative anemia associated with hemolysis, thrombocytopenia, and elevated sideremia, ferritin, and transferrin saturation levels. Megaloblastic anemia was confirmed with undetectable blood vitamin B12 and typical cytological findings like hyper-segmented neutrophils in blood and megaloblasts in bone marrow. The patient received vitamin B12 supplementation. At 3 months, biological parameters reached normal values. Hepcidin kinetics from diagnosis to 3 months inversely correlated with those of erythroferrone and growth differentiation factor-15. Conclusions This case suggests that iron-overload mechanisms of dyserythropoietic anemias may apply to megaloblastic anemias.

Campylobacter spp., Yersinia enterocolitica, and Salmonella enterica and Their Simultaneous Occurrence in German Fattening Pig Herds and Their Environment

2013 ◽  
Vol 76 (10) ◽  
pp. 1704-1711 ◽  
Author(s):  
C. NATHUES ◽  
P. GRÜNING ◽  
A. FRUTH ◽  
J. VERSPOHL ◽  
T. BLAHA ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Yersinia Enterocolitica ◽  
Salmonella Enterica ◽  
Odds Ratio ◽  
Control Measures ◽  
The Other ◽  
Simultaneous Occurrence ◽  
Risk Category ◽  
Herd Level ◽  
Campylobacter Spp

Campylobacter spp., Salmonella enterica, and Yersinia enterocolitica are common causes of foodborne infections in humans with pork as a potential source. Monitoring programs at farm level are, to date, only implemented for S. enterica, while epidemiological knowledge of the other two pathogens is still lacking. This study aimed to assess the pathogen load (in the pigs' environment) in fattening pig herds, their simultaneous occurrence, and the occurrence of Campylobacter spp. and Y. enterocolitica in herds in different Salmonella risk categories. In 50 fattening pig herds in northern Germany, four pooled fecal samples and 10 swab samples from the pigs' direct environment (pen walls, nipple drinkers), indirect environment (hallways, drive boards), and flies and rodent droppings were collected from each herd and submitted for cultural examination. Campylobacter spp. were detected in 38.1% of fecal, 32.7% of direct environment, 5.3% of indirect environment, and 4.6% of flies/pests samples collected, and Y. enterocolitica in 17.1, 8.1, 1.2, and 3.1% and S. enterica in 11.2, 7.7, 4.1, and 1.5%, respectively. For Campylobacter spp., Y. enterocolitica, and S. enterica, 80, 48, and 32% of herds were positive, respectively; 22 herds were positive for both Campylobacter spp. and Y. enterocolitica, 12 for Campylobacter spp. and S. enterica, and 7 for Y. enterocolitica and S. enterica. There was no significant association between the pathogens at herd level. Campylobacter spp. and Y. enterocolitica were found more often in samples from the low Salmonella risk category (odds ratio, 0.51; confidence interval, 0.36 to 0.73, and 0.3, 0.17 to 0.57), and this was also the case for Y. enterocolitica at herd level (odds ratio, 0.08; confidence interval, 0.02 to 0.3). This study provides evidence that the pigs' environment should be accounted for when implementing control measures on farms against Campylobacter spp. and Y. enterocolitica. An extrapolation from the current Salmonella monitoring to the other two pathogens does not seem feasible.

scholarly journals Infection with Yersinia enterocolitica in patients with iron overload.

BMJ ◽  
1986 ◽  
Vol 292 (6513) ◽  
pp. 97-97 ◽  
Author(s):  
H Y Chiu ◽  
D M Flynn ◽  
A V Hoffbrand ◽  
D Politis
Keyword(s):  
Iron Overload ◽  
Yersinia Enterocolitica

Other Yersinia infections: yersiniosis

2010 ◽  
pp. 776-777
Author(s):  
Michael B. Prentice
Keyword(s):  
Abdominal Pain ◽  
Yersinia Enterocolitica ◽  
Erythema Multiforme ◽  
Reactive Arthritis ◽  
Yersinia Pseudotuberculosis ◽  
Systemic Infection ◽  
Late Complications ◽  
Gram Negative ◽  
Contaminated Food ◽  
Gram Negative Organisms

Yersiniosis is caused by the enteropathogenic Gram-negative organisms Yersinia enterocolitica and Yersinia pseudotuberculosis, which are worldwide zoonotic pathogens. Disease is acquired by consumption of contaminated food or water and is commonest in childhood, and in colder climates. Presentation is with diarrhoea, fever and abdominal pain, which may mimic appendicitis. Late complications include reactive arthritis, erythema nodosum, and erythema multiforme. Systemic infection is more likely with ...

scholarly journals Systematic Yersinia enterocolitica in an iron overloaded and immunocompromised thalassemic patient

2017 ◽  
Vol 32 (3) ◽  
Author(s):  
Sophia Delicou ◽  
Aikaterini Petrocheilou ◽  
Myria Pougiouka ◽  
Konstantinos Maragkos
Keyword(s):  
Iron Overload ◽  
Yersinia Enterocolitica ◽  
Yersinia Pseudotuberculosis ◽  
Outer Membrane Proteins ◽  
Lower Abdominal Pain ◽  
Maculopapular Rash ◽  
Left Knee ◽  
Thalassemic Patient ◽  
End Stage ◽  
Oral Ciprofloxacin

We report the case of a 43-year-old woman who presented with lower abdominal pain, maculopapular rash, arthritis of the left knee and left ankle joints, with a history of thalassemia and heavy iron overload. She was also on haemodialysis therapy three times a week for end stage renal therapy. <em>Yersinia enterocolitica</em> and <em>Yersinia pseudotuberculosis</em> cause yersiniosis, a diarrhoeal illness. Members of the genus <em>Yersinia</em> are gram-negative coccobacilli; they are facultative anaerobes in the family <em>Enterobacteriaceae</em>. Serological examinations revealed positive IgA and IgG antibodies against <em>Yersinia</em> <em>enterocolitica</em> outer membrane proteins (Yops) for YopD(4a) and Yop M(2a) and IgG for LorV (V antigen). Enteritis an reactive arthritis presented as the primary manifestation of <em>Y. enterocolitica</em> infection. Important risk factors include iron overload, cirrhosis, and immune suppression. The patient was successfully treated with oral ciprofloxacin.

Reactive Arthritis following Asymptomatic Yersinia Infection

1980 ◽  
Vol 25 (4) ◽  
pp. 327-328 ◽  
Author(s):  
A. A. Dunk ◽  
D. T. Dobbie ◽  
D. A. Pitkeathly
Keyword(s):  
Clinical Improvement ◽  
Yersinia Enterocolitica ◽  
Reactive Arthritis ◽  
Stool Culture ◽  
Lower Limbs ◽  
Serological Tests ◽  
Recent Infection ◽  
Initial Infection ◽  
Yersinia Infection ◽  
Enterocolitica Infection

A case of an acute asymmetrical polyarthritis occurring in a teenage boy is described. This was shown by serological tests to be secondary to a recent infection with Yersinia enterocolitica. Reactive arthritis following infection by this organism is well recognised in Scandinavia. Only recently have two cases been reported in the U.K. (1,2). This is the first reported case in Scotland and is unusual in that the initial infection was asymptomatic. Clinical improvement was associated with falling Y. enterocolitica titres and a reduction in the E.S.R. The patient was HLA B 27 positive. It is suggested that all patients presenting with an acute asymmetrical polyarthritis predominantly affecting the lower limbs should be screened by stool culture and serology for recent Y. enterocolitica infection.

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