Systematic Yersinia enterocolitica in an iron overloaded and immunocompromised thalassemic patient

Sophia Delicou; Aikaterini Petrocheilou; Myria Pougiouka; Konstantinos Maragkos

doi:10.4081/mm.2017.6873

Systematic Yersinia enterocolitica in an iron overloaded and immunocompromised thalassemic patient

Microbiologia Medica ◽

10.4081/mm.2017.6873 ◽

2017 ◽

Vol 32 (3) ◽

Cited By ~ 2

Author(s):

Sophia Delicou ◽

Aikaterini Petrocheilou ◽

Myria Pougiouka ◽

Konstantinos Maragkos

Keyword(s):

Iron Overload ◽

Yersinia Enterocolitica ◽

Yersinia Pseudotuberculosis ◽

Outer Membrane Proteins ◽

Lower Abdominal Pain ◽

Maculopapular Rash ◽

Left Knee ◽

Thalassemic Patient ◽

End Stage ◽

Oral Ciprofloxacin

We report the case of a 43-year-old woman who presented with lower abdominal pain, maculopapular rash, arthritis of the left knee and left ankle joints, with a history of thalassemia and heavy iron overload. She was also on haemodialysis therapy three times a week for end stage renal therapy. Yersinia enterocolitica and Yersinia pseudotuberculosis cause yersiniosis, a diarrhoeal illness. Members of the genus Yersinia are gram-negative coccobacilli; they are facultative anaerobes in the family Enterobacteriaceae. Serological examinations revealed positive IgA and IgG antibodies against Yersinia enterocolitica outer membrane proteins (Yops) for YopD(4a) and Yop M(2a) and IgG for LorV (V antigen). Enteritis an reactive arthritis presented as the primary manifestation of Y. enterocolitica infection. Important risk factors include iron overload, cirrhosis, and immune suppression. The patient was successfully treated with oral ciprofloxacin.

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The Role of Iron Overload in Yersinia enterocolitica and Yersinia pseudotuberculosis Bacteremia in Hemodialysis Patients

The Journal of Infectious Diseases ◽

10.1093/infdis/156.2.384 ◽

1987 ◽

Vol 156 (2) ◽

pp. 384-387 ◽

Cited By ~ 54

Author(s):

J. R. Boelaert ◽

H. W. van Landuyt ◽

Y. J. Valcke ◽

B. Cantinieaux ◽

W. F. Lornoy ◽

...

Keyword(s):

Iron Overload ◽

Yersinia Enterocolitica ◽

Yersinia Pseudotuberculosis ◽

Hemodialysis Patients

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Arthritis in children as a result of a previous infection caused by Yersinia enterocolitica and Yersinia pseudotuberculosis

Annales UMCS Medicina ◽

10.2478/v10079-008-0056-5 ◽

2008 ◽

Vol 63 (2) ◽

pp. 88-92

Author(s):

Michał Szczyrek ◽

Anna Mełges ◽

Alina Olender ◽

Konrad Jarząbek ◽

Jacek Postępski

Keyword(s):

Yersinia Enterocolitica ◽

Yersinia Pseudotuberculosis ◽

Previous Infection

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Iron Chelation Therapy in CAPD: A New and Effective Treatment of Iron Overload Disease in Esrd Patients

Peritoneal Dialysis International ◽

10.1177/089686088300300214 ◽

1983 ◽

Vol 3 (2) ◽

pp. 99-101 ◽

Cited By ~ 13

Author(s):

Glen H Stanbaugh ◽

A. W, Holmes Diane Gillit ◽

George W. Reichel ◽

Mark Stranz

Keyword(s):

Peritoneal Dialysis ◽

Iron Overload ◽

End Stage Renal Disease ◽

Chelation Therapy ◽

Iron Chelation ◽

Iron Chelation Therapy ◽

Peritoneal Dialysate ◽

Stage Renal Disease ◽

End Stage ◽

Esrd Patients

A patient with end-stage renal disease on CAPD, and with massive iron overload is reported. This patient had evidence of myocardial and hepatic damage probably as a result of iron overload. Treatment with desferoxamine resulted in removal of iron in the peritoneal dialysate. On the basis of preliminary studies in this patient it would appear that removal of iron by peritoneal dialysis in conjunction with chelation therapy is safe and effective. This finding should have wide-ranging signficance for patients with ESRD.

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Functional Mapping of YadA- and Ail-Mediated Binding of Human Factor H to Yersinia enterocolitica Serotype O:3

Infection and Immunity ◽

10.1128/iai.00314-08 ◽

2008 ◽

Vol 76 (11) ◽

pp. 5016-5027 ◽

Cited By ~ 45

Author(s):

Marta Biedzka-Sarek ◽

Saara Salmenlinna ◽

Markus Gruber ◽

Andrei N. Lupas ◽

Seppo Meri ◽

...

Keyword(s):

Yersinia Enterocolitica ◽

Alternative Pathway ◽

Outer Membrane Proteins ◽

Factor H ◽

Complement Alternative Pathway ◽

Human Host ◽

Serotype O ◽

Complement Resistance ◽

Sense And Respond ◽

Active Complement

ABSTRACT Yersinia enterocolitica is an enteric pathogen that exploits diverse means to survive in the human host. Upon Y. enterocolitica entry into the human host, bacteria sense and respond to variety of signals, one of which is the temperature. Temperature in particular has a profound impact on Y. enterocolitica gene expression, as most of its virulence factors are expressed exclusively at 37°C. These include two outer membrane proteins, YadA and Ail, that function as adhesins and complement resistance (CR) factors. Both YadA and Ail bind the functionally active complement alternative pathway regulator factor H (FH). In this study, we characterized regions on both proteins involved in CR and the interaction with FH. Twenty-eight mutants having short (7 to 41 amino acids) internal deletions within the neck and stalk of YadA and two complement-sensitive site-directed Ail mutants were constructed to map the CR and FH binding regions of YadA and Ail. Functional analysis of the YadA mutants revealed that the stalk of YadA is required for both CR and FH binding and that FH appears to target several conformational and discontinuous sites of the YadA stalk. On the other hand, the complement-sensitive Ail mutants were not affected in FH binding. Our results also suggested that Ail- and YadA-mediated CR does not depend solely on FH binding.

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