scholarly journals Multilocular Hepatic Abscess Formation and Sepsis due to Yersinia enterocolitica in a Patient with Hereditary Hemochromatosis and Type 2 Diabetes Mellitus

2017 ◽  
Vol 11 (3) ◽  
pp. 724-728
Author(s):  
Matthias Sauter ◽  
Stephan R. Vavricka ◽  
Pascal Locher ◽  
Benjamin Preiswerk ◽  
Dominik Weishaupt ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Iron Overload ◽  
Yersinia Enterocolitica ◽  
Hereditary Hemochromatosis ◽  
Systemic Infection ◽  
Hepatic Abscess ◽  
Patient Refusal ◽  
High Degree ◽  
Diagnosis Of Diabetes Mellitus

Infection with Yersinia enterocolitica (YE) typically presents with mild gastroenteritis without systemic infection. However, systemic YE infection has been described in states of iron overload. We present the case of a patient with sepsis with hepatic abscesses due to YE infection. Workup revealed a past diagnosis of diabetes mellitus and hemochromatosis which had been untreated for the previous 5 years due to patient refusal. This case highlights risk factors for systemic infection with YE. A high degree of suspicion for YE infection is warranted in patients with iron overload, diabetes mellitus, or immunosuppression.

scholarly journals Hemochromatosis and Yersiniosis

1990 ◽  
Vol 4 (4) ◽  
pp. 160-162 ◽  
Author(s):  
Paul C Adams ◽  
James Gregor
Keyword(s):  
Iron Overload ◽  
Yersinia Enterocolitica ◽  
Hip Prosthesis ◽  
Systemic Infection ◽  
Simultaneous Occurrence ◽  
Yersinia Infection ◽  
Previously Treated

Two patients with documented hemochromatosis and systemic infection with Yersinia enterocolitica are described. The first patient presented with Y enterocolitica septicemia and an infected hip prosthesis which led to the diagnosis of hemochromatosis. The second patient was previously treated for Y enterocolitica with antibiotics but did not recover fully until aggressive phlebotomy therapy was started. The simultaneous occurrence of these two uncommon diseases is related to the ability of the yersinia organism to thrive in the presence of large amounts of iron. The association between iron overload and susceptibility to yersinia infection is reviewed within the context of these two cases.

Hepcidin in Iron Homeostasis: Diagnostic and Therapeutic Implications in Type 2 Diabetes Mellitus Patients

2017 ◽  
Vol 138 (4) ◽  
pp. 183-193 ◽  
Author(s):  
Sintayehu Ambachew ◽  
Belete Biadgo
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Iron Overload ◽  
Iron Metabolism ◽  
Iron Homeostasis ◽  
Diabetic Patients ◽  
Hepatitis C Infection ◽  
Body Iron

The prevalence of type 2 diabetes is increasing in epidemic proportions worldwide. Evidence suggests body iron overload is frequently linked and observed in patients with type 2 diabetes. Body iron metabolism is based on iron conservation and recycling by which only a part of the daily need is replaced by duodenal absorption. The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism. It directly binds to ferroportin, the sole iron exporter, resulting in the internalization and degradation of ferroportin. However, inappropriate production of hepcidin has been shown to play a role in the pathogenesis of type 2 diabetes mellitus and its complications, based on the regulation and expression in iron-abundant cells. Underexpression of hepcidin results in body iron overload, which triggers the production of reactive oxygen species simultaneously thought to play a major role in diabetes pathogenesis mediated both by β-cell failure and insulin resistance. Increased hepcidin expression results in increased intracellular sequestration of iron, and is associated with the complications of type 2 diabetes. Besides, hepcidin concentrations have been linked to inflammatory cytokines, matriptase 2, and chronic hepatitis C infection, which have in turn been reported to be associated with diabetes by several approaches. Either hepcidin-targeted therapy alone or as adjunctive therapy with phlebotomy, iron chelators, or dietary iron restriction may be able to alter iron parameters in diabetic patients. Therefore, measuring hepcidin may improve differential diagnosis and the monitoring of disorders of iron metabolism.

scholarly journals Brevibacterium Bacteremia in the Setting of Pyogenic Liver Abscess: A Case Report with Accompanying Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Sarah Hossain ◽  
Afif Hossain ◽  
Aldo Barajas-Ochoa ◽  
Michael A. Jaker
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Abdominal Pain ◽  
Oral Intake ◽  
Hepatic Abscess ◽  
Pyogenic Liver Abscess ◽  
The Past ◽  
Unculturable Bacteria

A 71-year-old Pakistani man with poorly controlled type 2 diabetes mellitus presenting with worsening mental status, abdominal pain, and oral intake for the past seven days was found to have pyogenic hepatic abscess with unculturable bacteria and subsequently found to have rare Brevibacterium bacteremia.

scholarly journals Relative Iron "Overload" in Offspring of Patients with Type 2 Diabetes Mellitus: A New Component in the Conundrum of Insulin Resistance Syndrome?

HORMONES ◽  
2003 ◽  
Vol 2 (3) ◽  
pp. 161-168 ◽  
Author(s):  
Agathoklis Psyrogiannis ◽  
Venetsana Kyriazopoulou ◽  
Argiris Symeonidis ◽  
Michalis Leotsinidis ◽  
Apostolos Vagenakis
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Iron Overload ◽  
Insulin Resistance Syndrome

He Went Wee, Wee, Wee All Night Long

2020 ◽  
pp. 159-168
Author(s):  
Ajay K. Puri ◽  
Melissa A. McGuire
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mortality Rate ◽  
Laboratory Testing ◽  
Pediatric Population ◽  
Unique Challenge ◽  
Hyperosmolar Hyperglycemic Syndrome ◽  
High Degree

Hyperosmolar hyperglycemic syndrome is a condition occurring with increasing frequency in the pediatric population that carries a high mortality rate. Obese males of African American descent are most at risk. Diagnosis requires a high degree of suspicion as patients often present with nonspecific symptoms. A fingerstick glucose sample and laboratory testing are primary identifiers of type 2 diabetes mellitus. The hallmark of management of these patients involves aggressive fluid resuscitation and close management of their electrolytes. Patients may present with features of diabetic ketoacidosis, which presents a unique challenge to treatment. Complications such as rhabdomyolysis, malignant hyperthermia, and cerebral edema need to be identified early and managed promptly.

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