Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats

2002 ◽  
Vol 283 (5) ◽  
pp. G1035-G1041 ◽  
Author(s):  
Keishi Kawakubo ◽  
Hong Yang ◽  
Yvette Taché
Keyword(s):  
Protective Effect ◽  
Receptor Agonist ◽  
Peptide Yy ◽  
Gastric Injury ◽  
Blood Levels ◽  
Gastric Lesions ◽  
Gastroprotective Effect ◽  
Anesthetized Rats ◽  
Peak Blood

The influence of intravenous peptide YY (PYY) on the gastric injury induced by 45% ethanol was investigated in urethane-anesthetized rats. PYY (25, 75, 125, and 250 pmol · kg−1 · h−1) significantly reduced gastric lesions by 36, 59, 40, and 38%, respectively. Antibody against ratPYY (2 mg/rat) injected intravenously completely prevented the gastroprotective effect of intravenous PYY (75 pmol · kg−1 · h−1), whereas injected intracisternally (460 μg/20 μl), it significantly prevented intracisternal PYY (24 pmol/rat)-induced 58% reduction of ethanol lesions but not that induced by intravenous PYY. Vagotomy did not influence the gastroprotective effect of intravenous PYY. The Y1/“PYY-preferring” receptor agonist [Pro34]PYY (75 pmol · kg−1 ·h−1iv) significantly decreased ethanol-induced gastric lesions by 82%, whereas [Leu31, Pro34]NPY, a Y1/Y3 agonist, and PYY-(3–36), a Y2 agonist, had no effect. These data indicate that PYY-infused intravenously at doses reported to mimic postprandial peak blood levels prevents ethanol-induced gastric injury through vagal independent pathways and PYY-preferring receptors.

scholarly journals Gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana on aspirin and histamine-induced gastric ulcer in rats

2020 ◽  
Vol 8 (1) ◽  
pp. 70
Author(s):  
Ibrahim Abubakar ◽  
Hassan Muhammad Yankuzo ◽  
Yusha'u Shuaibu Baraya ◽  
Mu'azu Abubakar Gusau
Keyword(s):  
Protective Effect ◽  
Ph Value ◽  
Gastrointestinal Diseases ◽  
Gastric Volume ◽  
Total Acidity ◽  
Gastric Lesions ◽  
Ulcer Index ◽  
Ulcer Disease ◽  
Gastroprotective Effect ◽  
Ulcer Model

Background: Peptic ulcer disease remains endemic in our society affecting about four million people every year worldwide. Hannoa klaineana is used traditionally in the treatment of various gastrointestinal diseases including ulcer.Aim: This study aims at evaluating the gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana (Simaroubaceae).Methods: The gastroprotective effect of ethylacetate fraction of the Hannoa klaineana (50, 100 and 200mg/kg b.wt) was evaluated using aspirin and histamine induced ulcer models.Results: In aspirin-induced ulcer model, the ethylacetate fraction of the Hannoa klaineana demonstrated significant (p<0.001) decreased in mean ulcer index with the maximum protective effect (99.84%) at 200 mg/kg against the gastric damages. While histamine-induced ulcer model, the solvent fraction significantly (p<0.001) decreased mean ulcer index with the protective effect up to 99.83% against the gastric lesions. In both models, a significant (p<0.001) increased in pH value coupled with significant (p<0.001) decreased in gastric volume, free and total acidity in rats pre-treated with varying doses of the ethylacetate fraction was found.Conclusion: The mechanism of gastroprotective effects of ethylacetate fraction of the Hannoa klaineana could be attributed to its ability to stimulate prostaglandins secretion or possess prostaglandins like-substances or suppression of histamine-induced vasospastic effect and gastric secretion.   

Protective effect of trillin against ethanol-induced acute gastric lesions in an animal model

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 20081-20088 ◽  
Author(s):  
Tong Chen ◽  
Wenjiao Jiang ◽  
Huixin Zhang ◽  
Xintong You ◽  
Manling Liu ◽  
...  
Keyword(s):  
Animal Model ◽  
Protective Effect ◽  
Gastric Lesions ◽  
Gastroprotective Effect ◽  
Mucosal Lesions

The purpose of the present study was to evaluate gastroprotective effect of trillin on mucosal lesions induced by ethanol.

Intracisternal PYY increases gastric mucosal resistance: role of cholinergic, CGRP, and NO pathways

1999 ◽  
Vol 277 (3) ◽  
pp. G555-G562 ◽  
Author(s):  
Hong Yang ◽  
Keishi Kawakubo ◽  
Yvette Taché
Keyword(s):  
Peptide Yy ◽  
Antisense Oligodeoxynucleotide ◽  
Intragastric Administration ◽  
Gastric Lesions ◽  
Protective Mechanisms ◽  
Gastroprotective Effect ◽  
Calcitonin Gene ◽  
Cgrp Receptor Antagonist ◽  
Synthase Inhibitor

The influence of intracisternal injection of peptide YY (PYY) on gastric lesions induced by ethanol was studied in urethan-anesthetized rats. Gastric lesions covered 15–22% of the corpus as monitored 1 h after intragastric administration of 45% ethanol (5 ml/kg) in intracisternal vehicle control groups. PYY, at doses of 23, 47, or 117 pmol 30 min before ethanol, decreased gastric lesions by 27%, 63%, and 59%, respectively. Thyrotropin-releasing hormone (TRH) receptor antisense oligodeoxynucleotide pretreatment (intracisternally, 48 and 24 h before intracisternal PYY) did not influence the gastroprotective effect of intracisternal PYY (47 pmol) but abolished that of intracisternal TRH analog RX-77368 (4 pmol). RX-77368 (2.6 pmol) and PYY (6 pmol) were ineffective when injected intracisternally alone but reduced ethanol lesions by 44% when injected simultaneously. Atropine (subcutaneously), the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8—37) (intravenously), or the nitric oxide (NO) synthase inhibitor N G-nitro-l-arginine methyl ester (l-NAME, intravenously) completely abolished the gastroprotective effect of intracisternal PYY (47 pmol), whereas indomethacin (intraperitoneally) had no effect. The l-NAME action was reversed by l-arginine but not by d-arginine (intravenously). These results suggest that intracisternal PYY acts independently of medullary TRH to decrease ethanol-induced gastric lesions. The PYY action involves vagal cholinergic-mediated CGRP/NO protective mechanisms.

scholarly journals Gastroprotective Effect of Enteral Nutrition Formula in Mice Injected Subcutaneously with Indomethacin

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3297
Author(s):  
Yoshiaki Yamagishi ◽  
Rei Saiki ◽  
Takeshi Yoshimi ◽  
Toshiyuki Kudo ◽  
Kiyomi Ito
Keyword(s):  
Gastrointestinal Tract ◽  
Enteral Nutrition ◽  
Oral Administration ◽  
Protective Effect ◽  
Direct Interaction ◽  
Gastric Lesions ◽  
Icr Mice ◽  
Gastroprotective Effect ◽  
Time Courses

We have previously shown that two enteral nutrition formulas suppressed gastric lesions induced by the oral administration of indomethacin (IND) in mice. However, the mechanism of their protective effect is unknown. In this study, the effect of the two enteral nutrition formulas on gastric lesions induced by subcutaneous IND injection was investigated, with the objective of exploring the possibility that they may interact directly with IND in the gastrointestinal tract. Ten-week-old, male, ICR mice were fasted, then orally given either purified water, Mermed® One, or 2-fold diluted Terumeal® 2.0α as enteral nutrition formula (25 mL/kg). IND was injected subcutaneously at 20 mg/kg after 30 min, and the stomach was removed 6 h later and fixed in formalin. The number and area of lesions in the stomachs of mice given enteral nutrition formula was reduced to 56–89% and 34–61%, respectively, compared with the mice given purified water. The time courses of plasma IND concentrations were comparable among the three groups. These results suggested that the effect of these enteral nutrition formulas on gastric lesions did not originate from their direct interaction with IND in the gastrointestinal tract or their effect on the disposition of IND.

Mechanism of oleic acid-induced inhibition on gastric acid secretion in rats

1991 ◽  
Vol 260 (4) ◽  
pp. G564-G570 ◽  
Author(s):  
J. C. Rhee ◽  
T. M. Chang ◽  
K. Y. Lee ◽  
Y. H. Jo ◽  
W. Y. Chey
Keyword(s):  
Oleic Acid ◽  
Acid Secretion ◽  
Peptide Yy ◽  
Acid Output ◽  
Inhibitory Effect ◽  
Rabbit Serum ◽  
Similar Degree ◽  
Normal Rabbit Serum ◽  
Anesthetized Rats ◽  
Acid Acid

We investigated the existence of an enterogastrone in rats induced by duodenal administration of oleic acid. Acid secretion by the luminally perfused stomach was stimulated in anesthetized rats by intravenous infusion of 0.3 micrograms.kg-1.h-1 pentagastrin. Intraduodenal administration of 3 mmol of oleic acid produced a profound inhibition (94%) of pentagastrin-stimulated acid output in 10 rats (P less than 0.01). Of several peptides in plasma including secretin, neurotensin, somatostatin, and peptide YY, only secretin was found to increase significantly (P less than 0.001). A similar degree of inhibition of acid output (93%) was caused by porcine secretin, 5.6 pmol.kg-1.h-1, given intravenously to mimic the plasma level of secretin produced by oleic acid infusion. The inhibitory effect of oleic acid on the acid secretion was completely reversed by intravenous injection of a rabbit antisecretin serum but not by a normal rabbit serum. These observations strongly suggest that the inhibition was mediated via circulating secretin. The inhibition produced by either oleic acid or secretin was completely blocked by indomethacin. The blocking action was completely reversed by intravenous administration of 48 micrograms.kg-1.h-1 prostaglandin E2. We conclude that endogenous secretin is a major enterogastrone released by oleic acid in anesthetized rats and that the inhibitory action of secretin requires endogenous prostaglandins.

Protective effect of Bojungikki-tang, a traditional herbal formula, against alcohol-induced gastric injury in rats

2012 ◽  
Vol 142 (2) ◽  
pp. 346-353 ◽  
Author(s):  
Mee-Young Lee ◽  
In-Sik Shin ◽  
Woo-Young Jeon ◽  
Chang-Seob Seo ◽  
Hyekyung Ha ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Injury ◽  
Herbal Formula

scholarly journals Role of some types of serotonin receptors in murine hypophyseal-testicular complex activation induced by the presence of a female

2003 ◽  
Vol 49 (6) ◽  
pp. 53-56
Author(s):  
T. G. Amstislavskaya ◽  
N. K. Popova
Keyword(s):  
Serotonin Receptors ◽  
Receptor Agonist ◽  
Serotonin Receptor ◽  
Receptive Female ◽  
Plasma Testosterone ◽  
Blood Levels ◽  
Inhibitory Effects ◽  
Sexual Activation ◽  
Different Types

Placement of a sexually receptive female mouse behind a partition that prevents physical contacts, but permits it to see and smell caused an increase in the blood levels of testosterone in male mice. The selective 5-HTIA-serotonin receptor agonist 08-OH- DPAT (0.1 mg/kg) and the mixed 5-HTIA/IB agonist eltoprazine, 3.0 and 10.0 mg/kg, blocked the activating effect of female exposure on the male pituitary-testicular system. The 5-HT/-receptor agonist p-MPPI (0.2 mg/kg) prevented the inhibitory effects of 8-OH-DPATand eltoprazine. The 5-HT/B-receptor agonist CGS- 12066A (1.0 and 2.0 mg/kg) exerted no effect while the mixed 5-HTIB/2C-receptor agonist TFMPP (5.2 mg/kg) inhibited a female-induced increase in the levels of male blood testosterone. The 5-HT/-receptor agonist keranserin (1.0 and 2.0 mg/kg) prevented a female-induced increase in the levels of testosterone. The 5-HT3-receptor agonist ondansetron (0.05 and 0.1 mg/kg) elevated the baseline level of plasma testosterone, but blocked receptive female-induced activation of the male hypothalamic-pituitary-testicular system (HPTS). It is concluded that 5-HTIA-receptors are involved in the control of male sexual activation. At the same time different types and even subtypes of the same type of 5-HT-receptors produce varying inhibitory and activating effects on the receptive female-induced activation of HPTS. Blocking of the female-induced activation of HPTS seems to be realized by involving 5-HTu- and 5-HT2C-receptors and its activation occurs with the participation of 5-HT^- and 5- HT3-receptors.

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