Protective effect of trillin against ethanol-induced acute gastric lesions in an animal model

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 20081-20088 ◽  
Author(s):  
Tong Chen ◽  
Wenjiao Jiang ◽  
Huixin Zhang ◽  
Xintong You ◽  
Manling Liu ◽  
...  
Keyword(s):  
Animal Model ◽  
Protective Effect ◽  
Gastric Lesions ◽  
Gastroprotective Effect ◽  
Mucosal Lesions

The purpose of the present study was to evaluate gastroprotective effect of trillin on mucosal lesions induced by ethanol.

scholarly journals Gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana on aspirin and histamine-induced gastric ulcer in rats

2020 ◽  
Vol 8 (1) ◽  
pp. 70
Author(s):  
Ibrahim Abubakar ◽  
Hassan Muhammad Yankuzo ◽  
Yusha'u Shuaibu Baraya ◽  
Mu'azu Abubakar Gusau
Keyword(s):  
Protective Effect ◽  
Ph Value ◽  
Gastrointestinal Diseases ◽  
Gastric Volume ◽  
Total Acidity ◽  
Gastric Lesions ◽  
Ulcer Index ◽  
Ulcer Disease ◽  
Gastroprotective Effect ◽  
Ulcer Model

Background: Peptic ulcer disease remains endemic in our society affecting about four million people every year worldwide. Hannoa klaineana is used traditionally in the treatment of various gastrointestinal diseases including ulcer.Aim: This study aims at evaluating the gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana (Simaroubaceae).Methods: The gastroprotective effect of ethylacetate fraction of the Hannoa klaineana (50, 100 and 200mg/kg b.wt) was evaluated using aspirin and histamine induced ulcer models.Results: In aspirin-induced ulcer model, the ethylacetate fraction of the Hannoa klaineana demonstrated significant (p<0.001) decreased in mean ulcer index with the maximum protective effect (99.84%) at 200 mg/kg against the gastric damages. While histamine-induced ulcer model, the solvent fraction significantly (p<0.001) decreased mean ulcer index with the protective effect up to 99.83% against the gastric lesions. In both models, a significant (p<0.001) increased in pH value coupled with significant (p<0.001) decreased in gastric volume, free and total acidity in rats pre-treated with varying doses of the ethylacetate fraction was found.Conclusion: The mechanism of gastroprotective effects of ethylacetate fraction of the Hannoa klaineana could be attributed to its ability to stimulate prostaglandins secretion or possess prostaglandins like-substances or suppression of histamine-induced vasospastic effect and gastric secretion.   

scholarly journals Gastroprotective Effect of Enteral Nutrition Formula in Mice Injected Subcutaneously with Indomethacin

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3297
Author(s):  
Yoshiaki Yamagishi ◽  
Rei Saiki ◽  
Takeshi Yoshimi ◽  
Toshiyuki Kudo ◽  
Kiyomi Ito
Keyword(s):  
Gastrointestinal Tract ◽  
Enteral Nutrition ◽  
Oral Administration ◽  
Protective Effect ◽  
Direct Interaction ◽  
Gastric Lesions ◽  
Icr Mice ◽  
Gastroprotective Effect ◽  
Time Courses

We have previously shown that two enteral nutrition formulas suppressed gastric lesions induced by the oral administration of indomethacin (IND) in mice. However, the mechanism of their protective effect is unknown. In this study, the effect of the two enteral nutrition formulas on gastric lesions induced by subcutaneous IND injection was investigated, with the objective of exploring the possibility that they may interact directly with IND in the gastrointestinal tract. Ten-week-old, male, ICR mice were fasted, then orally given either purified water, Mermed® One, or 2-fold diluted Terumeal® 2.0α as enteral nutrition formula (25 mL/kg). IND was injected subcutaneously at 20 mg/kg after 30 min, and the stomach was removed 6 h later and fixed in formalin. The number and area of lesions in the stomachs of mice given enteral nutrition formula was reduced to 56–89% and 34–61%, respectively, compared with the mice given purified water. The time courses of plasma IND concentrations were comparable among the three groups. These results suggested that the effect of these enteral nutrition formulas on gastric lesions did not originate from their direct interaction with IND in the gastrointestinal tract or their effect on the disposition of IND.

Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats

2002 ◽  
Vol 283 (5) ◽  
pp. G1035-G1041 ◽  
Author(s):  
Keishi Kawakubo ◽  
Hong Yang ◽  
Yvette Taché
Keyword(s):  
Protective Effect ◽  
Receptor Agonist ◽  
Peptide Yy ◽  
Gastric Injury ◽  
Blood Levels ◽  
Gastric Lesions ◽  
Gastroprotective Effect ◽  
Anesthetized Rats ◽  
Peak Blood

The influence of intravenous peptide YY (PYY) on the gastric injury induced by 45% ethanol was investigated in urethane-anesthetized rats. PYY (25, 75, 125, and 250 pmol · kg−1 · h−1) significantly reduced gastric lesions by 36, 59, 40, and 38%, respectively. Antibody against ratPYY (2 mg/rat) injected intravenously completely prevented the gastroprotective effect of intravenous PYY (75 pmol · kg−1 · h−1), whereas injected intracisternally (460 μg/20 μl), it significantly prevented intracisternal PYY (24 pmol/rat)-induced 58% reduction of ethanol lesions but not that induced by intravenous PYY. Vagotomy did not influence the gastroprotective effect of intravenous PYY. The Y1/“PYY-preferring” receptor agonist [Pro34]PYY (75 pmol · kg−1 ·h−1iv) significantly decreased ethanol-induced gastric lesions by 82%, whereas [Leu31, Pro34]NPY, a Y1/Y3 agonist, and PYY-(3–36), a Y2 agonist, had no effect. These data indicate that PYY-infused intravenously at doses reported to mimic postprandial peak blood levels prevents ethanol-induced gastric injury through vagal independent pathways and PYY-preferring receptors.

scholarly journals Protective Effect of Corni Fructus Extracts on MIA-induced Animal Model of Osteoarthritis: Effect of Corni Fructus Extracts on OA

2020 ◽  
Vol 41 (1) ◽  
pp. 1-13
Author(s):  
Kyungmin Baek ◽  
Yu-min An ◽  
Mi-Rae Shin ◽  
Min Ju Kim ◽  
Jin A Lee ◽  
...  
Keyword(s):  
Animal Model ◽  
Protective Effect ◽  
Corni Fructus

scholarly journals Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes.

1990 ◽  
Vol 171 (3) ◽  
pp. 729-743 ◽  
Author(s):  
J Lefkowith ◽  
G Schreiner ◽  
J Cormier ◽  
E S Handler ◽  
H K Driscoll ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Animal Model ◽  
Fatty Acid ◽  
Protective Effect ◽  
Essential Fatty Acid ◽  
Autoimmune Diabetes ◽  
Spontaneous Diabetes ◽  
Bb Rat ◽  
Deficiency State ◽  
Bb Rats

Essential fatty acid (EFA) deficiency exerts a striking protective effect in several animal models of autoimmune disease. We now report that EFA deprivation prevents diabetes in the BB rat, an animal model of human insulin-dependent diabetes mellitus. In diabetes-prone (DP)-BB rats, the incidences of spontaneous diabetes and insulitis (the pathological substrate of autoimmune diabetes) were greatly reduced by EFA deficiency. This beneficial effect of the deficiency state was also seen in diabetes-resistant (DR)-BB rats that, after treatment with antibody to eliminate RT6+ T cells, would otherwise have become diabetic. The susceptibility of EFA-deprived DP-BB rats to spontaneous diabetes was restored when they were given dietary supplements of linoleate at 70 d of age (during the usual period of susceptibility), but not when they were repleted beginning at 120 d (after the peak incidence of diabetes). EFA deficiency did lead to growth retardation, but calorically restricted control rats demonstrated that the protective effect of the deficiency state was not a function of decreased weight. To examine the relationship between the biochemical changes of EFA deficiency and its physiological effects in this system, we compared the fatty acid changes that occurred in EFA-deficient animals that did and did not develop diabetes. Nondiabetic animals had significantly lower levels of (n-6) fatty acids (i.e., linoleate and arachidonate) and higher levels of oleate, an (n-9) fatty acid, than did diabetic animals. Levels of 20:3(n-9), the fatty acid that uniquely characterizes EFA deficiency, were similar in both groups, however. Among diabetic EFA-deficient rats, the age at onset of diabetes was found to correlate inversely with the level of (n-6) fatty acids, the least depleted animals becoming diabetic earliest, whereas there was no correlation with levels of 20:3(n-9). Among animals repleted with linoleate beginning at 70 d, restoration of susceptibility to diabetes correlated with normalization of the level of arachidonate. In summary, EFA deprivation reduced the frequency of diabetes in both DP and RT6-depleted DR-BB rats. This protective effect was strongly associated with depletion of (n-6) fatty acids, particularly arachidonate, but not with accumulation of the abnormal 20:3(n-9). Conjecturally, arachidonate and/or a metabolite may play a key role in mediating inflammatory injury in this animal model of autoimmune diabetes.

Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats

2015 ◽  
Vol 173 ◽  
pp. 134-138 ◽  
Author(s):  
Joana Sagradas ◽  
Gustavo Costa ◽  
Artur Figueirinha ◽  
Maria Margarida Castel-Branco ◽  
António Manuel Silvério Cabrita ◽  
...  
Keyword(s):  
Gastric Lesions ◽  
Cymbopogon Citratus ◽  
Gastroprotective Effect ◽  
Acute Ethanol
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