scholarly journals Pediatric Brain: No Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-weighted MR Images after Consecutive Exposure to a Macrocyclic Gadolinium-based Contrast Agent

Radiology ◽  
2017 ◽  
Vol 283 (3) ◽  
pp. 828-836 ◽  
Author(s):  
Alexander Radbruch ◽  
Robert Haase ◽  
Philipp Kickingereder ◽  
Philipp Bäumer ◽  
Sebastian Bickelhaupt ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
Mr Images ◽  
Pediatric Brain

Dentate nucleus signal intensity changes on T1-weighted MRI after repeated administrations of linear and macrocyclic gadolinium-based contrast agents: a pediatric intraindividual case-control study

2021 ◽  
pp. 028418512110188
Author(s):  
Kerem Ozturk ◽  
David Nascene
Keyword(s):  
Repeated Measures ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
Pearson Correlation ◽  
Gadopentetate Dimeglumine ◽  
Control Groups ◽  
Significant Difference ◽  
Intensity Changes ◽  
Cerebellar Peduncle ◽  
Pediatric Brain

Background An association between consecutive administrations of macrocyclic gadolinium-based contrast agent (mcGBCA) gadobutrol and linear (L)-GBCA gadopentetate dimeglumine and gadolinium retention in the pediatric brain remains incompletely understood. Purpose To compare signal intensity (SI) changes in the dentate nucleus (DN) on unenhanced T1-weighted imaging (T1WI) in children who obtained mcGBCA gadobutrol with those who had previously received L-GBCA gadopentetate dimeglumine. Material and Methods This retrospective study included 27 children who received L-GBCA gadopentetate dimeglumine followed by mcGBCA gadobutrol and two different control groups matched for age and sex for both periods, each involving 27 individuals with no GBCA administration from January 2010 to January 2020. DN-to-middle cerebellar peduncle (MCP) SI ratios on T1WI were determined. A repeated-measures ANOVA was performed to compare the T1WI SI ratio between children exposed to GBCA in each of the two periods and controls. Pearson correlation analysis was conducted to determine any correlation between SI ratios and confounding parameters. Results T1WI SI ratio was significantly higher in those who had only L-GBCA (1.005±0.087) or subsequent mcGBCA gadobutrol (1.002±0.104) than in control groups 1 (0.927±0.041; P<0.001) and 2 (0.930±0.041; P=0.002), respectively, but no significant difference of the T1WI SI ratio was noted between L-GBCA period and subsequent mcGBCA gadobutrol period ( P=0.917). T1WI SI ratios and the L-GBCA administration number revealed a modest but significant correlation (correlation coefficient=0.034; P=0.016). Conclusion Previous administration of gadopentetate dimeglumine is associated with increased T1WI SI in the DN, while subsequent administration of gadobutrol does not demonstrate any additional SI increase in the pediatric brain.

scholarly journals Lack of increased signal intensity in the dentate nucleus after repeated administration of a macrocyclic contrast agent in multiple sclerosis

Medicine ◽  
2016 ◽  
Vol 95 (39) ◽  
pp. e4624 ◽  
Author(s):  
Philipp Eisele ◽  
Angelika Alonso ◽  
Kristina Szabo ◽  
Anne Ebert ◽  
Melissa Ong ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Contrast Agent ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
Repeated Administration

Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children

2017 ◽  
Vol 47 (10) ◽  
pp. 1345-1352 ◽  
Author(s):  
Maria Camilla Rossi Espagnet ◽  
Bruno Bernardi ◽  
Luca Pasquini ◽  
Lorenzo Figà-Talamanca ◽  
Paolo Tomà ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agent ◽  
Globus Pallidus ◽  
Signal Intensity ◽  
Dentate Nucleus

scholarly journals No Signal Intensity Increase in the Dentate Nucleus on Unenhanced T1-weighted MR Images after More than 20 Serial Injections of Macrocyclic Gadolinium-based Contrast Agents

Radiology ◽  
2017 ◽  
Vol 282 (3) ◽  
pp. 699-707 ◽  
Author(s):  
Alexander Radbruch ◽  
Robert Haase ◽  
Pascal J. Kieslich ◽  
Lukas D. Weberling ◽  
Philipp Kickingereder ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
Intensity Increase ◽  
Mr Images

Erratum to: Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children

2017 ◽  
Vol 47 (10) ◽  
pp. 1366-1366 ◽  
Author(s):  
Maria Camilla Rossi Espagnet ◽  
Bruno Bernardi ◽  
Luca Pasquini ◽  
Lorenzo Figà-Talamanca ◽  
Paolo Tomà ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agent ◽  
Globus Pallidus ◽  
Signal Intensity ◽  
Dentate Nucleus

scholarly journals Dentate Nucleus Signal Intensity Decrease on T1-weighted MR Images after Switching from Gadopentetate Dimeglumine to Gadobutrol

Radiology ◽  
2018 ◽  
Vol 287 (3) ◽  
pp. 816-823 ◽  
Author(s):  
Ashkan Heshmatzadeh Behzadi ◽  
Zerwa Farooq ◽  
Yize Zhao ◽  
George Shih ◽  
Martin R. Prince
Keyword(s):  
Signal Intensity ◽  
Dentate Nucleus ◽  
Gadopentetate Dimeglumine ◽  
Mr Images ◽  
Intensity Decrease
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