Progressive increase of T1 signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images in the pediatric brain exposed to multiple doses of gadolinium contrast

2016 ◽  
Vol 38 (3) ◽  
pp. 331-336 ◽  
Author(s):  
Donna R. Roberts ◽  
Kenton R. Holden
Keyword(s):  
Globus Pallidus ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
Progressive Increase ◽  
Mr Images ◽  
Gadolinium Contrast ◽  
Multiple Doses ◽  
Pediatric Brain

scholarly journals Pediatric Brain: No Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-weighted MR Images after Consecutive Exposure to a Macrocyclic Gadolinium-based Contrast Agent

Radiology ◽  
2017 ◽  
Vol 283 (3) ◽  
pp. 828-836 ◽  
Author(s):  
Alexander Radbruch ◽  
Robert Haase ◽  
Philipp Kickingereder ◽  
Philipp Bäumer ◽  
Sebastian Bickelhaupt ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
Mr Images ◽  
Pediatric Brain

scholarly journals Signal intensity increases in dentate nucleus/globus pallidus/pulvinar on unenhanced T1WI MR images after multiple examinations with gadodiamide

2019 ◽  
Vol 32 (3) ◽  
pp. 215-224
Author(s):  
Takao Koiso ◽  
Masaaki Yamamoto ◽  
Shinya Watanabe ◽  
Bierta E Barfod
Keyword(s):  
Globus Pallidus ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
Estimated Glomerular Filtration Rate ◽  
Total Bilirubin Level ◽  
Neurological Status ◽  
Mr Images ◽  
Adverse Health Effects ◽  
Younger Age

Background and purpose Elevated signal intensity (SI) in the dentate nucleus (DN), globus pallidus (GP) and pulvinar (PUL) was reportedly observed on unenhanced T1-weighted (T1WI) magnetic resonance (MR) images in patients receiving multiple enhanced MR examinations. We aimed to clarify whether this phenomenon influences the long-term neurological status of patients. Materials and methods We studied 196 radiosurgically treated patients undergoing ≥10 MR examinations using a single dose of gadodiamide and the same 1.5 Tesla MR unit. SI ratios were calculated by referencing the brainstem (BS) for the DN and the thalamus (TH) for the GP and PUL. We compared the SI ratios at the first, fifth, and 10th, and at the most recent examinations. The neurological symptoms of all 196 patients were assessed at each MR examination by one of the authors (MY). Results The DN/BS and GP/TH SI ratios were significantly increased at the fifth examination ( p < .0001, p = 0.0094) and, thereafter, gradually increased. Although the PUL/TH SI ratio was not significantly increased at the fifth examination ( p = 0.2515), a significant increase was noted at the 10th examination ( p < .0001). There were no significant predictive factors for DN/BS SI increases. Younger age, no brain metastasis, and normal estimated glomerular filtration rate were related to GP/TH SI ratio increases ( p = 0.0308, p = 0.0001, p = 0.0306). Higher age and total bilirubin level were related to an increased PUL/TH SI ratio ( p = 0.0276, p = 0.0097). No patients experienced gadodiamide-related health problems. Conclusions Although the SI ratios rose as numbers of gadodiamide administrations increased, no adverse health effects have developed to date.

scholarly journals High Signal Intensity in Globus Pallidus and Dentate Nucleus on Unenhanced T1-weighted MR Images: Evaluation of Two Linear Gadolinium-based Contrast Agents

Radiology ◽  
2015 ◽  
Vol 276 (3) ◽  
pp. 836-844 ◽  
Author(s):  
Joana Ramalho ◽  
Mauricio Castillo ◽  
Mamdoh AlObaidy ◽  
Renato H. Nunes ◽  
Miguel Ramalho ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Globus Pallidus ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
High Signal Intensity ◽  
High Signal ◽  
Mr Images

Dentate nucleus signal intensity changes on T1-weighted MRI after repeated administrations of linear and macrocyclic gadolinium-based contrast agents: a pediatric intraindividual case-control study

2021 ◽  
pp. 028418512110188
Author(s):  
Kerem Ozturk ◽  
David Nascene
Keyword(s):  
Repeated Measures ◽  
Signal Intensity ◽  
Dentate Nucleus ◽  
Pearson Correlation ◽  
Gadopentetate Dimeglumine ◽  
Control Groups ◽  
Significant Difference ◽  
Intensity Changes ◽  
Cerebellar Peduncle ◽  
Pediatric Brain

Background An association between consecutive administrations of macrocyclic gadolinium-based contrast agent (mcGBCA) gadobutrol and linear (L)-GBCA gadopentetate dimeglumine and gadolinium retention in the pediatric brain remains incompletely understood. Purpose To compare signal intensity (SI) changes in the dentate nucleus (DN) on unenhanced T1-weighted imaging (T1WI) in children who obtained mcGBCA gadobutrol with those who had previously received L-GBCA gadopentetate dimeglumine. Material and Methods This retrospective study included 27 children who received L-GBCA gadopentetate dimeglumine followed by mcGBCA gadobutrol and two different control groups matched for age and sex for both periods, each involving 27 individuals with no GBCA administration from January 2010 to January 2020. DN-to-middle cerebellar peduncle (MCP) SI ratios on T1WI were determined. A repeated-measures ANOVA was performed to compare the T1WI SI ratio between children exposed to GBCA in each of the two periods and controls. Pearson correlation analysis was conducted to determine any correlation between SI ratios and confounding parameters. Results T1WI SI ratio was significantly higher in those who had only L-GBCA (1.005±0.087) or subsequent mcGBCA gadobutrol (1.002±0.104) than in control groups 1 (0.927±0.041; P<0.001) and 2 (0.930±0.041; P=0.002), respectively, but no significant difference of the T1WI SI ratio was noted between L-GBCA period and subsequent mcGBCA gadobutrol period ( P=0.917). T1WI SI ratios and the L-GBCA administration number revealed a modest but significant correlation (correlation coefficient=0.034; P=0.016). Conclusion Previous administration of gadopentetate dimeglumine is associated with increased T1WI SI in the DN, while subsequent administration of gadobutrol does not demonstrate any additional SI increase in the pediatric brain.

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