scholarly journals No Signal Intensity Increase in the Dentate Nucleus on Unenhanced T1-weighted MR Images after More than 20 Serial Injections of Macrocyclic Gadolinium-based Contrast Agents

Radiology ◽  
2017 ◽  
Vol 282 (3) ◽  
pp. 699-707 ◽  
Author(s):  
Alexander Radbruch ◽  
Robert Haase ◽  
Pascal J. Kieslich ◽  
Lukas D. Weberling ◽  
Philipp Kickingereder ◽  
...  
Radiology ◽  
2015 ◽  
Vol 276 (3) ◽  
pp. 836-844 ◽  
Author(s):  
Joana Ramalho ◽  
Mauricio Castillo ◽  
Mamdoh AlObaidy ◽  
Renato H. Nunes ◽  
Miguel Ramalho ◽  
...  

Author(s):  
Yasin Ertuğ Çekdemir ◽  
Nuri Karabay

Objective: To investigate the correlation between cumulative doses of gadolinium-based contrast agents and increased signal intensity (SI) in the dentate nucleus (DN) and globus pallidus (GP). Methods: Our retrospective trial involved 21 multiple sclerosis patients (11 women, 10 men; mean age: 39.21±10.24, range: 20 to 57 years) who underwent a serial number of multiple cranial magnetic resonance imaging (MRI) examinations in the radiology department of our tertiary care center. Average signal intensities on the DN, pons, GP and thalamus on unenhanced T1-weighted magnetic resonance images were taken into account. The signal intensity in the DN was proportioned to the signal intensity in the pons, whereas the signal intensity in GP to the signal intensity in the thalamus. Any relationship between the DN-to-pons or GP-to-thalamus signal intensity ratios and previous gadolinium-based contrast administrations was sought by means of repeated measures ANOVA. Results: Increases in both DN-to-pons and GP-to-thalamus signal intensity ratios displayed a significant correlation with previous administrations of gadolinium-based contrast agents (p<0.001 for both). A remarkable increase was detected in DN-to-pons and GP-to-thalamus signal intensity ratios between the first and last MRI examinations (p<0.001 for both). Conclusion: Our results support the association between increase in the SI of the DN and GP to the number of gadolinium-enhanced MRI scans in MS patients. The increase in T1 SI seems to be linked with the number of enhanced MRI scans.


Radiology ◽  
2018 ◽  
Vol 287 (3) ◽  
pp. 816-823 ◽  
Author(s):  
Ashkan Heshmatzadeh Behzadi ◽  
Zerwa Farooq ◽  
Yize Zhao ◽  
George Shih ◽  
Martin R. Prince

Radiology ◽  
2017 ◽  
Vol 283 (3) ◽  
pp. 828-836 ◽  
Author(s):  
Alexander Radbruch ◽  
Robert Haase ◽  
Philipp Kickingereder ◽  
Philipp Bäumer ◽  
Sebastian Bickelhaupt ◽  
...  

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