scholarly journals Algorithm/Architecture Co-optimisation Technique for Automatic Data Reduction of Wireless Read-Out in High-Density Electrode Arrays

2018 ◽  
Vol 17 (3) ◽  
pp. 1-19
Author(s):  
Yahya H. Yassin ◽  
Francky Catthoor ◽  
Fabian Kloosterman ◽  
Jyh-Jang Sun ◽  
JoãO Couto ◽  
...  
Keyword(s):  
Data Reduction ◽  
High Density ◽  
Electrode Arrays ◽  
Automatic Data ◽  
Optimisation Technique

Multiscale functional connectivity estimation on low-density neuronal cultures recorded by high-density CMOS Micro Electrode Arrays

2012 ◽  
Vol 207 (2) ◽  
pp. 161-171 ◽  
Author(s):  
Alessandro Maccione ◽  
Matteo Garofalo ◽  
Thierry Nieus ◽  
Mariateresa Tedesco ◽  
Luca Berdondini ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
High Density ◽  
Neuronal Cultures ◽  
Low Density ◽  
Electrode Arrays ◽  
Micro Electrode Arrays

scholarly journals Multi-shanks SiNAPS Active Pixel Sensor CMOS probe: 1024 simultaneously recording channels for high-density intracortical brain mapping

2019 ◽  
Author(s):  
Fabio Boi ◽  
Nikolas Perentos ◽  
Aziliz Lecomte ◽  
Gerrit Schwesig ◽  
Stefano Zordan ◽  
...  
Keyword(s):  
Neural Activity ◽  
Brain Activity ◽  
Brain Area ◽  
Large Population ◽  
Brain Structures ◽  
High Density ◽  
Single Neurons ◽  
Electrode Arrays ◽  
Unit Recording ◽  
Recording Channels

AbstractThe advent of implantable active dense CMOS neural probes opened a new era for electrophysiology in neuroscience. These single shank electrode arrays, and the emerging tailored analysis tools, provide for the first time to neuroscientists the neurotechnology means to spatiotemporally resolve the activity of hundreds of different single-neurons in multiple vertically aligned brain structures. However, while these unprecedented experimental capabilities to study columnar brain properties are a big leap forward in neuroscience, there is the need to spatially distribute electrodes also horizontally. Closely spacing and consistently placing in well-defined geometrical arrangement multiple isolated single-shank probes is methodologically and economically impractical. Here, we present the first high-density CMOS neural probe with multiple shanks integrating thousand’s of closely spaced and simultaneously recording microelectrodes to map neural activity across 2D lattice. Taking advantage from the high-modularity of our electrode-pixels-based SiNAPS technology, we realized a four shanks active dense probe with 256 electrode-pixels/shank and a pitch of 28 µm, for a total of 1024 simultaneously recording channels. The achieved performances allow for full-band, whole-array read-outs at 25 kHz/channel, show a measured input referred noise in the action potential band (300-7000 Hz) of 6.5 ± 2.1µVRMS, and a power consumption <6 µW/electrode-pixel. Preliminary recordings in awake behaving mice demonstrated the capability of multi-shanks SiNAPS probes to simultaneously record neural activity (both LFPs and spikes) from a brain area >6 mm2, spanning cortical, hippocampal and thalamic regions. High-density 2D array enables combining large population unit recording across distributed networks with precise intra- and interlaminar/nuclear mapping of the oscillatory dynamics. These results pave the way to a new generation of high-density and extremely compact multi-shanks CMOS-probes with tunable layouts for electrophysiological mapping of brain activity at the single-neurons resolution.

Specplot - An Interactive Data Reduction and Display Program for Spectral Data

1979 ◽  
Vol 23 ◽  
pp. 305-311 ◽  
Author(s):  
Raymond P. Goehner
Keyword(s):  
Spectral Data ◽  
Data Reduction ◽  
Usual Method ◽  
Spectral Lines ◽  
Digital Data ◽  
Strip Chart Recorder ◽  
Automatic Data ◽  
Chart Recorder ◽  
Rapid Pace ◽  
Interactive Data

The automation of analytical equipment is proceeding at a rapid pace, particularly since the introduction of inexpensive microcomputer systems. Most of this equipment has one characteristic in common, that is, they produce digital spectral data. The usual method of recording spectral data has been the strip chart recorder. Strip charts require the hand encoding of position and intensities of the spectral lines. This requires that all of the lines be on scale or that the sample be run several times in order to amplify weaker lines. This problem is eliminated by recording the data digitally. Digital data can then be rapidly plotted on a cathode ray terminal to any desired scale. The user of digital data has access to a great variety of automatic data reduction programs.

Active High-Density Electrode Arrays: Technology and Applications in Neuronal Cell Cultures

2019 ◽  
pp. 253-273 ◽  
Author(s):  
Davide Lonardoni ◽  
Hayder Amin ◽  
Stefano Zordan ◽  
Fabio Boi ◽  
Aziliz Lecomte ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Neuronal Cell ◽  
High Density ◽  
Electrode Arrays ◽  
Neuronal Cell Cultures

scholarly journals Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis

Micromachines ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 944 ◽  
Author(s):  
Douglas Shire ◽  
Marcus Gingerich ◽  
Patricia Wong ◽  
Michael Skvarla ◽  
Stuart Cogan ◽  
...  
Keyword(s):  
High Density ◽  
Visual Prosthesis ◽  
Massachusetts Institute Of Technology ◽  
Electrode Arrays ◽  
Retinal Implant ◽  
Micro Fabrication ◽  
Bionic Eye ◽  
Startup Company ◽  
Problems And Solutions ◽  
Institute Of Technology

We present a retrospective of unique micro-fabrication problems and solutions that were encountered through over 10 years of retinal prosthesis product development, first for the Boston Retinal Implant Project initiated at the Massachusetts Institute of Technology and at Harvard Medical School’s teaching hospital, the Massachusetts Eye and Ear—and later at the startup company Bionic Eye Technologies, by some of the same personnel. These efforts culminated in the fabrication and assembly of 256+ channel visual prosthesis devices having flexible multi-electrode arrays that were successfully implanted sub-retinally in mini-pig animal models as part of our pre-clinical testing program. We report on the processing of the flexible multi-layered, planar and penetrating high-density electrode arrays, surgical tools for sub-retinal implantation, and other parts such as coil supports that facilitated the implantation of the peri-ocular device components. We begin with an overview of the implantable portion of our visual prosthesis system design, and describe in detail the micro-fabrication methods for creating the parts of our system that were assembled outside of our hermetically-sealed electronics package. We also note the unique surgical challenges that sub-retinal implantation of our micro-fabricated components presented, and how some of those issues were addressed through design, materials selection, and fabrication approaches.

scholarly journals Author Correction: Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays

2018 ◽  
Vol 13 (10) ◽  
pp. 972-972 ◽  
Author(s):  
Michele Dipalo ◽  
Giovanni Melle ◽  
Laura Lovato ◽  
Andrea Jacassi ◽  
Francesca Santoro ◽  
...  
Keyword(s):  
High Density ◽  
Intracellular Recordings ◽  
Electrode Arrays

An Automatic Data Reduction System

1954 ◽  
Vol 26 (5) ◽  
pp. 947-947
Author(s):  
Bill G. Watters ◽  
Jordan J. Baruch ◽  
George W. Kamperman
Keyword(s):  
Data Reduction ◽  
Automatic Data ◽  
Reduction System

scholarly journals An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays

2021 ◽  
Author(s):  
Alessio Paolo Buccino ◽  
Xinyue Yuan ◽  
Vishalini Emmenegger ◽  
Xiaohan Xue ◽  
Tobias Gaenswein ◽  
...  
Keyword(s):  
Action Potential ◽  
Action Potentials ◽  
Electrical Potential ◽  
Simulated Data ◽  
Signal Propagation ◽  
High Density ◽  
Electrode Arrays ◽  
Action Potential Propagation ◽  
Automated Method ◽  
Propagation Velocities

Neurons communicate with each other by sending action potentials through their axons. The velocity of axonal signal propagation describes how fast electrical action potentials can travel, and can be affected in a human brain by several pathologies, including multiple sclerosis, traumatic brain injury and channelopathies. High-density microelectrode arrays (HD-MEAs) provide unprecedented spatio-temporal resolution to extracellularly record neural electrical activity. The high density of the recording electrodes enables to image the activity of individual neurons down to subcellular resolution, which includes the propagation of axonal signals. However, axon reconstruction, to date, mainly relies on a manual approach to select the electrodes and channels that seemingly record the signals along a specific axon, while an automated approach to track multiple axonal branches in extracellular action-potential recordings is still missing. In this article, we propose a fully automated approach to reconstruct axons from extracellular electrical-potential landscapes, so-called "electrical footprints" of neurons. After an initial electrode and channel selection, the proposed method first constructs a graph, based on the voltage signal amplitudes and latencies. Then, the graph is interrogated to extract possible axonal branches. Finally, the axonal branches are pruned and axonal action-potential propagation velocities are computed. We first validate our method using simulated data from detailed reconstructions of neurons, showing that our approach is capable of accurately reconstructing axonal branches. We then apply the reconstruction algorithm to experimental recordings of HD-MEAs and show that it can be used to determine axonal morphologies and signal-propagation velocities at high throughput. We introduce a fully automated method to reconstruct axonal branches and estimate axonal action-potential propagation velocities using HD-MEA recordings. Our method yields highly reliable and reproducible velocity estimations, which constitute an important electrophysiological feature of neuronal preparations.

scholarly journals A modular high-density 294-channel μECoG system on macaque vlPFC for auditory cognitive decoding

2019 ◽  
Author(s):  
Chia-Han Chiang ◽  
Jaejin Lee ◽  
Charles Wang ◽  
Ashley J. Williams ◽  
Timothy H. Lucas ◽  
...  
Keyword(s):  
High Resolution ◽  
Auditory Perception ◽  
Large Scale ◽  
Electrode Array ◽  
Auditory Pathway ◽  
Sound Level ◽  
High Density ◽  
Electrode Arrays ◽  
Spatiotemporal Resolution

AbstractOBJECTIVEA fundamental goal of the auditory system is to parse the auditory environment into distinct perceptual representations. Auditory perception is mediated by the ventral auditory pathway, which includes the ventrolateral prefrontal cortex (vlPFC) late. Because large-scale recordings of auditory signals are quite rare, the spatiotemporal resolution of the neuronal code that underlies vlPFC’s contribution to auditory perception has not been fully elucidated. Therefore, we developed a modular, chronic, high-resolution, multi-electrode array system with long-term viability.APPROACHWe molded three separate μECoG arrays into one and implanted this system in a non-human primate. A custom 3D-printed titanium chamber was mounted on left hemisphere. The molded 294-contact μECoG array was implanted subdurally over vlPFC. μECoG activity was recorded while the monkey participated in a “hearing-in-noise” task in which they reported hearing a “target” vocalization from a background “chorus” of vocalizations. We titrated task difficulty by varying the sound level of the target vocalization, relative to the chorus (target-to-chorus ratio, TCr).MAIN RESULTSWe decoded the TCr and the monkey’s behavioral choices from the μECoG signal. We analyzed decoding capacity as a function of neuronal frequency band, spatial resolution, and time from implantation. Over a one-year period, we were successfully able to record μECoG signals. Although we found significant decoding with as few as two electrodes, we found near-perfect decoding with ∼16 electrodes. Decoding further improved when we included more electrodes. Finally, because the decoding capacity of individual electrodes varied on a day-by-day basis, high-density electrode arrays ensure robust decoding in the long term.SIGNIFICANCEOur results demonstrate the utility and robustness of high-resolution chronic µECoG recording. We developed a new high-resolution surface electrode array that can be scaled to cover larger cortical areas without increasing the chamber footprint.

scholarly journals High-density surface electromyography signals during isometric contractions of elbow muscles of healthy humans

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Mónica Rojas-Martínez ◽  
Leidy Yanet Serna ◽  
Mislav Jordanic ◽  
Hamid Reza Marateb ◽  
Roberto Merletti ◽  
...  
Keyword(s):  
Upper Limb ◽  
Biceps Brachii ◽  
High Density ◽  
Isometric Contractions ◽  
Myoelectric Activity ◽  
Electrode Arrays ◽  
Triceps Brachii ◽  
Healthy Humans ◽  
Limb Muscles ◽  
Density Surface

AbstractThis paper presents a dataset of high-density surface EMG signals (HD-sEMG) designed to study patterns of sEMG spatial distribution over upper limb muscles during voluntary isometric contractions. Twelve healthy subjects performed four different isometric tasks at different effort levels associated with movements of the forearm. Three 2-D electrode arrays were used for recording the myoelectric activity from five upper limb muscles: biceps brachii, triceps brachii, anconeus, brachioradialis, and pronator teres. Technical validation comprised a signals quality assessment from outlier detection algorithms based on supervised and non-supervised classification methods. About 6% of the total number of signals were identified as “bad” channels demonstrating the high quality of the recordings. In addition, spatial and intensity features of HD-sEMG maps for identification of effort type and level, have been formulated in the framework of this database, demonstrating better performance than the traditional time-domain features. The presented database can be used for pattern recognition and MUAP identification among other uses.

Sign in / Sign up

Export Citation Format

Share Document