Splenectomy impairs aerobic swim performance in trout

1991 ◽  
Vol 69 (8) ◽  
pp. 2089-2092 ◽  
Author(s):  
M. P. Pearson ◽  
E. Don Stevens

Critical swim speed (Ucrit) measurements show that trout (Oncorhynchus mykiss) with an intact spleen perform aerobic exercise better than those without (control: Ucrit = 2.19 body lengths/s; splenectomized: Ucrit = 1.84 body lengths/s). Their better performance is correlated with higher blood haemoglobin concentration at exhaustion (control: 9.92 g/dL; splenectomized: 7.96 g/dL), derived from release of red cells from the spleen.

2020 ◽  
Author(s):  
Yugeesh R. Lankadeva ◽  
Clive N. May ◽  
Andrew D. Cochrane ◽  
Bruno Marino ◽  
Sally G. Hood ◽  
...  

1973 ◽  
Vol 18 (6) ◽  
pp. 177-181 ◽  
Author(s):  
J. Hopkins ◽  
G. R. Tudhope

Erythrocyte reduced glutathione (GSH) has been measured in 17 normal subjects and in 70 patients with anaemia of various causes; the red cells of most of the anaemic patients contained abnormally high levels of GSH. In the group of cases of untreated megaloblastic anaemia in which the haemoglobin concentration was less than 8.0 g. per 100 ml., there was an inverse relationship between the erythrocyte GSH level and the haemoglobin concentration. During initial therapy in megaloblastic anaemia, as the haemoglobin concentration increased, the GSH level decreased towards normal; the time taken for the GSH level to reach a value 2 standard deviations above the normal mean was inversely related to the initial haemoglobin concentration. In the red cells of patients with anaemia there was no correlation between the GSH level and the activity of glutathione peroxidase. The significance of these findings is discussed.


1987 ◽  
Vol 15 (4) ◽  
pp. 421-424 ◽  
Author(s):  
A. K. Ronai ◽  
J. J. Glass ◽  
A. S. Shapiro

The efficacy of red cell salvage was assessed under circumstances which simulated blood loss managed with sponges or suction. Expired banked blood was equally divided and processed by either suction, or absorbing the blood on a sponge followed by rinsing the sponge in saline. These two techniques were used to harvest washed, centrifuged erythrocytes. The volume, haematocrit and free haemoglobin concentration of the banked blood and the processed units were measured, and smears from all units were examined microscopically. The red cell mass was calculated as the product of the volume and haematocrit. The red cell mass recovered by suction and from sponges averaged 93% and 87% respectively. Blood lost in sponges can be recovered and used to increase the available autologous blood, thereby reducing the need for donor blood.


1995 ◽  
Vol 52 (11) ◽  
pp. 2476-2482 ◽  
Author(s):  
Barry A. Berejikian

Differences in selection regimes between hatchery and natural environments and environmental stimuli, among other factors, have the potential to cause differences in predator avoidance ability between hatchery and wild steelhead trout fry (Oncorhynchus mykiss). In two separate laboratory experiments, fry raised from eggs of wild Quinault River steelhead trout survived predation by prickly sculpin (Cottus asper) significantly better than size-matched offspring of a locally derived hatchery population, which were reared under similar conditions. Wild fry also survived predation better than hatchery fry in natural stream enclosures over a 3-day test period. Experience, in the form of 50-min visual exposure to sculpin predation on "sacrificial" steelhead trout, improved the ability of fry from both populations to avoid predation by sculpin. Wild-experienced fry were eaten in the fewest number of trials followed by wild-naive, hatchery-experienced, and hatchery-naive fry. The results of this study are consistent with the hypothesis that innate predator avoidance ability has been negatively altered through domestication and that attempts to condition hatchery-reared steelhead to avoid predators may be limited for domesticated populations.


1988 ◽  
Vol 59 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Susan Southon ◽  
I. T. Johnson ◽  
Jennifer M. Gee ◽  
K. R. Price

1. Immature, male Wistar rats were allocated to one of six groups and caged individually. The first group was given a semi-synthetic diet containing 38 mg iron and 55 mg zinc/kg (basal group). The second and third groups were given a diet containing 10 mg Zn and 12 mg Fe/kg respectively (low-Zn and low-Fe groups). Groups four, five and six were given similar diets containing 20 gGypsophilasaponins/kg. After 21 d the Fe and Zn status of the rats was estimated and plasma cholesterol concentration determined.2. Measurements of whole blood haemoglobin concentration, packed cell volume and liver Fe stores indicated that rats in the basal + saponin and low-Fe + saponin groups had a significantly reduced Fe status when compared with their controls. Rats in the low-Zn + saponin group also showed a trend toward reduced Fe stores.3. Zn status, as judged by femur Zn concentration, was not adversely affected by the inclusion ofGypsophilasaponins in the diet.4. Consumption of the saponins resulted in a significant reduction in blood cholesterol concentration, with rats in both the low-Fe groups having significantly lower concentrations than their basal and low-Zn counterparts.5. In view of suggestions that the consumption of saponins should be encouraged because of their ability to lower blood cholesterol, possible effects on Fe metabolism should be investigated further, particularly with respect to the levels and sources of saponin in the human diet.


2002 ◽  
Vol 545 (2) ◽  
pp. 715-728 ◽  
Author(s):  
J. A. L. Calbet ◽  
G. Rådegran ◽  
R. Boushel ◽  
H. Søndergaard ◽  
B. Saltin ◽  
...  

2003 ◽  
Vol 90 (3) ◽  
pp. 541-550 ◽  
Author(s):  
Uma Devi ◽  
C. Mohan Rao ◽  
Vinod K. Srivastava ◽  
Pramod K. Rath ◽  
Bhabani S. Das

Anaemia is a common complication of pulmonary tuberculosis. The precise mechanism of anaemia in pulmonary tuberculosis is not clearly known, but anaemia of inflammation as well as of Fe deficiency has been implicated. Both are common in developing countries. It is extremely difficult to distinguish anaemia of Fe deficiency from anaemia of inflammation with the haematological indices used routinely. Therefore, Fe preparations are usually prescribed for all anaemic patients irrespective of the aetiology. This approach has been questioned. The present study aimed to assess the effect of Fe supplementation on anaemic patients with pulmonary tuberculosis. Adult male patients 15–60 years of age with pulmonary tuberculosis and a blood haemoglobin concentration 80–110 g/l were included in the study; healthy adult males matched for age and socio-economic status were taken as controls. Blood haemoglobin concentration, total erythrocyte count (TEC), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin and serum Fe, total Fe-binding capacity and ferritin were estimated before treatment and 1, 2 and 6 months after treatment. The patients were divided randomly into three groups and during the initial 2 months of treatment were provided with one of three supplementary regimens consisting of placebo, Fe alone or Fe with other haematinics. Significant improvements in haematological indices and Fe status were noticed in all three groups. Blood haemoglobin concentration, MCV and PCV were significantly higher at 1 month in both Fe-supplemented groups than the placebo group. This difference, however, disappeared at 2 and 6 months with similar values in all three groups. The increase of other haematological indices was similar in all groups. Serum Fe and Fe saturation of transferrin were significantly higher in both Fe-supplemented groups than the placebo group up to 2 months; this effect, however, disappeared at 6 months. There was a consistent increase in TEC and decrease in ferritin values up to 6 months in all groups. Radiological and clinical improvement was similar in all three groups. These observations suggest that Fe supplementation in mild to moderate anaemia associated with pulmonary tuberculosis accelerated the normal resumption of haematopoiesis in the initial phases by increasing Fe saturation of transferrin. However, consistent improvement of haematological status was dependent only on the improvement of the disease process.


Author(s):  
S Linpisarn ◽  
O Thanangkul ◽  
C Suwanraj ◽  
R Kaewvichit ◽  
L J Kricka ◽  
...  

Iron deficiency is a common problem, particularly in developing countries, but traditional laboratory methods of detecting this condition are unreliable. The prevalence of iron deficiency in a Northern Thai population (pre-school, school children, adult women) has been assessed by means of plasma ferritin concentrations. The results were compared with prevalences based on blood haemoglobin concentrations. Estimations of prevalences based on plasma ferritin values were 10–24% in non-vegetarian and 49–71% in vegetarian groups, whilst those based on blood haemoglobin were 11–21% (non-vegetarian) and 24–50% (vegetarian). Dietary supplementation with iron produced dramatic rises in plasma ferritin in all of the groups studied. The effects on blood haemoglobin concentration and haematocrit were less marked. These results highlight the extent of iron deficiency in a Thai population and demonstrate the sensitivity of plasma ferritin as a test for detecting this condition and assessing the response to dietary supplementation.


1946 ◽  
Vol 104 (4) ◽  
pp. 408-410 ◽  
Author(s):  
A. Brown ◽  
Margaret R. Connolly

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