Influence of blood haemoglobin concentration on renal haemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep

2020 ◽  
Author(s):  
Yugeesh R. Lankadeva ◽  
Clive N. May ◽  
Andrew D. Cochrane ◽  
Bruno Marino ◽  
Sally G. Hood ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Haemoglobin Concentration ◽  
Renal Haemodynamics ◽  
Blood Haemoglobin

Haemolysis due to active venous drainage during cardiopulmonary bypass: comparison of two different techniques

Perfusion ◽  
2001 ◽  
Vol 16 (4) ◽  
pp. 313-318 ◽  
Author(s):  
Silvia Cirri ◽  
Luca Negri ◽  
Marco Babbini ◽  
Giorgio Latis ◽  
Boutros Khlat ◽  
...  
Keyword(s):  
Platelet Count ◽  
Cardiopulmonary Bypass ◽  
Centrifugal Pump ◽  
Statistical Significance ◽  
Postoperative Bleeding ◽  
Haemoglobin Concentration ◽  
Venous Drainage ◽  
Valvular Surgery ◽  
Group A ◽  
Group B

To facilitate mini-access for cardiac surgery, two different methods of active venous drainage are used: vacuum assisted drainage and centrifugal pump aspiration on the venous line. The aim of this study was to compare the haemolysis produced using these two techniques. From June to December 1999, 50 consecutive patients were operated on using a ministernotomy. All of these patients had valvular surgery for either valve repair or valve replacement (9 MVRepair, 11 MVR, 29 AVR, 1 AVR+MVR). They were randomized into two groups: Group A, 25 patients who underwent surgery where vacuum assisted drainage was used, and Group B, 25 patients where kinetic asssisted venous drainage with centrifugal pump venous aspiration was used. Patient characteristics of both groups were similar for age, gender, body weight, body surface area, height, cardiopulmonary bypass (CPB) time, aortic crossclamp time, priming volume, cardioplegia volume, haemoglobin concentration, haematocrit, serum creatinine, bilirubin, lactate dehydrogenase (LDH), serum glutamic oxaloacetic transaminase (sGOT), serum glutamic pyruvic transaminase (sGPT), aptoglobin, reticulocytes, and platelet count. We checked all these laboratory parameters preoperatively, at the end of CPB, and 2 and 24 h after operation. We also checked haemoglobinuria at these same time points. We assessed blood loss at 6, 12, and 24 h after the operation and calculated total postoperative bleeding. There was a tendency towards a greater increase in LDH, sGOT and sGPT in Group A more than in Group B, but these data did not reach statistical significance. Platelet count was always lower in Group A and aptoglobin increased in Group A more than in Group B. More patients in Group A had haemoglobinuria. These findings indicate that haemolysis is increased more in patients treated with vacuum assisted drainage, when compared to the rise in haemolysis in those treated with centrifugal pump venous drainage. Total bleeding is also greater in Group A.

scholarly journals The effect of Gypsophila saponins in the diet on mineral status and plasma cholesterol concentration in the rat

1988 ◽  
Vol 59 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Susan Southon ◽  
I. T. Johnson ◽  
Jennifer M. Gee ◽  
K. R. Price
Keyword(s):  
Plasma Cholesterol ◽  
Haemoglobin Concentration ◽  
Blood Cholesterol ◽  
Cholesterol Concentration ◽  
Plasma Cholesterol Concentration ◽  
Lower Blood Cholesterol ◽  
Basal Group ◽  
Male Wistar Rats ◽  
Blood Haemoglobin ◽  
Zn Status

1. Immature, male Wistar rats were allocated to one of six groups and caged individually. The first group was given a semi-synthetic diet containing 38 mg iron and 55 mg zinc/kg (basal group). The second and third groups were given a diet containing 10 mg Zn and 12 mg Fe/kg respectively (low-Zn and low-Fe groups). Groups four, five and six were given similar diets containing 20 gGypsophilasaponins/kg. After 21 d the Fe and Zn status of the rats was estimated and plasma cholesterol concentration determined.2. Measurements of whole blood haemoglobin concentration, packed cell volume and liver Fe stores indicated that rats in the basal + saponin and low-Fe + saponin groups had a significantly reduced Fe status when compared with their controls. Rats in the low-Zn + saponin group also showed a trend toward reduced Fe stores.3. Zn status, as judged by femur Zn concentration, was not adversely affected by the inclusion ofGypsophilasaponins in the diet.4. Consumption of the saponins resulted in a significant reduction in blood cholesterol concentration, with rats in both the low-Fe groups having significantly lower concentrations than their basal and low-Zn counterparts.5. In view of suggestions that the consumption of saponins should be encouraged because of their ability to lower blood cholesterol, possible effects on Fe metabolism should be investigated further, particularly with respect to the levels and sources of saponin in the human diet.

scholarly journals Effect of blood haemoglobin concentration on V̇ o2,max and cardiovascular function in lowlanders acclimatised to 5260 m

2002 ◽  
Vol 545 (2) ◽  
pp. 715-728 ◽  
Author(s):  
J. A. L. Calbet ◽  
G. Rådegran ◽  
R. Boushel ◽  
H. Søndergaard ◽  
B. Saltin ◽  
...  
Keyword(s):  
Haemoglobin Concentration ◽  
Cardiovascular Function ◽  
Blood Haemoglobin

scholarly journals Effect of iron supplementation on mild to moderate anaemia in pulmonary tuberculosis

2003 ◽  
Vol 90 (3) ◽  
pp. 541-550 ◽  
Author(s):  
Uma Devi ◽  
C. Mohan Rao ◽  
Vinod K. Srivastava ◽  
Pramod K. Rath ◽  
Bhabani S. Das
Keyword(s):  
Placebo Group ◽  
Pulmonary Tuberculosis ◽  
Binding Capacity ◽  
Haemoglobin Concentration ◽  
Disease Process ◽  
Fe Deficiency ◽  
Adult Males ◽  
Blood Haemoglobin ◽  
Haematological Indices ◽  
Moderate Anaemia

Anaemia is a common complication of pulmonary tuberculosis. The precise mechanism of anaemia in pulmonary tuberculosis is not clearly known, but anaemia of inflammation as well as of Fe deficiency has been implicated. Both are common in developing countries. It is extremely difficult to distinguish anaemia of Fe deficiency from anaemia of inflammation with the haematological indices used routinely. Therefore, Fe preparations are usually prescribed for all anaemic patients irrespective of the aetiology. This approach has been questioned. The present study aimed to assess the effect of Fe supplementation on anaemic patients with pulmonary tuberculosis. Adult male patients 15–60 years of age with pulmonary tuberculosis and a blood haemoglobin concentration 80–110 g/l were included in the study; healthy adult males matched for age and socio-economic status were taken as controls. Blood haemoglobin concentration, total erythrocyte count (TEC), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin and serum Fe, total Fe-binding capacity and ferritin were estimated before treatment and 1, 2 and 6 months after treatment. The patients were divided randomly into three groups and during the initial 2 months of treatment were provided with one of three supplementary regimens consisting of placebo, Fe alone or Fe with other haematinics. Significant improvements in haematological indices and Fe status were noticed in all three groups. Blood haemoglobin concentration, MCV and PCV were significantly higher at 1 month in both Fe-supplemented groups than the placebo group. This difference, however, disappeared at 2 and 6 months with similar values in all three groups. The increase of other haematological indices was similar in all groups. Serum Fe and Fe saturation of transferrin were significantly higher in both Fe-supplemented groups than the placebo group up to 2 months; this effect, however, disappeared at 6 months. There was a consistent increase in TEC and decrease in ferritin values up to 6 months in all groups. Radiological and clinical improvement was similar in all three groups. These observations suggest that Fe supplementation in mild to moderate anaemia associated with pulmonary tuberculosis accelerated the normal resumption of haematopoiesis in the initial phases by increasing Fe saturation of transferrin. However, consistent improvement of haematological status was dependent only on the improvement of the disease process.

Iron Deficiency in a Northern Thai Population: The Effects of Iron Supplements Studied by Means of Plasma Ferritin Estimations

1984 ◽  
Vol 21 (4) ◽  
pp. 268-274 ◽  
Author(s):  
S Linpisarn ◽  
O Thanangkul ◽  
C Suwanraj ◽  
R Kaewvichit ◽  
L J Kricka ◽  
...  
Keyword(s):  
Developing Countries ◽  
Iron Deficiency ◽  
School Children ◽  
Haemoglobin Concentration ◽  
Dietary Supplementation ◽  
Adult Women ◽  
Thai Population ◽  
Laboratory Methods ◽  
Iron Supplements ◽  
Blood Haemoglobin

Iron deficiency is a common problem, particularly in developing countries, but traditional laboratory methods of detecting this condition are unreliable. The prevalence of iron deficiency in a Northern Thai population (pre-school, school children, adult women) has been assessed by means of plasma ferritin concentrations. The results were compared with prevalences based on blood haemoglobin concentrations. Estimations of prevalences based on plasma ferritin values were 10–24% in non-vegetarian and 49–71% in vegetarian groups, whilst those based on blood haemoglobin were 11–21% (non-vegetarian) and 24–50% (vegetarian). Dietary supplementation with iron produced dramatic rises in plasma ferritin in all of the groups studied. The effects on blood haemoglobin concentration and haematocrit were less marked. These results highlight the extent of iron deficiency in a Thai population and demonstrate the sensitivity of plasma ferritin as a test for detecting this condition and assessing the response to dietary supplementation.

The effects of adrenaline on blood haemoglobin concentration

1946 ◽  
Vol 104 (4) ◽  
pp. 408-410 ◽  
Author(s):  
A. Brown ◽  
Margaret R. Connolly
Keyword(s):  
Haemoglobin Concentration ◽  
Blood Haemoglobin

Clonal diversity within infections and the virulence of a malaria parasite,Plasmodium mexicanum

Parasitology ◽  
2008 ◽  
Vol 135 (12) ◽  
pp. 1363-1372 ◽  
Author(s):  
A. M. Vardo-ZALIK ◽  
J. J. Schall
Keyword(s):  
Malaria Parasite ◽  
Blood Clotting ◽  
Haemoglobin Concentration ◽  
Clonal Diversity ◽  
Sceloporus Occidentalis ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Parasite Plasmodium ◽  
Blood Haemoglobin ◽  
The Cost

SUMMARYBoth verbal and mathematical models of parasite virulence predict that genetic diversity of microparasite infections will influence the level of costs suffered by the host. We tested this idea by manipulating the number of co-existing clones ofPlasmodium mexicanumin its natural vertebrate host, the fence lizardSceloporus occidentalis. We established replicate infections ofP.mexicanummade up of 1, 2, 3, or >3 clones (scored using 3 microsatellite loci) to observe the influence of clone number on several measures of parasite virulence. Clonal diversity did not affect body growth or production of immature erythrocytes. Blood haemoglobin concentration was highest for the most genetically complex infections (equal to that of non-infected lizards), and blood glucose levels and rate of blood clotting was highest for the most diverse infections (with greater glucose and more rapid clotting than non-infected animals). Neither specific clones nor parasitaemia were associated with virulence. In this first experiment that manipulated the clonal diversity of a naturalPlasmodium-host system, the cost of infection with 1 or 2 clones ofP.mexicanumwas similar to that previously reported for infected lizards, but the most complex infections had either no cost or could be beneficial for the host.

Splenectomy impairs aerobic swim performance in trout

1991 ◽  
Vol 69 (8) ◽  
pp. 2089-2092 ◽  
Author(s):  
M. P. Pearson ◽  
E. Don Stevens
Keyword(s):  
Oncorhynchus Mykiss ◽  
Aerobic Exercise ◽  
Haemoglobin Concentration ◽  
Red Cells ◽  
Swim Performance ◽  
Blood Haemoglobin ◽  
Better Than

Critical swim speed (Ucrit) measurements show that trout (Oncorhynchus mykiss) with an intact spleen perform aerobic exercise better than those without (control: Ucrit = 2.19 body lengths/s; splenectomized: Ucrit = 1.84 body lengths/s). Their better performance is correlated with higher blood haemoglobin concentration at exhaustion (control: 9.92 g/dL; splenectomized: 7.96 g/dL), derived from release of red cells from the spleen.

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