Hypoglycemia in Malathion-treated chick embryos

1975 ◽  
Vol 53 (8) ◽  
pp. 1055-1057 ◽  
Author(s):  
A. L. Arsenault ◽  
M. A. Gibson ◽  
M. E. Mader
Keyword(s):  
Blood Sugar ◽  
Incubation Period ◽  
Chick Embryos ◽  
Incubation Stage ◽  
Sugar Levels

Chick embryos were exposed to a teratogenic dose of Malathion at the 5-day incubation stage, and the effect of this treatment on blood sugar levels was studied from the 9th day of incubation to hatching. The Malathion caused a decrease in blood sugars and this hypoglycemia persisted throughout the incubation period until day 19.

Some effects of glucagon on chick embryo development

Development ◽  
1981 ◽  
Vol 62 (1) ◽  
pp. 95-107
Author(s):  
William A. Anderson ◽  
M. A. Gibson
Keyword(s):  
Insulin Secretion ◽  
Chick Embryo ◽  
Blood Sugar ◽  
Incubation Period ◽  
Embryo Development ◽  
Survival Rates ◽  
Liver Glycogen ◽  
Glycogen Storage ◽  
Chick Embryos ◽  
Sugar Levels

Glucagon concentrations ranging from 1·16 to 300·0 μg/0·1 ml diluent were injected into the yolk of chick embryos on incubation days 8,10, and 12. Studies of survival rates, embryo weights, blood sugars, liver and tibiotarsus glycogen histochemistry, and pancreatic alpha and beta tissue histogenesis were undertaken during the 9- to 16-day incubation period. Glucagon dosages of 37·5 and 1500 μg/0·1 ml diluent gave the best survival rates. Glucagon caused an increase in embryo weight, increased liver glycogen storage, a chondrocyte glycogen storage pattern which correlated with blood sugar levels, an increase in pancreatic beta tissue and a decrease in pancreatic alpha tissue. Studies of blood sugars following glucagon treatment showed that most concentrations caused an initial (first 16h) hyperglycemia. Following this, two general patterns were exhibited: (1) the lower glucagon concentrations caused hypoglycemia after about 24 h, and (2) the higher concentrations caused a more prolonged hyperglycemia when administered on incubation day 10 but caused hypoglycemia when administered on days 8 and 12. Interpretation of these results is based on the contribution of three factors to the expression and duration of the glucagon effect: (1) concentration of glucagon administered, (2) insulin secretion, and (3) levels of glycogen storage at the incubation stage of administration.

Association of hypoglycemia and pancreatic islet tissue with micromelia in Malathion-treated chick embryos

1977 ◽  
Vol 55 (2) ◽  
pp. 261-264 ◽  
Author(s):  
Bertil O. Laley ◽  
M. A. Gibson
Keyword(s):  
Blood Glucose ◽  
Incubation Period ◽  
Pancreatic Islet ◽  
Chick Embryos ◽  
Leg Length ◽  
Incubation Stage ◽  
Islet Tissue

Chick embryos were given a teratogenic dose of Malathion at the 5-day incubation stage and the effects of this treatment on leg length, blood glucose, and amounts of pancreatic islet tissue were studied during the 11- to 19-day incubation period. The Malathion caused a reduction in leg length (micromelia) and hypoglycemia, which persisted throughout the period studied. The severity of the micromelic condition correlated with the degree of hypoglycemia: the least micromelic embryos were the least hypoglycemic, the moderately micromelic embryos were moderately hypoglycemic, and the severely micromelic embryos were the most severely hypoglycemic. Finally, the Malathion increased differentiation of pancreatic islet tissue, particularly beta tissue. Again, the greatest increases in islet tissue were shown by those embryos exhibiting the most severe micromelic and hypoglycemic conditions.

Plasminogen Activation in Diabetes Mellitus: Normalization of Blood Sugar Levels Improves Impaired Enzyme Kinetics In Vitro

1985 ◽  
Vol 54 (02) ◽  
pp. 413-414 ◽  
Author(s):  
Margarethe Geiger ◽  
Bernd R Binder
Keyword(s):  
Plasminogen Activator ◽  
Blood Sugar ◽  
Metabolic Disorders ◽  
Normal Values ◽  
Diabetic Patients ◽  
Type I ◽  
Plasminogen Activation ◽  
Lag Period ◽  
Sugar Levels

SummaryWe have demonstrated previously that fibrin enhanced plasmin formation by the vascular plasminogen activator was significantly impaired, when components isolated from the plasma of three uncontrolled diabetic patients (type I) were used to study plasminogen activation in vitro. In the present study it can be demonstrated that functional properties of the vascular plasminogen activators as well as of the plasminogens from the same three diabetic patients are significantly improved after normalization of blood sugar levels and improvement of HbAlc values. Most pronounced the Km of diabetic vascular plasminogen activator in the presence of fibrin returned to normal values, and for diabetic plasminogen the prolonged lag period until maximal plasmin formation occurred was shortened to almost control values. From these data we conclude that the observed abnormalities of in vitro fibrinolysis are not primarily associated with the diabetic disease, but might be secondary to metabolic disorders caused by diabetes.

Effects of Rapid Infusion of Ethanol on some Factors Controlling Blood Sugar Levels in Man

1972 ◽  
Vol 33 (3) ◽  
pp. 722-733 ◽  
Author(s):  
John W. Dundee ◽  
Martin Isaac ◽  
Elizabeth A. Davis ◽  
Brian Sheridan
Keyword(s):  
Blood Sugar ◽  
Rapid Infusion ◽  
Sugar Levels

Effects of Myrtus communis leaf extracts on CdCl2-induced metabolic disturbance in male wistar rats

2020 ◽  
Vol 9 (5) ◽  
pp. 185-192
Author(s):  
Hafsa Dellaoui ◽  
Abdelkrim Berroukche ◽  
Bakhta Bouzouira ◽  
Narimen Taibi ◽  
Mohamed Zouidi ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Methanol Extract ◽  
Cadmium Accumulation ◽  
Male Rats ◽  
Myrtus Communis ◽  
Leaf Extracts ◽  
Male Wistar Rats ◽  
Sugar Levels ◽  
Induced Changes ◽  
Preventive Effects

Cadmium (Cd) is widespread in the environment. Cd toxicity targets liver and renal tissues and generates oxidative stress. Medicinal plants produce antioxidants scavenging reactive oxygen species (ROS) and chelate heavy metals. This study aimed to investigate the preventive effects of Myrtus communis leaves hydro-methanol extract (HME) and aqueous extract (AE) on Cdinduced toxicity. The experiments were carried out, during 30 days, on male rats; GR1 (controls), GR2 treated with CdCl2 (18 mg/kg), GR3 co-treated with HME (1 g/kg) and Cd (18 mg/kg), GR4 co-treated with AE (1 g/kg) and Cd (18 mg/kg), GR5 with HME and GR6 with AE. Cd induced changes in biochemical parameters (transaminases, urea, creatinine and blood sugar)related to hepato renal function, increased tissue mortification and decreased animals’ body weight. While the treatment animals, with M. communis leaves (HME) or (AE), regulated blood sugar levels. Hepatic steatosis and loss of glomeruli were particularly induced either by Cd or a co-treatment with Cd and plant extracts. M. communis extracts (HME and EA) can regulate blood sugar levels and prevent cadmium accumulation.

PLASMA FREE FATTY ACID AND BLOOD SUGAR LEVELS IN NEWBORN INFANTS AND THEIR MOTHERS

PEDIATRICS ◽  
1966 ◽  
Vol 37 (4) ◽  
pp. 597-604
Author(s):  
Doman K. Keele ◽  
Jacob L. Kay
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Newborn Infants ◽  
Plasma Free Fatty Acid ◽  
Significant Negative Correlation ◽  
The Mean ◽  
Sugar Levels ◽  
Diabetic Mothers

Simultaneous plasma free fatty acid (FFA) and blood sugar levels were determined for fasting newborn infants during the first 24 hours of life, for their cord bloods, and for their mothers at delivery. The following observations were made. In control infants the mean FFA level rose about three times the cord level after birth and was accompanied by a 25% drop in the mean blood sugar level. Thereafter, the mean blood sugar level remained relatively constant, but the mean FFA level varied from 2½ to 3 times the cord level. There was no significant correlation between the length of maternal fasting prior to delivery and the infant FFA level; there was, however a significant negative correlation between the length of maternal fasting prior to delivery and the infant blood sugar level at 24 hours of age. High FFA levels occurred in the infants of obese mothers and low levels were observed in infants with delayed respirations, in infants of preeclamptic mothers, and in infants of diabetic mothers.

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