scholarly journals Allometry (scaling) of blood components in mammals: connection with economy of energy?

2008 ◽  
Vol 86 (8) ◽  
pp. 890-899 ◽  
Author(s):  
M. Kjeld ◽  
Ö. Ólafsson
Keyword(s):  
Metabolic Rate ◽  
Muscle Mass ◽  
Body Mass ◽  
Small Mammals ◽  
Total Protein ◽  
Scaling Exponent ◽  
Blood Components ◽  
Serum Concentrations ◽  
Serum Total Protein ◽  
Leg Muscles

Hematocrit (HCT), blood hemoglobin (HGB), and serum concentrations of 14 commonly measured serum constituents in mammals were extracted from 131 publications published within the last 35 years and then subjected to allometric study (Y = aWb, where Y is the characteristic studied, W is body mass, and b is the scaling exponent). HCT and HGB values decreased (b < 0; p < 0.001) with body mass (W), as did serum K+, glucose, triglycerides, and urea values. In contrast, serum total protein and creatinine values increased (b > 0; p < 0.02 and p < 0.001, respectively) with W. The associations of HCT, HGB, glucose, triglycerides, and urea values with W may be assumed to coincide with the well-known reduction of metabolic rate per unit mass with increasing W of mammals. The decrease in serum K+values (p < 0.001) has yet to be adequately explained. Despite the ratio of muscle mass and W being constant for large and small mammals, serum values of creatinine rose (b = 0.14; p < 0.0001) with W. This suggests increased phosphocreatine turnover in muscles with W, which in turn might be connected to the increased efficiency reported for leg muscles in larger animals and, conceivably, might affect the measurement of metabolic rate and hence its scaling in mammals.

scholarly journals Allometry of mitochondrial efficiency is set by metabolic intensity

2019 ◽  
Vol 286 (1911) ◽  
pp. 20191693 ◽  
Author(s):  
Boël Mélanie ◽  
Romestaing Caroline ◽  
Voituron Yann ◽  
Roussel Damien
Keyword(s):  
Metabolic Rate ◽  
Body Mass ◽  
Coupling Efficiency ◽  
Energy Output ◽  
Scaling Exponent ◽  
Metabolic Rates ◽  
Mammal Species ◽  
Skeletal Muscle Mitochondria ◽  
Metabolic Intensity ◽  
Mitochondrial Efficiency

Metabolic activity sets the rates of individual resource uptake from the environment and resource allocations. For this reason, the relationship with body size has been heavily documented from ecosystems to cells. Until now, most of the studies used the fluxes of oxygen as a proxy of energy output without knowledge of the efficiency of biological systems to convert oxygen into ATP. The aim of this study was to examine the allometry of coupling efficiency (ATP/O) of skeletal muscle mitochondria isolated from 12 mammal species ranging from 6 g to 550 kg. Mitochondrial efficiencies were measured at different steady states of phosphorylation. The efficiencies increased sharply at higher metabolic rates. We have shown that body mass dependence of mitochondrial efficiency depends on metabolic intensity in skeletal muscles of mammals. Mitochondrial efficiency positively depends on body mass when mitochondria are close to the basal metabolic rate; however, the efficiency is independent of body mass at the maximum metabolic rate. As a result, it follows that large mammals exhibit a faster dynamic increase in ATP/O than small species when mitochondria shift from basal to maximal activities. Finally, the invariant value of maximal coupling efficiency across mammal species could partly explain why scaling exponent values are very close to 1 at maximal metabolic rates.

scholarly journals Organ-Tissue Level Model of Resting Energy Expenditure Across Mammals: New Insights into Kleiber's Law

ISRN Zoology ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
ZiMian Wang ◽  
Junyi Zhang ◽  
Zhiliang Ying ◽  
Steven B. Heymsfield
Keyword(s):  
Energy Expenditure ◽  
Metabolic Rate ◽  
Body Mass ◽  
Resting Energy Expenditure ◽  
Tissue Level ◽  
Scaling Exponent ◽  
Level Model ◽  
Organ Tissue ◽  
Kleiber’S Law ◽  
Resting Energy

Background. Kleiber’s law describes the quantitative association between whole-body resting energy expenditure (REE, in kcal/d) and body mass (M, in kg) across mature mammals as REE =70.0×M0.75. The basis of this empirical function is uncertain. Objectives. The study objective was to establish an organ-tissue level REE model across mammals and to explore the body composition and physiologic basis of Kleiber’s law. Design. We evaluated the hypothesis that REE in mature mammals can be predicted by a combination of two variables: the mass of individual organs/tissues and their corresponding specific resting metabolic rates. Data on the mass of organs with high metabolic rate (i.e., liver, brain, heart, and kidneys) for 111 species ranging in body mass from 0.0075 (shrew) to 6650 kg (elephant) were obtained from a literature review. Results. REEp predicted by the organ-tissue level model was correlated with body mass (correlation r=0.9975) and resulted in the function REEp=66.33×M0.754, with a coefficient and scaling exponent, respectively, close to 70.0 and 0.75 (P>0.05) as observed by Kleiber. There were no differences between REEp and REEk calculated by Kleiber’s law; REEp was correlated (r=0.9994) with REEk. The mass-specific REEp, that is, (REE/M)p, was correlated with body mass (r=0.9779) with a scaling exponent −0.246, close to −0.25 as observed with Kleiber’s law. Conclusion. Our findings provide new insights into the organ/tissue energetic components of Kleiber’s law. The observed large rise in REE and lowering of REE/M from shrew to elephant can be explained by corresponding changes in organ/tissue mass and associated specific metabolic rate.

scholarly journals Temperature effects on metabolic scaling of a keystone freshwater crustacean depend on fish-predation regime

2020 ◽  
Vol 223 (21) ◽  
pp. jeb232322 ◽  
Author(s):  
Douglas S. Glazier ◽  
Jeffrey P. Gring ◽  
Jacob R. Holsopple ◽  
Vojsava Gjoni
Keyword(s):  
Metabolic Rate ◽  
Body Mass ◽  
Interactive Effects ◽  
Effect Of Temperature ◽  
Scaling Exponent ◽  
Important Indicator ◽  
Metabolic Scaling ◽  
Physical Constraints ◽  
Habitat Differences ◽  
Fish Predators

ABSTRACTAccording to the metabolic theory of ecology, metabolic rate, an important indicator of the pace of life, varies with body mass and temperature as a result of internal physical constraints. However, various ecological factors may also affect metabolic rate and its scaling with body mass. Although reports of such effects on metabolic scaling usually focus on single factors, the possibility of significant interactive effects between multiple factors requires further study. In this study, we show that the effect of temperature on the ontogenetic scaling of resting metabolic rate of the freshwater amphipod Gammarus minus depends critically on habitat differences in predation regime. Increasing temperature tends to cause decreases in the metabolic scaling exponent (slope) in population samples from springs with fish predators, but increases in population samples from springs without fish. Accordingly, the temperature sensitivity of metabolic rate is not only size-specific, but also its relationship to body size shifts dramatically in response to fish predators. We hypothesize that the dampened effect of temperature on the metabolic rate of large adults in springs with fish, and of small juveniles in springs without fish are adaptive evolutionary responses to differences in the relative mortality risk of adults and juveniles in springs with versus without fish predators. Our results demonstrate a complex interaction among metabolic rate, body mass, temperature and predation regime. The intraspecific scaling of metabolic rate with body mass and temperature is not merely the result of physical constraints related to internal body design and biochemical kinetics, but rather is ecologically sensitive and evolutionarily malleable.

scholarly journals Fast ontogenetic growth drives steep evolutionary scaling of metabolic rate

2021 ◽  
Author(s):  
Tommy Norin
Keyword(s):  
Metabolic Rate ◽  
Body Mass ◽  
Fish Larvae ◽  
Juvenile Fish ◽  
Scaling Exponent ◽  
Natural Mortality ◽  
Metabolic Scaling ◽  
Fast Growing ◽  
Scaling Relationship ◽  
Selection For

Metabolic rate (MR) changes with body mass (BM) as MR = aBMb, where a is a normalisation constant (log–log intercept) and b the scaling exponent (log–log slope). This scaling relationship is fundamental to biology and widely applied, yet a century of research has provided little consensus on why and how steeply metabolic rate scales with body mass. I here show that ontogenetic (within-individual) b can be strongly and positively related to growth rates of juvenile fish when food availability is naturally restricted, with fast growing individuals having steep and near-isometric metabolic scaling (b ≈ 1). I suggest that the steep evolutionary (among-species) scaling also found for fishes (b also approaching 1) is a by-product of natural selection for these fast growing individuals early in ontogeny, and that a weaker relationship between metabolic scaling and growth later in life causes variation in b at lower taxonomic levels (within orders or species). I support these ideas by showing that b within fish orders is linked to natural mortality rates of fish larvae.

scholarly journals Growth and Development of Homeothermy in Nestling European Shags (Phalacrocorax Aristotelis)

The Auk ◽  
2001 ◽  
Vol 118 (4) ◽  
pp. 983-995
Author(s):  
Jan Eivind Østnes ◽  
BjØrn Munro Jenssen ◽  
Claus Bech ◽  
D. Nettleship
Keyword(s):  
Metabolic Rate ◽  
Muscle Mass ◽  
Body Mass ◽  
Growth Parameters ◽  
Thermal Conductance ◽  
Growth Period ◽  
The Body ◽  
Small Island ◽  
Main Site ◽  
Water Fraction

Abstract European Shag (Phalacrocorax aristotelis) nestlings were studied on a small island off the coast of central Norway. Increase in body mass (BM) with age (t, days) was described by the logistic equation: BM = 1,622 g/[1 + e−0.172(t−19.9)]. All growth parameters measured (body mass, and length of tarsus, wing and head) showed highest relative growth rate when the nestlings were 5–10 days old, that is, before the nestlings had achieved homeothermy. An incipient endothermic response was noted when nestlings were 9 days old, and they became homeothermic at ages of 15–18 days. Respective mass-specific resting metabolic rates for nestlings 0, 15, and 45 days old were 47, 261, and 147% of the predicted value for adult nonpasserine birds of similar body masses. Mass-specific minimal thermal conductance decreased from 366% of predicted adult value at hatching, to 220% of that predicted when nestlings were 21 days old. For nestlings 15 days old, the factorial metabolic scope (resting metabolic rate/peak metabolic rate) was only 1.5, but that increased rapidly thereafter. Rapid increase in the mass-specific RMR and decrease in minimal thermal conductance is suggested to contribute importantly to improve homeothermic ability during the first two weeks of the developmental period. At hatching, leg and pectoral muscles constituted 5.3 and 2.2%, respectively, of total wet body mass. Relative leg-muscle mass increased rapidly and had almost reached adult proportions when the nestlings were 25–30 days old. In contrast, pectoral-muscle mass increased in an almost direct proportion to the body mass during the first 30 days of the growth period, and increased rapidly thereafter. At hatching, the water fraction (water content/lipid-free wet mass) was significantly lower in the leg than in the pectoral muscles (0.920 vs. 0.931). The water fraction of leg muscles also remained lower during the entire growth period. Judging from the proportionately greater mass and higher degree of maturity of the leg compared to pectoral muscles, the former would seem to be the main site of cold-induced heat production during early development of homeothermy in European Shag nestlings.

Effects of a resistance training community programme in older adults

2021 ◽  
pp. 1-16
Author(s):  
Majid Mufaqam Syed-Abdul ◽  
Chrissa L. McClellan ◽  
Elizabeth J. Parks ◽  
Stephen D. Ball
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Resistance Training ◽  
Muscle Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Training Programme ◽  
Haemoglobin A1c ◽  
Community Based ◽  
Resistance Training Programme

Abstract Ageing is associated with reduced muscle mass, strength, flexibility and balance, resulting in a poor quality of life (QOL). Past studies have occurred in highly controlled laboratory settings which provide strong support to determine whether similar gains can be made in community programmes. Twenty participants were enrolled in an eight-week community-based resistance training programme (mean age = 61.3 (standard error (SE) = 0.9) years); Body Mass Index = 32.0 (SE = 1.3) kg/m2). All participants completed surveys to assess outcomes associated with QOL. Given the relationship between muscle function and nerve health, nerve conduction studies (NCS) were also conducted in a separate group of participants (mean age = 64.9 (SE = 2.0) years; Body Mass Index = 32.6 (SE = 1.9) kg/m2). This community-based training programme significantly improved QOL measures in older adults (p < 0.001). Although weight loss was not the primary outcome of the study, participants reduced their body weights (p < 0.001), by primarily reducing fat mass (p = 0.007) while maintaining muscle mass. Significant improvements were observed in muscle strength (2.2%), flexibility and balance (3.2–464.2%, p ⩽ 0.05 for all). Improvements were also observed in plasma glucose (p = 0.05), haemoglobin A1C (p = 0.06) and aldolase enzyme levels (p < 0.001). Scores for surveys on memory and sleep improved (p < 0.05). Improved QOL was associated with increased lean mass (r = −0.714, p = 0.002), decreased fat mass (r = −0.702, p = 0.003) and improved flexibility and balance (r = −0.627, p = 0.008). An eight-week, community-based resistance training programme significantly improved QOL in older adults. Influence on the lipid profile and NCS still needs further investigation.

scholarly journals Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anandini Swaminathan ◽  
Andrej Fokin ◽  
Tomas Venckūnas ◽  
Hans Degens
Keyword(s):  
Skeletal Muscle ◽  
Glucose Tolerance ◽  
Muscle Mass ◽  
Body Mass ◽  
High Fat Diet ◽  
Control Diet ◽  
Metabolic Health ◽  
High Fat ◽  
Methionine Restriction ◽  
Old Mice

AbstractMethionine restriction (MR) has been shown to reduce the age-induced inflammation. We examined the effect of MR (0.17% methionine, 10% kCal fat) and MR + high fat diet (HFD) (0.17% methionine, 45% kCal fat) on body mass, food intake, glucose tolerance, resting energy expenditure, hind limb muscle mass, denervation-induced atrophy and overload-induced hypertrophy in young and old mice. In old mice, MR and MR + HFD induced a decrease in body mass. Muscle mass per body mass was lower in old compared to young mice. MR restored some of the HFD-induced reduction in muscle oxidative capacity. The denervation-induced atrophy of the m. gastrocnemius was larger in animals on MR than on a control diet, irrespective of age. Old mice on MR had larger hypertrophy of m. plantaris. Irrespective of age, MR and MR + HFD had better glucose tolerance compared to the other groups. Young and old mice on MR + HFD had a higher resting VO2 per body mass than HFD group. Mice on MR and MR + HFD had a resting respiratory quotient closer to 0.70, irrespective of age, indicating an increased utilization of lipids. In conclusion, MR in combination with resistance training may improve skeletal muscle and metabolic health in old age even in the face of obesity.

scholarly journals Phytobiotics with Adsorbent to Mitigate Toxicity of Multiple Mycotoxins on Health and Growth of Pigs

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 442
Author(s):  
Debora Muratori Holanda ◽  
Young Ihn Kim ◽  
Wanpuech Parnsen ◽  
Sung Woo Kim
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Alanine Aminotransferase ◽  
Hepatic Function ◽  
Negative Effects ◽  
Serum Total Protein ◽  
Urea Nitrogen ◽  
Inflammatory Status ◽  
Tnf Α ◽  
Mycotoxin Adsorbent

Phytobiotics with a mycotoxin adsorbent were used to mitigate negative effects of multiple mycotoxins in diets fed to pigs. In experiment 1, 120 pigs (11.6 kg body weight; BW) were assigned to five treatments (three pigs/pen) and fed for 28 days. Treatments were CON (control), MTD (CON + 2.5 mg/kg of deoxynivalenol), DP (MTD + phytobiotics at 0.1%), and DPA1 and DPA2 (MTD + phytobiotics and adsorbent at 0.1% and 0.2%, respectively). In experiment 2, 96 pigs (28.5 kg BW) were assigned to four treatments (three pigs/pen) and fed for 26 days. Treatments were CON, MTAF (CON + 0.19 mg/kg of aflatoxin and 8 mg/kg of fumonisins), AFP (MTAF + phytobiotics at 0.1%), and AFPA (MTAF + phytobiotics and adsorbent at 0.1%). Growth performance was measured weekly, and blood was sampled at the end of study to measure hepatic function and inflammatory status (TNF-α). Data were analyzed using the MIXED procedure. In experiment 1, pigs fed MTD, DP, DPA1, and DPA2 had smaller (p < 0.05) BW than CON. Pigs fed DPA2 had greater (p < 0.05) BW than MTD. Pigs fed DP and DPA2 tended to have lower (p < 0.1) serum total protein than CON. Pigs fed MTD and DPA2 tended to have higher (p < 0.1) alanine aminotransferase than CON. Similarly, pigs fed MTD, DP, and DPA2 tended to have higher (p < 0.1) urea nitrogen/creatinine than CON. In experiment 2, pigs fed MTAF, AFP, and AFPA had smaller (p < 0.05) BW than CON. Pigs fed MTAF, AFP, and AFPA had smaller (p < 0.05) ADFI than CON. Pigs fed AFPA had higher (p < 0.05) aspartate aminotransferase than CON and MTAF. Pigs fed AFP and AFPA had higher (p < 0.05) alanine aminotransferase than CON. Pigs fed MTAF, AFP, and AFPA had lower (p < 0.05) urea nitrogen/creatinine than CON. Pigs fed AFPA had higher (p < 0.05) TNF-α than CON and MTAF. In conclusion, feeding an additional 2.5 mg/kg of deoxynivalenol or 0.19 mg/kg of aflatoxin with 8 mg/kg of fumonisins reduced the growth of pigs. Deoxynivalenol compromised the hepatic function of pigs. Phytobiotics with adsorbent could partly overcome the detrimental effects of mycotoxins.

scholarly journals Mitigative effect of Momordica cymbalaria fruit extract against sodium fluoride induced hepatotoxicity in Wistar male albino rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Raghavendra Mitta ◽  
Sushmitha Duddu ◽  
Raghuveer Yadav Pulala ◽  
Pradeepkumar Bhupalam ◽  
Venkatakirankumar Mandlem ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Blood Serum ◽  
Sodium Fluoride ◽  
Total Protein ◽  
Reduced Glutathione ◽  
Serum Biomarkers ◽  
Albino Rats ◽  
Serum Total Protein ◽  
Treatment Groups ◽  
Group I

AbstractObjectivesThe main objective of the present study is to evaluate the mitigative effect of hydroalcoholic extract of Momordica cymbalaria fruits against sodium fluoride (NaF) induced hepatotoxicity.MethodsIn this study, Wistar male albino rats were randomly divided into five groups of six rats each. Group I and II served as normal and toxic controls. Group III as plant control received extract at a dose of 400 mg/kg b. wt, p.o and Groups IV and V as treatment groups received extract at a dose 200 and 400 mg/kg b. wt, p.o for 30 days. All groups except Groups I and III received 100 ppm of NaF through drinking water. After completion of the study, blood collected for the estimation of liver blood serum biomarkers such as aspartate aminotransferases (AST), alanine aminotransferases (ALT), alkaline Phosphatase (ALP), direct and total bilirubin, total protein and albumin. The liver tissue homogenate was for estimation of lipid peroxidation, catalase, and reduced glutathione levels.ResultsThe results showed that NaF intoxication caused elevation of liver blood serum levels and lipid peroxidation; decreased levels of serum total protein, albumin and liver reduced glutathione, and catalase observed. The treatment groups showed decreased elevated serum biomarkers (ALT, AST, and ALP), liver lipid peroxidation and increased serum total protein and albumin, liver reduced glutathione and catalase levels in a dose-dependent manner. Histopathological studies also further strongly supported for mitigative effects of the plant.ConclusionsIn conclusion, our findings of the study indicated that M. cymbalaria fruits were a potential drug candidate in the treatment of NaF induced hepatotoxicity.

scholarly journals Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral Palsy

Toxins ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 278
Author(s):  
Dongwoo Lee ◽  
Jaewon Kim ◽  
Ja-Young Oh ◽  
Mi-Hyang Han ◽  
Da-Ye Kim ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Botulinum Toxin ◽  
Lean Body Mass ◽  
Muscle Mass ◽  
Body Mass ◽  
Botulinum Toxin Injection ◽  
Dual Energy ◽  
X Ray ◽  
Hemiplegic Cerebral Palsy

We aimed to evaluate muscle mass changes after injection of botulinum toxin (BoNT) in children with spastic hemiplegic cerebral palsy (CP). Children aged between 2 and 12 years who were diagnosed with hemiplegic CP with spastic equinus foot were prospectively recruited and administered BoNT in the affected leg. Lean body mass (LBM) of both legs and total limbs was measured by dual-energy X-ray absorptiometry (DXA) preinjection and 4 and 12 weeks after injection. A total of 15 children were enrolled into the study. LBM of both legs and total limbs increased significantly over 12 weeks of growth. The ratio of LBM of the affected leg to total limbs and to the unaffected leg significantly reduced at 4 weeks after injection compared with preinjection but significantly increased at 12 weeks after injection compared with 4 weeks after injection. In conclusion, the muscle mass of the affected leg after BoNT injection in children with hemiplegic spastic CP decreased at 4 weeks after BoNT injection but significantly recovered after 12 weeks after injection.

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