Ovarian follicular development and regression

1989 ◽  
Vol 67 (8) ◽  
pp. 953-953
Author(s):  
Peter C. K. Leung

Many exciting developments in mammalian reproductive research with far-reaching consequences have occurred in recent years. To highlight the significance of some of these developments, a symposium on the theme of ovarian follicular development and regression was organized, and held at the joint meeting of the American Physiological Society and the Canadian Physiological Society, in Montréal in October 1988. Several leading researchers, from both Canada and the U.S.A., in various aspects of ovarian research, participated in the symposium. The topics of discussion ranged from the role of growth factors and novel intraovarian regulators during follicular development, to molecular aspects of ovarian hormone production, to the functional regression of the corpus luteum. It is expected that the following proceedings will serve as a reference for researchers concerned with reproductive endocrinology as well as providing a foundation for future collaborative study.

1996 ◽  
Vol 46 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Hidetaka Katabuchi ◽  
Yukitoshi Fukumatsu ◽  
Masako Araki ◽  
Yoshito Suenaga ◽  
Hideyuki Ohtake ◽  
...  

2020 ◽  
Vol 103 (5) ◽  
pp. 1054-1068
Author(s):  
Xuan Shi ◽  
Tao Tang ◽  
Qiyuan Lin ◽  
Hongbo Liu ◽  
Yufeng Qin ◽  
...  

Abstract Bone morphogenetic protein 15 (BMP15), a member of the transforming growth factor beta superfamily, plays an essential role in ovarian follicular development in mono-ovulatory mammalian species. Studies using a biallelic knockout mouse model revealed that BMP15 potentially has just a minimal impact on female fertility and ovarian follicular development in polyovulatory species. In contrast, our previous study demonstrated that in vivo knockdown of BMP15 significantly affected porcine female fertility, as evidenced by the dysplastic ovaries containing significantly decreased numbers of follicles and an increased number of abnormal follicles. This finding implied that BMP15 plays an important role in the regulation of female fertility and ovarian follicular development in polyovulatory species. To further investigate the regulatory role of BMP15 in porcine ovarian and follicular development, here, we describe the efficient generation of BMP15-edited Yorkshire pigs using CRISPR/Cas9. Using artificial insemination experiments, we found that the biallelically edited gilts were all infertile, regardless of different genotypes. One monoallelically edited gilt #4 (Δ66 bp/WT) was fertile and could deliver offspring with a litter size comparable to that of wild-type gilts. Further analysis established that the infertility of biallelically edited gilts was caused by the arrest of follicular development at preantral stages, with formation of numerous structurally abnormal follicles, resulting in streaky ovaries and the absence of obvious estrous cycles. Our results strongly suggest that the role of BMP15 in nonrodent polyovulatory species may be as important as that in mono-ovulatory species.


2017 ◽  
Author(s):  
Malgorzata Duda ◽  
Kamil Wartalski ◽  
Zbigniew Tabarowski ◽  
Gabriela Gorczyca

2011 ◽  
Vol 28 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Koji Sugiura ◽  
Ryosuke Konuma ◽  
Kiyoshi Kano ◽  
Kunihiko Naito

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