scholarly journals The Role of Androgens in Ovarian Follicular Development: From Fertility to Ovarian Cancer

2017 ◽  
Author(s):  
Malgorzata Duda ◽  
Kamil Wartalski ◽  
Zbigniew Tabarowski ◽  
Gabriela Gorczyca
Keyword(s):  
Ovarian Cancer ◽  
Follicular Development ◽  
Ovarian Follicular Development

Ovarian follicular development and regression

1989 ◽  
Vol 67 (8) ◽  
pp. 953-953
Author(s):  
Peter C. K. Leung
Keyword(s):  
Collaborative Study ◽  
Follicular Development ◽  
Functional Regression ◽  
Ovarian Hormone ◽  
American Physiological Society ◽  
Hormone Production ◽  
Ovarian Follicular Development ◽  
Molecular Aspects ◽  
Reproductive Research

Many exciting developments in mammalian reproductive research with far-reaching consequences have occurred in recent years. To highlight the significance of some of these developments, a symposium on the theme of ovarian follicular development and regression was organized, and held at the joint meeting of the American Physiological Society and the Canadian Physiological Society, in Montréal in October 1988. Several leading researchers, from both Canada and the U.S.A., in various aspects of ovarian research, participated in the symposium. The topics of discussion ranged from the role of growth factors and novel intraovarian regulators during follicular development, to molecular aspects of ovarian hormone production, to the functional regression of the corpus luteum. It is expected that the following proceedings will serve as a reference for researchers concerned with reproductive endocrinology as well as providing a foundation for future collaborative study.

Role of Macrophages in Ovarian Follicular Development

1996 ◽  
Vol 46 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Hidetaka Katabuchi ◽  
Yukitoshi Fukumatsu ◽  
Masako Araki ◽  
Yoshito Suenaga ◽  
Hideyuki Ohtake ◽  
...  
Keyword(s):  
Follicular Development ◽  
Ovarian Follicular Development

Efficient generation of bone morphogenetic protein 15-edited Yorkshire pigs using CRISPR/Cas9†

2020 ◽  
Vol 103 (5) ◽  
pp. 1054-1068
Author(s):  
Xuan Shi ◽  
Tao Tang ◽  
Qiyuan Lin ◽  
Hongbo Liu ◽  
Yufeng Qin ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Transforming Growth Factor ◽  
Follicular Development ◽  
Female Fertility ◽  
Efficient Generation ◽  
Morphogenetic Protein ◽  
Yorkshire Pigs ◽  
Bone Morphogenetic Protein 15 ◽  
Ovarian Follicular Development

Abstract Bone morphogenetic protein 15 (BMP15), a member of the transforming growth factor beta superfamily, plays an essential role in ovarian follicular development in mono-ovulatory mammalian species. Studies using a biallelic knockout mouse model revealed that BMP15 potentially has just a minimal impact on female fertility and ovarian follicular development in polyovulatory species. In contrast, our previous study demonstrated that in vivo knockdown of BMP15 significantly affected porcine female fertility, as evidenced by the dysplastic ovaries containing significantly decreased numbers of follicles and an increased number of abnormal follicles. This finding implied that BMP15 plays an important role in the regulation of female fertility and ovarian follicular development in polyovulatory species. To further investigate the regulatory role of BMP15 in porcine ovarian and follicular development, here, we describe the efficient generation of BMP15-edited Yorkshire pigs using CRISPR/Cas9. Using artificial insemination experiments, we found that the biallelically edited gilts were all infertile, regardless of different genotypes. One monoallelically edited gilt #4 (Δ66 bp/WT) was fertile and could deliver offspring with a litter size comparable to that of wild-type gilts. Further analysis established that the infertility of biallelically edited gilts was caused by the arrest of follicular development at preantral stages, with formation of numerous structurally abnormal follicles, resulting in streaky ovaries and the absence of obvious estrous cycles. Our results strongly suggest that the role of BMP15 in nonrodent polyovulatory species may be as important as that in mono-ovulatory species.

scholarly journals CBX2 and the Ovary: Novel Insights into Regulatory Networks in Humans

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Ovarian Cancer ◽  
Granulosa Cells ◽  
Regulatory Networks ◽  
Polycystic Ovary ◽  
Follicular Development ◽  
Female Gonad ◽  
Ovary Syndrome ◽  
Interacting Protein ◽  
Human Ovaries

Background: Chromobox protein homolog 2 (CBX2) is a DNA-interacting protein present in humans in two isoforms, CBX2.1 and CBX2.2. Isoform-1 promotes testis development, butthe role of both variants in the female gonad pathway remains unknown. Methods: To understand its function in human ovaries, we evaluated expression of known female genes i.e.FOXL2, RSPO1 and WNT4 in human pre-granulosa cells after forced expression and RNA interference of CBX2 isoforms and vice versa. Results: The two isoforms appeared to be functionally distinct. CBX2.1 has proved to be a pro-male by enhancing SOX9, SF1 and androgen receptor (AR) expression, whereas CBX2.2 might be partly pro-female most likely via interaction with RSPO1 and the regulation of ovary developmental markers (i.e. OCT-4, AMH and ERβ). Conclusions: Both CBX2 isoforms might act as distinct regulatory agents protecting granulosa cells from uncontrolled growth and proliferation by adjusting WNT4 and RSPO1 signaling pathways, and participate to follicular development and fate by regulating the expression of SF1 and AR, thus potentially influencing fertility, menopause, ovarian cancer and perhaps polycystic ovary syndrome.

scholarly journals The role of tight junction proteins in ovarian follicular development and ovarian cancer

Reproduction ◽  
2018 ◽  
Vol 155 (4) ◽  
pp. R183-R198 ◽  
Author(s):  
Lingna Zhang ◽  
Tao Feng ◽  
Leon J Spicer
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Tight Junction ◽  
Protein Structures ◽  
Follicular Development ◽  
Current Evidence ◽  
Serum Factors ◽  
Cell Functions ◽  
Junction Protein ◽  
Ovarian Follicular Development

Tight junctions (TJ) are protein structures that control the transport of water, ions and macromolecules across cell layers. Functions of the transmembrane TJ protein, occluding (OCLN) and the cytoplasmic TJ proteins, tight junction protein 1 (TJP1; also known as zona occludens protein-1), cingulin (CGN) and claudins (CLDN) are reviewed, and current evidence of their role in the ovarian function is reviewed. Abundance ofOCLN,CLDNsandTJP1mRNA changed during follicular growth.In vitrotreatment with various growth factors known to affect ovarian folliculogenesis indicated thatCGN,OCLNandTJP1are hormonally regulated. The summarized studies indicate that expression of TJ proteins (i.e.,OCLN,CLDN,TJP1andCGN) changes with follicle size in a variety of vertebrate species but whether these changes in TJ proteins are increased or decreased depends on species and cell type. Evidence indicates that autocrine, paracrine and endocrine regulators, such as fibroblast growth factor-9, epidermal growth factor, androgens, tumor necrosis factor-α and glucocorticoids may modulate these TJ proteins. Additional evidence presented indicates that TJ proteins may be involved in ovarian cancer development in addition to normal follicular and luteal development. A model is proposed suggesting that hormonal downregulation of TJ proteins during ovarian follicular development could reduce barrier function (i.e., selective permeability of molecules between theca and granulosa cells) and allow for an increase in the volume of follicular fluid as well as allow additional serum factors into the follicle that may directly impact granulosa cell functions.

Role of Oocyte-derived Factors in Ovarian Follicular Development and Ovulation

2011 ◽  
Vol 28 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Koji Sugiura ◽  
Ryosuke Konuma ◽  
Kiyoshi Kano ◽  
Kunihiko Naito
Keyword(s):  
Follicular Development ◽  
Ovarian Follicular Development
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