The effect of starvation on obese mice

1981 ◽  
Vol 59 (4) ◽  
pp. 355-357 ◽  
Author(s):  
P. Hahn ◽  
J. P. Skala
Keyword(s):  
Fatty Acid ◽  
Plasma Levels ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Fatty Acid Synthetase ◽  
Brown Fat ◽  
Obese Group ◽  
Synthetase Activity ◽  
Obese Mice ◽  
Carnitine Acetyltransferase ◽  
Total Carnitine

Plasma levels of total and acylcarnitine and the activities of carnitine acetyltransferase (CAT) and carnitine, palmitoyltransferase (PCT) in liver and CAT in brown fat were determined in young obese (ob/ob) mice and their littermates during starvation. Plasma levels of acylcarnitine and β-hydroxybutyrate rose equally in both groups. Total carnitine levels, however, decreased in lean and rose in obese animals. Hepatic PCT and phosphoenolpyruvate carboxykinase activities rose more in lean than obese mice and brown fat CAT activity decreased in the obese group. Fatty acid synthetase activity decreased equally in the liver in obese mice and their lean littermates.

The Effects of Catecholamines, Glucagon, and Diet on Enzyme Activities in Brown Fat and Liver of the Rat

1974 ◽  
Vol 52 (9) ◽  
pp. 739-743 ◽  
Author(s):  
Peter Hahn ◽  
Lorne T. Kirby
Keyword(s):  
Body Weight ◽  
Fatty Acid ◽  
Malic Enzyme ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Fatty Acid Synthetase ◽  
High Carbohydrate Diet ◽  
Brown Fat ◽  
Carbohydrate Diet ◽  
High Carbohydrate ◽  
Cleavage Enzyme

The effects of a high carbohydrate diet fed to young rats for 24–48 h on phosphoenolpyruvate carboxykinase, malic enzyme, citrate-cleavage enzyme, and fatty acid synthetase could be overcome by injecting the animals with glucagon (1 mg/100 g body weight) or norepinephrine (20 μg/100 g body weight) four times a day. The same effect was achieved with 50 mg ephedrine added to the 24 h diet. The catecholamines were more effective in brown fat, whereas glucagon seemed somewhat more effective in the liver.

Regulation of Phosphoenolpyruvate Carboxykinase and Fatty Acid Synthetase in Brown Fat of Suckling Rats*

Endocrinology ◽  
1978 ◽  
Vol 103 (4) ◽  
pp. 1417-1424 ◽  
Author(s):  
PETER HAHN ◽  
DAVID SECCOMBE ◽  
LORNE KIRBY ◽  
JEAN GIRARD ◽  
R. ASSAN ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Fatty Acid Synthetase ◽  
Brown Fat ◽  
Suckling Rats

scholarly journals Fatty Acid Synthetase Activity in Mycobacterium phlei: Regulation by Polysaccharides

1971 ◽  
Vol 68 (1) ◽  
pp. 87-91 ◽  
Author(s):  
M. Ilton ◽  
A. W. Jevans ◽  
E. D. McCarthy ◽  
D. Vance ◽  
H. B. White ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthetase ◽  
Synthetase Activity ◽  
Mycobacterium Phlei ◽  
Fatty Acid Synthetase Activity

Évolution de la teneur en lipides de Leptosphaeria typhae en fonction de sa croissance et de sa reproduction sexuée : activité de synthèse et étude des lipides neutres et polaires

1985 ◽  
Vol 63 (12) ◽  
pp. 2460-2467
Author(s):  
Gérard Vidal
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acids ◽  
Lipid Content ◽  
Neutral Lipids ◽  
Fatty Acid Synthetase ◽  
Polar Lipids ◽  
Synthetase Activity ◽  
Lipid Turnover ◽  
Fatty Acid Synthetase Activity

When perithecia appear (on the 7th day of growth), the mycelial lipid content falls and the degree of fat insaturation increases; fatty acid synthetase activity greatly increases. Lipid turnover is therefore accelerated. Among neutral lipids, triglycerides constitute the largest pool and their proportion increases when perithecia appear. Free fatty acids also increase, confirming the lipid turnover's acceleration. Polar lipids especially disappear; the phosphatidylcholine/phosphatidylethanolamine ratio increases when the fungus ascosporulates.

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