Some Pharmacological Effects of Prodolic Acid, a New Anti-inflammatory Compound, Indicative of Inhibition of Prostaglandin Synthesis

1975 ◽  
Vol 53 (1) ◽  
pp. 186-189 ◽  
Author(s):  
R. Greenberg
Keyword(s):  
Electrical Stimulation ◽  
Guinea Pig ◽  
Portal Vein ◽  
Vas Deferens ◽  
Prostaglandin Synthesis ◽  
Pharmacological Effects ◽  
Prostaglandin Biosynthesis ◽  
Inhibition Of Prostaglandin Synthesis ◽  
Anti Inflammatory ◽  
Rabbit Vas Deferens

Prodolic acid, a new non-steroidal anti-inflammatory compound, inhibited bradykinin-induced bronchoconstriction but did not affect histamine-induced bronchoconstriction in the guinea pig. Prodolic acid potentiated the responses of the isolated rabbit vas deferens and portal vein to electrical stimulation without altering the response to noradrenaline. The potentiating effects of prodolic acid on the vas deferens were reversible but the potentiating effects in the portal vein were frequency-dependent. It is concluded that these effects of prodolic acid are probably related to its ability to inhibit prostaglandin biosynthesis.

scholarly journals The Beneficial Biological Properties of Salicylic Acid

2015 ◽  
Vol 32 (4) ◽  
pp. 259-265 ◽  
Author(s):  
Pavle Randjelović ◽  
Slavimir Veljković ◽  
Nenad Stojiljković ◽  
Dušan Sokolović ◽  
Ivan Ilić ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Well Being ◽  
Biological Properties ◽  
Vital Role ◽  
Prostaglandin Synthesis ◽  
Beneficial Effects ◽  
Inhibition Of Prostaglandin Synthesis ◽  
Anti Inflammatory ◽  
Antiinflammatory Effects

Summary Salicylic acid is a phytochemical with beneficial effects on human well-being. Salicylic acid is a phenolic compound and is present in various plants where it has a vital role in protection against pathogenic agents. Natural sources include fruits, vegetables and spices. The most famous and defined effect of salicylic acid is prostaglandin synthesis inhibition. Salicylic acid has antiinflammatory effects through suppression of transcription of genes for cyclooxygenase. Most of the pharmacological properties of salicylic acid can be contributed to the inhibition of prostaglandin synthesis. Also, it was discovered that salicylic acid has other in vivo cyclooxygenase-independent pathways. Since salicylic acid does not inhibit cyclooxygenase considerably, the anti-inflammatory effect is not a consequence of direct inhibition of cyclooxygenase activity. Because of its fundamental role, it was suggested that inhibition of nuclear factor kappa B by salicylic acid is one of the key anti-inflammatory mechanisms of action for salicylates. One of the most studied properties of salicylic acid is its antioxidative activity. Salicylic acid is a confirmed inhibitor of oxidative stress. Salicylic acid is capable of binding iron. This fact is significant for antioxidative effect of salicylic acid because iron has an important function in the course of lipid peroxidation.

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